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    DNA transfection system for the generation of negative strand RNA virus
    7.
    发明授权
    DNA transfection system for the generation of negative strand RNA virus 有权
    用于产生负链RNA病毒的DNA转染系统

    公开(公告)号：US08309099B2

    公开(公告)日：2012-11-13

    申请号：US13150426

    申请日：2011-06-01

    申请人： Erich Hoffmann

    发明人： Erich Hoffmann

    IPC分类号： A61K39/145 ,  C12N7/00

    CPC分类号： C07K14/005 ,  A61K2039/5252 ,  A61K2039/5254 ,  C12N7/00 ,  C12N2720/00063 ,  C12N2760/16122 ,  C12N2760/16151 ,  C12N2760/16163 ,  C12N2760/16222 ,  C12N2760/16263 ,  C12N2760/18663 ,  C12N2770/24263 ,  C12N2800/107 ,  C12N2800/40 ,  C12N2830/205 ,  C12N2830/34 ,  C12N2830/36 ,  C12N2830/85

    摘要： The present invention is based on the development of a dual promoter system (preferably a RNA pol I-pol II system) for the efficient intracellular synthesis of viral RNA. The resultant minimal plasmid-based system may be used to synthesize any RNA virus, preferably viruses with a negative single stranded RNA genome. The viral product of the system is produced when the plasmids of the system are introduced into a suitable host cell. One application of the system is production of attenuated, reassortant influenza viruses for use as antigens in vaccines. The reassortant viruses generated by cotransfection of plasmids may comprise genes encoding the surface glycoproteins hemagglutinin and neuraminidase from an influenza virus currently infecting the population and the internal genes from an attenuated influenza virus. An advantageous property of the present invention is its versatility; the system may be quickly and easily adapted to synthesize an attenuated version of any RNA virus. Attenuated or inactivated RNA viruses produced by the present invention may be administered to a patient in need of vaccination by any of several routes including intranasally or intramuscularly.

    摘要翻译： 本发明基于用于病毒RNA的有效细胞内合成的双重启动子系统（优选RNA pol I-pol II系统）的开发。 所得到的基于最小质粒的系统可用于合成任何RNA病毒，优选具有负单链RNA基因组的病毒。 当将系统的质粒引入合适的宿主细胞时，产生系统的病毒产物。 该系统的一个应用是生产用作疫苗抗原的减毒重配流感病毒。 通过共转染质粒产生的重配病毒可以包含编码来自目前感染群体的流感病毒的表面糖蛋白血凝素和神经氨酸酶的基因以及来自减毒流感病毒的内部基因。 本发明的优点是其多功能性; 该系统可以快速且容易地适应于合成任何RNA病毒的减毒版本。 通过本发明产生的减毒或灭活的RNA病毒可以通过包括鼻内或肌肉内的几种途径中的任何途径施用于需要接种疫苗的患者。

    DNA-transfection system for the generation of infectious influenza virus
    8.
    发明申请
    DNA-transfection system for the generation of infectious influenza virus 审中-公开
    用于产生感染性流感病毒的DNA转染系统

    公开(公告)号：US20080311149A1

    公开(公告)日：2008-12-18

    申请号：US11980762

    申请日：2007-10-31

    申请人： Erich Hoffmann

    发明人： Erich Hoffmann

    IPC分类号： A61K39/00 ,  C12N7/00 ,  A61P31/00 ,  C12P21/04

    CPC分类号： C07K14/005 ,  A61K2039/5252 ,  A61K2039/5254 ,  C12N7/00 ,  C12N2720/00063 ,  C12N2760/16122 ,  C12N2760/16151 ,  C12N2760/16163 ,  C12N2760/16222 ,  C12N2760/16263 ,  C12N2760/18663 ,  C12N2770/24263 ,  C12N2800/107 ,  C12N2800/40 ,  C12N2830/205 ,  C12N2830/34 ,  C12N2830/36 ,  C12N2830/85

    摘要： The present invention is based on the development of a dual promoter system (preferably a RNA pol I-pol II system) for the efficient intracellular synthesis of viral RNA. The resultant minimal plasmid-based system may be used to synthesize any RNA virus, preferably viruses with a negative single stranded RNA genome. The viral product of the system is produced when the plasmids of the system are introduced into a suitable host cell. One application of the system is production of attenuated, reassortant influenza viruses for use as antigens in vaccines. The reassortant viruses generated by cotransfection of plasmids may comprise genes encoding the surface glycoproteins hemagglutinin and neuraminidase from an influenza virus currently infecting the population and the internal genes from an attenuated influenza virus. An advantageous property of the present invention is its versatility; the system may be quickly and easily adapted to synthesize an attenuated version of any RNA virus. Attenuated or inactivated RNA viruses produced by the present invention may be administered to a patient in need of vaccination by any of several routes including intranasally or intramuscularly.

