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14 条记录 (耗时 0.017 秒)

    1,4-dihydro-2,6-dimethyl-4-nitrophenyl-3,5-pyridinedicarboxylic acid esters useful for treating renal insufficiency
    3.
    发明授权
    1,4-dihydro-2,6-dimethyl-4-nitrophenyl-3,5-pyridinedicarboxylic acid esters useful for treating renal insufficiency 失效
    可用于治疗肾功能不全的1,4-二氢-2,6-二甲基-4-硝基苯基-3,5-吡啶二羧酸酯

    公开(公告)号：US4582840A

    公开(公告)日：1986-04-15

    申请号：US726879

    申请日：1985-04-25

    申请人： Bernward Garthoff ,  Stanislav Kazda ,  Andreas Knorr ,  Gunter Thomas

    发明人： Bernward Garthoff ,  Stanislav Kazda ,  Andreas Knorr ,  Gunter Thomas

    IPC分类号： C07D211/90 ,  A61K31/44 ,  A61K31/455 ,  A61P7/10 ,  C07D213/55

    CPC分类号： A61K31/44

    摘要： A method of combating a disorder of the salt balance in a patient afflicted therewith comprising administering to such patient a salt-balance restoring effective amount of a vasodilating 1,4-dihydropyridine of the formula ##STR1## in which R.sup.1 and R.sup.2 each independently is alkyl with 1 to 4 carbon atoms, and the nitro radical is in the ortho- or meta-position of the phenyl radical.The salt balance disorder may accompany the hypertensive disease or may also be aggravated by administering to such a patient a hypertension reducing agent.

    摘要翻译： 一种防治患病患者的盐平衡紊乱的方法，其包括向所述患者施用盐平衡恢复有效量的式“IMAGE”的血管舒张性1,4-二氢吡啶，其中R 1和R 2各自独立地为烷基 具有1至4个碳原子，并且硝基在苯基的邻位或间位。 盐平衡障碍可伴随高血压疾病，或者也可通过向这样的患者施用高血压减轻剂而加重。

    Antihypertensive combination products containing a dihydropyridine and a pyridazodiazepine
    6.
    发明授权
    Antihypertensive combination products containing a dihydropyridine and a pyridazodiazepine 失效
    含有二氢吡啶和吡咯并二氮杂的抗高血压组合产品

    公开(公告)号：US4859665A

    公开(公告)日：1989-08-22

    申请号：US937867

    申请日：1986-12-02

    申请人： Bernward Garthoff ,  Marcel Gerold ,  Fridolin Hefti ,  Stanislav Kazda ,  Andreas Knorr

    发明人： Bernward Garthoff ,  Marcel Gerold ,  Fridolin Hefti ,  Stanislav Kazda ,  Andreas Knorr

    IPC分类号： A61K31/50 ,  A61K31/55 ,  A61P9/12

    CPC分类号： A61K31/55 ,  Y10S514/929

    摘要： Compositions for treating hypertension comprising an effective amount of a dihydropyridine of the formula ##STR1## in which X is 1 or 2 identical or different substituents from the group consisting of nitro, chlorine and trifluoromethyl, or together with the phenyl ring, the group ##STR2## R.sup.1 is alkyl of 1 to 4 C atoms, which is optionally substituted by alkoxy of 1 to 4 C atoms,R.sup.2 is alkyl of 1 to 12 C atoms, which is optionally substituted by alkoxy of 1 to 3 C atoms, fluorine or N-methyl-N-benzylamino andR.sup.3 is alkyl of 1 to 4 C atoms, cyano or hydroxymethyl, and a pyridazodiazepine of the formula ##STR3## in which R.sup.4 is aralkyl,R.sup.5 is hydrogen or alkyl of 1 to 8 C atoms,R.sup.6 is hydrogen or alkyl of 1 to 8 C atoms andR.sup.7 and R.sup.8 are hydrogen, or together, an oxo group, are described.

    摘要翻译： 用于治疗高血压的组合物，其包含有效量的式“IMAGE”的二氢吡啶，其中X是与硝基，氯和三氟甲基相同或不同的取代基，或与苯环一起，组IMA IMA > R 1为1〜4个C原子的烷基，其任选被1〜4个C原子的烷氧基取代，R 2为1〜12个C原子的烷基，其任选被1〜3个C原子的烷氧基取代，氟或N - 甲基-N-苄基氨基，R3为1-4个C原子的烷基，氰基或羟甲基，以及其中R 4为芳烷基，R 5为氢或1至8个C原子的烷基的式“IMAGE”的吡咯并二氮杂为R6 氢或1〜8个碳原子的烷基，R7和R8为氢，或一起为氧代基。

    Novel hypotensive imidazothiadiazolealkanecarboxamides
    8.
    发明授权
    Novel hypotensive imidazothiadiazolealkanecarboxamides 失效
    新型降压咪唑并噻二唑烷烃酰胺

