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公开(公告)号：US06428768B1
公开(公告)日：2002-08-06
申请号：US08442252
申请日：1995-05-15
IPC分类号： A61K5100
CPC分类号： A61K51/1282 , A61K2121/00
摘要： The present invention relates to the stabilization of radiopharmaceutical preparations and to the stabilization of components of radiopharmaceutical kits. In particular, the present invention relates to stabilization of lyophilized components of radiopharmaceutical kits by the addition of a cyclic oligosaccharide, such as, a modified or unmodified cyclodextrin, to the kit.
摘要翻译： 本发明涉及放射性药物制剂的稳定化和放射性药物试剂盒组分的稳定化。 特别地，本发明涉及通过向试剂盒中加入环状寡糖例如改性或未改性的环糊精来稳定放射性药物试剂盒的冻干组分。
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公开(公告)号：US5300280A
公开(公告)日：1994-04-05
申请号：US836644
申请日：1992-02-14
IPC分类号： A61K51/00 , A61K51/12 , A61K43/00 , A61K31/715 , A61K49/02
CPC分类号： A61K51/1282 , A61K2121/00
摘要： The present invention relates to the stabilization of radiopharmaceutical preparations and to the stabilization of components of radiopharmaceutical kits. In particular, the present invention relates to stabilization of lyophilized components of radiopharmaceutical kits by the addition of a cyclic oligosaccharide, such as, a modified or unmodified cyclodextrin, to the kit.
摘要翻译： 本发明涉及放射性药物制剂的稳定化和放射性药物试剂盒组分的稳定化。 特别地，本发明涉及通过向试剂盒中加入环状寡糖例如改性或未改性的环糊精来稳定放射性药物试剂盒的冻干组分。
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公开(公告)号：US5609850A
公开(公告)日：1997-03-11
申请号：US518124
申请日：1995-08-22
申请人： Edward A. Deutsch , Karen F. Deutsch , William P. Cacheris , William H. Ralston , David H. White , Dennis L. Nosco , Robert G. Wolfangel , Janet B. Wilking , Linda Meeh , Steven R. Woulfe
发明人： Edward A. Deutsch , Karen F. Deutsch , William P. Cacheris , William H. Ralston , David H. White , Dennis L. Nosco , Robert G. Wolfangel , Janet B. Wilking , Linda Meeh , Steven R. Woulfe
IPC分类号： A61B5/055 , A61B19/00 , A61K47/48 , A61K49/00 , A61K49/04 , A61K49/18 , A61K49/22 , C01B25/32 , C01G28/00 , C01G31/00 , C01G45/00 , C07F9/38 , A61B8/13
CPC分类号： A61K49/225 , A61K47/48861 , A61K49/1818 , A61K49/183 , A61K49/1842 , A61K49/1881 , A61B2090/3925 , A61B2090/3954 , A61B90/39 , Y10S977/722 , Y10S977/775 , Y10S977/881 , Y10S977/91 , Y10S977/927 , Y10S977/928 , Y10S977/929 , Y10S977/93 , Y10T436/24
摘要： Treated apatite particles are disclosed for enhancing radical diagnostic imaging such as magnetic resonance imaging ("MRI"), magnetic resonance spectroscopy ("MRS"), magnetic resonance spectroscopy imaging ("MRSI"), X-ray diagnostic imaging, and ultrasound imaging. Novel coating and manufacturing techniques are disclosed to control particle size and particle aggregation resulting in compositions for organ specific imaging of the liver, spleen, gastrointestinal tract, or tissue disease states is obtained. Depending on the diagnostic imaging technique, apatite particles are treated to be paramagnetic, radiopaque, or echogenic. The apatite particles may also be fluorinated to form stable fluoroapatite compositions useful for .sup.19 F imaging. Also disclosed are diagnostic compositions and methods of performing medical diagnostic procedures which involve administering to a warm-blooded animal a diagnostically effective amount of the abovedescribed apatite particles and then performing the medical diagnostic procedure.
