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    Hanging droplet plate
    1.
    发明授权
    Hanging droplet plate 有权
    悬挂液滴板

    公开(公告)号：US09267933B2

    公开(公告)日：2016-02-23

    申请号：US14002269

    申请日：2012-03-02

    Applicant: Christof Fattinger ,  Patrick Iaiza ,  Tom Kissling ,  Dieter Voegelin ,  Thomas Zumstein ,  Claudia Mcginnis

    Inventor： Christof Fattinger ,  Patrick Iaiza ,  Tom Kissling ,  Dieter Voegelin ,  Thomas Zumstein ,  Claudia Mcginnis

    IPC: G01N33/50 ,  C12M3/00 ,  B01L3/00 ,  C12M1/12 ,  B01L3/06

    CPC classification number: G01N33/5014 ,  B01L3/06 ,  B01L3/50853 ,  B01L3/5088 ,  B01L2300/042 ,  B01L2300/047 ,  B01L2300/0829 ,  C12M23/12 ,  C12M25/01

    Abstract: A hanging droplet plate (1) comprises a predetermined number of droplet compartments (10) each being capable of receiving a droplet of a liquid. The respective droplet compartment (10) comprises a circumferential microfluidic wetting barrier (102) which is arranged to surround a respective cavity (100) and which prevents a droplet from spreading beyond the microfluidic wetting barrier (102). The respective compartment (10) comprises a closed bottom (101) and at least one additional circumferential microfluidic wetting barrier (104), each additional circumferential microfluidic wetting barrier (104) which is arranged to surround a preceding circumferential microfluidic wetting barrier (102). A wettable area (103) is arranged between two adjacently arranged microfluidic wetting barriers (102, 104).

    Abstract translation: 悬挂的液滴板（1）包括预定数量的液滴隔室（10），每个液滴隔室（10）能够接收液滴。 相应的液滴隔室（10）包括周向微流体润湿屏障（102），其被布置成围绕相应的空腔（100）并且防止液滴扩散到微流体润湿屏障（102）之外。 相应的隔室（10）包括封闭的底部（101）和至少一个附加的周向微流体润湿屏障（104），每个附加的周向微流体润湿屏障（104）被布置成围绕先前的周向微流体润湿屏障（102）。 可湿性区域（103）布置在两个相邻布置的微流体润湿屏障（102,104）之间。

    Method For Obtaining And Analyzing Solids, Preferably Crystals
    3.
    发明申请
    Method For Obtaining And Analyzing Solids, Preferably Crystals 审中-公开
    获得和分析固体的方法，优选晶体

    公开(公告)号：US20090205412A1

    公开(公告)日：2009-08-20

    申请号：US12304800

    申请日：2006-07-17

    Applicant: Danny Dirk Pieter Willem Stam ,  Adrianus Hendricus Joseph Franciscus de Keijzer ,  Emilio Rene Bodenstaff ,  Mimoun Lamkadmi

    Inventor： Danny Dirk Pieter Willem Stam ,  Adrianus Hendricus Joseph Franciscus de Keijzer ,  Emilio Rene Bodenstaff ,  Mimoun Lamkadmi

    IPC: G01N1/28 ,  B01L3/06

    CPC classification number: G01N1/38 ,  B01J19/0046 ,  B01J2219/00317 ,  B01J2219/00333 ,  B01J2219/00423 ,  B01J2219/00585 ,  B01J2219/00599 ,  B01J2219/00756 ,  B01L3/06 ,  B01L3/50255 ,  B01L3/50853 ,  B01L2300/042 ,  B01L2300/0829 ,  G01N1/44 ,  G01N23/20 ,  G01N2223/056 ,  G01N2223/307 ,  G01N2223/602

    Abstract: The present invention pertains to a method for obtaining and analyzing solids, preferably crystals, which method comprises the following steps: providing a well plate, the well plate comprising a plurality of wells, each of the wells having a depth and an open upper end and each of the wells being provided with a filter having pores, which filter is arranged at a distance below the open upper end, each of the wells having an upper inner wall part above the filter that has a fluid contact surface and each filter having a top filter surface, at least both the fluid contact surface of the well and the top filter surface being of a material that is at least substantially inert for organic and/or aqueous solvents and/or mixtures of organic and aqueous solvents, providing one or more substances and one or more solvents in at least one of the wells of the well plate, applying conditions to dissolve the one or more substances in the one or more solvents; applying conditions for crystallizing at least a part of the substance so that solids are formed in the at least one well, substantially removing the part of the substance that remains in solution, thereby leaving the solids, preferably crystals, that were formed from the substance in the well of the well plate in which they were formed, performing further investigation of the solids, preferably crystals in the well of the well plate where they were formed.

