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1.发明申请Cartilage particle tissue mixtures optionally combined with a cancellous construct 审中-公开软骨颗粒组织混合物任选地与松质骨构建体组合公开(公告)号：US20100274362A1
公开(公告)日：2010-10-28
申请号：US12657207
申请日：2010-01-14
申请人： Avner Yayon , Katherine G. Truncale , Hilla Barkay-Olami , Alex B. Callahan , Arthur A. Gertzman , Yen-Chen Huang , Morris L. Jacobs , John C. Munson , Eric J. Semler , Roman Shikhanovich , Baruch Stern , Moon Hae Sunwoo , William W. Tomford , Judith I. Yannariello-Brown
发明人： Avner Yayon , Katherine G. Truncale , Hilla Barkay-Olami , Alex B. Callahan , Arthur A. Gertzman , Yen-Chen Huang , Morris L. Jacobs , John C. Munson , Eric J. Semler , Roman Shikhanovich , Baruch Stern , Moon Hae Sunwoo , William W. Tomford , Judith I. Yannariello-Brown
CPC分类号： A61K9/19 , A61K35/32 , A61K38/1825 , A61L27/3612 , A61L27/3654 , A61L27/54 , A61L2300/414 , A61L2300/602
摘要： Mixtures, such as gels or pastes, comprising freeze-milled cartilage particles and exogenous growth factors are used for repairing chondral defects. Such mixtures may be applied to constructs comprising cancellous bone for implantation at the defect site. Suitable growth factors include variants of FGF-2, particularly variants that include a sole amino acid substitution for asparagine at amino acid 111 of the β8-β9 loop of the FGF-2 peptide. Such FGF-2 variants are released slowly and continuously at a constant rate from cartilage pastes. In other embodiments, the amino acid substituted for asparigine is glycine. Other variants that may be used include FGF-9 variants having truncated chains and a sole amino acid substitution in the β8-β9 loop of the FGF-9 peptide either for tryptophan at amino acid 144 or for asparagine at amino acid 143.
摘要翻译： 使用包含冷冻研磨的软骨颗粒和外源生长因子的混合物，例如凝胶或糊剂来修复软骨缺陷。 可以将这样的混合物施用于包含用于在缺损部位植入的松质骨的构建体。 合适的生长因子包括FGF-2的变体，特别是包括在FGF-2肽的8-＆amp; B9环的氨基酸111处的天冬酰胺的唯一氨基酸取代的变体。 这样的FGF-2变体以软骨糊剂的恒定速率缓慢且连续地释放。 在其它实施方案中，取代天冬酰胺的氨基酸是甘氨酸。 可以使用的其它变体包括FGF-9变体，其具有截短的链和唯一的氨基酸取代在FGF-9肽的8-＆Bgr9环中，对于在氨基酸144处的色氨酸或在氨基酸143处的天冬酰胺 。
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2.发明申请CANCELLOUS CONSTRUCT WITH SUPPORT RING FOR REPAIR OF OSTEOCHONDRAL DEFECTS 审中-公开具有支撑环的康复结构用于修复骨质疏松症公开(公告)号：US20080220044A1
公开(公告)日：2008-09-11
申请号：US12043001
申请日：2008-03-05
申请人： Eric J. Semler , Roman Shikhanovich , Alex B. Callahan , Katherine G. Truncale , Judith I. Yannariello-Brown
发明人： Eric J. Semler , Roman Shikhanovich , Alex B. Callahan , Katherine G. Truncale , Judith I. Yannariello-Brown
CPC分类号： A61F2/28 , A61F2/30756 , A61F2/3859 , A61F2002/2817 , A61F2002/2839 , A61F2002/30057 , A61F2002/30059 , A61F2002/302 , A61F2002/30224 , A61F2002/30354 , A61F2002/30759 , A61F2002/30764 , A61F2002/30932 , A61F2220/0033 , A61F2230/0065 , A61F2230/0069 , A61K38/1825 , A61L27/3608 , A61L27/3654 , A61L27/446 , A61L27/48
摘要： The invention is directed toward an osteochondral repair assembly comprising a shaped allograft construct comprising an unbalanced barbell-shaped cylindrical cancellous bone primary member formed with a mineralized cylindrical base section having a smaller diameter cylindrical stem leading to a second cylindrical section which is demineralized. A mineralized ring-shaped support member is forced over the compressed demineralized second demineralized the aperture of the ring-shaped member to fit around the stem with one ring surface being adjacent the bottom surface to the second cylindrical section and the opposite ring surface being adjacent the upper surface of the mineralized cylindrical base section.
