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1.发明申请ARYLSULPHONYLGLYCINE DERIVATIVES, THE PREPARATION THEREOF AND THEIR USE AS MEDICAMENTS 审中-公开芳基磺酰胺衍生物，其制备方法及其作为药物使用公开(公告)号：US20110269761A1
公开(公告)日：2011-11-03
申请号：US12988452
申请日：2009-04-17
申请人： Elke Langkopf , Frank Himmelsbach , Juergen Mack , Alexander Pautsch , Corinna Schoelch , Annette Schuler-Metz , Ruediger Streicher , Holger Wagner
发明人： Elke Langkopf , Frank Himmelsbach , Juergen Mack , Alexander Pautsch , Corinna Schoelch , Annette Schuler-Metz , Ruediger Streicher , Holger Wagner
IPC分类号： A61K31/5377 , A61K31/277 , C07C271/12 , A61K31/27 , C07C309/65 , C07D271/06 , A61K31/4245 , C07D271/10 , C07D239/02 , A61K31/505 , C07D213/55 , A61K31/44 , C07D295/00 , A61K31/5375 , C07D241/04 , A61K31/495 , C07D215/38 , A61K31/47 , C07D403/04 , A61K31/506 , C07D413/04 , A61P3/10 , C07C255/57
CPC分类号： C07D271/06 , C07C311/21 , C07D213/40 , C07D213/74 , C07D215/40 , C07D239/26 , C07D271/10 , C07D295/108 , C07D295/15 , C07D307/52
摘要： The invention relates to substituted aryl-sulphonylglycine derivatives of general formula (I) wherein the groups Ra to Rf, A and Z are defined as in the specification and claims, which are suitable for preparing a pharmaceutical composition for the treatment of metabolic disorders, particularly type 1 or type 2 diabetes mellitus.
摘要翻译： 本发明涉及通式（I）的取代的芳基 - 磺酰基甘氨酸衍生物，其中基团Ra至Rf，A和Z如说明书和权利要求中所定义，其适于制备用于治疗代谢紊乱的药物组合物，特别是 1型或2型糖尿病。
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2.发明授权Substituted arylsulphonylglycines, the preparation thereof and the use thereof as pharmaceutical compositions 有权取代的芳基磺酰基甘氨酸，其制备方法及其作为药物组合物的用途公开(公告)号：US08232312B2
公开(公告)日：2012-07-31
申请号：US12530507
申请日：2008-03-14
申请人： Holger Wagner , Elke Langkopf , Matthias Eckhardt , Ruediger Streicher , Corinna Schoelch , Annette Schuler-Metz , Alexander Pautsch
发明人： Holger Wagner , Elke Langkopf , Matthias Eckhardt , Ruediger Streicher , Corinna Schoelch , Annette Schuler-Metz , Alexander Pautsch
IPC分类号： A61K31/5377 , A61K31/497 , A61K31/496 , A61K31/454 , A61K31/4439 , A61K31/428 , A61K31/4184 , A61K31/416 , A61K31/404 , C07D413/06 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D277/64 , C07D333/60 , C07D235/26 , C07D235/08 , C07D231/56 , C07D209/42 , C07D209/08 , C07D209/88
CPC分类号： C07D209/08 , C07D209/18 , C07D209/42 , C07D209/88 , C07D231/56 , C07D235/06 , C07D235/26 , C07D277/64 , C07D333/68 , C07D333/70 , C07D401/12 , C07D403/06 , C07D403/12 , C07F7/0812
摘要： The present invention relates to substituted arylsulphonylglycines of general formula (I) wherein R, X, Y and Z are defined as in claim 1, the tautomers, enantiomers, diastereomers, mixtures thereof and salts thereof, which have valuable pharmacological properties, particularly the suppression of the interaction of glycogen phosphorylase a with the GL subunit of glycogen-associated protein phosphatase 1 (PP1), and their use as pharmaceutical compositions.
