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    Medicament for the treatment of viral skin and tumour diseases
    4.
    发明申请
    Medicament for the treatment of viral skin and tumour diseases 有权
    用于治疗病毒性皮肤和肿瘤疾病的药物

    公开(公告)号：US20050032895A1

    公开(公告)日：2005-02-10

    申请号：US10495889

    申请日：2002-11-18

    申请人： Yunik Chang ,  Robert Lathrop ,  Erwin Bohm ,  Irene Gander-Meisterernst ,  Ulrich Moebius ,  Johanna Holldack ,  Ulrich Moebius

    发明人： Yunik Chang ,  Robert Lathrop ,  Erwin Bohm ,  Irene Gander-Meisterernst ,  Ulrich Moebius ,  Johanna Holldack ,  Ulrich Moebius

    IPC分类号： A61K31/12 ,  A61K31/20 ,  A61K31/23 ,  A61K31/25 ,  A61K31/353 ,  A61K36/18 ,  A61K45/00 ,  A61K45/06 ,  A61K47/06 ,  A61K47/10 ,  A61K47/14 ,  A61P15/00 ,  A61P17/00 ,  A61P17/12 ,  A61P31/12 ,  A61P31/20 ,  A61P31/22

    CPC分类号： A61K9/0014 ,  A61K31/23 ,  A61K31/353 ,  A61K47/06 ,  A61K47/10 ,  A61K47/14 ,  Y10S514/934 ,  Y10S514/947 ,  Y10S514/967 ,  Y10S514/969 ,  A61K2300/00

    摘要： The invention relates to a medicament containing a compound of general formula (1), where R1=independently, a straight or branched, saturated, singly- or multiply-unsaturated, optionally substituted C11-C21 alkyl, alkylene or alkinyl group, preferably a C11-C15 alkyl, alkylene or alkinyl group, particularly a C11-C13 alkyl, alkylene or alkinyl group, most preferably a C13 alkyl group, R2=independently, a straight or branched C1-C8 alkyl, alkylene or alkinyl group, preferably a C1-C6 alkyl, alkylene or alkinyl group, in particular a C2-C4 alkyl, alkylene or alkinyl group, most preferably a C3 alkyl group, a —[CH2—(CH2)m—O]nH group with n=1 to 10, preferably n=1 to 5, m==1 to 5, preferably m=1 to 3, a —CH2—[CH—(OH)]p[CH2-(R3)]— group, where R3=independent H or OH, p=1 to 7, preferably p=1 to 4, a pentose group or a hexose group, as therapeutically active agent, alone or in combination with one or several further pharmaceutical agents as a combination preparation for the treatment of viral skin diseases and/or tumour diseases, in particular caused by human papilloma virus (HPV) and/or herpes viruses and a topically acting medicament formulation and the use thereof.

    摘要翻译： 本发明涉及含有通式（1）化合物的药物，其中R1独立地为直链或支链的饱和的，单或多不饱和的任选取代的C 11 -C 21烷基，亚烷基或炔基，优选C 11 -C 15烷基，亚烷基或炔基，特别是C 11 -C 13烷基，亚烷基或炔基，最优选C 13烷基，R 2独立地为直链或支链C 1 -C 8烷基，亚烷基或炔基，优选C1- C 1 -C 6烷基，亚烷基或炔基，特别是C 2 -C 4烷基，亚烷基或炔基，最优选C 3烷基， - n = 1-10的α-[CH 2 - （CH 2）m O] n H基，优选n = 1〜5，m = 1〜5，优选m = 1〜3，-CH 2 - [CH-（OH）] p [CH 2 - （R 3）] - 基，其中R 3 =独立的H或OH，p = 1至7，优选p = 1至4，戊糖基或己糖基团，作为治疗活性剂，单独或与一种或几种其它药剂组合，作为用于治疗病毒的组合制剂 特别是由人乳头瘤病毒（HPV）和/或疱疹病毒引起的皮肤疾病和/或肿瘤疾病以及局部作用的药物制剂及其用途。

