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公开(公告)号：US20190010527A1
公开(公告)日：2019-01-10
申请号：US16031492
申请日：2018-07-10
Applicant: University of Copenhagen , Danmarks Tekniske Universitet , Evolva SA
Inventor： Björn Hamberger , Birger Lindberg Møller , Eirini Pateraki , Johan Andersen-Ranberg , Niels Bjerg Jensen
Abstract: The invention described materials and methods for producing oxidised 13R-MO, such as forskolin. In particular, the invention describes P450s involved in oxidation of 13R-MO including CYP76AH8, CYP76AH11, CYP76AH15, CYP76AH17, CYP71D381 and CYP76AH9. Host organisms expressing one or more of these P450s are useful in the production of oxidized 13R-MO.
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公开(公告)号：US10053717B2
公开(公告)日：2018-08-21
申请号：US15110795
申请日：2015-01-30
Applicant: University of Copenhagen , Danmarks Tekniske Universitet , Evolva SA
Inventor： Björn Hamberger , Birger Lindberg Møller , Eirini Pateraki , Johan Andersen-Ranberg , Niels Bjerg Jensen
CPC classification number: C12P17/06 , C12N9/0071 , C12P5/007 , C12Y114/14001
Abstract: The invention described materials and methods for producing oxidized 13R-MO, such as forskolin. In particular, the invention describes P450s involved in oxidation of 13R-MO including CYP76AH8, CYP76AH11, CYP76AH15, CYP76AH17, CYP71D381 and CYP76AH9. Host organisms expressing one or more of these P450s are useful in the production of oxidized 13R-MO.
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Patent Agency Ranking
公开(公告)号：US10240173B2
公开(公告)日：2019-03-26
申请号：US16031492
申请日：2018-07-10
Applicant: University of Copenhagen , Danmarks Tekniske Universitet , Evolva SA
Inventor： Björn Hamberger , Birger Lindberg Møller , Eirini Pateraki , Johan Andersen-Ranberg , Niels Bjerg Jensen
Abstract: The invention described materials and methods for producing oxidized 13R-MO, such as forskolin. In particular, the invention describes P450s involved in oxidation of 13R-MO including CYP76AH8, CYP76AH11, CYP76AH15, CYP76AH17, CYP71D381 and CYP76AH9. Host organisms expressing one or more of these P450s are useful in the production of oxidized 13R-MO.
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公开(公告)号：US20180112243A1
公开(公告)日：2018-04-26
申请号：US15565956
申请日：2016-04-14
Applicant: EVOLVA SA , University of Copenhagen
Inventor： Björn Hamberger , Johan Andersen-Ranberg , Niels Bjerg Jensen , Eirini Pateraki , Birger Lindberg Møller
CPC classification number: C12P17/06 , C12N9/1029 , C12P5/007
Abstract: The invention relates to recombinant microorganisms and methods for producing acetylated diterpenes, including oxidized and/or acetylated oxidized diterpenes such as forskolin.
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公开(公告)号：US10760062B2
公开(公告)日：2020-09-01
申请号：US15579415
申请日：2016-06-06
Applicant: EVOLVA SA
Inventor： Michael Naesby , Ernesto Simón Vecilla , Michael Eichenberger , Beata Joanna Lehka , Walden Emil Bjørn-Yoshimoto , Niels Bjerg Jensen
Abstract: Provided herein are methods and compositions for producing phenylpropanoid derivatives, such as chalcones and stilbenes, and dihydrophenylpropanoid derivatives, such as dihydrochalcones and dihydrostilbenes, in microorganisms. In particular, the disclosure provides recombinant microorganisms and methods of use thereof for producing phenylpropanoid derivative compounds and dihydrophenylpropanoid derivative compounds.
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公开(公告)号：US10208326B2
公开(公告)日：2019-02-19
申请号：US15523868
申请日：2015-11-13
Applicant: Evolva SA
Inventor： Niels Bjerg Jensen
IPC: C12P17/06 , C12N9/88 , C12P5/00 , C12P17/04 , C07D307/92 , C07D311/92 , C12N9/10
Abstract: The invention relates to recombinant microorganisms and methods for producing manoyl oxide.
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公开(公告)号：US20170314049A1
公开(公告)日：2017-11-02
申请号：US15523868
申请日：2015-11-13
Applicant: Evolva SA
Inventor： Niels Bjerg Jensen
IPC: C12P17/06 , C12P17/04 , C12N9/10 , C07D311/92 , C07D307/92 , C12N9/88
CPC classification number: C12P17/06 , C07D307/92 , C07D311/92 , C12N9/1085 , C12N9/88 , C12P5/007 , C12P17/04 , C12Y205/01029 , C12Y402/03 , C12Y402/03025
Abstract: The invention relates to recombinant microorganisms and methods for producing manoyl oxide.
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