公开(公告)号：US5759283A

公开(公告)日：1998-06-02

申请号：US645702

申请日：1996-05-14

申请人： Eric P. Ekern ,  Bimal Goculdas ,  Michael Donovan ,  Marc Hlavacek

发明人： Eric P. Ekern ,  Bimal Goculdas ,  Michael Donovan ,  Marc Hlavacek

IPC分类号： B01D61/14 ,  B01D61/16 ,  C13B20/00 ,  C13B20/02 ,  C13B20/04 ,  C13B20/12 ,  C13B20/16 ,  C13D1/08 ,  C13D1/14 ,  C13D3/12 ,  C13D3/16

CPC分类号： C13B20/02 ,  B01D61/145 ,  B01D61/147 ,  B01D61/16 ,  C13B20/00 ,  C13B20/04 ,  C13B20/12 ,  C13B20/165 ,  Y02P40/44

摘要： An efficient method for manufacturing a purified juice product from sugar beets. Untreated beet juice is initially prelimed using lime and CaCO.sub.3 to produce a prelimed juice product. Instead of subjecting the prelimed product to main liming and dual carbonation stages, the product is delivered to a porous filtration membrane which allows sugar molecules to pass therethrough which preventing the passage of solid matter and dissolved impurities. Optimum results are achieved if the prelimed product flows across the membrane from end to end. The membrane permeate is thereafter combined with CO.sub.2(g) in a single carbonation stage to remove dissolved lime. This step generates a purified juice product which can be processed to manufacture pure crystalline sugar. The membrane retentate can be combined with water and refiltered to collect residual sugar materials. The foregoing process uses less energy and raw materials (e.g. lime) compared with conventional methods.

摘要翻译： 从甜菜制造纯化果汁产品的有效方法。 未处理的甜菜汁最初使用石灰和CaCO3预先制备预制的果汁产品。 代替将预制产物进行主要石灰和双重碳酸化阶段，将产物输送到多孔过滤膜，其允许糖分子通过，从而阻止固体物质和溶解的杂质的通过。 如果预备的产品从端到端流过膜，则获得最佳结果。 然后将膜渗透物与CO 2（g）在单一碳酸化阶段中合并以除去溶解的石灰。 该步骤产生纯化的果汁产品，其可以被加工以制造纯结晶糖。 膜保留物可以与水结合并重新过滤以收集残留的糖材料。 与常规方法相比，上述方法使用更少的能量和原料（例如石灰）。

公开(公告)号：US06406548B1

公开(公告)日：2002-06-18

申请号：US09618830

申请日：2000-07-18

申请人： Michael Donovan ,  Robert P. Jansen ,  Richard C. Reisig ,  Marc Hlavacek ,  Gordon Walker ,  John C. Williams

发明人： Michael Donovan ,  Robert P. Jansen ,  Richard C. Reisig ,  Marc Hlavacek ,  Gordon Walker ,  John C. Williams

IPC分类号： C13D316

CPC分类号： C13B10/00 ,  C13B20/00 ,  C13B20/165

摘要： A process for producing sugar from cane includes the step of filtering a sucrose-containing feed juice, which has been obtained from macerated sugar cane, through a first ultrafiltration membrane that has a first molecular weight cutoff. This ultrafiltration step produces a first ultrafiltration permeate and a first ultrafiltration retentate. The first ultrafiltration permeate is filtered through a second ultrafiltration membrane that has a second molecular weight cutoff that is lower than the first molecular weight cutoff. This second ultrafiltration step produces a second ultrafiltration permeate and a second ultrafiltration retentate. The second ultrafiltration permeate is nanofiltered through a nanofiltration membrane, thereby producing a nanofiltration permeate and a nanofiltration retentate. The nanofiltration retentate has a higher concentration of sucrose on a dry solids basis than the feed juice in step (a), and can be used in evaporation and crystallization operations to produce crystals of white sugar. The process can optionally include ion exchange and/or electrodialysis purification steps, prior to or after the nanofiltration step. Recycle syrups can be treated with a chromatographic separator to remove excess invert, ash and color.

