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    Synthesis of N-vinylformamide
    1.
    发明授权
    Synthesis of N-vinylformamide 失效
    N-乙烯基甲酰胺的合成

    公开(公告)号：US07026511B2

    公开(公告)日：2006-04-11

    申请号：US10789900

    申请日：2004-02-27

    申请人： Eric J. Beckman ,  Toby M. Chapman ,  Cedrick Favero ,  Christopher C. Capelli ,  Harold E. Swift ,  William Eamon Carroll

    发明人： Eric J. Beckman ,  Toby M. Chapman ,  Cedrick Favero ,  Christopher C. Capelli ,  Harold E. Swift ,  William Eamon Carroll

    IPC分类号： C07C233/03

    CPC分类号： C07C231/12 ,  C07C233/03 ,  C07C233/05

    摘要： A process to produce N-vinylformamide includes the steps of: reacting hydroxyethyl formamide with a reactant comprising at least one cyclic anhydride group to form an ester, and dissociating the ester via heat in a thin film evaporation to synthesize N-vinylformamide and a compound comprising at least one diacid group, the N-vinylformamide separating from the diacid during the thin film evaporation. The reactant including at least one cyclic anhydride group can, for example, be succinic anhydride, maleic anhydride, phthalic anhydride, (2-docecen-1-yl)succinic anhydride, exo-3,6-epoxy-1,2,3,6-tetrahydrophthalic anhydride or a polymer including at least one cyclic anhydride group. A process to produce N-vinylformamide comprises the steps of: mixing acetaldehyde, formamide and a source of anhydride in a single reaction vessel, reacting the acetaldehyde, formamide and the source of anhydride in the reaction vessel under pressure, dissociating an ester formed by a reaction between the source of anhydride and hydroxyethyl formamide formed in the reaction vessel to synthesize N-vinylformamide and a compound comprising at least one diacid group.

    摘要翻译： 制备N-乙烯基甲酰胺的方法包括以下步骤：使羟乙基甲酰胺与包含至少一个环状酸酐基团的反应物反应形成酯，并在薄膜蒸发中通过热解离酯以合成N-乙烯基甲酰胺和包含 至少一个二酸基团，在薄膜蒸发期间与二酸分离的N-乙烯基甲酰胺。 包括至少一个环状酸酐基团的反应物可以是例如琥珀酸酐，马来酸酐，邻苯二甲酸酐，（2-多烯-1-基）琥珀酸酐，外部-3,6-环氧-1,2,3， 6-四氢邻苯二甲酸酐或包含至少一个环状酸酐基团的聚合物。 制备N-乙烯基甲酰胺的方法包括以下步骤：将乙醛，甲酰胺和酸酐源在单个反应容器中混合，在压力下使乙醛，甲酰胺和酸酐源在反应容器中反应，使由 在反应容器中形成的酸酐源和羟乙基甲酰胺之间的反应合成N-乙烯基甲酰胺和包含至少一个二酸基团的化合物。

    Synthesis of N-vinyl formamide
    2.
    发明授权
    Synthesis of N-vinyl formamide 失效
    N-乙烯基甲酰胺的合成

    公开(公告)号：US06965052B2

    公开(公告)日：2005-11-15

    申请号：US10652104

    申请日：2003-08-29

    申请人： Eric J. Beckman ,  Tody M. Chapman ,  Cedrick Gilbert Favero ,  Christopher C. Capelli ,  Harold E. Swift

    发明人： Eric J. Beckman ,  Tody M. Chapman ,  Cedrick Gilbert Favero ,  Christopher C. Capelli ,  Harold E. Swift

    IPC分类号： C07B61/00 ,  C07C231/12 ,  C07C233/03

    CPC分类号： C07C231/12 ,  C07C233/03

    摘要： A process to produce N-vinylformamide includes the steps of: reacting hydroxyethyl formamide with a reactant including at least one cyclic anhydride group to form an ester, and dissociating (or cracking) the ester to synthesize N-vinylformamide and a compound including at least one diacid group. The ester can be dissociated using heat. The reactant including at least one cyclic anhydride group can, for example, be succinic anhydride, maleic anhydride, phthalic anhydride, a polymer including at least one cyclic anhydride group, or a solid support to which at least one cyclic anhydride group is covalently tethered. Preferably, the cyclic anhydride is regenerated from the diacid formed in the synthesis of the ester by heating the diacid to dehydrate the diacid. The temperature required to dehydrate diacid groups is preferably higher than the temperature use to dissociate the ester.

