公开(公告)号：US10093609B2

公开(公告)日：2018-10-09

申请号：US15694982

申请日：2017-09-04

Applicant: Emory University

Inventor： Huw M. L. Davies ,  Spandan Chennamadhavuni ,  Andrei Bakin

IPC: A61K31/216 ,  A61K31/194 ,  C07C69/73 ,  C07C259/06 ,  C07C69/736 ,  C07C67/31 ,  C07C57/42 ,  C07C51/00 ,  A61K31/405 ,  A61K31/36 ,  A61K31/357 ,  A61K31/343 ,  C07D307/80 ,  C07D209/24 ,  C07C201/12 ,  C07C69/604 ,  C07C69/618 ,  C07C69/65 ,  C07C69/732 ,  C07C69/734 ,  C07C69/738 ,  C07D317/60 ,  C07D319/18 ,  C07D209/26 ,  C07D209/34 ,  C07D307/79 ,  C07C205/56 ,  C07D317/68

Abstract: The disclosure relates to TAK1 inhibitors, compositions, and uses related thereto. In certain embodiments, the disclosure relates to compounds of formula I, pharmaceutical compositions having a compound of formula I, and methods of treating or preventing cancer by administering an effective amount of a pharmaceutical composition having a compound of formula I to a subject in need thereof.

公开(公告)号：US20160244403A1

公开(公告)日：2016-08-25

申请号：US15145323

申请日：2016-05-03

Applicant: Emory University ,  Wake Forest University Health Sciences

Inventor： Huw M. Davies ,  Spandan Chennamadhavuni ,  Thomas J. Martin ,  Steven R. Childers

IPC: C07C229/46 ,  A61K31/216 ,  A61K45/06

CPC classification number: C07C229/46 ,  A61K31/195 ,  A61K31/216 ,  A61K45/06 ,  C07C67/313 ,  C07C69/757 ,  C07C227/04 ,  C07C227/16 ,  C07C2601/02 ,  A61K2300/00

Abstract: The disclosure relates to cyclopropyl derivatives and methods of use. In some embodiments, the disclosure relates to methods of managing medical disorders with pharmaceutical compositions disclosed herein administered to subject in need thereof. In certain embodiments, the disclosure relates to methods of managing mental disorders, mood disorders, pain, and fibromyalgia and related conditions with pharmaceutical compositions disclosed herein.

Abstract translation: 本公开涉及环丙基衍生物和使用方法。 在一些实施方案中，本公开涉及用本文公开的药物组合物管理医学病症的方法，其给予有需要的受试者。 在某些实施方案中，本公开涉及用本文公开的药物组合物治疗精神障碍，情绪障碍，疼痛和纤维肌痛以及相关病症的方法。

公开(公告)号：US10207984B2

公开(公告)日：2019-02-19

申请号：US15145323

申请日：2016-05-03

Applicant: Emory University ,  Wake Forest University Health Sciences

Inventor： Huw M. L. Davies ,  Spandan Chennamadhavuni ,  Thomas J. Martin ,  Steven R. Childers

IPC: C07C229/46 ,  A61K31/195 ,  A61K45/06 ,  C07C227/16 ,  C07C67/313 ,  C07C69/757 ,  C07C227/04 ,  A61K31/216

Abstract: The disclosure relates to cyclopropyl derivatives and methods of use. In some embodiments, the disclosure relates to methods of managing medical disorders with pharmaceutical compositions disclosed herein administered to subject in need thereof. In certain embodiments, the disclosure relates to methods of managing mental disorders, mood disorders, pain, and fibromyalgia and related conditions with pharmaceutical compositions disclosed herein.

公开(公告)号：US20170369417A1

公开(公告)日：2017-12-28

申请号：US15694982

申请日：2017-09-04

Applicant: Emory University

Inventor： Huw M. L. Davies ,  Spandan Chennamadhavuni ,  Andrei Bakin

IPC: C07C69/73 ,  A61K31/194 ,  C07D317/60 ,  C07D307/80 ,  C07D307/79 ,  C07D209/34 ,  C07D209/26 ,  C07D209/24 ,  C07C259/06 ,  C07C205/56 ,  C07C201/12 ,  C07C69/738 ,  C07C69/736 ,  C07C69/734 ,  C07C69/732 ,  C07C69/65 ,  C07C69/618 ,  C07C69/604 ,  C07C67/31 ,  C07C57/42 ,  C07C51/00 ,  A61K31/405 ,  A61K31/36 ,  A61K31/357 ,  A61K31/343 ,  A61K31/216 ,  C07D317/68 ,  C07D319/18

CPC classification number: C07C69/73 ,  A61K31/194 ,  A61K31/216 ,  A61K31/343 ,  A61K31/357 ,  A61K31/36 ,  A61K31/405 ,  C07C51/00 ,  C07C57/42 ,  C07C67/31 ,  C07C69/604 ,  C07C69/618 ,  C07C69/65 ,  C07C69/732 ,  C07C69/734 ,  C07C69/736 ,  C07C69/738 ,  C07C201/12 ,  C07C205/56 ,  C07C259/06 ,  C07D209/24 ,  C07D209/26 ,  C07D209/34 ,  C07D307/79 ,  C07D307/80 ,  C07D317/60 ,  C07D317/68 ,  C07D319/18

Abstract: The disclosure relates to TAK1 inhibitors, compositions, and uses related thereto. In certain embodiments, the disclosure relates to compounds of formula I, pharmaceutical compositions having a compound of formula I, and methods of treating or preventing cancer by administering an effective amount of a pharmaceutical composition having a compound of formula I to a subject in need thereof.