    2-bicyclobenzimidazoles, processes for their preparation and medicaments containing these compounds
    5.
    发明授权
    2-bicyclobenzimidazoles, processes for their preparation and medicaments containing these compounds 失效
    2-二环苯并咪唑，它们的制备方法和含有这些化合物的药物

    公开(公告)号：US5414088A

    公开(公告)日：1995-05-09

    申请号：US847060

    申请日：1992-04-14

    申请人： Wolfgang Von Der Saal ,  Harald Zilch ,  Erwin Bohm

    发明人： Wolfgang Von Der Saal ,  Harald Zilch ,  Erwin Bohm

    IPC分类号： A61K31/415 ,  A61K31/47 ,  A61P7/02 ,  C07D401/04 ,  C07D403/04 ,  C07D487/04 ,  C07D215/227 ,  C07D235/18

    CPC分类号： C07D401/04 ,  C07D403/04 ,  C07D487/04

    摘要： The invention concerns compounds of formula I ##STR1## where R.sup.1 is hydrogen, C.sub.1 -C.sub.6 -alkyl, C.sub.2 -C.sub.6 -alkenyl or C.sub.3 -C.sub.7 -cycloalkyl, R.sup.2 is C.sub.1 -C.sub.6 -alkyl, C.sub.2 -C.sub.6 -alkenyl, cyano, carboxy [carbonyl substituted by hydroxyl], C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -alkoxy, amino, C.sub.1 -C.sub.6 -alkylamino, di-C.sub.1 -C.sub.6 -alkylamino or hydrazino or R.sup.1 and R.sup.2 together are C.sub.2 -C.sub.6 -alkylidene or C.sub.3 -C.sub.6 -cycloalkylidene or R.sup.1 and R.sup.2, together with the carbon atoms to which they are attached, form a C.sub.3 -C.sub.7 -spirocycle, n is 0 or 1, R.sup.3 is hydrogen, C.sub.1 -C.sub.8 -alkyl, C.sub.2 -C.sub.6 -alkenyl, C.sub.2 -C.sub.6 -alkynyl, C.sub.3 -C.sub.7 -cycloalkyl, benzyl, carboxy-C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -alkyloxycarbonyl-C.sub.1 -C.sub.6 -alkyl or di-C.sub.1 -C.sub.6 -alkyloxophosphinyl-C.sub.1 -C.sub.6 -alkyl and R.sup.4 -R.sup. 6 are as in the specification. These compounds of formula I serve for the preparation of medicaments to inhibit erythrocyte and thrombocyte aggregation. Therefore, these compounds are useful for the treatment of diseases where these aggregations occur such as arterial occlusive or ischaemic conditions, venous insufficiency or diabetes mellitus.

    摘要翻译： PCT No.PCT / EP90 / 01663 Sec。 371日期：1992年4月14日 102（e）日期1992年4月14日PCT 1990年9月4日PCT PCT。 出版物WO91 / 04974 1991年4月18日，本发明涉及式I化合物（Ⅰ）其中R1是氢，C1-C6-烷基，C2-C6-烯基或C3-C7-环烷基，R2是C1-C6-烷基 ，C 2 -C 6 - 烯基，氰基，羧基[被羟基取代的羰基]，C 1 -C 6 - 烷基，C 1 -C 6 - 烷氧基，氨基，C 1 -C 6 - 烷基氨基，二-C 1 -C 6烷基氨基或肼基或R 1和R 2 一起是C 2 -C 6亚烷基或C 3 -C 6亚环烷基或R 1和R 2与它们连接的碳原子一起形成C 3 -C 7 - 螺环，n是0或1，R 3是氢，C 1 -C 8 - 烷基，C 2 -C 6 - 烯基，C 2 -C 6 - 炔基，C 3 -C 7 - 环烷基，苄基，羧基-C 1 -C 6 - 烷基，C 1 -C 6 - 烷氧基羰基-C 1 -C 6烷基或二-C 1 -C 6烷氧基氧膦 -C 1 -C 6烷基和R 4 -R 6如说明书中所述。 这些式I化合物用于制备抑制红细胞和血小板聚集的药物。 因此，这些化合物可用于治疗发生这些聚集的疾病，例如动脉闭塞或缺血性疾病，静脉功能不全或糖尿病。