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    Method and apparatus for implanting a hydrogel prosthesis for a nucleus pulposus
    1.
    发明授权
    Method and apparatus for implanting a hydrogel prosthesis for a nucleus pulposus 有权
    用于植入用于髓核的水凝胶假体的方法和装置

    公开(公告)号：US07850730B2

    公开(公告)日：2010-12-14

    申请号：US11391245

    申请日：2006-03-29

    申请人： Edward Vresilovic ,  Michael Keane ,  Thomas Peter Schaer ,  Amy Arthur ,  Wamis Singhatat

    发明人： Edward Vresilovic ,  Michael Keane ,  Thomas Peter Schaer ,  Amy Arthur ,  Wamis Singhatat

    IPC分类号： A61F2/44

    CPC分类号： A61F2/4657 ,  A61B2090/064 ,  A61F2/4611 ,  A61F2002/30075 ,  A61F2002/3009 ,  A61F2002/30235 ,  A61F2002/30581 ,  A61F2002/30617 ,  A61F2002/444 ,  A61F2002/4627 ,  A61F2002/4663 ,  A61F2002/4677 ,  A61F2002/4693 ,  A61F2002/4694 ,  A61F2210/0061 ,  A61F2230/0069 ,  A61F2250/0091 ,  A61F2250/0097

    摘要： An instrument for inserting an elongated hydrogel prosthesis into an intervertebral disc includes an insertion cannula that is inserted through the annulus fibrosus of an intervertebral disc to provide access to the nucleus region of the disc, an elongated hydrogel prosthesis packaged within a tubular container adapted to be coupled to a proximal end of the insertion cannula, and a source of fluid pressure adapted to be coupled to a proximal end of the tubular container. Auxiliary instruments for use in convenient insertion of the insertion cannula through the nucleus pulposus and providing for a complete and controlled passage of the hydrogel prosthesis through the insertion cannula are provided in a kit with the insertion cannula. A sizing apparatus for determining the volume of prosthesis to be inserted includes a catheter or cannula capable of being inserted through the insertion cannula into the nucleus region of the intervertebral disc and having at its distal end a balloon capable of being inflated within the intervertebral disc with a measurable volume of a fluid in order to determine the amount of hydrogel prosthesis to be injected.

    摘要翻译： 用于将细长水凝胶假体插入椎间盘的器械包括插入插入穿过椎间盘纤维环的插入套管，以提供进入椎间盘的细胞核区域的细长水凝胶假体， 耦合到插入套管的近端，以及适于联接到管状容器的近端的流体源的源。 用于通过髓核方便地插入插入插管并且通过插入套管提供水凝胶假体的完整和受控通道的辅助仪器在具有插入套管的套件中提供。 用于确定要插入的假体的体积的定径装置包括导管或套管，其能够穿过插入插管插入到椎间盘的细胞核区域中，并且在其远端具有能够在椎间盘内膨胀的气囊， 可测量体积的流体，以确定待注射的水凝胶假体的量。

    METHOD AND APPARATUS FOR IMPLANTING A HYDROGEL PROSTHESIS FOR A NUCLEUS PULPOSUS
    2.
    发明申请
    METHOD AND APPARATUS FOR IMPLANTING A HYDROGEL PROSTHESIS FOR A NUCLEUS PULPOSUS 有权
    用于植入NUCLEUS PULPOSUS的水凝胶预处理方法和装置

    公开(公告)号：US20110276140A1

    公开(公告)日：2011-11-10

    申请号：US12942720

    申请日：2010-11-09

    申请人： Edward Vresilovic ,  Michael Keane ,  Thomas Peter Schaer ,  Amy Arthur ,  Wamis Singhatat

    发明人： Edward Vresilovic ,  Michael Keane ,  Thomas Peter Schaer ,  Amy Arthur ,  Wamis Singhatat