    Abstract translation: 本发明涉及一种获得和分析固体，优选晶体的方法，该方法包括以下步骤：提供井板，井板包括多个井，每个井具有深度和敞开的上端， 每个井都设置有具有孔的过滤器，该过滤器布置在开口上端下方的距离处，每个井具有在过滤器上方的上内壁部分，其具有流体接触表面，并且每个过滤器具有顶部 过滤器表面，井的至少两个流体接触表面和顶部过滤器表面是对于有机和/或水性溶剂至少基本上惰性的材料和/或有机和水性溶剂的混合物，提供一种或多种物质 以及孔板的至少一个孔中的一种或多种溶剂，施加条件以溶解所述一种或多种溶剂中的一种或多种物质; 施加用于使至少一部分物质结晶的条件，使得在至少一个孔中形成固体，基本上除去残留在溶液中的物质的一部分，从而将由物质形成的固体，优选晶体留下 它们形成的井板的孔，进一步研究固体，优选在其形成的井板的井中的晶体。

    Crystal forming devices and systems and methods for using the same
    5.
    发明申请
    Crystal forming devices and systems and methods for using the same 有权
    晶体形成装置及其使用方法

    公开(公告)号：US20050201901A1

    公开(公告)日：2005-09-15

    申请号：US11043895

    申请日：2005-01-25

    Applicant: Robert Grossman ,  Marc Unger ,  Phillip Lam ,  Hou-Pu Chou ,  Jake Kimball ,  Martin Pieprzyk

    Inventor： Robert Grossman ,  Marc Unger ,  Phillip Lam ,  Hou-Pu Chou ,  Jake Kimball ,  Martin Pieprzyk

    IPC: B01J19/00 ,  B01L3/00 ,  B01L3/06 ,  B01L9/00 ,  B01L99/00 ,  C30B7/00 ,  C30B29/58

    CPC classification number: C12Q1/68 ,  B01L3/0293 ,  B01L3/06 ,  B01L3/5025 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L3/5635 ,  B01L3/565 ,  B01L9/527 ,  B01L2200/027 ,  B01L2200/0605 ,  B01L2300/0816 ,  B01L2300/14 ,  B01L2400/0487 ,  B01L2400/0655 ,  C30B7/00 ,  C30B29/58 ,  Y10T436/11

    Abstract: The present invention provides for microfluidic devices and methods for their use. The invention further provides for apparatus and systems for using the microfluidic devices, analyze reactions carried out in the microfluidic devices, and systems to generate, store, organize, and analyze data generated from using the microfluidic devices. The invention further provides methods of using and making microfluidic systems and devices which, in some embodiments, are useful for crystal formation. In one embodiment, an apparatus includes a platen having a platen face with one or more fluid ports therein. The fluid ports spatially correspond to one or more wells on a surface of the microfluidic device. A platform for holding the microfluidic device relative to the platen is included, and a platen actuator for urging the platen against the microfluidic device so that at least one of the fluid ports of the platen is urged against one of the wells to form a pressure chamber comprising the well and the port, so that when pressurized fluid is introduced or removed into or from the pressure chamber through one of the ports, fluid pressure is changed therein.

    Abstract translation: 本发明提供了微流体装置及其使用方法。 本发明还提供了用于使用微流体装置的装置和系统，分析在微流体装置中进行的反应，以及用于生成，存储，组织和分析使用微流体装置产生的数据的系统。 本发明还提供了使用和制造微流体系统和装置的方法，在一些实施方案中，它们可用于晶体形成。 在一个实施例中，一种装置包括具有其中具有一个或多个流体端口的压板面的压板。 流体端口在空间上对应于微流体装置表面上的一个或多个孔。 包括用于相对于压板保持微流体装置的平台，以及用于将压板压靠在微流体装置上的压板致动器，使得压板的至少一个流体端口被推压到一个井中以形成压力室 包括井和端口，使得当压力流体通过其中一个端口被引入或从压力室移除时，流体压力在其中改变。

    Vapor equilibration tray for growing protein crystals
    8.
    发明授权
    Vapor equilibration tray for growing protein crystals 失效
    用于生长蛋白质晶体的蒸气平衡盘

    公开(公告)号：US5419278A

    公开(公告)日：1995-05-30

    申请号：US249277

    申请日：1994-05-25

    Applicant: Daniel C. Carter

    Inventor： Daniel C. Carter

    IPC: B01L3/00 ,  B01L3/06 ,  C30B7/00 ,  C30B35/00

    CPC classification number: B01L3/06 ,  B01L3/5085 ,  C30B29/58 ,  C30B7/00 ,  Y10S117/901 ,  Y10T117/1024

    Abstract: In accordance with the present invention, a vapor equilibrium apparatus for growing and screening suitable protein crystals is provided which consists of a plastic tray having a plurality of roughly cylindrical chambers that act as reservoirs for vapor equilibrating solutions and include a plurality of rib members having flattened upper ends recessed from the top of the chamber which form retaining levels wherein glass cover slips can be retained horizontally across the chambers in order to carry out the vapor equilibrating process. The upper ends can also be formed in a step-shaped fashion so as to provide multiple retaining levels of differing inner diameters which can retain glass cover slips of different sizes in the same chamber. The crystal growth tray of the invention is particularly advantageous in that it can be used in a variety of different methods for growing crystals using vapor diffusion or equilibration, and the device is sealable with clear plastic tape which avoids the problems associated with the prior use of silicon grease or oil. In addition, the tray of the invention allows for easy visual inspection and rapid removal of the crystals, and is highly effective in allowing the growth of large, high-quality crystals whose structure can be determined using state-of-the-art high resolution X-ray crystallography.

