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    Modulating angiogenesis
    1.
    发明授权
    Modulating angiogenesis 失效
    调节血管发生

    公开(公告)号：US07491389B2

    公开(公告)日：2009-02-17

    申请号：US10392439

    申请日：2003-03-18

    申请人： Edward W. Scott ,  Maria Grant ,  W. Stratford May

    发明人： Edward W. Scott ,  Maria Grant ,  W. Stratford May

    IPC分类号： A61K39/395 ,  A61K39/00

    CPC分类号： C07K16/24 ,  A61K35/12 ,  A61K2039/505 ,  C12N5/0692

    摘要： Hemangioblasts in adult bone marrow participate in new blood vessel formation. By modulating the differentiation of hemangioblasts into blood vessel cells, angiogenesis in a particular tissue can be increased or decreased. Intravitreal injection of antibodies that block SDF-1 activity inhibited induced retinal neovascularization mediated by hemangioblasts.

    摘要翻译： 成骨髓细胞血管母细胞参与新血管形成。 通过调节成血管细胞分化成血管细胞，可以增加或减少特定组织中的血管发生。 玻璃体内注射阻断SDF-1活性的抗体抑制由成血成血管细胞介导的诱导的视网膜新生血管形成。

    Interactive applications generator for an interactive presentation environment
    3.
    发明授权
    Interactive applications generator for an interactive presentation environment 失效
    交互式应用程序生成器，用于交互式呈现环境

    公开(公告)号：US5675752A

    公开(公告)日：1997-10-07

    申请号：US307941

    申请日：1994-09-15

    申请人： Edward W. Scott ,  Richard Sagey ,  Toshiharu Fukui ,  Hussein F. Akasheh ,  Kunjan Zaveri ,  Marc Booth

    发明人： Edward W. Scott ,  Richard Sagey ,  Toshiharu Fukui ,  Hussein F. Akasheh ,  Kunjan Zaveri ,  Marc Booth

    IPC分类号： G06F3/14 ,  G06F3/048 ,  G06F9/06 ,  G06F9/44 ,  G11B27/034 ,  G11B27/34

    CPC分类号： G11B27/34 ,  G06F8/38 ,  G11B27/034 ,  Y10S715/972

    摘要： An interactive applications generator is utilized to generate an interactive application environment for use on a single server multi-client network computer system. The interactive applications generator permits a user to define a graphical user interface (GUI), that contains one or more display screens, for a customized interactive application environment. The interactive applications generator contains a screen template editor, a media frame editor, a screen editor, and an interactive presentation editor. The screen template editor is utilized to create generic screen templates, that contain generic screen template elements. The media frame editor is utilized to generate media frames by combining multimedia component elements in a time synchronized manner. The screen editor is utilized to generate the display screens including assigning functionality. In order to create a unique instance for each display screen for a particular interactive applications environment, the screen editor references generic screen templates and media frames. The interactive presentation editor is utilized to create the hierarchical structures that defines presentation of the display screens for the particular interactive presentation environment.

    摘要翻译： 交互式应用程序生成器用于生成在单个服务器多客户端网络计算机系统上使用的交互式应用程序环境。 交互式应用程序生成器允许用户为定制的交互式应用程序环境定义包含一个或多个显示屏幕的图形用户界面（GUI）。 交互式应用程序生成器包含屏幕模板编辑器，媒体帧编辑器，屏幕编辑器和交互式演示编辑器。 屏幕模板编辑器用于创建包含通用屏幕模板元素的通用屏幕模板。 媒体帧编辑器用于通过以时间同步的方式组合多媒体成分元素来生成媒体帧。 屏幕编辑器用于生成包括分配功能的显示屏幕。 为了为特定交互式应用程序环境的每个显示屏幕创建唯一的实例，屏幕编辑器引用通用屏幕模板和媒体帧。 交互式演示编辑器用于创建定义用于特定交互式呈现环境的显示屏幕的呈现的分层结构。

    Orchard error correction system
    5.
    发明授权
    Orchard error correction system 失效
    果园纠错系统

