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公开(公告)号：US08686376B2
公开(公告)日：2014-04-01
申请号：US12999639
申请日：2009-06-23
申请人： Reinhold Wimberger-Friedl , Peter Dirksen , Marius Iosif Boamfa , Erik Martinus Hubertus Petrus Van Dijk
发明人： Reinhold Wimberger-Friedl , Peter Dirksen , Marius Iosif Boamfa , Erik Martinus Hubertus Petrus Van Dijk
IPC分类号： F21V9/16
CPC分类号： G01N21/6452 , B01L3/5027 , G02B21/0028
摘要： A system for detecting a plurality of analytes in a sample includes an aperture array and a lens array for generating and focusing a plurality of excitation sub-beams on different sub-regions of a substrate. These sub-regions can be provided with different binding sites for binding different analytes in the sample. By detecting the different luminescent responses in a detector, the presence or amount of different analytes can be determined simultaneously. Alternatively or in addition, collection of the luminescence radiation can be performed using the lens array for directly collecting the luminescence response and for guiding the collected luminescence response to corresponding apertures. The excitation sub-beams may be focused at the side of the substrate opposite of the lens array, and an immersion fluid is provided between the lens array and the substrate to increase the collection efficiency of the luminescence radiation.
摘要翻译： 用于检测样品中多个分析物的系统包括孔径阵列和用于在衬底的不同子区域上产生和聚焦多个激发子束的透镜阵列。 这些子区域可以具有不同的结合位点，用于结合样品中的不同分析物。 通过检测检测器中的不同发光响应，可以同时测定不同分析物的存在或量。 或者或另外，可以使用透镜阵列来执行发光辐射的收集，用于直接收集发光响应并且用于将所收集的发光响应引导到相应的孔。 激发子光束可以聚焦在与透镜阵列相对的一侧的基板处，并且在透镜阵列和基板之间提供浸没流体以增加发光辐射的收集效率。
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公开(公告)号：US20110101243A1
公开(公告)日：2011-05-05
申请号：US12999639
申请日：2009-06-23
申请人： Reinhold Wimberger-Friedl , Peter Dirksen , Marius Iosif Boamfa , Erik Martinus Hubertus Petrus Van Dijk
发明人： Reinhold Wimberger-Friedl , Peter Dirksen , Marius Iosif Boamfa , Erik Martinus Hubertus Petrus Van Dijk
IPC分类号： G01N21/64
CPC分类号： G01N21/6452 , B01L3/5027 , G02B21/0028
摘要： A system and method is described for detecting a plurality of analytes in a sample. The characterization system (100) comprises an aperture array (108) and a lens array (110) for generating and focusing a plurality of excitation sub-beams on different sub-regions of a substrate. These sub-regions can be provided with different binding sites for binding different analytes in the sample. By detecting the different luminescent responses in a detector, the presence or amount of different analytes can be determined simultaneously. Alternatively or in addition thereto collection of the luminescence radiation can be performed using the lens array for directly collecting the luminescence response and for guiding the collected luminescence response to corresponding apertures. In a preferred embodiment, the excitation sub-beams are focused at the side of the substrate opposite of the lens array and an immersion fluid is provided between the lens array and the substrate to increase the collection efficiency of the luminescence radiation.
摘要翻译： 描述了用于检测样品中多个分析物的系统和方法。 表征系统（100）包括孔径阵列（108）和透镜阵列（110），用于在衬底的不同子区域上产生和聚焦多个激励子束。 这些子区域可以具有不同的结合位点，用于结合样品中的不同分析物。 通过检测检测器中的不同发光响应，可以同时测定不同分析物的存在或量。 或者或另外，可以使用透镜阵列来进行发光辐射的收集，用于直接收集发光响应并且用于将所收集的发光响应引导到相应的孔。 在优选实施例中，激发子光束在与透镜阵列相对的一侧聚焦，并且在透镜阵列和基板之间提供浸没流体，以增加发光辐射的收集效率。
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公开(公告)号：US20100270478A1
公开(公告)日：2010-10-28
申请号：US12747522
申请日：2008-12-10
IPC分类号： G01J1/58
CPC分类号： G01N21/6456
摘要： A detection system, comprising: a radiation source (24) for providing input radiation; a radiation focusing arrangement (26) for providing the input radiation to an analysis region of a sample (20);—a radiation collection (26) arrangement for collecting output radiation from the analysis region of the sample resulting from interaction of the input radiation with the sample; a radiation detector (28) for detecting the collected output radiation; operating means (40,50,60) for operating the detection device in a first detection mode and a second detection mode, wherein in the first detection mode the analysis has a first size and/or shape and wherein in the second detection mode the analysis region has a second size and/or shape that is different from the first size and/or shape.