摘要翻译： 本发明涉及通式（I）的取代芳基磺酰基甘氨酸，其中R，X，Y和Z如权利要求1所定义，其互变异构体，对映异构体，非对映体，其混合物及其盐具有有价值的药理学性质，特别是抑制 的糖原磷酸化酶a与糖原相关蛋白磷酸酶1（PP1）的GL亚基的相互作用，以及它们作为药物组合物的用途。
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3.发明授权Substituted arylsulfonylaminomethylphosphonic acid derivatives, their preparation and their use in the treatment of type I and II diabetes mellitus 有权取代的芳基磺酰氨基甲基膦酸衍生物，其制备及其在治疗I型和II型糖尿病中的应用公开(公告)号：US08211923B2
公开(公告)日：2012-07-03
申请号：US12669979
申请日：2008-07-25
申请人： Holger Wagner , Elke Langkopf , Matthias Eckhardt , Ruediger Streicher , Corinna Schoelch , Annette Schuler-Metz , Alexander Pautsch
发明人： Holger Wagner , Elke Langkopf , Matthias Eckhardt , Ruediger Streicher , Corinna Schoelch , Annette Schuler-Metz , Alexander Pautsch
IPC分类号： A61K31/404 , A61K31/416 , A61K31/4184 , A61K31/423 , A61K31/428 , C07D277/62 , C07D263/54 , C07D235/04 , C07D231/56 , C07D209/04
CPC分类号： C07F9/5728 , C07F9/65038 , C07F9/65068 , C07F9/65324 , C07F9/6541 , C07F9/655354 , C07F9/65583 , C07F9/65586
摘要： The present invention relates to substituted arylsulphonylaminomethyl-phosphonic acid derivatives of general formula wherein R, X, Y and Z are defined as in claim 1, the tautomers, enantiomers, diastereomers, mixtures thereof and salts thereof which have valuable pharmacological properties, particularly the suppression of the interaction of glycogen phosphorylase a with the GL subunit of glycogen-associated protein phosphatase 1 (PP1), and their use as pharmaceutical compositions.
摘要翻译： 本发明涉及以下通式的取代芳基磺酰氨基甲基膦酸衍生物其中R，X，Y和Z如权利要求1所定义，其互变异构体，对映异构体，非对映体，其混合物及其盐具有有价值的药理学性质， 的糖原磷酸化酶a与糖原相关蛋白磷酸酶1（PP1）的GL亚基的相互作用，以及它们作为药物组合物的用途。
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4.发明申请SUBSTITUTED ARYLSULFONYLAMINOMETHYLPHOSPHONIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF TYPE I AND II DIABETES MELLITUS 有权取代的芳基磺酰氨基乙基磷酸衍生物，其制备及其在治疗I型和II型糖尿病的用途公开(公告)号：US20100210595A1
公开(公告)日：2010-08-19
申请号：US12669979
申请日：2008-07-25
申请人： Holger Wagner , Elke Langkopf , Matthias Eckhardt , Ruediger Streicher , Corinna Schoelch , Annette Schuler-Metz , Alexander Pautsch
发明人： Holger Wagner , Elke Langkopf , Matthias Eckhardt , Ruediger Streicher , Corinna Schoelch , Annette Schuler-Metz , Alexander Pautsch
IPC分类号： A61K31/675 , C07F9/572 , C07F9/6541 , C07F9/653 , C07F9/6533 , C07F9/6558 , A61K31/683 , C07F9/59 , C07F9/6509 , A61P3/10
CPC分类号： C07F9/5728 , C07F9/65038 , C07F9/65068 , C07F9/65324 , C07F9/6541 , C07F9/655354 , C07F9/65583 , C07F9/65586
摘要： The present invention relates to substituted arylsulphonylaminomethyl-phosphonic acid derivatives of general formula wherein R, X, Y and Z are defined as in claim 1, the tautomers, enantiomers, diastereomers, mixtures thereof and salts thereof which have valuable pharmacological properties, particularly the suppression of the interaction of glycogen phosphorylase a with the GL subunit of glycogen-associated protein phosphatase 1 (PP1), and their use as pharmaceutical compositions.
摘要翻译： 本发明涉及以下通式的取代芳基磺酰氨基甲基膦酸衍生物其中R，X，Y和Z如权利要求1所定义，其互变异构体，对映异构体，非对映体，其混合物及其盐具有有价值的药理学性质， 的糖原磷酸化酶a与糖原相关蛋白磷酸酶1（PP1）的GL亚基的相互作用，以及它们作为药物组合物的用途。
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5.发明申请ARYLSULFONYLAMINOMETHYLPHOSPHONIC ACID DERIVATIVES, THE PREPARATION THEREOF AND THE USE THEREOF AS PHARMACEUTICAL COMPOSITIONS 有权芳基磺酰氨基乙基磷酸衍生物，其制备方法及其作为药物组合物的用途公开(公告)号：US20100261677A1
公开(公告)日：2010-10-14
申请号：US12676319
申请日：2008-09-04
申请人： Elke Langkopf , Alexander Pautsch , Corinna Schoelch , Annette Schuler-Metz , Ruediger Streicher , Holger Wagner
发明人： Elke Langkopf , Alexander Pautsch , Corinna Schoelch , Annette Schuler-Metz , Ruediger Streicher , Holger Wagner
IPC分类号： A61K31/675 , C07F9/28 , A61K31/662 , A61P3/10
CPC分类号： C07D215/38 , C07D217/22 , C07D219/08 , C07D231/56 , C07D237/28 , C07D239/42 , C07D239/72 , C07D239/74 , C07D241/42 , C07D263/56 , C07D277/66 , C07D471/04
摘要： The invention relates to substituted arylsulphonylaminomethylphosphonic acid derivatives of general formula (I) wherein the groups Ra to Rf, A and Z are defined as mentioned in the specification and claims, which are suitable for preparing a medicament for the treatment of metabolic disorders, particularly type 1 or type 2 diabetes mellitus.
