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公开(公告)号：US20190169557A1
公开(公告)日：2019-06-06
申请号：US16226229
申请日：2018-12-19
申请人： EMULATE, Inc.
发明人： Daniel Levner , Josiah Daniel Sliz , Christopher David Hinojosa , Guy Robert Thompson, II , Petrus Wilhelmus Martinus van Ruijven , Matthew Daniel Solomon , Christian Alexander Potzner , Patrick Sean Tuohy , Joshua Gomes , Norman Wen , Jacob Freake , Doug Sabin
IPC分类号： C12M3/06 , C12M1/00 , B01L9/00 , A01N1/02 , C12M1/42 , C12M1/34 , B01L3/00 , C12M3/00 , C12N5/071 , C12M1/36
摘要： A perfusion manifold assembly is described that allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells that mimic cells in an organ in the body, that is detachably linked with said assembly so that fluid enters ports of the microfluidic device from a fluid reservoir, optionally without tubing, at a controllable flow rate.Drop-to-drop connection schemes are described for putting a microfluidic device in fluidic communication with a fluid source or another microfluidic device, including but not limited to, putting a microfluidic device in fluidic communication with the perfusion manifold assembly.
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公开(公告)号：US10988722B2
公开(公告)日：2021-04-27
申请号：US16226229
申请日：2018-12-19
申请人： EMULATE, Inc.
发明人： Daniel Levner , Josiah Daniel Sliz , Christopher David Hinojosa , Guy Robert Thompson, II , Petrus Wilhelmus Martinus van Ruijven , Matthew Daniel Solomon , Christian Alexander Potzner , Patrick Sean Tuohy , Joshua Gomes , Norman Wen , Jacob Freake , Doug Sabin
IPC分类号： C12M3/06 , C12M1/00 , B01L3/00 , C12M1/42 , C12M1/34 , C12N5/071 , A01N1/02 , C12M3/00 , C12M1/36 , B01L9/00
摘要： The invention relates to a perfusion manifold assembly that allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells that mimic cells in an organ in the body, that is detachably linked with an assembly so that fluid enters ports of the microfluidic device from a fluid reservoir, optionally without tubing, at a controllable flow rate.
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公开(公告)号：US10125342B2
公开(公告)日：2018-11-13
申请号：US15248509
申请日：2016-08-26
申请人： EMULATE, Inc.
发明人： Daniel Levner , Josiah Daniel Sliz , Christopher David Hinojosa , Guy Robert Thompson, II , Petrus Wilhelmus Martinus van Ruijven , Matthew Daniel Solomon , Christian Alexander Potzner , Patrick Sean Tuohy
IPC分类号： B01L3/00 , C12M1/00 , C12M3/00 , C12M3/06 , C12M1/42 , C12M1/34 , C12N5/071 , A01N1/02 , C12M1/36
摘要： Drop-to-drop connection schemes are described for putting a microfluidic device in fluidic communication with a fluid source or another microfluidic device, including but not limited to, putting a microfluidic device in fluidic communication with the perfusion manifold assembly.
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公开(公告)号：US20170058243A1
公开(公告)日：2017-03-02
申请号：US15248509
申请日：2016-08-26
申请人： EMULATE, Inc.
发明人： Daniel Levner , Josiah Daniel Sliz , Christopher David Hinojosa , Guy Robert Thompson , Petrus Wilhelmus Martinus van Ruijven , Matthew Daniel Solomon , Christian Alexander Potzner , Patrick Sean Tuohy
CPC分类号： C12M23/16 , A01N1/021 , A01N1/0247 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L2200/025 , B01L2200/027 , B01L2200/12 , B01L2300/0681 , B01L2300/0887 , B01L2300/123 , B01L2300/14 , B01L2300/161 , B01L2300/165 , B01L2400/0481 , B01L2400/0487 , B01L2400/06 , C12M21/08 , C12M23/38 , C12M23/40 , C12M23/42 , C12M29/10 , C12M35/04 , C12M41/40 , C12M41/48 , C12N5/0602 , C12N2521/00
摘要： Drop-to-drop connection schemes are described for putting a microfluidic device in fluidic communication with a fluid source or another microfluidic device, including but not limited to, putting a microfluidic device in fluidic communication with the perfusion manifold assembly.
摘要翻译： 描述了用于将微流体装置与流体源或另一微流体装置流体连通的液滴连接方案，包括但不限于将微流体装置与灌注歧管组件流体连通。
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公开(公告)号：US20170056880A1
公开(公告)日：2017-03-02
申请号：US15248588
申请日：2016-08-26
申请人： EMULATE, Inc.
发明人： Daniel Levner , Josiah Daniel Sliz , Christopher David Hinojosa , Guy Robert Thompson , Petrus Wilhelmus Martinus van Ruijven , Matthew Daniel Solomon , Christian Alexander Potzner , Patrick Sean Tuohy , Joshua Gomes
CPC分类号： C12M23/16 , A01N1/021 , A01N1/0247 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L9/527 , B01L2200/025 , B01L2200/027 , B01L2200/12 , B01L2300/0681 , B01L2300/0887 , B01L2300/123 , B01L2300/14 , B01L2300/161 , B01L2300/165 , B01L2400/0481 , B01L2400/0487 , B01L2400/06 , C12M21/08 , C12M23/38 , C12M23/40 , C12M23/42 , C12M29/10 , C12M35/04 , C12M41/40 , C12M41/48 , C12N5/0602 , C12N2521/00
摘要： Drop-to-drop connection schemes are described for putting a microfluidic device in fluidic communication with a fluid source or another microfluidic device. Methods for establishing fluid connections with guide mechanisms are described.