    公开(公告)号：US4657905A

    公开(公告)日：1987-04-14

    申请号：US789689

    申请日：1985-10-21

    申请人： Axel Ingendoh ,  Horst Meyer ,  Bernward Garthoff

    发明人： Axel Ingendoh ,  Horst Meyer ,  Bernward Garthoff

    IPC分类号： A61K31/415 ,  A61K31/445 ,  A61P7/10 ,  A61P9/12 ,  C07D513/04 ,  A61K31/41 ,  A61K31/535 ,  A61K31/55

    CPC分类号： C07D513/04 ,  Y10S514/869

    摘要： Imidazothiadiazolealkenecarboxamides of the formula ##STR1## in which R.sup.1 is hydrogen, aryl, substituted aryl or a cyclic or aliphatic hydrocarbon radical which is optionally interrupted by O, S, N, N-alkyl, N-aryl or N-aralkyl and which is optionally substituted,R.sup.8 having the meaning indicated for R.sup.1, andX representing oxygen, sulphur or the radical NR.sup.9 R.sup.10,the other radical having various definitions, and acid addition salts thereof, exhibit hypotensive activity.

    摘要翻译： 其中R 1是氢，芳基，取代的芳基或任选地被O，S，N，N-烷基，N-芳基或N-芳烷基中断的环状或脂族烃基的咪唑并噻二唑烯烃酰胺，其任选地 取代的R 8具有R1表示的含义，X代表氧，硫或NR9R10基团，另一个具有不同定义的基团及其酸加成盐，表现为降血压活性。

    Imidazothiadiazolealkylene carboxylic acids
    10.
    发明授权
    Imidazothiadiazolealkylene carboxylic acids 失效

    公开(公告)号：US4709031A

    公开(公告)日：1987-11-24

    申请号：US884561

    申请日：1986-07-11

    申请人： Axel Ingendoh ,  Horst Meyer ,  Bernward Garthoff

    发明人： Axel Ingendoh ,  Horst Meyer ,  Bernward Garthoff

    IPC分类号： A61K31/415 ,  A61K31/445 ,  A61P7/10 ,  A61P9/12 ,  C07D513/04 ,  A61K31/425 ,  C07D285/12

    CPC分类号： C07D513/04 ,  Y10S514/869

    摘要： An alkenecarboxylic acid of the formula ##STR1## in which R.sup.1 denotes hydrogen, aryl, substituted aryl or a straight-chain or cyclic, saturated or unsaturated aliphatic hydrocarbon radical, which is optionally interrupted by O, S, N, N-alkyl, N-aryl or N-aralkyl, and which is optionally substituted by hydroxyl, alkoxy, alkyl, trifluoromethyl, halogen, phenyl, alkoxycarbonyl or dialkylamino, the two alkyl radicals together with the nitrogen atom optionally forming a 5 to 7-membered ring, which optionally contains a heteroatom from the group comprising O, S, NH or N-alkyl and these aforementioned alkyl and phenyl radicals in turn optionally being substituted by halogen, trifluoromethyl, alkyl, aryl, aralkyl, alkoxy, alkylmercapto or SO.sub.2 -alkyl,R.sup.2 represents the radical CXR.sup.8, R.sup.8 having the meaning indicated for R.sup.1 and being identical to or different from R.sup.1, andX representing oxygen, sulphur or the radical NR.sup.9 R.sup.10, R.sup.9 and R.sup.10 being identical or different and each having the meanings of R.sup.1 and being identical to or different from R.sup.1 ; or represents the radical SO.sub.n R.sup.11, n denoting 1 or 2 and R.sup.11 having the meaning indicated for R.sup.1 and being identical to or different from R.sup.1, orR.sup.1 and R.sup.2 together represents a group of the general formula .dbd.C(R.sup.12)(Y--R.sup.13), Y representing oxygen, sulphur, NH or N-alkyl, and R.sup.12 and R.sup.13 each having the meaning indicated for R.sup.1, being identical to or different from one another and R.sup.1, and optionally together forming, with inclusion of .dbd.C--Y, a 5 to 7-membered ring, which optionally contains a heteroatom from the group comprising O, S, NH or N-alkyl,R.sup.3 has the meaning indicated for R.sup.1 and is identical to or different from R.sup.1, or represents furyl, phenyl, thienyl, pyrimidyl, pyrazinyl, quinolinyl, isoquinolinyl or pyridyl, the rings optionally being substituted by 1, 2 or 3 identical or different substituents from the group comprising alkyl, aryl, alkoxy, halogen, nitro, trifluoromethyl, SO.sub.n -alkyl (n=0, 1 or 2) or NR.sup.9 R.sup.10, R.sup.9 and R.sup.10 having the meaning indicated above, R.sup.4 represents hydrogen, trifluoromethyl or alkyl, and R.sup.5 represents hydrogen, alkyl, cyano, halogen, nitro, SO.sub.n -alkyl (n=0, 1 or 2) or CXR.sup.8. These alkene carboxylic acids can be reacted with amine of the formula HNR.sup.6 R.sup.7 to give amides which are useful as antihypertnsives, diuretics and uricosuric agents.