公开(公告)号：US09731289B2

公开(公告)日：2017-08-15

申请号：US14653727

申请日：2013-12-18

申请人： EUROPEAN MOLECULAR BIOLOGY LABORATORY

发明人： Florent Cipriani ,  Jose Antonio Marquez

IPC分类号： B01L3/06 ,  B01L3/00 ,  G01N1/04 ,  G01N35/10 ,  G01N35/00 ,  G01N35/02 ,  C12M1/32 ,  C12M1/34 ,  C12M1/36 ,  G01N35/04

CPC分类号： B01L3/06 ,  B01L3/5085 ,  B01L3/50853 ,  B01L2200/025 ,  B01L2200/10 ,  B01L2300/044 ,  B01L2300/0893 ,  B01L2300/12 ,  B01L2300/16 ,  C12M23/12 ,  C12M41/36 ,  C12M41/48 ,  G01N1/04 ,  G01N35/0099 ,  G01N35/028 ,  G01N35/10 ,  G01N35/1079 ,  G01N2001/045 ,  G01N2035/0403

摘要： The present invention relates to the automation of incubation, processing, harvesting and analysis of samples in a multi-cell plate. In particular, a multi-cell plate including a body with a plurality of cells is presented. Furthermore, an automated crystal harvesting and processing system with a cutting unit, a fluid unit and a removing device is presented. The multi-cell plate further includes a sealing film for sealing the cells on a first side of the body and a sample film for sealing the cells on a second side of the body. The sample film is adapted for accommodating a biological material for crystallization. Furthermore, the sample film is of a thickness and composition that makes it compatible with x-rays and also with laser ablation. The design of the multi-cell plate and the automated crystal harvesting and processing system allows for several steps of incubation, processing, harvesting and analysis of the samples to be automated.