摘要翻译： 公开了处理的磷灰石颗粒，用于增强诸如磁共振成像（“MRI”），磁共振光谱（“MRS”），磁共振光谱成像（“MRSI”），X射线诊断成像和超声成像的基础诊断成像。 公开了新颖的涂层和制造技术来控制颗粒尺寸和颗粒聚集，从而获得用于肝脏，脾脏，胃肠道或组织疾病状态的器官特异性成像的组合物。 根据诊断成像技术，磷灰石颗粒被治疗为顺磁性，不透射线或回声。 磷灰石颗粒也可以被氟化以形成用于19F成像的稳定的氟磷灰石组合物。 还公开了执行医学诊断程序的诊断组合物和方法，其涉及向温血动物施用诊断有效量的上述磷灰石颗粒，然后执行医学诊断程序。
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4.发明授权Treated calcium/oxyanion-containing particles for medical diagnostic imaging 失效用于医学诊断成像的经处理的含钙/含氧阴离子颗粒
公开(公告)号：US5595724A
公开(公告)日：1997-01-21
申请号：US373152
申请日：1995-01-13
申请人： Edward A. Deutsch , Karen F. Deutsch , Dennis L. Nosco , William H. Ralston , David H. White , Janet B. Wilking , Robert G. Wolfangel , Steven R. Woulfe , William P. Cacheris , Linda Meeh
发明人： Edward A. Deutsch , Karen F. Deutsch , Dennis L. Nosco , William H. Ralston , David H. White , Janet B. Wilking , Robert G. Wolfangel , Steven R. Woulfe , William P. Cacheris , Linda Meeh
IPC分类号： A61B5/055 , A61B8/00 , A61B19/00 , A61K47/48 , A61K49/00 , A61K49/04 , A61K49/18 , A61K49/22 , A61K51/00 , A61K51/12 , C01B25/32 , C01G28/00 , C01G31/00 , C01G45/00 , C07F9/38 , G01R33/28
CPC分类号： A61K51/1241 , A61K47/48861 , A61K49/0414 , A61K49/1818 , A61K49/1842 , A61K49/1878 , A61K49/1881 , A61K49/225 , A61B2090/3925 , A61B2090/3954 , A61B90/39 , G01R33/281 , Y10S977/722 , Y10S977/881 , Y10S977/927 , Y10S977/928 , Y10S977/929 , Y10S977/93 , Y10T436/24
摘要： Treated calcium/oxyanion-containing particles are disclosed for enhancing medical diagnostic imaging such as magnetic resonance imaging ("MRI"), magnetic resonance spectroscopy ("MRS"), magnetic resonance spectroscopy imaging ("MRSI"), X-ray diagnostic imaging, and ultrasound imaging. Novel coating and manufacturing techniques are disclosed to control particle size and particle aggregation resulting in compositions for organ specific imaging of the liver, spleen, or tissue disease states is obtained. Depending on the diagnostic imaging technique, calcium/oxyanion-containing particles are treated to be paramagnetic, radiopaque, or echogenic. Also disclosed are diagnostic compositions and methods of performing medical diagnostic procedures which involve administering to a warm-blooded animal a diagnostically effective amount of the above-described particles and then performing the medical diagnostic procedure.