摘要翻译： 从甘蔗生产糖的方法包括通过具有第一分子量截留值的第一超滤膜过滤从浸出的甘蔗获得的含蔗糖的进料汁的步骤。 该超滤步骤产生第一超滤渗透物和第一超滤滞留物。 第一超滤渗透物通过具有低于第一分子量截止值的第二分子量截止值的第二超滤膜过滤。 该第二超滤步骤产生第二超滤渗透物和第二超滤滞留物。 第二超滤渗透物通过纳滤膜进行纳滤，从而产生纳滤膜渗透物和纳滤膜渗余物。 纳米过滤滞留物在干固体基础上具有比步骤（a）中的进料汁更高的蔗糖浓度，并且可用于蒸发和结晶操作以产生白糖晶体。 该方法可任选地包括在纳滤过程之前或之后的离子交换和/或电渗析纯化步骤。 回收糖浆可以用色谱分离器处理，以去除多余的反转，灰分和颜色。

公开(公告)号：US06406547B1

公开(公告)日：2002-06-18

申请号：US09618416

申请日：2000-07-18

申请人： Michael Donovan ,  Robert P. Jansen ,  Marc Hlavacek ,  Gordon Walker ,  John C. Williams

发明人： Michael Donovan ,  Robert P. Jansen ,  Marc Hlavacek ,  Gordon Walker ,  John C. Williams

IPC分类号： C13D316

CPC分类号： C13B10/00 ,  C13B20/00 ,  C13B20/165

摘要： A process for producing sugar from beets includes the step of filtering a sucrose-containing feed juice, which has been obtained by diffusion from sliced sugar beets, through a first ultrafiltration membrane that has a first molecular weight cutoff. This ultrafiltration step produces a first ultrafiltration permeate and a first ultrafiltration retentate. The first ultrafiltration permeate is filtered through a second ultrafiltration membrane that has a second molecular weight cutoff that is lower than the first molecular weight cutoff. This second ultrafiltration step produces a second ultrafiltration permeate and a second ultrafiltration retentate. The second ultrafiltration permeate is nanofiltered through a nanofiltration membrane, thereby producing a nanofiltration permeate and a nanofiltration retentate. The nanofiltration retentate has a higher concentration of sucrose on a dry solids basis than the feed juice in step (a), and can be used in evaporation and crystallization operations to produce crystals of white sugar. The process can optionally include ion exchange and/or electrodialysis purification steps, prior to or after the nanofiltration step. Recycle syrups can be treated with enzyme or a chromatographic separator to remove raffinose.

摘要翻译： 从甜菜制备糖的方法包括将通过从切片的甜菜中扩散获得的含蔗糖的进料汁通过具有第一分子量截留值的第一超滤膜过滤的步骤。 该超滤步骤产生第一超滤渗透物和第一超滤滞留物。 第一超滤渗透物通过具有低于第一分子量截止值的第二分子量截止值的第二超滤膜过滤。 该第二超滤步骤产生第二超滤渗透物和第二超滤滞留物。 第二超滤渗透物通过纳滤膜进行纳滤，从而产生纳滤膜渗透物和纳滤膜渗余物。 纳米过滤滞留物在干固体基础上具有比步骤（a）中的进料汁更高的蔗糖浓度，并且可用于蒸发和结晶操作以产生白糖晶体。 该方法可任选地包括在纳滤过程之前或之后的离子交换和/或电渗析纯化步骤。 可以用酶或色谱分离器处理回收糖浆以除去棉子糖。

公开(公告)号：US06406546B1

公开(公告)日：2002-06-18

申请号：US09618234

申请日：2000-07-18

申请人： Michael Donovan ,  Marc Hlavacek

发明人： Michael Donovan ,  Marc Hlavacek

IPC分类号： C13D116

CPC分类号： C13B30/12 ,  C13B20/165

摘要： A nanofiltration process for obtaining sucrose uses a feed syrup, such as molasses, that comprises sucrose and no less than about 2% by weight invert sugars (on a dry solids basis). The nanofiltration produces a permeate and retentate. The nanofiltration permeate will comprise invert sugars that have passed from the feed through the nanofiltration membrane, and preferably will also comprise ash from the feed. The nanofiltration retentate has a higher concentration of sucrose and a lower concentration of invert sugars than the feed syrup. Sucrose can then be crystallized from the nanofiltration retentate. The reduction of the invert content in the syrup facilitates crystallization and thus enhances sucrose recovery.