摘要翻译： 一种检测系统，包括：用于提供输入辐射的辐射源（24）; 用于将输入辐射提供给样品（20）的分析区域的辐射聚焦装置（26）; - 辐射收集（26）装置，用于收集来自所述样品的分析区域的输出辐射，所述分析区域由所述输入辐射与 例子; 用于检测所收集的输出辐射的辐射检测器（28）; 用于在第一检测模式和第二检测模式下操作所述检测装置的操作装置（40,50,60），其中在所述第一检测模式中，所述分析具有第一尺寸和/或形状，并且其中在所述第二检测模式中，所述分析 区域具有与第一尺寸和/或形状不同的第二尺寸和/或形状。
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公开(公告)号：US08987684B2
公开(公告)日：2015-03-24
申请号：US12747522
申请日：2008-12-10
CPC分类号： G01N21/6456
摘要： A detection system, comprising: a radiation source (24) for providing input radiation; a radiation focusing arrangement (26) for providing the input radiation to an analysis region of a sample (20);—a radiation collection (26) arrangement for collecting output radiation from the analysis region of the sample resulting from interaction of the input radiation with the sample; a radiation detector (28) for detecting the collected output radiation; operating means (40,50,60) for operating the detection device in a first detection mode and a second detection mode, wherein in the first detection mode the analysis has a first size and/or shape and wherein in the second detection mode the analysis region has a second size and/or shape that is different from the first size and/or shape.
摘要翻译： 一种检测系统，包括：用于提供输入辐射的辐射源（24）; 用于将输入辐射提供给样品（20）的分析区域的辐射聚焦装置（26）; - 辐射收集（26）装置，用于收集来自所述样品的分析区域的输出辐射，所述分析区域由所述输入辐射与 例子; 用于检测所收集的输出辐射的辐射检测器（28）; 用于在第一检测模式和第二检测模式下操作所述检测装置的操作装置（40,50,60），其中在所述第一检测模式中，所述分析具有第一尺寸和/或形状，并且其中在所述第二检测模式中，所述分析 区域具有与第一尺寸和/或形状不同的第二尺寸和/或形状。
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公开(公告)号：US20090309049A1
公开(公告)日：2009-12-17
申请号：US12374006
申请日：2007-07-05
CPC分类号： G01N21/6428 , G01J3/02 , G01J3/021 , G01J3/10 , G01J3/36 , G01J3/4406 , G01N21/645 , G01N2021/6419 , G01N2021/6421 , G01N2021/6441 , G01N2021/6463
摘要： A detection system is described (100) for detecting luminescence sites on a substrate (6). The detection system (100) typically comprises an irradiation unit (102) for generating at least one excitation irradiation beam for exciting luminescence sites on the substrate (6). The at least one excitation irradiation beam may be a plurality of excitation irradiation beams. The detection system (100) also comprises a first optical element, e.g. refractive element (25), adapted for receiving at least two irradiation beams of different wavelengths or wavelength ranges, the at least two irradiation beams being excitation irradiation beam(s) to be focused on a substrate and/or luminescence irradiation beam(s) to be collected from the excited luminescence sites on the substrate (6). The detection system (100) also comprises an optical compensator for adjusting at least one of the at least two irradiation beams of different wavelengths or wavelength ranges so as to reduce or compensate for optical aberrations. The present invention also relates to a corresponding method for detecting, a phase plate and a method for designing such a phase plate.