摘要翻译： 本发明涉及一种软骨软骨修复组件，其包括成形的同种异体移植物构建体，其包括不平衡的杠铃形圆柱形松质骨主要构件，其形成有具有较小直径的圆柱形杆的矿化圆柱形基部，其通向软化的第二圆柱形部分。 矿化的环形支撑构件被迫超过压缩的软化的第二软化环形构件的孔以使其适配于杆的周围，一个环表面邻近底表面到第二圆柱形部分，并且相对的环表面邻近 矿化圆柱形基部的上表面。
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3.发明申请Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles 审中-公开松质骨构建体，软骨颗粒和松质骨构建体和软骨颗粒的组合公开(公告)号：US20090319045A1
公开(公告)日：2009-12-24
申请号：US12381072
申请日：2009-03-05
申请人： Katherine G. Truncale , Eric J. Semler , Arthur A. Gertzman , Moon Hae Sunwoo , William W. Tomford , Roman Shikhanovich , Alex B. Callahan , Judith I. Yannariello-Brown , Morris L. Jacobs , John C. Munson , Yen-Chen Huang
发明人： Katherine G. Truncale , Eric J. Semler , Arthur A. Gertzman , Moon Hae Sunwoo , William W. Tomford , Roman Shikhanovich , Alex B. Callahan , Judith I. Yannariello-Brown , Morris L. Jacobs , John C. Munson , Yen-Chen Huang
CPC分类号： A61F2/30756 , A61B17/00491 , A61F2/28 , A61F2/3094 , A61F2/3859 , A61F2/3872 , A61F2002/2817 , A61F2002/2839 , A61F2002/2842 , A61F2002/30057 , A61F2002/30059 , A61F2002/30062 , A61F2002/30224 , A61F2002/30225 , A61F2002/30227 , A61F2002/30233 , A61F2002/30235 , A61F2002/30327 , A61F2002/30331 , A61F2002/30354 , A61F2002/30387 , A61F2002/30448 , A61F2002/30459 , A61F2002/30461 , A61F2002/30492 , A61F2002/30604 , A61F2002/30759 , A61F2002/30762 , A61F2002/30764 , A61F2002/30772 , A61F2002/30785 , A61F2002/30789 , A61F2002/30795 , A61F2002/3085 , A61F2002/30932 , A61F2002/3096 , A61F2002/4635 , A61F2002/4646 , A61F2002/4649 , A61F2210/0004 , A61F2220/0025 , A61F2220/0033 , A61F2220/005 , A61F2220/0066 , A61F2220/0075 , A61F2230/0069 , A61F2250/0039 , A61F2310/00365 , A61L27/3608 , A61L27/3612 , A61L27/3654 , A61L27/48 , A61L27/54 , A61L2300/414 , A61L2300/43 , A61L2430/06 , C08L89/00
摘要： Constructs that are at least partially constructed of allograft cancellous bone are disclosed, along with cartilage particles that may be used with the constructs for repairing articular cartilage defects. A multi-piece construct includes a base member, a cap member and at least one pin that secures the cap member to the base member. The base member may be constructed of mineralized cancellous bone, and is used to replace the subchondral bone removed when a surgeon cuts a bore in the area of an adjacent cartilage defect. The base member includes a blind bore and first and second through-going transverse bores in opposite sides of a wall of the base member. The cap member includes an upper section that has a thickness that is similar to that of a patient's surrounding articular cartilage layer and a stem depending from the upper section that is dimensioned to be received in and by the blind bore of the base member. The stem includes a transverse through-going bore, which may be aligned with the transverse through-going bores of the base member to receive the pin therein when the construct has been assembled. The cap member is at least partially formed of demineralized allograft cancellous bone, into which a mixture containing lyophilized, freeze-milled allograft cartilage particles may be infused for the repair of articular cartilage defects. The cartilage particles have a size within a range of from about 10 microns to about 210 microns.