摘要翻译： 描述了用于将微流体装置与流体源或另一微流体装置流体连通的液滴连接方案。 描述了与引导机构建立流体连接的方法。
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公开(公告)号：US20170055522A1
公开(公告)日：2017-03-02
申请号：US15248633
申请日：2016-08-26
申请人： EMULATE, Inc.
发明人： Daniel Levner , Josiah Daniel Sliz , Christopher David Hinojosa , Guy Robert Thompson , Petrus Wilhelmus Martinus van Ruijven , Matthew Daniel Solomon , Christian Alexander Potzner , Patrick Sean Tuohy , Joshua Gomes , Norman Wen , Jacob Freake , Doug Sabin
CPC分类号： C12M23/16 , A01N1/021 , A01N1/0247 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502738 , B01L2200/025 , B01L2200/027 , B01L2200/12 , B01L2300/0681 , B01L2300/0887 , B01L2300/123 , B01L2300/14 , B01L2300/161 , B01L2300/165 , B01L2400/0481 , B01L2400/0487 , B01L2400/06 , C12M21/08 , C12M23/38 , C12M23/40 , C12M23/42 , C12M29/10 , C12M35/04 , C12M41/40 , C12M41/48 , C12N5/0602 , C12N2521/00
摘要： A perfusion manifold assembly is described that allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells that mimic cells in an organ in the body, that is detachably linked with said assembly so that fluid enters ports of the microfluidic device from a fluid reservoir, optionally without tubing, at a controllable flow rate.Drop-to-drop connection schemes are described for putting a microfluidic device in fluidic communication with a fluid source or another microfluidic device, including but not limited to, putting a microfluidic device in fluidic communication with the perfusion manifold assembly.
摘要翻译： 描述了用于将微流体装置与流体源或另一微流体装置流体连通的液滴连接方案，包括但不限于将微流体装置与灌注歧管组件流体连通。
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公开(公告)号：US10689608B2
公开(公告)日：2020-06-23
申请号：US16108827
申请日：2018-08-22
申请人： EMULATE, Inc.
发明人： Daniel Levner , Josiah Daniel Sliz , Christopher David Hinojosa , Guy Robert Thompson, II , Petrus Wilhelmus Martinus van Ruijven , Matthew Daniel Solomon , Christian Alexander Potzner , Patrick Sean Tuohy
IPC分类号： B01L3/00 , C12M1/00 , C12M1/16 , C12M3/00 , C12N5/071 , C12M3/06 , C12M1/42 , C12M1/34 , A01N1/02 , C12M1/36 , B01L9/00
摘要： Drop-to-drop connection schemes are described for putting a microfluidic device in fluidic communication with a fluid source or another microfluidic device, including but not limited to, putting a microfluidic device in fluidic communication with the perfusion manifold assembly.
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公开(公告)号：US10273441B2
公开(公告)日：2019-04-30
申请号：US15248633
申请日：2016-08-26
申请人： EMULATE, Inc.
发明人： Daniel Levner , Josiah Daniel Sliz , Christopher David Hinojosa , Guy Robert Thompson, II , Petrus Wilhelmus Martinus van Ruijven , Matthew Daniel Solomon , Christian Alexander Potzner , Patrick Sean Tuohy , Joshua Gomes , Norman Wen , Jacob Freake , Doug Sabin
IPC分类号： C12M1/34 , C12M1/36 , A01N1/02 , C12M3/06 , B01L3/00 , C12M1/00 , C12M1/42 , C12N5/071 , C12M3/00 , B01L9/00
摘要： The invention relates to a perfusion manifold assembly that allows for perfusion of a microfluidic device, such as an organ on a chip microfluidic device comprising cells that mimic cells in an organ in the body, that is detachably linked with an assembly so that fluid enters ports of the microfluidic device from a fluid reservoir, optionally without tubing, at a controllable flow rate. The invention further relates to a drop-to-drop connection scheme for putting a microfluidic device in fluidic communication with a fluid source or another microfluidic device, including but not limited to, putting a microfluidic device in fluidic communication with the perfusion manifold assembly.
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公开(公告)号：US20190002811A1
公开(公告)日：2019-01-03
申请号：US16108827
申请日：2018-08-22
申请人： Emulate, Inc.
发明人： Daniel Levner , Josiah Daniel Sliz , Christopher David Hinojosa , Guy Robert Thompson, II , Petrus Wilhelmus Martinus van Ruijven , Matthew Daniel Solomon , Christian Alexander Potzner , Patrick Sean Tuohy
IPC分类号： C12M3/06 , C12N5/071 , C12M1/00 , B01L3/00 , B01L9/00 , C12M3/00 , C12M1/36 , C12M1/34 , C12M1/42 , A01N1/02
摘要： Drop-to-drop connection schemes are described for putting a microfluidic device in fluidic communication with a fluid source or another microfluidic device, including but not limited to, putting a microfluidic device in fluidic communication with the perfusion manifold assembly.
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