摘要翻译： 描述了用于检测衬底（6）上的发光部位的检测系统（100）。 检测系统（100）通常包括用于产生用于激发衬底（6）上的发光位点的至少一个激发照射束的照射单元（102）。 所述至少一个激发照射光束可以是多个激发照射光束。 检测系统（100）还包括第一光学元件，例如， 折射元件（25），适于接收不同波长或波长范围的至少两个照射光束，所述至少两个照射光束是被聚焦在基底和/或发光照射光束上的激发照射光束 从基底（6）上的激发的发光部位收集。 检测系统（100）还包括用于调整不同波长或波长范围的至少两个照射束中的至少一个的光学补偿器，以便减少或补偿光学像差。 本发明还涉及用于检测相位板和相位板的设计方法的相应方法。
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6.发明授权Multi-color biosensor for detecting luminescence sites on a substrate having a refractive optical element for adjusting and focusing at least two incident irradiation beams of different wavelengths 失效用于检测具有折射光学元件的基板上的发光位置的多色生物传感器，用于调节和聚焦至少两个不同波长的入射照射光束公开(公告)号：US08120002B2
公开(公告)日：2012-02-21
申请号：US12374006
申请日：2007-07-05
IPC分类号： G01N21/86
CPC分类号： G01N21/6428 , G01J3/02 , G01J3/021 , G01J3/10 , G01J3/36 , G01J3/4406 , G01N21/645 , G01N2021/6419 , G01N2021/6421 , G01N2021/6441 , G01N2021/6463
摘要： A detection system for detecting luminescence sites on a substrate and including an irradiation unit for generating at least one excitation irradiation beam for exciting luminescence sites on the substrate; a first optical element, e.g. refractive element adapted for receiving at least two irradiation beams of different wavelengths or wavelength ranges, the at least two irradiation beams being excitation irradiation beam(s) to be focused on a substrate and/or luminescence irradiation beam(s) to be collected from the excited luminescence sites on the substrate; and an optical compensator for adjusting at least one of the at least two irradiation beams of different wavelengths or wavelength ranges so as to reduce or compensate for optical aberrations.
摘要翻译： 一种用于检测衬底上发光部位的检测系统，包括用于产生用于激发衬底上的发光部位的至少一个激发照射束的照射单元; 第一光学元件，例如。 用于接收不同波长或波长范围的至少两个照射光束的折射元件，所述至少两个照射光束是要聚焦在基底上的激发照射光束和/或从所述至少两个照射光束收集的发光照射光束 基底上激发的发光位点; 以及用于调整不同波长或波长范围的至少两个照射束中的至少一个的光学补偿器，以便减少或补偿光学像差。
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公开(公告)号：US09387484B2
公开(公告)日：2016-07-12
申请号：US13500446
申请日：2010-09-27
CPC分类号： B03C1/01 , B01L3/502761 , B03C1/015 , B03C1/288 , G01N35/0098 , Y10T436/25375
摘要： A method and apparatus for extracting magnetic particles from a sample includes placing the sample near a liquid carrier, which is immiscible with it, in a configuration stable under the influence of gravity. The magnetic particles are moved by a magnetic field from the sample and into the carrier. The magnetic particles are non-wetting with respect to the carrier and will therefore form agglomerates in the carrier.
摘要翻译： 从样品中提取磁性颗粒的方法和装置包括将样品放置在与其不混溶的液体载体附近，在重力作用下稳定的构型。 磁性颗粒通过磁场从样品移动到载体中。 磁性颗粒相对于载体是不润湿的，因此在载体中形成附聚物。
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公开(公告)号：US20130299015A1
公开(公告)日：2013-11-14
申请号：US13980586
申请日：2012-01-20
IPC分类号： F16K51/00
CPC分类号： F16K51/00 , B01L3/502738 , B01L2300/0874 , B01L2300/0887 , B01L2400/0655 , F16K99/0001 , F16K99/0015 , F16K99/0057 , F16K99/0059 , F16K2099/008 , F16K2099/0084 , F16K2099/0094 , Y10T137/794
摘要： The invention relates to a micro valve for use in a biosensor, a micro fluidic device, use of such a device, and a micro fluidic element. Biosensors are used for detection of molecules and/or ions, such as protein, drug, DNA, RNA, hormone, glucose, insulin, enzyme, fungus, bacterium, etc., in a biological sample. The sensor can be used for diagnostic application, but for instance also drugs, either therapeutic or abuse, may be detected in for instance blood, urine and saliva.
