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1.发明授权Use of a pneumococcal P4 peptide for enhancing opsonophagocytosis in response to a pathogen 有权使用肺炎球菌P4肽来增强针对病原体的调理吞噬作用公开(公告)号：US08431134B2
公开(公告)日：2013-04-30
申请号：US13056522
申请日：2009-07-31
申请人： Edwin W. Ades , Gowrisankar Rajam , Sandra Steiner , George M. Carlone , Nikkoj Melnick , Jacquelyn S. Sampson , Joseph E. Martinez , Julie M. Skinner
发明人： Edwin W. Ades , Gowrisankar Rajam , Sandra Steiner , George M. Carlone , Nikkoj Melnick , Jacquelyn S. Sampson , Joseph E. Martinez , Julie M. Skinner
IPC分类号： A61K39/09 , A61K39/085 , C07K16/00
CPC分类号： A61K38/164 , A61K31/00 , A61K31/53 , A61K38/1725 , A61K39/395 , A61K39/40 , A61K39/42 , A61K45/06 , A61K2300/00
摘要： Methods for enhancing opsonophagocytosis of a pathogen of interest are disclosed. The disclosed methods include administering to a subject an isolated P4 peptide, which includes the amino acid sequence set forth as SEQ ID NO: 1 and optionally an isolated opsonic antibody or a fragment thereof that specifically binds to an antigen present on the surface of the pathogen of interest. In some examples isolated complement protein or a fragment thereof (for example, a C3a, C3b, iC3b, C3d, C4b, or C5a fragment of a complement protein) is also administered. Compositions containing isolated P4 peptide and one or more isolated opsonic antibodies or a fragment thereof that specifically binds to an antigen present of the surface of a pathogen of interest are also disclosed. In some examples, the compositions also include isolated complement protein or fragment thereof, such as one or more of C3a, C3b, iC3b, C3d, C4b, or C5a.
摘要翻译： 公开了增加目的病原体的调理吞噬作用的方法。 所公开的方法包括向受试者施用分离的P4肽，其包括SEQ ID NO：1所示的氨基酸序列和任选的特异性结合存在于病原体表面上的抗原的分离的调理蛋白抗体或其片段 出于兴趣。 在一些实施例中，还给予分离的补体蛋白或其片段（例如，补体蛋白的C3a，C3b，iC3b，C3d，C4b或C5a片段）。 还公开了包含分离的P4肽和一种或多种分离的调理抗体或其特异性结合目的病原体表面存在的抗原的片段的组合物。 在一些实例中，组合物还包括分离的补体蛋白或其片段，例如C3a，C3b，iC3b，C3d，C4b或C5a中的一种或多种。
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2.发明申请公开(公告)号：US20110195075A1
公开(公告)日：2011-08-11
申请号：US13056522
申请日：2009-07-31
申请人： Edwin W. Ades , Gowrisankar Rajam , Sandra Steiner , George M. Carlone , Nikkol Melnick , Jacquelyn S. Sampson , Joseph E. Martinez , Julie M. Skinner
发明人： Edwin W. Ades , Gowrisankar Rajam , Sandra Steiner , George M. Carlone , Nikkol Melnick , Jacquelyn S. Sampson , Joseph E. Martinez , Julie M. Skinner
IPC分类号： A61K39/42 , A61K39/395 , A61K39/40 , A61K38/16 , A61P31/00
CPC分类号： A61K38/164 , A61K31/00 , A61K31/53 , A61K38/1725 , A61K39/395 , A61K39/40 , A61K39/42 , A61K45/06 , A61K2300/00
摘要： Methods for enhancing opsonophagocytosis of a pathogen of interest are disclosed. The disclosed methods include administering to a subject an isolated P4 peptide, which including the amino acid sequence set forth as SEQ ID NO: 1 and optionally an isolated opsonic antibody or a fragment thereof that specifically binds to an antigen present of the surface of the pathogen of interest. In some examples isolated complement protein or a fragment thereof (for example, a C3a, C3b, iC3b, C3d, C4b, or C5a fragment of a complement protein) is also administering. Compositions contain isolated P4 peptide and one or more isolated opsonic antibodies or a fragment thereof that specifically binds to an antigen present of the surface of a pathogen of interest are also disclosed. In some examples, the compositions also isolated complement protein or fragment thereof, such as one or more of C3a, C3b, iC3b, C3d, C4b, or C5a.