摘要翻译： 本发明涉及通式（I）的取代芳基磺酰基氨基甲基膦酸衍生物，其中基团Ra至Rf，A和Z定义如说明书和权利要求中所述，其适用于制备用于治疗代谢紊乱的药物，特别是类型 1或2型糖尿病。
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6.发明授权Substituted arylsulfonylaminomethylphosphonic acid derivatives, their preparation and their use in the treatment of type I and II diabetes mellitus 有权取代的芳基磺酰氨基甲基膦酸衍生物，其制备及其在治疗I型和II型糖尿病中的应用公开(公告)号：US08357689B2
公开(公告)日：2013-01-22
申请号：US12669978
申请日：2008-07-25
申请人： Holger Wagner , Elke Langkopf , Matthias Eckhardt , Ruediger Streicher , Corinna Schoelch , Annette Schuler-Metz , Alexander Pautsch
发明人： Holger Wagner , Elke Langkopf , Matthias Eckhardt , Ruediger Streicher , Corinna Schoelch , Annette Schuler-Metz , Alexander Pautsch
IPC分类号： A61K31/404 , A61K31/416 , A61K31/4184 , A61K31/423 , A61K31/428 , C07D237/04 , C07D403/04
CPC分类号： C07F9/5728 , C07F9/65038 , C07F9/65068 , C07F9/65324 , C07F9/6541 , C07F9/655354 , C07F9/65583 , C07F9/65586
摘要： The present invention relates to substituted arylsulphonylaminomethyl-phosphonic acid derivatives of general formula wherein R, X, Y and Z are defined as in claim 1, the tautomers, enantiomers, diastereomers, mixtures thereof and salts thereof which have valuable pharmacological properties, particularly the suppression of the interaction of glycogen phosphorylase a with the GL subunit of glycogen-associated protein phosphatase 1 (PP1), and their use as pharmaceutical compositions.
摘要翻译： 本发明涉及以下通式的取代芳基磺酰氨基甲基膦酸衍生物其中R，X，Y和Z如权利要求1所定义，其互变异构体，对映异构体，非对映体，其混合物及其盐具有有价值的药理学性质， 的糖原磷酸化酶a与糖原相关蛋白磷酸酶1（PP1）的GL亚基的相互作用，以及它们作为药物组合物的用途。
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公开(公告)号：US20100210594A1
公开(公告)日：2010-08-19
申请号：US12669978
申请日：2008-07-25
申请人： Holger Wagner , Elke Langkopf , Matthias Eckhardt , Ruediger Streicher , Corinna Schoelch , Annette Schuler-Metz , Alexander Pautsch
发明人： Holger Wagner , Elke Langkopf , Matthias Eckhardt , Ruediger Streicher , Corinna Schoelch , Annette Schuler-Metz , Alexander Pautsch
IPC分类号： A61K31/675 , C07F9/6512 , C07F9/572 , C07F9/6509 , C07F9/645 , C07F9/6533 , C07F9/6521 , C07F9/6544 , C07F9/6503 , A61P3/10
CPC分类号： C07F9/5728 , C07F9/65038 , C07F9/65068 , C07F9/65324 , C07F9/6541 , C07F9/655354 , C07F9/65583 , C07F9/65586
摘要： The present invention relates to substituted arylsulphonylaminomethyl-phosphonic acid derivatives of general formula wherein R, X, Y and Z are defined as in claim 1, the tautomers, enantiomers, diastereomers, mixtures thereof and salts thereof which have valuable pharmacological properties, particularly the suppression of the interaction of glycogen phosphorylase a with the GL subunit of glycogen-associated protein phosphatase 1 (PP1), and their use as pharmaceutical compositions.
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8.发明授权Arylsulfonylaminomethylphosphonic acid derivatives, the preparation thereof and the use thereof as pharmaceutical compositions 有权芳基磺酰氨基甲基膦酸衍生物，其制备方法及其作为药物组合物的用途公开(公告)号：US08163911B2
公开(公告)日：2012-04-24
申请号：US12676319
申请日：2008-09-04
申请人： Elke Langkopf , Alexander Pautsch , Corinna Schoelch , Annette Schuler-Metz , Ruediger Streicher , Holger Wagner
发明人： Elke Langkopf , Alexander Pautsch , Corinna Schoelch , Annette Schuler-Metz , Ruediger Streicher , Holger Wagner
IPC分类号： C07F9/28
CPC分类号： C07D215/38 , C07D217/22 , C07D219/08 , C07D231/56 , C07D237/28 , C07D239/42 , C07D239/72 , C07D239/74 , C07D241/42 , C07D263/56 , C07D277/66 , C07D471/04
摘要： The invention relates to substituted arylsulphonylaminomethylphosphonic acid derivatives of general formula (I) wherein the groups Ra to Rf, A and Z are defined as mentioned in the specification and claims, which are suitable for preparing a medicament for the treatment of metabolic disorders, particularly type 1 or type 2 diabetes mellitus.