摘要翻译： 用于获得蔗糖的纳滤方法使用包含蔗糖和不少于约2重量％转化糖（基于干固体）的饲料糖浆，例如糖蜜。 纳米过滤产生渗透物和渗余物。 纳米过滤渗透物将包含从进料通过纳滤膜的转化糖，并且优选还包含来自进料的灰分。 纳滤过滤滞留物具有较高浓度的蔗糖和较低浓度的转化糖比饲料糖浆。 然后可以从纳滤过滤滞留物中结晶蔗糖。 糖浆中反转含量的减少有助于结晶，从而提高蔗糖回收率。

公开(公告)号：US06440222B1

公开(公告)日：2002-08-27

申请号：US09618831

申请日：2000-07-18

申请人： Michael Donovan ,  Robert P. Jansen ,  Richard C. Reisig ,  Marc Hlavacek ,  Gordon Walker ,  John C. Williams

发明人： Michael Donovan ,  Robert P. Jansen ,  Richard C. Reisig ,  Marc Hlavacek ,  Gordon Walker ,  John C. Williams

IPC分类号： C13D108

CPC分类号： B01D61/142 ,  B01D61/16 ,  B01D2311/04 ,  C13B10/00 ,  C13B20/00 ,  C13B20/165 ,  B01D2311/103 ,  B01D2311/246 ,  B01D2311/2623 ,  B01D2311/268

摘要： A process for producing sugar from beets includes the step of filtering a sucrose-containing feed juice, which has been obtained from macerated sugar beets, through a first ultrafiltration membrane that has a first molecular weight cutoff. This ultrafiltration step produces a first ultrafiltration permeate and a first ultrafiltration retentate. The first ultrafiltration permeate is filtered through a second ultrafiltration membrane that has a second molecular weight cutoff that is lower than the first molecular weight cutoff. This second ultrafiltration step produces a second ultrafiltration permeate and a second ultrafiltration retentate. The second ultrafiltration permeate is nanofiltered through a nanofiltration membrane, thereby producing a nanofiltration permeate and a nanofiltration retentate. The nanofiltration retentate has a higher concentration of sucrose on a dry solids basis than the feed juice in step (a), and can be used in evaporation and crystallization operations to produce crystals of white sugar. The process can optionally include ion exchange and/or electrodialysis purification steps, prior to or after the nanofiltration step. Recycle syrups can be treated with enzyme or a chromatographic separator to remove raffinose.

摘要翻译： 从甜菜制备糖的方法包括通过具有第一分子量截留值的第一超滤膜过滤从浸出的甜菜获得的含蔗糖的进料汁的步骤。 该超滤步骤产生第一超滤渗透物和第一超滤滞留物。 第一超滤渗透物通过具有低于第一分子量截止值的第二分子量截止值的第二超滤膜过滤。 该第二超滤步骤产生第二超滤渗透物和第二超滤滞留物。 第二超滤渗透物通过纳滤膜进行纳滤，从而产生纳滤膜渗透物和纳滤膜渗余物。 纳米过滤滞留物在干固体基础上具有比步骤（a）中的进料汁更高的蔗糖浓度，并且可用于蒸发和结晶操作以产生白糖晶体。 该方法可任选地包括在纳滤过程之前或之后的离子交换和/或电渗析纯化步骤。 可以用酶或色谱分离器处理回收糖浆以除去棉子糖。