摘要翻译： 公开了至少部分由同种异体移植松质骨构成的构造物，以及可用于修复关节软骨缺损的构建体的软骨颗粒。 多件式构件包括底座构件，帽构件以及将盖构件固定到基座构件的至少一个销。 基部构件可以由矿化松质骨构成，并且当外科医生切割相邻软骨缺损区域中的孔时，用于替代被去除的软骨下骨。 基部构件包括盲孔以及在基部构件的壁的相对侧中的第一和第二穿过横向孔。 盖构件包括具有与患者周围的关节软骨层的厚度相似的厚度的上部部分和从上部部分延伸的杆部，该上部部分的尺寸设计成被接纳在基部构件的盲孔内和通过该盲孔。 所述杆包括横向通孔，所述横向通孔可以与所述基部构件的横向贯穿孔对齐，以在所述构造件已经组装时将其插入其中。 盖构件至少部分地由软化的同种异体移植松质骨形成，含有冻干的冷冻研磨的同种异体移植软骨颗粒的混合物可以被注入其中，用于修复关节软骨缺损。 软骨颗粒的尺寸在约10微米至约210微米的范围内。
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公开(公告)号：US20090149893A1
公开(公告)日：2009-06-11
申请号：US12328306
申请日：2008-12-04
CPC分类号： A61F2/28 , A61F2/30756 , A61F2/3859 , A61F2002/2817 , A61F2002/2839 , A61F2002/30057 , A61F2002/30059 , A61F2002/30225 , A61F2002/30227 , A61F2002/30233 , A61F2002/30235 , A61F2002/30327 , A61F2002/30354 , A61F2002/30448 , A61F2002/30492 , A61F2002/30604 , A61F2002/30616 , A61F2002/30759 , A61F2002/30764 , A61F2002/30766 , A61F2002/30772 , A61F2002/30789 , A61F2002/30795 , A61F2002/30932 , A61F2002/3096 , A61F2002/4635 , A61F2002/4646 , A61F2002/4649 , A61F2002/4681 , A61F2220/0025 , A61F2220/0033 , A61F2220/005 , A61F2230/0069 , A61F2250/0039 , A61F2310/00017 , A61F2310/00179 , A61F2310/00365 , A61L27/3608 , A61L27/3654 , A61L27/3683 , A61L27/3804 , A61L27/3852 , A61L27/54 , A61L2300/25 , A61L2300/414
摘要： The invention is directed toward a cartilage repair assembly comprising a shaped allograft construct comprising a cylindrical mineralized cancellous bone base member and a demineralized cancellous bone cap member having a cylindrical top portion and a stem extending from the top portion mounted to the bone base member. The base member has a central bore and a transverse bore which intersect the central bore and the cap member stem has a through going bore which is aligned with the base member transverse bore when the stem is mounted in the central bore to receive a pin member. Milled cartilage particles having a size ranging from 10 to 212 microns are mixed with a biocompatible carrier and a cartilage growth factor, with the mixture being infused in the cap member to generate cartilage growth.