    Abstract translation: 根据本发明，提供了一种用于生长和筛选合适的蛋白质晶体的蒸汽平衡装置，其由具有多个大致圆柱形的室的塑料托盘组成，其作为用于蒸气平衡溶液的储存器，并且包括具有扁平的多个肋构件 从腔室的顶部凹陷的上端形成保持水平，其中玻璃盖滑动件可以水平地保持在腔室中，以便执行蒸汽平衡过程。 上端还可以以阶梯形式形成，以便提供不同内径的多个保持水平，其可以在相同的室中保持不同尺寸的玻璃盖滑动。 本发明的晶体生长托盘特别有利的是，它可以用于使用蒸气扩散或平衡来生长晶体的各种不同方法，并且该装置可用透明塑料带密封，这避免了与先前使用的 硅油或油。 此外，本发明的托盘允许容易地目视检查和快速去除晶体，并且在允许生长大型高质量晶体的情况下非常有效，其结构可以使用最先进的高分辨率 X射线晶体学。

    Protein crystal growth tray assembly
    9.
    发明授权
    Protein crystal growth tray assembly 失效
    蛋白质晶体生长盘组装

    公开(公告)号：US5130105A

    公开(公告)日：1992-07-14

    申请号：US601954

    申请日：1990-10-23

    Applicant: Daniel C. Carter ,  Teresa Y. Miller

    Inventor： Daniel C. Carter ,  Teresa Y. Miller

    IPC: B01D9/00 ,  B01L3/00 ,  B01L3/06 ,  C30B7/00 ,  C30B30/08

    CPC classification number: C30B30/08 ,  B01D9/00 ,  B01L3/06 ,  B01L3/5025 ,  C30B29/58 ,  C30B7/00 ,  Y10S117/901 ,  Y10T117/1092

    Abstract: A protein crystal growth tray assembly includes a tray that has a plurality of individual crystal growth chambers. Each chamber has a movable pedestal which carries a protein crystal growth compartment at an upper end. The several pedestals for each tray assembly are ganged together for concurrent movement so that the solutions in the various pedestal growth compartments can be separated from the solutions in the tray's growth chambers until the experiment is to be activated.

    Abstract translation: 蛋白质晶体生长托盘组件包括具有多个单独晶体生长室的托盘。 每个室具有可移动的底座，其在上端携带蛋白质晶体生长室。 每个托盘组件的几个基座被联合在一起用于并行运动，使得各个基座生长室中的溶液可以与托盘的生长室中的溶液分离直到实验被激活。

    Process, cell and device for crystal growth, particularly for space vessel
    10.
    发明授权
    Process, cell and device for crystal growth, particularly for space vessel 失效
    用于晶体生长的工艺，电池和器件，特别是用于太空船

    公开(公告)号：US4917707A

    公开(公告)日：1990-04-17

    申请号：US193650

    申请日：1988-03-30

    Applicant: Manuel P. Claramonte ,  Guy M. Bonnet ,  Jean-Claude Auffret

    Inventor： Manuel P. Claramonte ,  Guy M. Bonnet ,  Jean-Claude Auffret

    IPC: C30B7/14 ,  B01L3/06 ,  C30B7/00 ,  C30B29/58

    CPC classification number: C30B7/00 ,  C30B29/58 ,  B01L3/06 ,  Y10T117/1024 ,  Y10T117/1092

    Abstract: Process of crystal growth by diffusion, particularly intended to be carried out on board a space vessel and according to which a substance (5) to be crystallized, contained in a crucible (4), is brought into presence with a precipitating agent (9) through a diffusion wall (6) obturating said crucible. According to the invention:in a first recipient (1) is arranged said crucible (4) containing the substance to be crystallized and obturated by said wall;said first recipient (1) is obturated by a stopper (3) of porous material;in a second recipient (12) is arranged a porous body (19);said first and second recipients are brought together so that said porous body and said stopper of porous material are in contact with each other; andsaid precipitating agent is injected into said porous body (19) of said second recipient (12) through (15).

    Abstract translation: PCT No.PCT / FR87 / 00386 Sec。 371日期1988年3月30日 102（e）1988年3月30日PCT PCT 1987年10月8日PCT公布。 出版物WO88 / 02794 日期：1988年4月21日。通过扩散进行晶体生长的过程，特别是要在空间容器上进行，并且将含有坩埚（4）中待结晶的物质（5） 与沉淀剂（9）通过堵塞所述坩埚的扩散壁（6）。 根据本发明：在第一接收器（1）中，所述坩埚（4）布置成包含要被结晶并被所述壁堵塞的物质; 所述第一容器（1）被多孔材料的塞子（3）封闭; 在第二接收器（12）中布置有多孔体（19）; 所述第一和第二接收器被接合在一起，使得所述多孔体和多孔材料的所述塞子彼此接触; 并且所述沉淀剂通过（15）注入所述第二容器（12）的所述多孔体（19）中。

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