公开(公告)号：US10093609B2

公开(公告)日：2018-10-09

申请号：US15694982

申请日：2017-09-04

Applicant: Emory University

Inventor： Huw M. L. Davies ,  Spandan Chennamadhavuni ,  Andrei Bakin

IPC: A61K31/216 ,  A61K31/194 ,  C07C69/73 ,  C07C259/06 ,  C07C69/736 ,  C07C67/31 ,  C07C57/42 ,  C07C51/00 ,  A61K31/405 ,  A61K31/36 ,  A61K31/357 ,  A61K31/343 ,  C07D307/80 ,  C07D209/24 ,  C07C201/12 ,  C07C69/604 ,  C07C69/618 ,  C07C69/65 ,  C07C69/732 ,  C07C69/734 ,  C07C69/738 ,  C07D317/60 ,  C07D319/18 ,  C07D209/26 ,  C07D209/34 ,  C07D307/79 ,  C07C205/56 ,  C07D317/68

Abstract: The disclosure relates to TAK1 inhibitors, compositions, and uses related thereto. In certain embodiments, the disclosure relates to compounds of formula I, pharmaceutical compositions having a compound of formula I, and methods of treating or preventing cancer by administering an effective amount of a pharmaceutical composition having a compound of formula I to a subject in need thereof.

公开(公告)号：US20170369417A1

公开(公告)日：2017-12-28

申请号：US15694982

申请日：2017-09-04

Applicant: Emory University

Inventor： Huw M. L. Davies ,  Spandan Chennamadhavuni ,  Andrei Bakin

IPC: C07C69/73 ,  A61K31/194 ,  C07D317/60 ,  C07D307/80 ,  C07D307/79 ,  C07D209/34 ,  C07D209/26 ,  C07D209/24 ,  C07C259/06 ,  C07C205/56 ,  C07C201/12 ,  C07C69/738 ,  C07C69/736 ,  C07C69/734 ,  C07C69/732 ,  C07C69/65 ,  C07C69/618 ,  C07C69/604 ,  C07C67/31 ,  C07C57/42 ,  C07C51/00 ,  A61K31/405 ,  A61K31/36 ,  A61K31/357 ,  A61K31/343 ,  A61K31/216 ,  C07D317/68 ,  C07D319/18

CPC classification number: C07C69/73 ,  A61K31/194 ,  A61K31/216 ,  A61K31/343 ,  A61K31/357 ,  A61K31/36 ,  A61K31/405 ,  C07C51/00 ,  C07C57/42 ,  C07C67/31 ,  C07C69/604 ,  C07C69/618 ,  C07C69/65 ,  C07C69/732 ,  C07C69/734 ,  C07C69/736 ,  C07C69/738 ,  C07C201/12 ,  C07C205/56 ,  C07C259/06 ,  C07D209/24 ,  C07D209/26 ,  C07D209/34 ,  C07D307/79 ,  C07D307/80 ,  C07D317/60 ,  C07D317/68 ,  C07D319/18

Abstract: The disclosure relates to TAK1 inhibitors, compositions, and uses related thereto. In certain embodiments, the disclosure relates to compounds of formula I, pharmaceutical compositions having a compound of formula I, and methods of treating or preventing cancer by administering an effective amount of a pharmaceutical composition having a compound of formula I to a subject in need thereof.