公开(公告)号：US5213975A

公开(公告)日：1993-05-25

申请号：US783448

申请日：1991-10-24

申请人： Eiichiro Fukusaki ,  Hiroshi Takahama ,  Minako Hada ,  Yasuyuki Kimura ,  Hiroyuki Yuasa ,  Yutaka Nakazono ,  Shuji Senda ,  Tetsuo Omata

发明人： Eiichiro Fukusaki ,  Hiroshi Takahama ,  Minako Hada ,  Yasuyuki Kimura ,  Hiroyuki Yuasa ,  Yutaka Nakazono ,  Shuji Senda ,  Tetsuo Omata

IPC分类号： C07D303/14 ,  C07D303/16 ,  C12P17/02 ,  C12P41/00

CPC分类号： C12P41/004 ,  C07D303/14 ,  C07D303/16 ,  C12P17/02

摘要： This invention relates to the methods of preparing optically active epoxy alcohol which is caracterized by the steps of adding carboxylic anhydride to racemic epoxy alcohol (formula 1) in the presence of a hydrolase in an organic solvent, esterifying (-)-form of the epoxy alcohol preferentially to be epoxy ester (formula 2), separating optically active epoxy ester (formula 2) from optically active epoxy alcohol (formula 3) to yield optically active epoxy alcohol (formula 4), so that epoxy alcohol (formula 1) in high purity can be obtained easily and safely at ordinary temperature. ##STR1##

公开(公告)号：US5677155A

公开(公告)日：1997-10-14

申请号：US547926

申请日：1995-10-25

申请人： Eiichiro Fukusaki ,  Tetsuo Omata ,  Shuji Senda

发明人： Eiichiro Fukusaki ,  Tetsuo Omata ,  Shuji Senda

IPC分类号： C12P7/04 ,  A01N43/44 ,  C07D303/04 ,  C07D303/14 ,  C07D303/16 ,  C12P17/02 ,  C12P41/00 ,  C12P7/00 ,  C12N9/14 ,  C12N9/20

CPC分类号： C07D303/14 ,  C07D303/04 ,  C07D303/16 ,  C12P17/02 ,  C12P41/004

摘要： A process for preparing the sex pheromone of Lymantria dispar L. effectively which comprises the steps of reacting 1-bromodecane and propargyl alcohol tetrahydropyranylether in the presence of sodium hydroxide to give 1-tetrahydropyranyloxy-2-tridecyne, treating the tetrahydropyranyloxy-2-tridecyne with p-toluenesulfonic acid to give 2-tridecyn-1-ol, catalystic-hydrogenating the 2-tridecyn-1-ol in the presence of Lindlar catalyst to give (Z)-2-tridecen-1-ol, oxidizing the (Z)-2-tridecen-1-ol with peroxide to give (.+-.)-cis-2,3-epoxy-1-tridecanol, reacting the (.+-.)-cis-2,3-epoxy-1-tridecanol with acid anhydride in the presence of hydrolase in an organic solvent for a stereoselective acylation and recovering unreacted optically active (2R, 3S)-cis-2,3-epoxy-1-tridecanol after the acylation, reacting the optically active (2R, 3S)-cis-2,3-epoxy-1-tridecanol with toluenesulfonylchloride to give (2R, 3S)-cis-1-p-toluenesulfoxy-2,3-epoxytridecane, and reacting the (2R, 3S)-cis-1-p-toluenesulfoxy-2,3-epoxytridecane with di(4-methylpentyl) lithium copper reagent to yield (7R, 8S)-cis-2-methyl-7,8-epoxyoctadecane which is the sex pheromone of Lymantria dispar L.

摘要翻译： 一种用于制备Lymantria dispar L.的性信息素的方法，其包括在氢氧化钠存在下使1-溴癸烷和炔丙醇四氢吡喃基醚反应，得到1-四氢吡喃氧基-2-三癸基，用四氢吡喃氧基-2-三癸基 对甲苯磺酸，得到2-三癸基-1-醇，在Lindlar催化剂存在下催化氢化2-三癸基-1-醇，得到（Z）-2-十三碳烯-1-醇，氧化（Z） （+/-） - 顺式-2,3-环氧-1-十三烷醇，使（+/-） - 顺式-2,3-环氧-1-十三烷醇与 酸酐在水解酶存在下在有机溶剂中进行立体选择性酰化，并在酰化后回收未反应的光学活性（2R，3S） - 顺式-2,3-环氧-1-十三烷醇，使光学活性（2R，3S） - 顺式-2,3-环氧-1-十三烷醇与甲苯磺酰氯反应，得到（2R，3S） - 顺式-1-对甲苯磺酰-2,3-环氧十三烷，并使（2R，3S） - 顺式-1- -toluenesul （4-甲基戊基）锂铜试剂，得到（7R，8S） - 顺式-2-甲基-7,8-环十八烷，是Lymantria dispar L的性信息素。

