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    Novel norbornane- and norbornene-carboxylic acid amides thromboxan antagonists
    4.
    发明授权
    Novel norbornane- and norbornene-carboxylic acid amides thromboxan antagonists 失效
    新型降冰片烷和降冰片烯 - 羧酸酰胺血栓素拮抗剂

    公开(公告)号：US4622339A

    公开(公告)日：1986-11-11

    申请号：US691088

    申请日：1985-01-11

    申请人： Folker Lieb ,  Hermann Oediger ,  Hans-Joachim Kabbe ,  Ulrich Niewohner ,  Elisabeth Perzborn ,  Friedel Seuter

    发明人： Folker Lieb ,  Hermann Oediger ,  Hans-Joachim Kabbe ,  Ulrich Niewohner ,  Elisabeth Perzborn ,  Friedel Seuter

    IPC分类号： A61K31/19 ,  A61K31/215 ,  A61P7/02 ,  A61P9/08 ,  A61P9/10 ,  A61P11/00 ,  A61P37/08 ,  A61P43/00 ,  C07C51/00 ,  C07C59/46 ,  C07C67/00 ,  C07C69/732 ,  C07C231/00 ,  C07C231/02 ,  C07C233/58 ,  C07D521/00 ,  A61K31/44

    CPC分类号： C07C59/46

    摘要： Norbornane- and norbornene-carboxylic acid amides of the formula ##STR1## in which ##STR2## represents the part structure ##STR3## A represents a ##STR4## or --CH.sub.2 --CH.sub.2 -- group, R.sup.1 and R.sup.2 each independently is hydrogen or an alkyl radical with 1-6 carbon atoms,R.sup.3 is alkyl or alkenyl which has 1-8 carbon atoms and is optionally substituted by halogen or alkyl with 1 or 2 carbon atoms, cycloalkyl or cycloalkeny wtih 3 to 7 carbon atoms, an aromatic radical which has 6 or 10 carbon atoms and and is optionally substituted by halogen, by alkyl with 1 or 2 carbon atoms or by halogenoalkyl with 1 or 2 carbon atoms, or is a five-membered or six-membered heteroaromatic radical,R.sup.4 is hydrogen or a hydroxyl group,R.sup.5 and R.sup.6 each independently is hydrogen or alkyl with 1 to 4 carbon atoms, andn is a number from 2 to 6,and, if R.sup.1 is hydrogen, also physiologically acceptable salts thereof, perform as thromboxan antagonists.

    摘要翻译： 其中代表部分结构的降冰片烯 - 和降冰片烯 - 羧酸酰胺代表“IMAGE”或-CH 2 -CH 2 - 基团，R 1和R 2各自独立地是氢或烷基 具有1-6个碳原子的基团，R3是具有1-8个碳原子并且任选地被卤素或具有1或2个碳原子的烷基取代的烷基或烯基，具有3至7个碳原子的环烷基或环烯基，具有 6或10个碳原子，并且任选被卤素，具有1或2个碳原子的烷基或具有1或2个碳原子的卤代烷基取代，或者是五元或六元杂芳族基团，R 4是氢或羟基 基团，R 5和R 6各自独立地是氢或具有1至4个碳原子的烷基，n是2至6的数，并且如果R 1是氢，则其生理上可接受的盐也作为血栓素拮抗剂进行。