摘要翻译： 公开了增加目的病原体的调理吞噬作用的方法。 所公开的方法包括向受试者施用分离的P4肽，其包括如SEQ ID NO：1所示的氨基酸序列和任选的特异性结合病原体表面存在的抗原的分离的调理蛋白抗体或其片段 出于兴趣。 在一些实例中，还施用了分离的补体蛋白或其片段（例如，补体蛋白的C3a，C3b，iC3b，C3d，C4b或C5a片段）。 还公开了组合物含有分离的P4肽和一种或多种分离的调理抗体或其特异性结合目的病原体表面存在的抗原的片段。 在一些实例中，组合物还分离补体蛋白或其片段，例如C3a，C3b，iC3b，C3d，C4b或C5a中的一种或多种。
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3.发明授权Functional epitopes of Streptococcus pneumoniae PsaA antigen and uses thereof 有权肺炎链球菌PsaA抗原的功能表位及其用途公开(公告)号：US07919104B2
公开(公告)日：2011-04-05
申请号：US11992719
申请日：2005-07-29
申请人： Edwin W. Ades , Jacquelyn S. Sampson , Sandra Steiner , George M. Carlone , Joseph J. Caba , GowriSankar Rajam
发明人： Edwin W. Ades , Jacquelyn S. Sampson , Sandra Steiner , George M. Carlone , Joseph J. Caba , GowriSankar Rajam
CPC分类号： C07K14/3156 , A61K39/00 , A61K2039/505 , Y10S530/825
摘要： Provided is a P4 peptide, which contains functional epitopes of the PsaA protein of Streptococcus pneumoniae, and related methods and compositions. P4 peptide mimetics having a conformational structure identical or similar to the conformation of P4 (e.g., SEQ ID NO: 1 and SEQ ID NO:2) are provided. An antibody that specifically binds to the epitope defined by the disclosed peptides is provided. A P4-specific antibody is PsaA-specific since P4 defines an epitope specific for PsaA. Immunogenic compositions comprising the peptide of SEQ ID NO: 1 and a pharmaceutical carrier or the peptide of SEQ ID NO:2 and a pharmaceutical carrier are also provided. Methods of using the peptides and antibodies of the invention are provided.
摘要翻译： 提供了含有肺炎链球菌PsaA蛋白的功能性表位的P4肽及其相关方法和组合物。 提供了具有与P4的构象相同或相似的构象结构的P4肽模拟物（例如，SEQ ID NO：1和SEQ ID NO：2）。 提供了特异性结合由公开的肽定义的表位的抗体。 P4特异性抗体是PsaA特异性的，因为P4定义了PsaA特异性表位。 还提供了包含SEQ ID NO：1的肽和药物载体或SEQ ID NO：2的肽的药物载体的免疫原性组合物。 提供使用本发明的肽和抗体的方法。
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4.发明申请Functional Epitopes of Streptococcus Pneumoniae PsaA Antigen and Uses Thereof 有权肺炎链球菌PsaA抗原的功能表位及其用途公开(公告)号：US20080305123A1
公开(公告)日：2008-12-11
申请号：US11992719
申请日：2005-07-29
申请人： Edwin W. Ades , Jacquelyn S. Sampson , Sandra Steiner , George M. Carlone , Joseph J. Caba , GowriSankar Rajam
发明人： Edwin W. Ades , Jacquelyn S. Sampson , Sandra Steiner , George M. Carlone , Joseph J. Caba , GowriSankar Rajam
CPC分类号： C07K14/3156 , A61K39/00 , A61K2039/505 , Y10S530/825
摘要： Provided is a P4 peptide, which contains functional epitopes of the PsaA protein of Streptococcus pneumoniae, and related methods and compositions. A peptide that comprises the amino acid sequence defined in SEQ ID NO:1 (an example of the P4 peptide) is provided. Also provided is a peptide comprising the amino acid sequence defined as VPSLFVDSSVDDRPMKTVSQDTNIPIYAQIFTDS (SEQ ID NO:2). P4 peptide mimetics having a conformational structure identical or similar to the conformation of P4 (e.g., SEQ ID NO: 1 and SEQ ID NO:2) are provided. An antibody that specifically binds to the epitope defined by the disclosed peptides is provided. For example, the antibody can specifically bind to a peptide comprising the sequence set forth in SEQ ID NO: 1 and having the conformation defined by the peptide consisting of SEQ ID NO: 1. An antibody that specifically binds to a peptide comprising the sequence set forth in SEQ ID NO:2 and having the conformation defined by the peptide consisting of SEQ ID NO:2 is also provided. A P4-specific antibody is PsaA-specific since P4 defines an epitope specific for PsaA. A vaccine comprising the peptide of SEQ ID NO: 1 and a pharmaceutical carrier is provided. A vaccine comprising a peptide of SEQ ID NO:2 and a pharmaceutical carrier is also provided. Methods of using the peptides and antibodies of the invention are provided. Diagnostic kits comprising a P4 peptide is also provided.