公开(公告)号：US5272069A

公开(公告)日：1993-12-21

申请号：US634914

申请日：1990-12-27

申请人： Eiichiro Fukusaki ,  Shuji Senda ,  Yutaka Nakazono ,  Tetsuo Omata ,  Ken Hibino ,  Hiromichi Ota ,  Takeshi Sugai

发明人： Eiichiro Fukusaki ,  Shuji Senda ,  Yutaka Nakazono ,  Tetsuo Omata ,  Ken Hibino ,  Hiromichi Ota ,  Takeshi Sugai

IPC分类号： C07C69/732 ,  C12P7/62 ,  C12P17/04 ,  C12P41/00 ,  C12P7/40

CPC分类号： C12P17/04 ,  C12P41/005 ,  C12P7/62

摘要： This invention relates to methods for producing optically active hydroxyesters and also to methods for producing and purifying optically active five-membered ring lactones.More specifically, the invention provides methods for efficiently, safely, and selectively producing and purifying optically active (R)-hydroxyester (shown by formula 1) and optically active (S)-hydroxyester (shown by formula 2) in high state of purity at ordinary temperature.The invention also relates to application of the interconvertible optically active (R)-five-membered ring lacton (shown by formula 5).They are intermediates for synthesizing various medicines, agricultural chemicals, and biologically active substances, however especially useful for synthesizing pheromone of a noxious insect, Popillia japonica Newman. ##STR1## (Here, R.sub.1 denotes --C.tbd.C--R.sub.3 or --C.dbd.C--R.sub.3 ; R.sub.2 and R.sub.3 denote straight chain or branched alkyl groups containing 1 to 10 carbon atoms; R.sub.4 denotes alkyl groups, aralkyl groups, or haloalkyl groups containing 1 to 12 carbon atoms and the end group of R.sub.4 may be carboxyl groups; * denotes asymmetricrbon atoms.)

公开(公告)号：US20060008841A1

公开(公告)日：2006-01-12

申请号：US11224268

申请日：2005-09-12

申请人： Keisaku Okada ,  Shuji Senda ,  Akio Kobayashi ,  Eiichiro Fukusaki ,  Takeshi Honda ,  Itaru Yanagihara ,  Tsuyoshi Nakanishi

发明人： Keisaku Okada ,  Shuji Senda ,  Akio Kobayashi ,  Eiichiro Fukusaki ,  Takeshi Honda ,  Itaru Yanagihara ,  Tsuyoshi Nakanishi

IPC分类号： C12Q1/68

CPC分类号： C12N15/115

摘要： The present invention provides a method for obtaining an aptamer capable of specifically adsorbing to Verotoxin-1 produced by Enterohemorrhagic Escherichia coli by an in vitro selection method utilizing affinity chromatography, particularly, a method including use of an affinity column immobilizing thereon a peptide having an amino acid sequence of Verotoxin-1, for the affinity chromatography, and a single strand nucleic acid molecule, which is an aptamer capable of specifically adsorbing to Verotoxin-1.

摘要翻译： 本发明提供了一种获得能够通过使用亲和层析的体外选择方法特异性吸收由肠出血性大肠杆菌产生的Verotoxin-1的适体的方法，特别是包括使用固定在其上的亲和柱的方法， Verotoxin-1的酸序列用于亲和层析，以及单链核酸分子，其是能够特异性吸附到Verotoxin-1的适体。

公开(公告)号：US20050282226A1

公开(公告)日：2005-12-22

申请号：US11214437

申请日：2005-08-29

申请人： Keisaku Okada ,  Shuji Senda ,  Akio Kobayashi ,  Eiichiro Fukusaki ,  Itaru Yanagihara ,  Tsuyoshi Nakanishi

发明人： Keisaku Okada ,  Shuji Senda ,  Akio Kobayashi ,  Eiichiro Fukusaki ,  Itaru Yanagihara ,  Tsuyoshi Nakanishi

IPC分类号： C12Q1/68 ,  C12Q1/6811 ,  C07H21/04

CPC分类号： C12Q1/6811

摘要： The present invention provides an aptamer capable of specifically adsorbing to bisphenol A suspected to be an endocrine disrupter as a target molecule, a method for obtaining an aptamer capable of specifically adsorbing to bisphenol A by an in vitro selection method utilizing affinity chromatography using a carrier immobilizing bisphenol A, particularly, a method including use of an antagonistic elution buffer containing an amphiprotic organic solvent for elution by the affinity chromatography, and a single-strand nucleic acid molecule which is an aptamer obtained thereby.