摘要翻译： 公开了用于增强医学诊断成像例如磁共振成像（“MRI”），磁共振光谱（“MRS”），磁共振光谱成像（“MRSI”），X射线诊断成像， 和超声成像。 公开了新颖的涂层和制造技术来控制颗粒尺寸和颗粒聚集，从而获得用于肝脏，脾脏或组织疾病状态的器官特异性成像的组合物。 根据诊断成像技术，含钙/含氧阴离子的颗粒被处理为顺磁性，不透射线的或回声的。 还公开了执行医学诊断程序的诊断组合物和方法，其涉及向温血动物施用诊断有效量的上述颗粒，然后进行医学诊断程序。
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公开(公告)号：US5344640A
公开(公告)日：1994-09-06
申请号：US948540
申请日：1992-09-22
申请人： Edward A. Deutsch , Karen F. Deutsch , William P. Cacheris , William H. Ralston , David H. White , Dennis L. Nosco , Robert G. Wolfangel , Janet B. Wilking , Linda Meeh , Steven R. Woulfe
发明人： Edward A. Deutsch , Karen F. Deutsch , William P. Cacheris , William H. Ralston , David H. White , Dennis L. Nosco , Robert G. Wolfangel , Janet B. Wilking , Linda Meeh , Steven R. Woulfe
IPC分类号： A61B5/055 , A61B19/00 , A61K47/48 , A61K49/00 , A61K49/04 , A61K49/18 , A61K49/22 , C01B25/32 , C01G28/00 , C01G31/00 , C01G45/00 , C07F9/38
CPC分类号： A61K49/225 , A61K47/48861 , A61K49/1818 , A61K49/183 , A61K49/1842 , A61K49/1881 , A61B2090/3925 , A61B2090/3954 , A61B90/39 , Y10S977/722 , Y10S977/775 , Y10S977/881 , Y10S977/91 , Y10S977/927 , Y10S977/928 , Y10S977/929 , Y10S977/93 , Y10T436/24
摘要： Treated apatite particles are disclosed for enhancing medical diagnostic imaging such as magnetic resonance imaging ("MRI"), magnetic resonance spectroscopy ("MRS"), magnetic resonance spectroscopy imaging ("MRSI"), X-ray diagnostic imaging, and ultrasound imaging. Novel coating and manufacturing techniques are disclosed to control particle size and particle aggregation resulting in compositions for organ specific imaging of the liver, spleen, gastrointestinal tract, or tissue disease states is obtained. Depending on the diagnostic imaging technique, apatite particles are treated to be paramagnetic, radiopaque, or echogenic. The apatite particles may also be fluorinated to form stable fluoroapatite compositions useful for .sup.19 F imaging. Also disclosed are diagnostic compositions and methods of performing medical diagnostic procedures which involve administering to a warm-blooded animal a diagnostically effective amount of the above-described apatite particles and then performing the medical diagnostic procedure.
摘要翻译： 公开了治疗磷灰石颗粒用于增强诸如磁共振成像（“MRI”），磁共振光谱（“MRS”），磁共振光谱成像（“MRSI”），X射线诊断成像和超声成像的医学诊断成像。 公开了新颖的涂层和制造技术来控制颗粒尺寸和颗粒聚集，从而获得用于肝脏，脾脏，胃肠道或组织疾病状态的器官特异性成像的组合物。 根据诊断成像技术，磷灰石颗粒被治疗为顺磁性，不透射线或回声。 磷灰石颗粒也可以被氟化以形成用于19F成像的稳定的氟磷灰石组合物。 还公开了执行医学诊断程序的诊断组合物和方法，其涉及向温血动物施用诊断有效量的上述磷灰石颗粒，然后进行医学诊断程序。
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公开(公告)号：US5468465A
公开(公告)日：1995-11-21
申请号：US271921
申请日：1994-07-06
申请人： Edward A. Deutsch , Karen F. Deutsch , William P. Cacheris , William H. Ralston , David H. White , Dennis L. Nosco , Robert G. Wolfangel , Janet B. Wilking , Linda Meeh , Steven R. Woulfe
发明人： Edward A. Deutsch , Karen F. Deutsch , William P. Cacheris , William H. Ralston , David H. White , Dennis L. Nosco , Robert G. Wolfangel , Janet B. Wilking , Linda Meeh , Steven R. Woulfe