摘要翻译： 提供了含有肺炎链球菌PsaA蛋白的功能性表位的P4肽及其相关方法和组合物。 提供了包含SEQ ID NO：1中定义的氨基酸序列（P4肽的实例）的肽。 还提供了包含定义为VPSLFVDSSV DDRPMKTVSQDTNIPIYAQIFTDS（SEQ ID NO：2）的氨基酸序列的肽。 提供了具有与P4的构象相同或相似的构象结构的P4肽模拟物（例如，SEQ ID NO：1和SEQ ID NO：2）。 提供了特异性结合由公开的肽定义的表位的抗体。 例如，抗体可以特异性结合包含SEQ ID NO：1所示序列并具有由SEQ ID NO：1组成的肽所定义的构象的肽。特异性结合包含序列集的肽的抗体 还提供了具有由SEQ ID NO：2组成的肽定义的构象的SEQ ID NO：2中的SEQ ID NO：2。 P4特异性抗体是PsaA特异性的，因为P4定义了PsaA特异性表位。 提供了包含SEQ ID NO：1的肽和药物载体的疫苗。 还提供了包含SEQ ID NO：2的肽和药物载体的疫苗。 提供使用本发明的肽和抗体的方法。 还提供了包含P4肽的诊断试剂盒。
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5.发明申请Multiple-Valent Opsonophagocytic Assay Selection Panel Arrays And Uses Therefor 有权多层次Opsonophagocytic Assay Selection面板数组及其用途公开(公告)号：US20080193966A1
公开(公告)日：2008-08-14
申请号：US11910517
申请日：2006-04-21
IPC分类号： C12Q1/18
摘要： This application discloses a multivalent opsonophagocytosis assay that does not rely on counting of bacterial colonies to determine bacteria viability following opsonophagocytosis. Instead, the method uses a metabolic colorimetric indicator to determine if viable bacteria are present. Also disclosed are arrays that can be used to determine the viability of bacteria following opsonophagocytosis.
摘要翻译： 本申请公开了一种多价调理吞噬作用试验，其不依赖于细菌菌落的计数以确定调理吞噬作用后的细菌活力。 相反，该方法使用代谢比色指示剂来确定是否存在活细菌。 还公开了可以用于确定调理吞噬作用后细菌生存力的阵列。
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6.发明授权Multiple-valent opsonophagocytic assay selection panel arrays and uses therefor 有权多价调理吞噬细胞测定选择面板阵列及其用途公开(公告)号：US07642068B2
公开(公告)日：2010-01-05
申请号：US11910517
申请日：2006-04-21
IPC分类号： C12Q1/18 , C12Q1/00 , G01N33/43 , G01N33/567 , C12Q1/20
摘要： This application discloses a multivalent opsonophagocytosis assay that does not rely on counting of bacterial colonies to determine bacteria viability following opsonophagocytosis. Instead, the method uses a metabolic colorimetric indicator to determine if viable bacteria are present. Also disclosed are arrays that can be used to determine the viability of bacteria following opsonophagocytosis.
