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    Organs-on-chips as a platform for epigenetics discovery
    1.
    发明授权
    Organs-on-chips as a platform for epigenetics discovery 有权

    公开(公告)号：US12036548B2

    公开(公告)日：2024-07-16

    申请号：US16997509

    申请日：2020-08-19

    Applicant: EMULATE, INC.

    Inventor： Catherine Karalis ,  Ville Kujala

    IPC: B01L3/00 ,  C12M3/06 ,  C12Q1/6809 ,  G01N33/50 ,  C12M1/12

    CPC classification number: B01L3/5027 ,  C12M23/16 ,  C12Q1/6809 ,  G01N33/5023 ,  G01N33/5064 ,  G01N33/5091 ,  B01L2300/0819 ,  B01L2400/0487 ,  C12M25/02

    Abstract: The present invention relates to microfluidic fluidic devices, methods and systems for use in identifying epigenetic signatures in a range of sample types, e.g., cells established on a “chip” (including but not limited to single cell samples, cell populations, C cell layers and whole tissues, such as a biopsy), immune cells, cfDNA, exosomes, and the like. More specifically, in some embodiments, a microfluidic chip containing a sample is contacted with a test compound (e.g. DNA altering test compound, an RNA expression altering test compound, etc.) for use in providing a diagnostic epigenetic signature for that type of sample (or cell type) exposed to that specific test compound. In some embodiments, after contact with a test compound, effluent fluids (e.g. fluids exiting the “chip” that contacted the cells) are derived for testing as a “virtual blood draw.” In some embodiments, epigenetic signatures include (but are not limited to) identifying specific combinations of modifications of chromosomes and specific modifications of DNA.

    ORGANS-ON-CHIPS AS A PLATFORM FOR EPIGENETICS DISCOVERY
    2.
    发明公开
    ORGANS-ON-CHIPS AS A PLATFORM FOR EPIGENETICS DISCOVERY 审中-公开

    公开(公告)号：US20240299932A1

    公开(公告)日：2024-09-12

    申请号：US18659536

    申请日：2024-05-09

    Applicant: EMULATE, INC.

    Inventor： Catherine Karalis ,  Ville Kujala

    IPC: B01L3/00 ,  C12M1/12 ,  C12M3/06 ,  C12Q1/6809 ,  G01N33/50

    CPC classification number: B01L3/5027 ,  C12M23/16 ,  C12Q1/6809 ,  G01N33/5023 ,  G01N33/5064 ,  G01N33/5091 ,  B01L2300/0819 ,  B01L2400/0487 ,  C12M25/02

    Abstract: The present invention relates to microfluidic fluidic devices, methods and systems for use in identifying epigenetic signatures in a range of sample types, e.g., cells established on a “chip” (including but not limited to single cell samples, cell populations, cell layers and whole tissues, such as a biopsy), immune cells, cfDNA, exosomes, and the like. More specifically, in some embodiments, a microfluidic chip containing a sample is contacted with a test compound (e.g. DNA altering test compound, an RNA expression altering test compound, etc.) for use in providing a diagnostic epigenetic signature for that type of sample (or cell type) exposed to that specific test compound. In some embodiments, after contact with a test compound, effluent fluids (e.g. fluids exiting the “chip” that contacted the cells) are derived for testing as a “virtual blood draw.” In some embodiments, epigenetic signatures include (but are not limited to) identifying specific combinations of modifications of chromosomes and specific modifications of DNA.

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