    公开(公告)号：US4435807A

    公开(公告)日：1984-03-06

    申请号：US343109

    申请日：1982-01-27

    申请人： Edward W. Scott ,  Daniel B. Goetschel

    发明人： Edward W. Scott ,  Daniel B. Goetschel

    IPC分类号： G11B20/18 ,  H03M13/09 ,  H04L1/00 ,  G06F11/10

    CPC分类号： H04L1/0057 ,  G11B20/1833 ,  H04L1/0041 ,  H04L1/005 ,  H04L1/0066

    摘要： An error correcting system involves the addition of parity type correction bits to each word in a series of digital word forming data to be transmitted or processed. When a person is passing an orchard where a field of partially grown trees are planted, you can look directly down the rows of trees perpendicular to the side of the field, and you can also look at an angle 45 degrees forward and down an open path 45 degrees to the rear of your path along the side of the orchard. In the present system, the error correction parity bits are summed over digits representing more then one vector through the words of data information, which are quite similar to the prospect along three different vectors in an orchard, as mentioned above. Following transmission through a data link in which errors may be introduced by the reversal of certain bits, the bits are summed along the same vectors in an error correcting circuit, and a pattern of error correction "flag" bits is associated with each word with the error correction bits representing sums along vectors which did not have the predetermined parity. A first error correction circuit is provided for correcting single errors within the pattern covered by the vectors; and a second multiple error correcting circuit receives the data from the first error correction circuit after the single errors have been corrected both in the data, the associated correction bits, and in the associated error detection bits, and the residual multiple errors are then corrected in this second error detection circuit. Additional levels of error correction can also be provided by increasing the number of vectors encoded and the number of correction circuits.

    摘要翻译： 纠错系统涉及将要发送或处理的一系列数字字形成数据中的每个字加上奇偶校验类型校正位。 当一个人正在通过一个种植有部分种植的树木的果园时，可以直观地看着垂直于田野边的树上的树丛，还可以看到一个45度向前和向下的开放路径 沿着果园边的路径的后方45度。 在本系统中，如上所述，纠错奇偶校验位通过与果园中的三个不同向量的前景非常相似的数据信息的字表示多于一个矢量的数字相加。 在通过数据链路进行传输之后，通过某些比特的反转可能导致错误，这些比特在纠错电路中沿着相同的向量相加，并且纠错“标志”比特的模式与每个单词相关联，其中 纠错位表示沿着不具有预定奇偶性的向量的和。 提供第一纠错电路用于校正由向量覆盖的图案内的单个错误; 并且在数据，相关联的校正位和相关联的错误检测位中校正了单个错误之后，第二个多重纠错电路接收来自第一纠错电路的数据，然后将剩余的多个错误校正在 该第二错误检测电路。 还可以通过增加编码的矢量的数量和校正电路的数量来提供附加的纠错水平。

    COLON STEM CELLS ASSOCIATED WITH COLITISAND COLORECTAL CANCER AND METHODS OF USE
    7.
    发明申请
    COLON STEM CELLS ASSOCIATED WITH COLITISAND COLORECTAL CANCER AND METHODS OF USE 审中-公开
    与COLITISAND COLORECTAL CANCER相关的结肠癌细胞和使用方法