摘要翻译： 本发明涉及一种软骨修复组件，其包括成形的同种异体移植物构建体，其包括圆柱形矿化的松质骨基底构件和具有圆柱顶部的软化松质骨盖构件和从安装到骨基构件的顶部延伸的杆。 基部构件具有与中心孔相交的中心孔和横向孔，并且盖构件杆具有通孔，当杆安装在中心孔中以接收销构件时，该通孔与基部构件横向孔对准。 具有10至212微米尺寸的研磨软骨颗粒与生物相容性载体和软骨生长因子混合，将混合物注入盖构件中以产生软骨生长。
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5.发明申请Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles 有权松质骨构建体，软骨颗粒和松质骨构建体和软骨颗粒的组合公开(公告)号：US20110166669A1
公开(公告)日：2011-07-07
申请号：US12931427
申请日：2011-02-01
申请人： Katherine G. Truncale , Eric J. Semler , Arthur A. Gertzman , Moon Hae Sunwoo , William W. Tomford , Roman Shikhanovich
发明人： Katherine G. Truncale , Eric J. Semler , Arthur A. Gertzman , Moon Hae Sunwoo , William W. Tomford , Roman Shikhanovich
IPC分类号： A61F2/28
CPC分类号： A61F2/30756 , A61B17/00491 , A61F2/28 , A61F2/3094 , A61F2/3859 , A61F2/3872 , A61F2002/2817 , A61F2002/2839 , A61F2002/2842 , A61F2002/30057 , A61F2002/30059 , A61F2002/30062 , A61F2002/30224 , A61F2002/30225 , A61F2002/30227 , A61F2002/30233 , A61F2002/30235 , A61F2002/30327 , A61F2002/30331 , A61F2002/30354 , A61F2002/30387 , A61F2002/30448 , A61F2002/30459 , A61F2002/30461 , A61F2002/30492 , A61F2002/30604 , A61F2002/30759 , A61F2002/30762 , A61F2002/30764 , A61F2002/30772 , A61F2002/30785 , A61F2002/30789 , A61F2002/30795 , A61F2002/3085 , A61F2002/30932 , A61F2002/3096 , A61F2002/4635 , A61F2002/4646 , A61F2002/4649 , A61F2210/0004 , A61F2220/0025 , A61F2220/0033 , A61F2220/005 , A61F2220/0066 , A61F2220/0075 , A61F2230/0069 , A61F2250/0039 , A61F2310/00365 , A61L27/3608 , A61L27/3612 , A61L27/3654 , A61L27/48 , A61L27/54 , A61L2300/414 , A61L2300/43 , A61L2430/06 , C08L89/00
摘要： Constructs that are at least partially constructed of allograft cancellous bone are disclosed, along with cartilage particles that may be used with the constructs for repairing articular cartilage defects. A multi-piece construct includes a base member, a cap member and at least one pin that secures the cap member to the base member. The base member may be constructed of mineralized cancellous bone, and is used to replace the subchondral bone removed when a surgeon cuts a bore in the area of an adjacent cartilage defect. The base member includes a blind bore and first and second through-going transverse bores in opposite sides of a wall of the base member. The cap member includes an upper section that has a thickness that is similar to that of a patient's surrounding articular cartilage layer and a stem depending from the upper section that is dimensioned to be received in and by the blind bore of the base member. The stem includes a transverse through-going bore, which may be aligned with the transverse through-going bores of the base member to receive the pin therein when the construct has been assembled. The cap member is at least partially formed of demineralized allograft cancellous bone, into which a mixture containing lyophilized, freeze-milled allograft cartilage particles may be infused for the repair of articular cartilage defects. The cartilage particles have a size within a range of from about 10 microns to about 210 microns.
