公开(公告)号：US10207984B2

公开(公告)日：2019-02-19

申请号：US15145323

申请日：2016-05-03

Applicant: Emory University ,  Wake Forest University Health Sciences

Inventor： Huw M. L. Davies ,  Spandan Chennamadhavuni ,  Thomas J. Martin ,  Steven R. Childers

IPC: C07C229/46 ,  A61K31/195 ,  A61K45/06 ,  C07C227/16 ,  C07C67/313 ,  C07C69/757 ,  C07C227/04 ,  A61K31/216

Abstract: The disclosure relates to cyclopropyl derivatives and methods of use. In some embodiments, the disclosure relates to methods of managing medical disorders with pharmaceutical compositions disclosed herein administered to subject in need thereof. In certain embodiments, the disclosure relates to methods of managing mental disorders, mood disorders, pain, and fibromyalgia and related conditions with pharmaceutical compositions disclosed herein.

公开(公告)号：US20170369417A1

公开(公告)日：2017-12-28

申请号：US15694982

申请日：2017-09-04

Applicant: Emory University

Inventor： Huw M. L. Davies ,  Spandan Chennamadhavuni ,  Andrei Bakin

IPC: C07C69/73 ,  A61K31/194 ,  C07D317/60 ,  C07D307/80 ,  C07D307/79 ,  C07D209/34 ,  C07D209/26 ,  C07D209/24 ,  C07C259/06 ,  C07C205/56 ,  C07C201/12 ,  C07C69/738 ,  C07C69/736 ,  C07C69/734 ,  C07C69/732 ,  C07C69/65 ,  C07C69/618 ,  C07C69/604 ,  C07C67/31 ,  C07C57/42 ,  C07C51/00 ,  A61K31/405 ,  A61K31/36 ,  A61K31/357 ,  A61K31/343 ,  A61K31/216 ,  C07D317/68 ,  C07D319/18

CPC classification number: C07C69/73 ,  A61K31/194 ,  A61K31/216 ,  A61K31/343 ,  A61K31/357 ,  A61K31/36 ,  A61K31/405 ,  C07C51/00 ,  C07C57/42 ,  C07C67/31 ,  C07C69/604 ,  C07C69/618 ,  C07C69/65 ,  C07C69/732 ,  C07C69/734 ,  C07C69/736 ,  C07C69/738 ,  C07C201/12 ,  C07C205/56 ,  C07C259/06 ,  C07D209/24 ,  C07D209/26 ,  C07D209/34 ,  C07D307/79 ,  C07D307/80 ,  C07D317/60 ,  C07D317/68 ,  C07D319/18

Abstract: The disclosure relates to TAK1 inhibitors, compositions, and uses related thereto. In certain embodiments, the disclosure relates to compounds of formula I, pharmaceutical compositions having a compound of formula I, and methods of treating or preventing cancer by administering an effective amount of a pharmaceutical composition having a compound of formula I to a subject in need thereof.

公开(公告)号：US20240190804A1

公开(公告)日：2024-06-13

申请号：US18276736

申请日：2022-02-10

Applicant: Emory University

Inventor： Huw M. L. Davies ,  Joshua Sailer ,  Jack C. Sharland ,  Bo Wei

IPC: C07C67/343 ,  B01J31/22 ,  C07F15/00

CPC classification number: C07C67/343 ,  B01J31/223 ,  C07F15/0053 ,  B01J2231/4283 ,  B01J2531/0219 ,  B01J2531/821 ,  C07C2531/22 ,  C07C2601/02 ,  C07C2601/14

Abstract: This disclosure relates to compositions comprising diruthenium catalysts and uses related thereto. In certain embodiments, the diruthenium catalyst comprises a cyclopropyl ring substituted with a carboxylic acid ligand. In certain embodiments, the diruthenium catalyst comprises an N-(sulfonyl)pyrrolidine ring substituted with a carboxylic acid ligand. In certain embodiments, the diruthenium catalyst comprises a 2-(1,3-dioxoisoindolin-2-yl)acetic acid ligand. In certain embodiments, this disclosure relates to methods of using catalysts in chemical transformations disclosed herein.

公开(公告)号：US10093609B2

公开(公告)日：2018-10-09

申请号：US15694982

申请日：2017-09-04

Applicant: Emory University

Inventor： Huw M. L. Davies ,  Spandan Chennamadhavuni ,  Andrei Bakin

IPC: A61K31/216 ,  A61K31/194 ,  C07C69/73 ,  C07C259/06 ,  C07C69/736 ,  C07C67/31 ,  C07C57/42 ,  C07C51/00 ,  A61K31/405 ,  A61K31/36 ,  A61K31/357 ,  A61K31/343 ,  C07D307/80 ,  C07D209/24 ,  C07C201/12 ,  C07C69/604 ,  C07C69/618 ,  C07C69/65 ,  C07C69/732 ,  C07C69/734 ,  C07C69/738 ,  C07D317/60 ,  C07D319/18 ,  C07D209/26 ,  C07D209/34 ,  C07D307/79 ,  C07C205/56 ,  C07D317/68

Abstract: The disclosure relates to TAK1 inhibitors, compositions, and uses related thereto. In certain embodiments, the disclosure relates to compounds of formula I, pharmaceutical compositions having a compound of formula I, and methods of treating or preventing cancer by administering an effective amount of a pharmaceutical composition having a compound of formula I to a subject in need thereof.

公开(公告)号：US20140155643A1

公开(公告)日：2014-06-05

申请号：US14123389

申请日：2012-06-01

Applicant: EMORY UNIVERSITY

Inventor： Huw M. L. Davies ,  Jørn H. Hansen ,  Changming Qin

IPC: C07F15/00

CPC classification number: C07F15/0073 ,  B01J31/2239 ,  B01J2231/325 ,  B01J2531/0219 ,  B01J2531/822 ,  C07F15/008

Abstract: This disclosure relates to compositions comprising dirhodium catalysts and uses related thereto, e.g., in enantioselective transformations of donor/acceptor carbenoids. In certain embodiments, the dirhodium catalyst comprises a cyclopropyl ring substituted with a carboxylic acid ligand. In certain embodiments, the disclosure relates to compositions comprising a compound of the following formula, or salts thereof wherein, R1, R2, and R3 are defined herein.

Abstract translation: 本公开涉及包含铑催化剂和与其有关的用途的组合物，例如在供体/受体carb体的对映选择性转化中。 在某些实施方案中，二铑催化剂包含被羧酸配体取代的环丙基环。 在某些实施方案中，本公开涉及包含下式化合物或其盐的组合物，其中R 1，R 2和R 3在本文中定义。