摘要翻译： 本发明涉及用于生物传感器的微型阀，微流体装置，这种装置的使用以及微流体元件。 生物传感器用于检测生物样品中的分子和/或离子，例如蛋白质，药物，DNA，RNA，激素，葡萄糖，胰岛素，酶，真菌，细菌等。 该传感器可以用于诊断应用，但是例如也可以在例如血液，尿液和唾液中检测治疗或滥用的药物。
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公开(公告)号：US20120270332A1
公开(公告)日：2012-10-25
申请号：US13500446
申请日：2010-09-27
CPC分类号： B03C1/01 , B01L3/502761 , B03C1/015 , B03C1/288 , G01N35/0098 , Y10T436/25375
摘要： The invention relates to means for extracting magnetic particles (M) from a sample (S). The sample (S) is arranged adjacent to a liquid carrier (C), which is immiscible with it, in a configuration stable under the influence of gravity, and the magnetic particles (M) are moved by a magnetic field (B) from the sample (S) into the carrier (C). Preferably, the magnetic particles (M) are non-wetting with respect to the carrier (C) and will therefore form agglomerates in the carrier (C).
摘要翻译： 本发明涉及从样品（S）中提取磁性颗粒（M）的方法。 样品（S）以与重力不同的液体载体（C）相邻配置，在重力作用下是稳定的，磁性粒子（M）通过磁场（B）从 样品（S）进入载体（C）。 优选地，磁性颗粒（M）相对于载体（C）不润湿，因此将在载体（C）中形成附聚物。
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10.发明申请公开(公告)号：US20090130025A1
公开(公告)日：2009-05-21
申请号：US11577820
申请日：2005-10-25
IPC分类号： A61K49/22
CPC分类号： B01F3/04439 , A61K49/223 , B01F5/0475 , B01F5/0476
摘要： Disclosed is a method of making gas bubbles in a liquid, the bubbles having substantially uniform size suitable for responding to ultrasound or other diagnostic tools. Gas (P2) is forced through one or more pores or nozzles, into the liquid (P1), the nozzles or pores being of substantially uniform diameter, the flow of the gas being controlled to thereby cause the formation of substantially monodisperse gas bubbles in the liquid. Moreover, an apparatus is disclosed for making a suspension of gas bubbles in a liquid of a size suitable for responding to ultrasound or other diagnostic tools. Said apparatus comprises means for forcing a gas through an array of nozzles or pores into the liquid, the nozzles or pores being of substantially uniform diameter, and first means for controlling; a flow parameter of the gas so that gas is suspended as substantially monodisperse gas bubbles in the liquid. Furthermore a kit for preparing a dispersion of gas bubbles of substantially uniform size suitable for ultrasound purposes, is disclosed.
摘要翻译： 公开了一种在液体中制造气泡的方法，气泡具有适合于响应超声波或其它诊断工具的基本均匀的尺寸。 气体（P2）被迫通过一个或多个孔或喷嘴进入液体（P1），喷嘴或孔具有基本上均匀的直径，气体的流动受到控制，从而在该气体中形成基本上单分散的气泡 液体。 此外，公开了一种用于使气泡悬浮在适于响应于超声波或其它诊断工具的尺寸的液体中的装置。 所述设备包括用于迫使气体通过喷嘴或孔阵列进入液体的装置，喷嘴或孔具有基本均匀的直径，以及用于控制的第一装置; 气体的流动参数，使得气体作为基本上单分散的气泡悬浮在液体中。 此外，公开了一种用于制备适合于超声波目的基本均匀尺寸的气泡分散体的试剂盒。
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