摘要翻译： 本发明提供了能够特异性吸附到怀疑是作为内分泌干扰物的双酚A作为靶分子的适体，获得能够通过使用载体固定的亲和层析的体外选择方法获得能够特异性吸附到双酚A的适体的方法 双酚A，特别是包括使用含有两亲性有机溶剂的拮抗性洗脱缓冲液用​​于通过亲和色谱法洗脱的方法和由其获得的适体的单链核酸分子。

公开(公告)号：US5077043A

公开(公告)日：1991-12-31

申请号：US535637

申请日：1990-06-11

申请人： Miklos Toth ,  Hans-Rudolf Buser ,  Heinrich Arn ,  Kenji Mori ,  Yasuo Ninomiya ,  Tetsuo Omata ,  Shuji Senda ,  Tadashi Takeuchi ,  Masakazu Aburatani

发明人： Miklos Toth ,  Hans-Rudolf Buser ,  Heinrich Arn ,  Kenji Mori ,  Yasuo Ninomiya ,  Tetsuo Omata ,  Shuji Senda ,  Tadashi Takeuchi ,  Masakazu Aburatani

IPC分类号： A01N43/04 ,  A01N43/20 ,  C07C47/21 ,  C07D303/04 ,  C07D303/14

CPC分类号： A01N43/20 ,  C07D303/04 ,  C07D303/14

摘要： The present invention provides mainly (3Z,6Z)-cis-9,10-epoxy-1,3,6-heneicosatriene (formula 1) and (3Z, 6Z)-cis-9,10-epoxy-1,3,6-elcosatriene (formula 2) which are Hyphantria cunea sex pheromones. The invention provides attractant components having high attraction effect for Hyphantria cunea, that is, Hyphantria cumea sex pheromones having high attraction activity and the intermediates which can selectively synthesize such pheromones with great ease.Furthermore, the invention provides attractant compositions with high attraction effect for Hyphantria cunea including such above noted pheromones.Consequently, this invention is completed. ##STR1##

摘要翻译： 本发明主要提供（3Z，6Z） - 顺-9,10-环氧-1,3,6 - 二十碳三烯（式1）和（3Z，6Z） - 顺式-9,10-环氧-1,3,6 - 三氯三烯（式2），它们是Hyphantria cunea性信息素。 本发明提供了具有高吸引力的吸引效果的吸引成分，即具有高吸附活性的Hyphantria cumea性信息素和可以非常容易地选择性合成这种信息素的中间体。 此外，本发明提供具有高吸引力效果的引诱剂组合物，其包括上述信息素。 因此，本发明完成。 （公式1）（公式2）

公开(公告)号：US4808340A

公开(公告)日：1989-02-28

申请号：US136041

申请日：1987-12-21

申请人： Shuji Senda ,  Tetsuo Omata

发明人： Shuji Senda ,  Tetsuo Omata

IPC分类号： C07C69/738 ,  B01J31/02 ,  C07B61/00 ,  C07C67/32 ,  C07C67/343 ,  C07C68/02 ,  C07C69/606 ,  C11C3/04

CPC分类号： C07C69/606

摘要： A process for preparing methyl 4-oxo-5-tetradecynoate useful as an intermediate for synthesizing (R,Z)-5-dec-1-enyl-oxacyclopentan-2-one, which comprises reacting monomethyl succinate with an alkyl chlorocarbonate in the presence of a base to form an acid anhydride and reacting the acid anhydride with a Grignard reagent of 1-decyne. Methyl 4-oxo-5-tetradecynoate can be prepared in high yields at high purities by this process.