    摘要翻译： 本发明基于用于病毒RNA的有效细胞内合成的双重启动子系统（优选RNA pol I-pol II系统）的开发。 所得到的基于最小质粒的系统可用于合成任何RNA病毒，优选具有负单链RNA基因组的病毒。 当将系统的质粒引入合适的宿主细胞时，产生系统的病毒产物。 该系统的一个应用是生产用作疫苗抗原的减毒重配流感病毒。 通过共转染质粒产生的重配病毒可以包含编码来自目前感染群体的流感病毒的表面糖蛋白血凝素和神经氨酸酶的基因以及来自减毒流感病毒的内部基因。 本发明的优点是其多功能性; 该系统可以快速且容易地适应于合成任何RNA病毒的减毒版本。 通过本发明产生的减毒或灭活的RNA病毒可以通过包括鼻内或肌肉内的几种途径中的任何途径施用于需要接种疫苗的患者。

    Water filter
    9.
    发明授权
    Water filter 失效
    净水器

    公开(公告)号：US5800707A

    公开(公告)日：1998-09-01

    申请号：US594831

    申请日：1996-01-31

    申请人： Hans-Jurgen Mehnert ,  Erich Hoffmann ,  Dorothea Pytlik

    发明人： Hans-Jurgen Mehnert ,  Erich Hoffmann ,  Dorothea Pytlik

    IPC分类号： A47J31/60 ,  C02F1/00 ,  C02F1/28 ,  A47J31/06 ,  A47J31/24 ,  C02F1/42

    CPC分类号： A47J31/605 ,  C02F1/003

    摘要： The present invention concerns a water filter designed to be inserted into a drinking water circuit. The water filter has a support designed to house removably one or more different filters each having a different filtering property and adapted to be mounted either independently of each other or associated in a particular combination so as to effect a filtration of the drinking water according to its composition.

    摘要翻译： 本发明涉及一种设计成插入饮用水回路中的水过滤器。 水过滤器具有设计成可拆卸地容纳一个或多个不同过滤器的支撑件，每个过滤器具有不同的过滤性能，并且适于彼此独立地安装或者以特定组合相关联，以便根据其过滤饮用水 组成。

    Bisphenol derivatives, process for their manufacture, and their use as surfactants
    10.
    发明授权
    Bisphenol derivatives, process for their manufacture, and their use as surfactants 失效
    双酚衍生物，其制备方法及其作为表面活性剂的用途

    公开(公告)号：US4960935A

    公开(公告)日：1990-10-02

    申请号：US477837

    申请日：1983-03-23

    申请人： Erwin Dietz ,  Erich Hoffmann ,  Joachim Weide

    发明人： Erwin Dietz ,  Erich Hoffmann ,  Joachim Weide

    IPC分类号： C08G65/00 ,  B01F17/42 ,  B01F17/46 ,  C07C67/00 ,  C07C213/00 ,  C07C213/04 ,  C07C217/08 ,  C07C217/32 ,  C07C217/50 ,  C08G59/14 ,  C08G59/50 ,  C08G59/64 ,  C08G65/08 ,  C08G65/26 ,  C09B67/46 ,  C09D5/00 ,  C09D5/02 ,  C09D11/02

    CPC分类号： C08G65/08 ,  C08G59/64 ,  C08G65/26 ,  C09B67/0089

    摘要： Compounds of the general formulaX--Y--O--(A--O--Y--O).sub.m --A--O--Y--X (1)wherein X is a radical of the general formula[R.sup.1 --G.sub.p --(O--CHR.sup.2 --CHR.sup.3 --).sub.n ].sub.2 N--(1a)in which R.sup.1 is a saturated aliphatic radical of from 6 to 30 carbon atoms or an unsaturated aliphatic radical having one or several ethylenic bonds and being of from 6 to 30 carbon atoms, G is phenylene or naphthylene, p is zero or 1, R.sup.2 and R.sup.3 are hydrogen or methyl, but are not both methyl, and n is a number from 0 to 25, Y is a radical of the formula ##STR1## in which R.sup.2 and R.sup.3 have the indicated meanings and q represents identical or different numbers from 0 to about 200, A is a radical of the general formula ##STR2## in which R.sup.4 and R.sup.5 are hydrogen or alkyl of from 1 to 3 carbon atoms, and m is a number from zero to 5, n and q not being both zero; and their use, in particular as dispersing agents, are disclosed.

    摘要翻译： 通式XYO-（AOYO）mAOYX（1）的化合物，其中X是通式[R1-Gp-（O-CHR2-CHR3-）n] 2N-（1a）的基团，其中R1是饱和脂族 具有6至30个碳原子的基团或具有一个或几个烯键并且具有6至30个碳原子的不饱和脂族基团，G是亚苯基或亚萘基，p是0或1，R2和R3是氢或甲基，但是 不是甲基，n是0至25的数，Y是式（1b）的基团，其中R2和R3具有指定的含义，q表示0至约200的相同或不同的数字， A是通式为（Ia）的基团，其中R 4和R 5是氢或1至3个碳原子的烷基，m是从0到5的数，n和q不都是0; 并且其使用，特别是作为分散剂的用途被公开。