    摘要翻译： 制备N-乙烯基甲酰胺的方法包括以下步骤：使羟乙基甲酰胺与包含至少一个环状酸酐基团的反应物反应形成酯，并使酯解离（或开裂）以合成N-乙烯基甲酰胺和包含至少一种 二酸组。 酯可以使用热分解。 包括至少一个环状酸酐基团的反应物可以是例如琥珀酸酐，马来酸酐，邻苯二甲酸酐，包含至少一个环状酸酐基团的聚合物或至少一个环状酸酐基团共价连接的固体载体。 优选地，通过加热二酸以脱水二酸，从酯合成中形成的二酸中再生环酐。 脱水二酸基团所需的温度优选高于解离酯的温度。

    DEVICES AND METHODS FOR INHIBITING FIBROSIS
    3.
    发明申请
    DEVICES AND METHODS FOR INHIBITING FIBROSIS 审中-公开
    用于抑制纤维化的装置和方法

    公开(公告)号：US20080160064A1

    公开(公告)日：2008-07-03

    申请号：US11963032

    申请日：2007-12-21

    申请人： Christopher C. Capelli ,  Andrew P. Dennis

    发明人： Christopher C. Capelli ,  Andrew P. Dennis

    IPC分类号： A61F2/02 ,  A61K33/00 ,  A61P17/00

    CPC分类号： A61L27/34 ,  A61K33/00 ,  A61K33/08 ,  A61L27/54 ,  A61L29/085 ,  A61L29/16 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/10 ,  A61L2300/602 ,  A61L2300/802 ,  A61K2300/00

    摘要： The present invention relates to compositions and methods for rendering medical devices less prone to fibrous encapsulation comprising the use of non-gaseous CO dissolved in a reservoir material. Upon exposure to a biological environment, non-gaseous CO is slowly desorbed and/or dissolved from the reservoir material which provides anti-fibrotic activity. These compositions and methods may be used directly on soft tissue implants and/or medical devices to treat and/or prevent conditions and disease states related to fibrosis. Furthermore, the compositions can be incorporated into materials that are used to create soft tissue implants and/or medical devices to imbue implants and devices with anti-fibrotic properties.

    摘要翻译： 本发明涉及用于使医疗器械不易于纤维状包封的组合物和方法，其包括使用溶解在贮存器材料中的非气态CO。 在暴露于生物环境中，非气态CO被缓慢解吸和/或从提供抗纤维化活性的储层材料中溶解。 这些组合物和方法可以直接用于软组织植入物和/或医疗装置以治疗和/或预防与纤维化相关的病症和疾病状态。 此外，组合物可以结合到用于产生软组织植入物和/或医疗装置以浸渍具有抗纤维化性质的植入物和装置的材料中。

    Energy harvesting circuits and associated methods
    5.
    发明授权
    Energy harvesting circuits and associated methods 有权
    能量收集电路及相关方法

    公开(公告)号：US06856291B2

    公开(公告)日：2005-02-15

    申请号：US10624051

    申请日：2003-07-21

    申请人： Marlin H. Mickle ,  Christopher C. Capelli ,  Harold Swift

    发明人： Marlin H. Mickle ,  Christopher C. Capelli ,  Harold Swift

    IPC分类号： H01Q9/27 ,  H01Q1/22 ,  H01Q1/24 ,  H01Q1/26

    CPC分类号： H01Q1/2225 ,  H01Q1/22 ,  H01Q1/248

    摘要： An inherently tuned antenna has a circuit for harvesting energy transmitted in space and includes portions that are structured to provide regenerative feedback into the antenna to produce an inherently tuned antenna which has an effective area substantially greater than its physical area. The inherently tuned antenna includes inherent distributive inductive, inherent distributive capacitive and inherent distributive resistive elements which cause the antenna to resonate responsive to receipt of energy at a particular frequency and to provide feedback to regenerate the antenna. The circuit may be provided on an integrated circuit chip. An associated method is provided.

    摘要翻译： 固有调谐的天线具有用于收集在空间中传输的能量的电路，并且包括被构造为向天线提供再生反馈以产生固有调谐天线的部分，天线的有效面积显着大于其物理面积。 固有调谐天线包括固有的分布式电感性，固有的分布式电容性和固有的分布式电阻元件，其使得天线响应于在特定频率处的能量的接收而谐振并提供反馈以再生天线。 电路可以设置在集成电路芯片上。 提供了一种相关联的方法。

    Recharging method and associated apparatus
    10.
    发明授权
    Recharging method and associated apparatus 有权
    充电方法及相关设备

    公开(公告)号：US07383064B2

    公开(公告)日：2008-06-03

    申请号：US11266139

    申请日：2005-11-03

    申请人： Marlin H. Mickle ,  Christopher C. Capelli ,  Harold Swift

    发明人： Marlin H. Mickle ,  Christopher C. Capelli ,  Harold Swift

    IPC分类号： H04B1/38 ,  H04B1/00

    CPC分类号： H02J50/20 ,  H02J7/025 ,  H02J17/00

    摘要： The present invention provides apparatus and an associated method for remotely energizing power storage devices. Energization may preferably be effected through the use of RF energy within frequencies of the wireless fidelity standards. The remote station preferably has at least one antenna having an effective area greater than its physical area. The invention may advantageously be used on wireless fidelity products which are energized by the power storage device.

    摘要翻译： 本发明提供了用于远程激励蓄电装置的装置和相关方法。 可以优选地通过在无线保真度标准的频率内使用RF能量来实现通电。 远程站优选地具有至少一个具有大于其物理区域的有效面积的天线。 本发明可有利地用于由蓄电装置通电的无线保真产品上。