摘要翻译： 公开了至少部分由同种异体移植松质骨构成的构造物，以及可用于修复关节软骨缺损的构建体的软骨颗粒。 多件式构件包括底座构件，帽构件以及将盖构件固定到基座构件的至少一个销。 基部构件可以由矿化松质骨构成，并且当外科医生切割相邻软骨缺损区域中的孔时，用于替代被去除的软骨下骨。 基部构件包括盲孔以及在基部构件的壁的相对侧中的第一和第二穿过横向孔。 盖构件包括具有与患者周围的关节软骨层的厚度相似的厚度的上部部分和从上部部分延伸的杆部，该上部部分的尺寸设计成被接纳在基部构件的盲孔内和通过该盲孔。 所述杆包括横向通孔，所述横向通孔可以与所述基部构件的横向贯穿孔对齐，以在所述构造件已经组装时将其插入其中。 盖构件至少部分地由软化的同种异体移植松质骨形成，含有冻干的冷冻研磨的同种异体移植软骨颗粒的混合物可以被注入其中，用于修复关节软骨缺损。 软骨颗粒的尺寸在约10微米至约210微米的范围内。
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6.发明授权Cancellous constructs, cartilage particles and combinations of cancellous constructs and cartilage particles 有权松质骨构建体，软骨颗粒和松质骨构建体和软骨颗粒的组合公开(公告)号：US08292968B2
公开(公告)日：2012-10-23
申请号：US12931427
申请日：2011-02-01
申请人： Katherine G. Truncale , Eric J. Semler , Arthur A. Gertzman , Moon Hae Sunwoo , William W. Tomford , Roman Shikhanovich
发明人： Katherine G. Truncale , Eric J. Semler , Arthur A. Gertzman , Moon Hae Sunwoo , William W. Tomford , Roman Shikhanovich
IPC分类号： A61F2/28
CPC分类号： A61F2/30756 , A61B17/00491 , A61F2/28 , A61F2/3094 , A61F2/3859 , A61F2/3872 , A61F2002/2817 , A61F2002/2839 , A61F2002/2842 , A61F2002/30057 , A61F2002/30059 , A61F2002/30062 , A61F2002/30224 , A61F2002/30225 , A61F2002/30227 , A61F2002/30233 , A61F2002/30235 , A61F2002/30327 , A61F2002/30331 , A61F2002/30354 , A61F2002/30387 , A61F2002/30448 , A61F2002/30459 , A61F2002/30461 , A61F2002/30492 , A61F2002/30604 , A61F2002/30759 , A61F2002/30762 , A61F2002/30764 , A61F2002/30772 , A61F2002/30785 , A61F2002/30789 , A61F2002/30795 , A61F2002/3085 , A61F2002/30932 , A61F2002/3096 , A61F2002/4635 , A61F2002/4646 , A61F2002/4649 , A61F2210/0004 , A61F2220/0025 , A61F2220/0033 , A61F2220/005 , A61F2220/0066 , A61F2220/0075 , A61F2230/0069 , A61F2250/0039 , A61F2310/00365 , A61L27/3608 , A61L27/3612 , A61L27/3654 , A61L27/48 , A61L27/54 , A61L2300/414 , A61L2300/43 , A61L2430/06 , C08L89/00
摘要： A construct for repairing articular cartilage defects includes a cap member and a base member. The cap member has an upper section and a stem depending from a central region thereof. The upper section includes a peripheral region. The stem includes a cavity. The base member has first and second ends, the first end including an annular recess dimensioned such that the stem is receivable therein. The first end also includes an annular edge positioned laterally outwardly from the annular recess, for abutting and supporting the peripheral region of the upper section when the stem is received in the annular recess. The base member further includes an island which is surrounded by the annular recess and receivable in the cavity of the stem, such that the island is abuttable with and may thereby support the central region of the upper section when the stem is received in the annular recess.