    公开(公告)号：US20110111434A1

    公开(公告)日：2011-05-12

    申请号：US13003888

    申请日：2009-07-14

    申请人： Emina H. Huang ,  Edward W. Scott ,  Joseph E. Carpentino

    发明人： Emina H. Huang ,  Edward W. Scott ,  Joseph E. Carpentino

    IPC分类号： G01N33/566 ,  C12N5/071 ,  C12Q1/02 ,  C12N5/09

    CPC分类号： G01N33/5073 ,  A61K38/00 ,  C12N5/068 ,  C12N5/0693 ,  C12Q1/32 ,  G01N33/57419 ,  G01N2800/50

    摘要： The disclosure provides methods of isolating and propagating self-renewing colonic stem/progenitor cells (CS/PCs) that express aldehyde dehydrogenase (ALDH1), from colon cancer and colitis tissues, as well as from normal colon tissue, methods of identifying agents for modulating the proliferative status of such cells, an methods of screening patients having colitis for an increased risk of colorectal cancer. Novel methods of adherent cell culture propagation of CS/PC involving use of colon-specific fibroblastic stromal cells (CFSt) {i.e. the “niche” cells) as support cells (e.g., “feeder cells”). The present disclosure encompasses an isolated mammalian pluripotent colon epithelial stem/progenitor cell (CS/PC), or a population of said cells, where each CS/PC may comprise a detectable marker, where the detectable marker is aldehyde dehydrogenase 1 (ALDH1), and where the isolated population of mammalian pluripotent CS/PCs is substantially free of cells that do not have the detectable ALDH 1 marker. The disclosure encompasses further provides methods for determining the prognosis for a patient for developing a colon cancer, the method detecting the presence of at least one marker in a tissue section from a patient, the marker or plurality of markers indicating the presence of a pluripotent colon epithelial stem/progenitor cells and indicating the prognosis of the patient for developing a colon cancer.

    摘要翻译： 本公开提供了从结肠癌和结肠炎组织以及来自正常结肠组织分离和繁殖表达醛脱氢酶（ALDH1）的自我更新的结肠干/祖细胞（CS / PC）的方法，鉴定调节剂的方法 这种细胞的增殖状态，筛选具有结肠直肠癌风险增加的结肠炎患者的方法。 涉及使用结肠特异性成纤维细胞基质细胞（CFSt）的CS / PC的粘附细胞培养增殖的新方法{即 “利基”细胞）作为支持细胞（例如“饲养细胞”）。 本公开内容包括分离的哺乳动物多能结肠上皮干/祖细胞（CS / PC）或所述细胞群，其中每个CS / PC可包含可检测标记，其中可检测标记是醛脱氢酶1（ALDH1）， 并且其中哺乳动物多能CS / PC的孤立群体基本上不含不具有可检测的ALDH 1标记的细胞。 本公开包括进一步提供用于确定患者用于发展结肠癌的预后的方法，所述方法检测来自患者的组织切片中至少一个标记物的存在，所述标志物或多个标记物指示存在多能结肠 上皮干/祖细胞，并指示患者发展为结肠癌的预后。

    MODULATING ANGIOGENESIS
    10.
    发明申请
    MODULATING ANGIOGENESIS 审中-公开
    调节血管生成

    公开(公告)号：US20110280874A1

    公开(公告)日：2011-11-17

    申请号：US13145877

    申请日：2010-01-22

    申请人： Edward W. Scott ,  Christopher R. Cogle

    发明人： Edward W. Scott ,  Christopher R. Cogle

    IPC分类号： A61K39/395 ,  A61P35/00 ,  A61P35/02 ,  A61K31/7105

    CPC分类号： C07K16/24 ,  A01K2267/0331 ,  A01K2267/0375 ,  A61K35/12 ,  A61K2039/505 ,  C07K16/2866 ,  C07K2317/76 ,  C12N15/8509 ,  C12N2750/14143

    摘要： Hemangioblasts in adult bone marrow participate in new blood vessel formation. By modulating the differentiation of hemangioblasts into blood vessel cells, angiogenesis in a particular tissue can be increased or decreased. The present invention features compositions and methods for reducing tumor vasculogenesis, treating leukemia, and/or treating or preventing leukemia relapse. In particular, the invention provides an SDF-1 binding agent (e.g., antibody, antisense, ribozyme) for the treatment or prevention of a neoplasia, such as leukemia. Intravitreal injection of antibodies that block SDF-1 activity inhibited induced retinal neovascularization mediated by hemangioblasts. Anti-SDF-1 ribozymes and SDF-1 anti-sense RNA expression constructs significantly reduced migration of cells that create new vessels in the eye.

    摘要翻译： 成骨髓细胞血管母细胞参与新血管形成。 通过调节成血管细胞分化成血管细胞，可以增加或减少特定组织中的血管发生。 本发明的特征在于减少肿瘤血管发生，治疗白血病和/或治疗或预防白血病复发的组合物和方法。 特别地，本发明提供了用于治疗或预防肿瘤形成如白血病的SDF-1结合剂（例如抗体，反义核酶）。 玻璃体内注射阻断SDF-1活性的抗体抑制由成血成血管细胞介导的诱导的视网膜新生血管形成。 抗SDF-1核酶和SDF-1反义RNA表达构建体显着减少在眼睛中产生新血管的细胞迁移。