    IPC分类号： A61F2/44

    CPC分类号： A61F2/4657 ,  A61B2090/064 ,  A61F2/4611 ,  A61F2002/30075 ,  A61F2002/3009 ,  A61F2002/30235 ,  A61F2002/30581 ,  A61F2002/30617 ,  A61F2002/444 ,  A61F2002/4627 ,  A61F2002/4663 ,  A61F2002/4677 ,  A61F2002/4693 ,  A61F2002/4694 ,  A61F2210/0061 ,  A61F2230/0069 ,  A61F2250/0091 ,  A61F2250/0097

    摘要： An instrument for inserting an elongated hydrogel prosthesis into an intervertebral disc includes an insertion cannula that is inserted through the annulus fibrosus of an intervertebral disc to provide access to the nucleus region of the disc, an elongated hydrogel prosthesis packaged within a tubular container adapted to be coupled to a proximal end of the insertion cannula, and a source of fluid pressure adapted to be coupled to a proximal end of the tubular container. Auxiliary instruments for use in convenient insertion of the insertion cannula through the nucleus pulposus and providing for a complete and controlled passage of the hydrogel prosthesis through the insertion cannula are provided in a kit with the insertion cannula. A sizing apparatus for determining the volume of prosthesis to be inserted includes a catheter or cannula capable of being inserted through the insertion cannula into the nucleus region of the intervertebral disc and having at its distal end a balloon capable of being inflated within the intervertebral disc with a measurable volume of a fluid in order to determine the amount of hydrogel prosthesis to be injected.

    摘要翻译： 用于将细长的水凝胶假体插入椎间盘的器械包括插入插入穿过椎间盘的纤维环以提供通向椎间盘的核区域的插入套管，包封在管状容器内的细长水凝胶假体适于 耦合到插入套管的近端，以及适于联接到管状容器的近端的流体源的源。 用于通过髓核方便地插入插入插管并且通过插入套管提供水凝胶假体的完整和受控通道的辅助仪器在具有插入套管的套件中提供。 用于确定要插入的假体的体积的定径装置包括导管或套管，其能够穿过插入插管插入到椎间盘的细胞核区域中，并且在其远端具有能够在椎间盘内膨胀的气囊， 可测量体积的流体，以确定待注射的水凝胶假体的量。

    Method and apparatus for implanting a hydrogel prosthesis for a nucleus pulposus
    3.
    发明授权
    Method and apparatus for implanting a hydrogel prosthesis for a nucleus pulposus 有权
    用于植入用于髓核的水凝胶假体的方法和装置

    公开(公告)号：US08475532B2

    公开(公告)日：2013-07-02

    申请号：US12942720

    申请日：2010-11-09

    申请人： Edward Vresilovic ,  Michael Keane ,  Thomas Peter Schaer ,  Amy Arthur ,  Wamis Singhatat

    发明人： Edward Vresilovic ,  Michael Keane ,  Thomas Peter Schaer ,  Amy Arthur ,  Wamis Singhatat

    IPC分类号： A61F2/44

    CPC分类号： A61F2/4657 ,  A61B2090/064 ,  A61F2/4611 ,  A61F2002/30075 ,  A61F2002/3009 ,  A61F2002/30235 ,  A61F2002/30581 ,  A61F2002/30617 ,  A61F2002/444 ,  A61F2002/4627 ,  A61F2002/4663 ,  A61F2002/4677 ,  A61F2002/4693 ,  A61F2002/4694 ,  A61F2210/0061 ,  A61F2230/0069 ,  A61F2250/0091 ,  A61F2250/0097

    摘要： An instrument for inserting an elongated hydrogel prosthesis into an intervertebral disc includes an insertion cannula that is inserted through the annulus fibrosus of an intervertebral disc to provide access to the nucleus region of the disc, an elongated hydrogel prosthesis packaged within a tubular container adapted to be coupled to a proximal end of the insertion cannula, and a source of fluid pressure adapted to be coupled to a proximal end of the tubular container. Auxiliary instruments for use in convenient insertion of the insertion cannula through the nucleus pulposus and providing for a complete and controlled passage of the hydrogel prosthesis through the insertion cannula are provided in a kit with the insertion cannula. A sizing apparatus for determining the volume of prosthesis to be inserted includes a catheter or cannula capable of being inserted through the insertion cannula into the nucleus region of the intervertebral disc and having at its distal end a balloon capable of being inflated within the intervertebral disc with a measurable volume of a fluid in order to determine the amount of hydrogel prosthesis to be injected.