公开(公告)号：US06355110B1

公开(公告)日：2002-03-12

申请号：US09441988

申请日：1999-11-17

申请人： Michael Donovan ,  Marc Hlavacek

发明人： Michael Donovan ,  Marc Hlavacek

IPC分类号： C13D316

CPC分类号： C13B30/12 ,  C13B20/165

摘要： A nanofiltration process for obtaining sucrose uses a feed syrup, such as molasses, that comprises sucrose and no less than about 3% by weight invert sugars (on a dry solids basis). The nanofiltration produces a permeate and retentate. The nanofiltration permeate will comprise invert sugars that have passed from the feed through the nanofiltration membrane, and preferably will also comprise ash from the feed. The nanofiltration retentate has a higher concentration of sucrose and a lower concentration of invert sugars than the feed syrup. Sucrose can then be crystallized from the nanofiltration retentate. The reduction of the invert content in the syrup facilitates crystallization and thus enhances sucrose recovery.

摘要翻译： 用于获得蔗糖的纳滤方法使用包含蔗糖和不少于约3重量％转化糖（以干固体为基准）的饲料糖浆，例如糖蜜。 纳米过滤产生渗透物和渗余物。 纳米过滤渗透物将包含从进料通过纳滤膜的转化糖，并且优选还包含来自进料的灰分。 纳滤过滤滞留物具有较高浓度的蔗糖和较低浓度的转化糖比饲料糖浆。 然后可以从纳滤过滤滞留物中结晶蔗糖。 糖浆中反转含量的减少有助于结晶，从而提高蔗糖回收率。

公开(公告)号：US09858389B2

公开(公告)日：2018-01-02

申请号：US12462041

申请日：2009-07-27

申请人： Michael Donovan ,  Faisal Khan ,  Gerardo Fernandez ,  Ali Tabesh ,  Ricardo Mesa-Tejada ,  Carlos Cordon-Cardo ,  Jose Costa ,  Stephen Fogarasi ,  Yevgen Vengrenyuk

发明人： Michael Donovan ,  Faisal Khan ,  Gerardo Fernandez ,  Ali Tabesh ,  Ricardo Mesa-Tejada ,  Carlos Cordon-Cardo ,  Jose Costa ,  Stephen Fogarasi ,  Yevgen Vengrenyuk

IPC分类号： G06G7/48 ,  G06F19/00

CPC分类号： G16H50/20 ,  G06F19/00 ,  G16H50/30 ,  G16H50/50 ,  G16H50/70

摘要： Clinical information, molecular information and/or computer-generated morphometric information is used in a predictive model for predicting the occurrence of a medical condition. In an embodiment, a model predicts risk of prostate cancer progression in a patient, where the model is based on features including one or more (e.g., all) of preoperative PSA, dominant Gleason Grade, Gleason Score, at least one of a measurement of expression of AR in epithelial and stromal nuclei and a measurement of expression of Ki67-positive epithelial nuclei, a morphometric measurement of average edge length in the minimum spanning tree (MST) of epithelial nuclei, and a morphometric measurement of area of non-lumen associated epithelial cells relative to total tumor area. In some embodiments, the morphometric information is based on image analysis of tissue subject to multiplex immunofluorescence and may include characteristic(s) of a minimum spanning tree (MST) and/or a fractal dimension observed in the images.

公开(公告)号：US08340251B2

公开(公告)日：2012-12-25

申请号：US13158851

申请日：2011-06-13

申请人： William Bertozzi ,  Michael Donovan ,  Alexei Klimenko ,  Stephen E. Korbly ,  William Park

发明人： William Bertozzi ,  Michael Donovan ,  Alexei Klimenko ,  Stephen E. Korbly ,  William Park

IPC分类号： H01J35/18 ,  H01J35/10

CPC分类号： H05G2/00 ,  H01J35/12 ,  H01J2235/08 ,  H01J2235/1204 ,  H05H6/00

摘要： Methods and systems for generating bremsstrahlung with enhanced photon flux in a narrow cone at forward angles utilize a thin target of a high-Z material such as gold as radiator, supported on a tube of a low-Z material such as titanium, which tube contains a circulating fluid such as water which acts as a coolant and also may absorb the incident electron beam.