摘要翻译： 用于修复关节软骨缺损的构造包括帽构件和基底构件。 盖构件具有从其中心区域悬垂的上部部分和茎部。 上部包括外围区域。 杆包括一个空腔。 基部构件具有第一端和第二端，第一端包括尺寸为使得杆可接收在其中的环形凹部。 第一端还包括从环形凹部横向向外定位的环形边缘，用于当杆被容纳在环形凹部中时抵靠并支撑上部的周边区域。 基部构件还包括岛，该岛由环形凹部包围并且可接收在杆的空腔中，使得当杆被容纳在环形凹部中时，岛可抵靠并且从而支撑上部的中心区域 。
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7.发明授权公开(公告)号：US08435551B2
公开(公告)日：2013-05-07
申请号：US12508892
申请日：2009-07-24
申请人： Eric J. Semler , Roman Shikhanovich , Alex B. Callahan , Katherine Gomes Truncale , Judith I. Yannariello-Brown , Yen-Chen Huang
发明人： Eric J. Semler , Roman Shikhanovich , Alex B. Callahan , Katherine Gomes Truncale , Judith I. Yannariello-Brown , Yen-Chen Huang
IPC分类号： A61F2/28
CPC分类号： A61F2/28 , A61F2/30756 , A61F2/3859 , A61F2002/2817 , A61F2002/2839 , A61F2002/30057 , A61F2002/30059 , A61F2002/302 , A61F2002/30224 , A61F2002/30354 , A61F2002/30759 , A61F2002/30764 , A61F2002/30932 , A61F2220/0033 , A61F2230/0065 , A61F2230/0069 , A61K35/32 , A61K38/1825 , A61K38/1841 , A61K38/1875 , A61L27/3608 , A61L27/3654 , A61L27/446 , A61L27/48 , A61K2300/00
摘要： The invention is directed toward an osteochondral repair assembly comprising a shaped allograft construct comprising an unbalanced barbell-shaped cylindrical cancellous bone primary member formed with a mineralized cylindrical base section having a smaller diameter cylindrical stem leading to a second cylindrical section which is demineralized. A mineralized ring-shaped support member is forced over the compressed demineralized second demineralized the aperture of the ring-shaped member to fit around the stem with one ring surface being adjacent the bottom surface to the second cylindrical section and the opposite ring surface being adjacent the upper surface of the mineralized cylindrical base section.
摘要翻译： 本发明涉及一种软骨软骨修复组件，其包括成形的同种异体移植物构建体，其包括不平衡的杠铃形圆柱形松质骨主要构件，其形成有具有较小直径的圆柱形杆的矿化圆柱形基部，其通向软化的第二圆柱形部分。 矿化的环形支撑构件被迫超过压缩的软化的第二软化环形构件的孔以使其适配于杆的周围，一个环表面邻近底表面到第二圆柱形部分，并且相对的环表面邻近 矿化圆柱形基部的上表面。
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8.发明申请公开(公告)号：US20100015202A1
公开(公告)日：2010-01-21
申请号：US12508892
申请日：2009-07-24
申请人： Eric J. Semler , Roman Shikhanovich , Alex B. Callahan , Katherine Gomes Truncale , Judith I. Yannariello-Brown , Yen-Chen Huang
发明人： Eric J. Semler , Roman Shikhanovich , Alex B. Callahan , Katherine Gomes Truncale , Judith I. Yannariello-Brown , Yen-Chen Huang
CPC分类号： A61F2/28 , A61F2/30756 , A61F2/3859 , A61F2002/2817 , A61F2002/2839 , A61F2002/30057 , A61F2002/30059 , A61F2002/302 , A61F2002/30224 , A61F2002/30354 , A61F2002/30759 , A61F2002/30764 , A61F2002/30932 , A61F2220/0033 , A61F2230/0065 , A61F2230/0069 , A61K35/32 , A61K38/1825 , A61K38/1841 , A61K38/1875 , A61L27/3608 , A61L27/3654 , A61L27/446 , A61L27/48 , A61K2300/00
摘要： The invention is directed toward an osteochondral repair assembly comprising a shaped allograft construct comprising an unbalanced barbell-shaped cylindrical cancellous bone primary member formed with a mineralized cylindrical base section having a smaller diameter cylindrical stem leading to a second cylindrical section which is demineralized. A mineralized ring-shaped support member is forced over the compressed demineralized second demineralized the aperture of the ring-shaped member to fit around the stem with one ring surface being adjacent the bottom surface to the second cylindrical section and the opposite ring surface being adjacent the upper surface of the mineralized cylindrical base section.
摘要翻译： 本发明涉及一种软骨软骨修复组件，其包括成形的同种异体移植物构建体，其包括不平衡的杠铃形圆柱形松质骨主要构件，其形成有具有较小直径的圆柱形杆的矿化圆柱形基部，其通向软化的第二圆柱形部分。 矿化的环形支撑构件被迫超过压缩的软化的第二软化环形构件的孔以使其适配于杆的周围，一个环表面邻近底表面到第二圆柱形部分，并且相对的环表面邻近 矿化圆柱形基部的上表面。
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