    摘要翻译： 用于将细长水凝胶假体插入椎间盘的器械包括插入插入穿过椎间盘纤维环的插入套管，以提供进入椎间盘的细胞核区域的细长水凝胶假体， 耦合到插入套管的近端，以及适于联接到管状容器的近端的流体源的源。 用于通过髓核方便地插入插入插管并且通过插入套管提供水凝胶假体的完整和受控通道的辅助仪器在具有插入套管的套件中提供。 用于确定要插入的假体的体积的定径装置包括导管或套管，其能够穿过插入插管插入到椎间盘的细胞核区域中，并且在其远端具有能够在椎间盘内膨胀的气囊， 可测量体积的流体，以确定待注射的水凝胶假体的量。

    Supplementation or replacement of a nucleus pulposus of an intervertebral disc
    6.
    发明申请
    Supplementation or replacement of a nucleus pulposus of an intervertebral disc 审中-公开
    补充或更换椎间盘髓核

    公开(公告)号：US20060122704A1

    公开(公告)日：2006-06-08

    申请号：US11189753

    申请日：2005-07-27

    申请人： Edward Vresilovic ,  Michael Keane ,  Thomas Schaer

    发明人： Edward Vresilovic ,  Michael Keane ,  Thomas Schaer

    IPC分类号： A61F2/44

    CPC分类号： A61F2/442 ,  A61B17/86 ,  A61F2/28 ,  A61F2/4611 ,  A61F2002/2839 ,  A61F2002/30224 ,  A61F2002/30242 ,  A61F2002/444 ,  A61F2002/4445 ,  A61F2002/4627 ,  A61F2002/4631 ,  A61F2230/0069 ,  A61F2230/0071

    摘要： A degenerated nucleus pulposus located in a central core region of an intervertebral disc within the annulus fibrosus is supplemented or replaced by a method wherein an amount of a biocompatible material is introduced into the central core region by a process including the steps of 1) forming a channel through a vertebral body adjacent to said intervertebral disc, extending from an exterior surface of the vertebral body to the central core region of the annulus fibrosus; 2) introducing an amount of a biocompatible material through the channel into the central core region of the annulus fibrosus; 3) pressurizing the biocompatible material through the channel to a postsurgical pressure sufficient to alleviate symptoms caused by the degenerated nucleus pulposus; and 4) sealing the channel while maintaining the sufficient postsurgical pressure. After sealing the channel, a vertebroplasty may optionally be performed in the vertebra.

    摘要翻译： 位于纤维环内的椎间盘的中心核心区域的退化的髓核被补充或替换，其中通过包括以下步骤的方法将生物相容性材料的量引入中心核心区域的方法包括以下步骤：1） 通过与所述椎间盘相邻的椎体从椎体的外表面延伸到纤维环的中心纤芯区域; 2）通过通道将一定量的生物相容性物质引入到纤维环的中心纤芯区域; 3）通过通道将生物相容性材料加压至足以减轻由退化的髓核引起的症状的术后压力; 和4）密封通道同时保持足够的术后压力。 在密封通道之后，椎骨成形术可以可选地在椎骨中进行。

    Hydrogel balloon prosthesis for nucleus pulposus
    7.
    发明申请
    Hydrogel balloon prosthesis for nucleus pulposus 有权
    水髓球囊假体为髓核

    公开(公告)号：US20070073402A1

    公开(公告)日：2007-03-29

    申请号：US11510747

    申请日：2006-08-25

    申请人： Edward Vresilovic ,  Michele Marcolongo ,  Anthony Lowman ,  Alastair Clemow ,  Michael Keane

    发明人： Edward Vresilovic ,  Michele Marcolongo ,  Anthony Lowman ,  Alastair Clemow ,  Michael Keane