摘要翻译： 用作合成（R，Z）-5-癸-1-烯基 - 氧环戊烷-2-酮的中间体的4-氧代-5-十四碳酸甲酯的制备方法，其包括在存在下使琥珀酸甲酯与氯代碳酸烷基酯反应 的碱形成酸酐，并使酸酐与1-癸炔的格利雅试剂反应。 通过该方法可以高纯度的高产率制备4-氧代-5-十四碳酸甲酯。

公开(公告)号：US5374766A

公开(公告)日：1994-12-20

申请号：US828067

申请日：1992-01-30

申请人： Shuji Senda ,  Eiichiro Fukuzaki ,  Yutaka Nakazono ,  Tetsuo Omata

发明人： Shuji Senda ,  Eiichiro Fukuzaki ,  Yutaka Nakazono ,  Tetsuo Omata

IPC分类号： C07C69/24 ,  C07C69/007 ,  C07C69/76 ,  C12P7/26 ,  C12P7/62 ,  C12P41/00

CPC分类号： C12P7/62 ,  C07C69/007 ,  C12P41/004

摘要： This invention relates to a novel ester which presents as (CF 1) and a method for the production of the same as well as a process for hydrolysis and a method for the determination of an optical purity using this ester, and the object thereof is to provide an intermediate for the synthesis or various natural products, which has high stability, and the optical purity of which can readily be determined, according to the esterification of 1-oxo-5-hydroxymethyl-2-cyclohexene which is unstable to acids and alkalis. ##STR1##

摘要翻译： 本发明涉及以（CF 1）表示的新型酯及其制造方法以及水解方法以及使用该酯测定光学纯度的方法，其目的在于 提供合成中间体或各种天然产物，其具有高稳定性，并且根据对酸和碱不稳定的1-氧代-5-羟甲基-2-环己烯的酯化，可以容易地确定其光学纯度 。 （图）（CF1）

公开(公告)号：US5024832A

公开(公告)日：1991-06-18

申请号：US450112

申请日：1989-12-13

申请人： Tetsuo Omata ,  Shuji Senda ,  Tamaki Tanaka ,  Eriko Kumagai ,  Chikara Kajimoto ,  Yutaka Nakazono

发明人： Tetsuo Omata ,  Shuji Senda ,  Tamaki Tanaka ,  Eriko Kumagai ,  Chikara Kajimoto ,  Yutaka Nakazono

IPC分类号： A01N31/02

CPC分类号： A01N31/02 ,  Y10S424/08 ,  Y10S424/11

摘要： A termites trail-marking pheromone which is (3Z,6Z,8E)-dodecatrienol, and a composition which comprises (3Z,6Z,8E)-dodecatrienol as an essential component and another component which is a trail-marking pheromone-like substance, and a method of detecting termites by using this composition or (3Z,6Z,8E)-dodecatrienol.The trail-marking pheromone and composition are highly safe in that they have no residual toxicity, and they have a stable, long-term trail-marking effect for termites. This invention provides a simple and rapid method of detecting termites, and a simple and effective method of capturing termites.

摘要翻译： 作为（3Z，6Z，8E） - 十二碳三烯酚的白蚁痕迹信息素，以（3Z，6Z，8E） - 十二碳三烯酚为必须成分的组合物和作为痕迹信息素样物质的其他成分， 以及通过使用该组合物或（3Z，6Z，8E） - 十二碳三烯酚来检测白蚁的方法。 痕迹信息素和组成是高度安全的，因为它们没有残留毒性，并且对白蚁具有稳定的长期跟踪效果。 本发明提供了一种检测白蚁的简单而快速的方法，也是捕获白蚁的简单而有效的方法。

公开(公告)号：US09436981B2

公开(公告)日：2016-09-06

申请号：US14363367

申请日：2012-12-10

申请人： Takashi Shibata ,  Akihiko Iketani ,  Shuji Senda

发明人： Takashi Shibata ,  Akihiko Iketani ,  Shuji Senda

IPC分类号： G06K9/00 ,  G06T5/00 ,  G06N99/00

CPC分类号： G06T5/003 ,  G06K9/00275 ,  G06N99/005 ,  G06T2207/20081 ,  G06T2207/20084

摘要： A dictionary creation device including a blurred image generation unit which outputs a blurred image generated by performing a blurring process to a learning image together with a blur parameter indicating a blurring state of the blurred image, a patch pair generation unit which generates a restoration patch and a blurred patch as a patch pair that is composed of the patches located at the corresponding positions of the learning image and the blurred image, and a registration unit which associates the patch pair with a blur parameter corresponding to the blurred patch in the patch pair and registers them in a dictionary.

摘要翻译： 一种词典创作装置，包括模糊图像生成单元，其通过对学习图像进行模糊处理而生成的模糊图像以及表示模糊图像的模糊状态的模糊参数，生成恢复贴片的贴片对生成单元， 由位于学习图像和模糊图像的对应位置处的贴片组成的贴片对的模糊贴片，以及配准单元，其将贴片对与对应于贴片对中的模糊贴片的模糊参数相关联， 将其注册在字典中。