摘要翻译： 本发明涉及通式（I）的取代芳基磺酰基氨基甲基膦酸衍生物，其中基团Ra至Rf，A和Z定义如说明书和权利要求中所述，其适用于制备用于治疗代谢紊乱的药物，特别是类型 1或2型糖尿病。
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9.发明申请SUBSTITUTED ARYLSULPHONYLGLYCINES, THE PREPARATION THEREOF AND THE USE THEREOF AS PHARMACEUTICAL COMPOSITIONS 有权取代的氨基磺酰胺，其制备方法及其作为药物组合物的用途公开(公告)号：US20100130557A1
公开(公告)日：2010-05-27
申请号：US12530507
申请日：2008-03-14
申请人： Holger Wagner , Elke Langkopf , Matthias Eckhardt , Ruediger Streicher , Corinna Schoelch , Annette Schuler-Metz , Alexander Pautsch
发明人： Holger Wagner , Elke Langkopf , Matthias Eckhardt , Ruediger Streicher , Corinna Schoelch , Annette Schuler-Metz , Alexander Pautsch
IPC分类号： A61K31/404 , A61K31/4439 , A61K31/403 , C07D401/12 , C07D209/82 , C07D209/04 , A61P3/10
CPC分类号： C07D209/08 , C07D209/18 , C07D209/42 , C07D209/88 , C07D231/56 , C07D235/06 , C07D235/26 , C07D277/64 , C07D333/68 , C07D333/70 , C07D401/12 , C07D403/06 , C07D403/12 , C07F7/0812
摘要： The present invention relates to substituted arylsulphonylglycines of general formula (I) wherein R, X, Y and Z are defined as in claim 1, the tautomers, enantiomers, diastereomers, mixtures thereof and salts thereof, which have valuable pharmacological properties, particularly the suppression of the interaction of glycogen phosphorylase a with the GL subunit of glycogen-associated protein phosphatase 1 (PP1), and their use as pharmaceutical compositions.
摘要翻译： 本发明涉及通式（I）的取代芳基磺酰基甘氨酸，其中R，X，Y和Z如权利要求1所定义，其互变异构体，对映异构体，非对映体，其混合物及其盐具有有价值的药理学性质，特别是抑制 的糖原磷酸化酶a与糖原相关蛋白磷酸酶1（PP1）的GL亚基的相互作用，以及它们作为药物组合物的用途。
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10.发明申请SUBSTITUTED ARYLSULPHONYLGLYCINES, THE PREPARATION THEREOF AND THE USE THEREOF AS PHARMACEUTICAL COMPOSITIONS 审中-公开取代的氨基磺酰胺，其制备方法及其作为药物组合物的用途公开(公告)号：US20100093703A1
公开(公告)日：2010-04-15
申请号：US12527249
申请日：2008-02-15
申请人： Holger Wagner , Elke Langkopf , Ruediger Streicher , Matthias Eckhardt , Annette Schuler-Metz , Alexander Pautsch , Corinna Schoelch
发明人： Holger Wagner , Elke Langkopf , Ruediger Streicher , Matthias Eckhardt , Annette Schuler-Metz , Alexander Pautsch , Corinna Schoelch
IPC分类号： A61K31/404 , C07D403/04 , C07D401/04 , C07D403/14 , C07D413/14 , C07D417/14 , A61K31/506 , A61K31/4178 , A61K31/4439 , A61K31/496 , A61K31/501 , A61K31/53 , A61K31/5377 , A61K31/541 , A61K31/551 , A61P3/10
CPC分类号： C07D209/04 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14
摘要： The present invention relates to substituted arylsulphonylglycines of general formula wherein R, R4, X, Y, Z and m are defined as in claim 1, the tautomers, enantiomers, diastereomers, mixtures thereof and salts thereof, which have valuable pharmacological properties, particularly the suppression of the interaction of glycogen phosphorylase a with the GL subunit of glycogen-associated protein phosphatase 1 (PP1), and their use as pharmaceutical compositions.
摘要翻译： 本发明涉及通式其中R，R 4，X，Y，Z和m如权利要求1中定义的取代芳基磺酰基甘氨酸，其互变异构体，对映异构体，非对映异构体，其混合物及其盐，其具有有价值的药理学性质， 抑制糖原磷酸化酶a与糖原相关蛋白磷酸酶1（PP1）的GL亚基的相互作用，以及它们作为药物组合物的用途。
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