IPC分类号： A61B5/055 , A61B19/00 , A61K47/48 , A61K49/00 , A61K49/04 , A61K49/18 , A61K49/22 , C01B25/32 , C01G28/00 , C01G31/00 , C01G45/00 , C07F9/38
CPC分类号： A61K49/225 , A61K47/48861 , A61K49/1818 , A61K49/183 , A61K49/1842 , A61K49/1881 , A61B2090/3925 , A61B2090/3954 , A61B90/39 , Y10S977/722 , Y10S977/775 , Y10S977/881 , Y10S977/91 , Y10S977/927 , Y10S977/928 , Y10S977/929 , Y10S977/93 , Y10T436/24
摘要： Treated apatite particles are disclosed for enhancing medical diagnostic imaging such as magnetic resonance imaging ("MRI"), magnetic resonance spectroscopy ("MRS"), magnetic resonance spectroscopy imaging (37 MRSI"), X-ray diagnostic imaging, and ultrasound imaging. Novel coating and manufacturing techniques are disclosed to control particle size and particle aggregation resulting in compositions for organ specific imaging of the liver, spleen, gastrointestinal tract, or tissue disease states is obtained. Depending on the diagnostic imaging technique, apatite particles are treated to be paramagnetic, radiopaque, or echogenic. The apatite particles may also be fluorinated to form stable fluoroapatite compositions useful for .sup.19 F imaging. Also disclosed are diagnostic compositions and methods of performing medical diagnostic procedures which involve administering to a warm-blooded animal a diagnostically effective amount of the abovedescribed apatite particles and then performing the medical diagnostic procedure.
摘要翻译： 公开了治疗磷灰石颗粒，用于增强诸如磁共振成像（“MRI”），磁共振光谱学（“MRS”），磁共振光谱成像（37MRSI“），X射线诊断成像和超声成像的医学诊断成像。 公开了新颖的涂层和制造技术来控制颗粒尺寸和颗粒聚集，从而获得用于肝脏，脾脏，胃肠道或组织疾病状态的器官特异性成像的组合物。根据诊断成像技术，将磷灰石颗粒处理为 磷灰石颗粒也可以被氟化以形成用于19F成像的稳定的氟磷灰石组合物。还公开了执行医学诊断程序的诊断组合物和方法，其涉及向温血动物施用诊断有效量的 上述磷灰石颗粒，然后执行药物 诊断程序。
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公开(公告)号：US5417958A
公开(公告)日：1995-05-23
申请号：US190766
申请日：1994-02-02
CPC分类号： A61K49/06 , A61K49/04 , A61K49/0433
摘要： The present invention relates to novel compounds for use as imaging agents. In particular, the present invention relates to imaging agents comprising a heavy metal cluster having 2 to 8 atoms of the same of different heavy metal elements, and at least one coordinating ligand having 1 to 8 atoms which bond to the cluster, and a number of supporting atoms making up the framework of the ligand.
摘要翻译： 本发明涉及用作成像剂的新型化合物。 特别地，本发明涉及包含具有不同重金属元素相同的2至8个原子的重金属簇和至少一个与该簇结合的具有1至8个原子的配位配体的成像剂，以及多个 支持构成配体框架的原子。
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8.发明授权
公开(公告)号：US5364953A
公开(公告)日：1994-11-15
申请号：US971789
申请日：1992-11-05
CPC分类号： C07F15/025 , A61K49/06 , C07F13/005
摘要： The present invention relates to novel compounds for use as imaging agents. In particular, the present invention relates to paramagnetic metal clusters having oxygen and/or nitrogen containing ligands useful as contrast agents for magnetic resonance imaging (MRI).