摘要翻译： 用于产生具有在前方角度的窄锥体中增强的光子通量的bre致辐射的方法和系统利用诸如金的高Z材料的薄靶作为散热器，其支撑在诸如钛的低Z材料的管上，该管包含 诸如水的循环流体，其作为冷却剂并且还可以吸收入射的电子束。

公开(公告)号：US07983396B2

公开(公告)日：2011-07-19

申请号：US12121515

申请日：2008-05-15

申请人： William Bertozzi ,  Michael Donovan ,  Alexei Klimenko ,  Stephen E. Korbly ,  William Park

发明人： William Bertozzi ,  Michael Donovan ,  Alexei Klimenko ,  Stephen E. Korbly ,  William Park

IPC分类号： H01J35/18 ,  H01J35/10

CPC分类号： H05G2/00 ,  H01J35/12 ,  H01J2235/08 ,  H01J2235/1204 ,  H05H6/00

摘要： Methods and systems for generating bremsstrahlung with enhanced photon flux in a narrow cone at forward angles utilize a thin target of a high-Z material such as gold as radiator, supported on a tube of a low-Z material such as titanium, which tube contains a circulating fluid such as water which acts as a coolant and also may absorb the incident electron beam.

摘要翻译： 用于产生具有在前方角度的窄锥体中增强的光子通量的bre致辐射的方法和系统利用诸如金的高Z材料的薄靶作为散热器，其支撑在诸如钛的低Z材料的管上，该管包含 诸如水的循环流体，其作为冷却剂并且还可以吸收入射的电子束。

公开(公告)号：US20100314026A1

公开(公告)日：2010-12-16

申请号：US12481805

申请日：2009-06-10

申请人： Michael Donovan ,  Jason M. Logsdon ,  Keith Chappell

发明人： Michael Donovan ,  Jason M. Logsdon ,  Keith Chappell

IPC分类号： E04F13/00 ,  B32B25/10 ,  B32B27/12 ,  B32B7/12 ,  B32B3/30 ,  C09K17/00

CPC分类号： B32B27/12 ,  B32B5/022 ,  B32B5/024 ,  B32B25/10 ,  B32B25/14 ,  B32B27/20 ,  B32B27/22 ,  B32B27/32 ,  B32B27/327 ,  B32B2255/10 ,  B32B2262/02 ,  B32B2262/023 ,  B32B2262/0238 ,  B32B2262/0253 ,  B32B2262/0261 ,  B32B2262/0276 ,  B32B2270/00 ,  B32B2272/00 ,  B32B2307/30 ,  B32B2307/308 ,  B32B2307/50 ,  B32B2307/5825 ,  B32B2307/71 ,  B32B2307/712 ,  B32B2307/72 ,  B32B2307/7265 ,  B32B2307/734 ,  B32B2419/00 ,  B32B2419/06 ,  E04D5/10 ,  E04D12/002 ,  E06B2001/628 ,  Y10T428/1471 ,  Y10T428/24612 ,  Y10T442/162 ,  Y10T442/164 ,  Y10T442/174 ,  Y10T442/198 ,  Y10T442/3886 ,  Y10T442/678

摘要： A window or door flashing or roofing material, containing no asphalt, either mechanically fastened or self-adhering comprising a mixture of: one or more ethylene based elastomers having a melting point below 160° F., in an amount of 10-40% based on the total weight of the product; one or more semi-crystalline, non-elastomer alpha olefin-based polymers having a melting point above 160° F. in an amount of about 10-40% based on the total weight of the product; and a rubber fraction of ground, vulcanized rubber having a size up to about 18 mesh, US Sieve Series, in an amount of about 10% to about 75%, based on the total weight of the product.

摘要翻译： 一种不含沥青的窗户或门窗，其机械紧固或自粘结，其包含以下混合物：一种或多种熔点低于160°F的乙烯基弹性体，其量为10-40％ 对产品的总重量; 一种或多种基于产品总重量的约10-40％的熔点高于160°F的半结晶非弹性体α-烯烃基聚合物; 和基于产品总重量的约10％至约75％的研磨的橡胶级分的硫化橡胶，其尺寸高达约18目，US筛系列。