摘要翻译： 本申请公开了一种多价调理吞噬作用试验，其不依赖于细菌菌落的计数以确定调理吞噬作用后的细菌活力。 相反，该方法使用代谢比色指示剂来确定是否存在活细菌。 还公开了可以用于确定调理吞噬作用后细菌生存力的阵列。
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公开(公告)号：US06815172B1
公开(公告)日：2004-11-09
申请号：US10009660
申请日：2001-12-07
IPC分类号： C12Q100
CPC分类号： G01N33/56911 , G01N2333/22 , G01N2333/315 , Y10S436/80
摘要： Methods and compositions comprising immunoassays for the detection of functional antibodies and the analysis of vaccine efficacy are described. In particular, the present invention provides opsonophagocytic assays. The assays are useful for the rapid and simultaneous detection of multiple different functional antibodies. In preferred embodiments, the assays include fluorescent labels of multiple colors and/or intensities.
摘要翻译： 描述了包含用于检测功能性抗体的免疫测定和疫苗功效分析的方法和组合物。 特别地，本发明提供调理吞噬试验。 该测定法可用于快速和同时检测多种不同功能的抗体。 在优选实施方案中，测定包括多种颜色和/或强度的荧光标记。
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公开(公告)号：US20100158860A1
公开(公告)日：2010-06-24
申请号：US12636999
申请日：2009-12-14
IPC分类号： A61K38/20 , C07D241/18 , C07D239/46 , A61K31/495 , A61K31/505 , A61K38/19 , A61K38/21 , A61P31/14
CPC分类号： C07D405/04 , C07D237/14 , C07D239/36 , C07D239/52 , C07D239/54 , C07D241/18 , C07D253/07
摘要： Compounds having the formula I wherein A, R1, R2, R3, R4a, R4b, R4c, R5, R6, R7a, R7b, Ar1, Rc, Rd, Re, Rf, X, n and p are as defined herein are Hepatitis C virus NS5b polymerase inhibitors. Also disclosed are compositions and methods for treating an HCV infection and inhibiting HCV replication.
摘要翻译： 具有式I的化合物，其中A，R1，R2，R3，R4a，R4b，R4c，R5，R6，R7a，R7b，Ar1，Rc，Rd，Re，Rf，X，n和p如本文所定义是丙型肝炎 病毒NS5b聚合酶抑制剂。 还公开了用于治疗HCV感染和抑制HCV复制的组合物和方法。
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公开(公告)号：US08178547B2
公开(公告)日：2012-05-15
申请号：US12636999
申请日：2009-12-14
IPC分类号： A01N43/54
CPC分类号： C07D405/04 , C07D237/14 , C07D239/36 , C07D239/52 , C07D239/54 , C07D241/18 , C07D253/07
摘要： Compounds having the formula I wherein A, R1, R2, R3, R4a, R4b, R4c, R5, R6, R7a, R7b, Ar1, Rc, Rd, Re, Rf, X, n and p are as defined herein are Hepatitis C virus NS5b polymerase inhibitors. Also disclosed are compositions and methods for treating an HCV infection and inhibiting HCV replication.
摘要翻译： 具有式I的化合物，其中A，R1，R2，R3，R4a，R4b，R4c，R5，R6，R7a，R7b，Ar1，Rc，Rd，Re，Rf，X，n和p如本文所定义是丙型肝炎 病毒NS5b聚合酶抑制剂。 还公开了用于治疗HCV感染和抑制HCV复制的组合物和方法。
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公开(公告)号：US20060024234A1
公开(公告)日：2006-02-02
申请号：US11231133
申请日：2005-09-19
申请人： N. Anderson , Sandra Steiner
发明人： N. Anderson , Sandra Steiner
IPC分类号： A61K49/00
摘要： Protein markers of toxicity and efficacy for antilipemic drugs are determined. Methods and reagents are disclosed for determining whether a patient receiving an antilipemic drug, especially a statin or HMGCoA reductase inhibiting drug, is experiencing drug efficacy and/or toxicity. Individual susceptibility is also determined prior to treatment. Also, drug discovery of similar acting candidates and their likelihood of being toxic or effective is determined by analysis of all proteins in a sample simultaneously by 2-dimensional gel electrophoresis.
摘要翻译： 测定抗疲劳药物的毒性和功效的蛋白质标记。 公开了用于确定接受抗血脂药物，特别是他汀类药物或HMGCoA还原酶抑制药物的患者是否正在经历药物功效和/或毒性的方法和试剂。 个体易感性也在治疗前确定。 此外，类似作用候选物的药物发现及其有毒或有效的可能性通过二维凝胶电泳同时分析样品中的所有蛋白质来确定。
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