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    Use of Polymeric Materials with Other Substances for Improved Performance
    1.
    发明申请
    Use of Polymeric Materials with Other Substances for Improved Performance 审中-公开
    使用高分子材料与其他物质提高性能

    公开(公告)号：US20090311235A1

    公开(公告)日：2009-12-17

    申请号：US12403788

    申请日：2009-03-13

    申请人： Eric Elenko ,  Eyal S. Ron ,  Yishai Zohar

    发明人： Eric Elenko ,  Eyal S. Ron ,  Yishai Zohar

    IPC分类号： A61K38/48 ,  A61K33/08 ,  A61K33/10 ,  A61K31/4439 ,  A61K31/426 ,  A61K31/4188 ,  A61K31/4164 ,  A61K31/365 ,  A61K31/341 ,  A61K31/135 ,  A61K31/137 ,  A61P11/00 ,  A61P3/00 ,  A61P25/00

    CPC分类号： A61K47/22 ,  A61K9/0065 ,  A61K31/785

    摘要： Methods of enabling or improving the ability of a hydrogel to swell in the stomach of an animal and/or increasing the amount of time said hydrogel remains swollen in the stomach are described herein. In one embodiment, a polymer is administered in combination with one or more pH modifying agents which raise and maintain the pH of the micro environment of the polymer and/or the stomach in order inducing swelling in the polymer. The polymer can be a homopolymer, a copolymer, or a polymer blend or composite. In one embodiment, the polymer is a superabsorbent polymer (“SAP”). The polymers can also be administered with one or more active agents, such as appetite suppressants. The pH modifying agent and/or the active agent can be administered simultaneously with the polymer in the same dosage form, simultaneously with the polymer in separate dosage forms, or sequentially. The compositions are formulated for oral administration. The formulation can include drugs for delivery to the stomach, such as antibiotics, or the hydrogel can be used as a filler, for example, for obesity control. The formulation an also be used to enhance gastric retention, for example, for controlled drug delivery. Methods of delivering a drug are also described herein, along with medicaments for carrying out the methods of the present invention.

    摘要翻译： 本文描述了能够或改善水凝胶在动物胃中膨胀的能力和/或增加所述水凝胶在胃中保持肿胀的时间量的方法。 在一个实施方案中，聚合物与一种或多种pH调节剂组合施用，其提高并保持聚合物和/或胃的微环境的pH，以便在聚合物中引起溶胀。 聚合物可以是均聚物，共聚物或聚合物共混物或复合材料。 在一个实施方案中，聚合物是超吸收聚合物（“SAP”）。 聚合物还可以与一种或多种活性剂一起施用，例如食欲抑制剂。 pH调节剂和/或活性剂可以与相同剂型的聚合物同时施用，与分开的剂型中的聚合物同时或依次施用。 将组合物配制成口服给药。 制剂可以包括用于递送到胃的药物，例如抗生素，或者水凝胶可以用作填充剂，例如用于肥胖控制。 制剂也可用于增强胃潴留，例如用于受控药物递送。 本文还描述了递送药物的方法以及用于实施本发明的方法的药物。