    IPC分类号： A61F2/44 ,  B29C41/14

    CPC分类号： A61L27/52 ,  A61F2/30767 ,  A61F2/441 ,  A61F2002/444

    摘要： A prosthesis for replacing or supplementing a nucleus pulposus of an intervertebral disk is an expandable container having flexible walls, the container being adapted to be inserted into a central cavity of an intervertebral disk through a narrow cannula, and the flexible walls are made from a biocompatible hydrogel. A preferred hydrogel is a cryogel formed from an aqueous solution of poly(vinyl alcohol) and poly(vinyl pyrrolidone). The prosthesis may be prepared by dip-coating a mandrel with an aqueous solution of a hydrogel-forming polymer or mixture of such polymers, gelling the coated solution by chilling, and subjecting the gelled coating to a series of repeated freeze-thaw treatments. In use, the prosthesis is inserted into a central cavity of an intervertebral disk and filled with biocompatible material, e.g., a biocompatible liquid, a biocompatible polymer, and a biocompatible hydrogel, particularly a thermogelling hydrogel.

    摘要翻译： 用于替换或补充椎间盘髓核的假体是具有柔性壁的可扩张容器，该容器适于通过狭窄的插管插入到椎间盘的中心空腔中，并且柔性壁由生物相容性 水凝胶。 优选的水凝胶是由聚（乙烯醇）和聚（乙烯基吡咯烷酮）的水溶液形成的冷冻凝胶。 假体可以通过用形成水凝胶的聚合物或这种聚合物的混合物的水溶液浸渍心轴来制备，通过冷却使涂覆的溶液凝胶化，并使凝胶涂层进行一系列重复的冻融处理。 在使用中，将假体插入到椎间盘的中心空腔中，并填充有生物相容性材料，例如生物相容性液体，生物相容性聚合物和生物相容性水凝胶，特别是热胶凝水凝胶。

    Supplementation or replacement of a nucleus pulposus of an intervertebral disc
    9.
    发明授权
    Supplementation or replacement of a nucleus pulposus of an intervertebral disc 有权
    补充或更换椎间盘髓核

    公开(公告)号：US08147553B2

    公开(公告)日：2012-04-03

    申请号：US12163407

    申请日：2008-06-27

    申请人： Edward Vresilovic ,  Michael F. Keane ,  Thomas P. Schaer

    发明人： Edward Vresilovic ,  Michael F. Keane ,  Thomas P. Schaer

    IPC分类号： A61F2/44

    CPC分类号： A61F2/442 ,  A61B17/86 ,  A61F2/28 ,  A61F2/4611 ,  A61F2002/2839 ,  A61F2002/30224 ,  A61F2002/30242 ,  A61F2002/444 ,  A61F2002/4445 ,  A61F2002/4627 ,  A61F2002/4631 ,  A61F2230/0069 ,  A61F2230/0071

    摘要： A degenerated nucleus pulposus located in a central core region of an intervertebral disc within the annulus fibrosus is supplemented or replaced by a method wherein an amount of a biocompatible material is introduced into the central core region by a process including the steps of 1) forming a channel through a vertebral body adjacent to said intervertebral disc, extending from an exterior surface of the vertebral body to the central core region of the annulus fibrosus; 2) introducing an amount of a biocompatible material through the channel into the central core region of the annulus fibrosus; 3) pressurizing the biocompatible material through the channel to a postsurgical pressure sufficient to alleviate symptoms caused by the degenerated nucleus pulposus; and 4) sealing the channel while maintaining the sufficient postsurgical pressure. After sealing the channel, a vertebroplasty may optionally be performed in the vertebra.

    摘要翻译： 位于纤维环内的椎间盘的中心核心区域的退化的髓核被补充或替换，其中通过包括以下步骤的方法将生物相容性材料的量引入中心核心区域的方法包括以下步骤：1） 通过与所述椎间盘相邻的椎体从椎体的外表面延伸到纤维环的中心纤芯区域; 2）通过通道将一定量的生物相容性物质引入到纤维环的中心纤芯区域; 3）通过通道将生物相容性材料加压至足以减轻由退化的髓核引起的症状的术后压力; 和4）密封通道同时保持足够的术后压力。 在密封通道之后，椎骨成形术可以可选地在椎骨中进行。