摘要翻译： 本发明涉及用作成像剂的新型化合物。 特别地，本发明涉及具有用作磁共振成像（MRI）造影剂的含氧和/或氮的配体的顺磁金属簇。
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9.发明授权Treated calcium/oxyanion-containing particles for medical diagnostic imaging 失效用于医学诊断成像的经处理的含钙/含氧阴离子颗粒
公开(公告)号：US5407659A
公开(公告)日：1995-04-18
申请号：US47129
申请日：1993-04-13
申请人： Edward A. Deutsch , Karen F. Deutsch , Dennis L. Nosco , William H. Ralston , David H. White , Janet B. Wilking , Robert G. Wolfangel , Steven R. Woulfe
发明人： Edward A. Deutsch , Karen F. Deutsch , Dennis L. Nosco , William H. Ralston , David H. White , Janet B. Wilking , Robert G. Wolfangel , Steven R. Woulfe
IPC分类号： A61B5/055 , A61B8/00 , A61B19/00 , A61K47/48 , A61K49/00 , A61K49/04 , A61K49/18 , A61K49/22 , A61K51/00 , A61K51/12 , C01B25/32 , C01G28/00 , C01G31/00 , C01G45/00 , C07F9/38 , G01R33/28
CPC分类号： A61K51/1241 , A61K47/48861 , A61K49/0414 , A61K49/1818 , A61K49/1842 , A61K49/1878 , A61K49/1881 , A61K49/225 , A61B2090/3925 , A61B2090/3954 , A61B90/39 , G01R33/281 , Y10S977/722 , Y10S977/881 , Y10S977/927 , Y10S977/928 , Y10S977/929 , Y10S977/93 , Y10T436/24
摘要： Treated calcium/oxyanion-containing particles are disclosed for enhancing medical diagnostic imaging such as magnetic resonance imaging ("MRI"), magnetic resonance spectroscopy ("MRS"), magnetic resonance spectroscopy imaging ("MRSI"), X-ray diagnostic imaging, and ultrasound imaging. Novel coating and manufacturing techniques are disclosed to control particle size and particle aggregation resulting in compositions for organ specific imaging of the liver, spleen, or tissue disease states is obtained. Depending on the diagnostic imaging technique, calcium/oxyanion-containing particles are treated to be paramagnetic, radiopaque, or echogenic. Also disclosed are diagnostic compositions and methods of performing medical diagnostic procedures which involve administering to a warm-blooded animal a diagnostically effective amount of the above-described particles and then performing the medical diagnostic procedure.
摘要翻译： 公开了用于增强医学诊断成像例如磁共振成像（“MRI”），磁共振光谱（“MRS”），磁共振光谱成像（“MRSI”），X射线诊断成像， 和超声成像。 公开了新颖的涂层和制造技术来控制颗粒尺寸和颗粒聚集，从而获得用于肝脏，脾脏或组织疾病状态的器官特异性成像的组合物。 根据诊断成像技术，含钙/含氧阴离子的颗粒被处理为顺磁性，不透射线的或回声的。 还公开了执行医学诊断程序的诊断组合物和方法，其涉及向温血动物施用诊断有效量的上述颗粒，然后进行医学诊断程序。
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公开(公告)号：US5320824A
公开(公告)日：1994-06-14
申请号：US47322
申请日：1993-04-16
CPC分类号： A61K51/1241 , A61K51/1255 , A61K2121/00
摘要： The present invention provides radiation synovectomy compositions for treating inflamed synovium containing a radionuclide complex bound to a substantially insoluble particle as the radiolabelled synovectomy agent in a sufficient amount of provide satisfactory synovectomy of the inflamed synovium together with a pharmaceutically acceptable vehicle, the radionuclide being a beta emitter that will substantially ablate the inflamed synovium, but not significantly damage underlying articular cartilage, the radionuclide complex being substantially kinetically stable, and if said radionuclide or radionuclide complex leaks from said joint it will be excreted from the body, the agent having a particle size such that there is essentially little or no leakage of the radionuclide complex from the joint after administration.
摘要翻译： 本发明提供了用于治疗发炎滑膜的放射性滑膜切除组合物，该组合物含有与实质上不溶性颗粒结合的放射性核素复合物作为放射性标记的滑膜切除剂，其量足以使得发炎的滑膜与药学上可接受的载体一起提供令人满意的滑膜切除术，放射性核素为β 发射器将基本上消融发炎的滑膜，但不显着损伤关节软骨，放射性核素复合物基本上是动态稳定的，并且如果所述放射性核素或放射性核素复合物从所述接头泄漏，则其将从体内排出， 使得放射性核素复合物在给药后几乎几乎没有或没有从关节泄漏。
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