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    Enteric-Coated Glucosinolates And Beta-Thioglucosidases
    2.
    发明申请
    Enteric-Coated Glucosinolates And Beta-Thioglucosidases 审中-公开
    肠溶包被的硫代葡萄糖苷和β-硫葡糖苷酶

    公开(公告)号：US20080311192A1

    公开(公告)日：2008-12-18

    申请号：US11761843

    申请日：2007-06-12

    申请人： Leslie George West ,  Nicole Lee Windsor ,  Anilkumar Ganapati Gaonkar ,  Nathan V. Matusheski ,  Nam-Cheol Kim ,  Cathy Jean Ludwig ,  Leslie Lewis Lawrence

    发明人： Leslie George West ,  Nicole Lee Windsor ,  Anilkumar Ganapati Gaonkar ,  Nathan V. Matusheski ,  Nam-Cheol Kim ,  Cathy Jean Ludwig ,  Leslie Lewis Lawrence

    IPC分类号： A61K9/14 ,  A61K38/47 ,  A61K9/48

    CPC分类号： A61K9/1652 ,  A61K9/5063 ,  A61K31/375 ,  A61K31/7028 ,  A61K38/47 ,  A61K2300/00

    摘要： The present invention relates to a particulate composition comprising enteric-coated glucosinolate and beta-thioglucosidase particles. The present invention further provides a method of converting glucosinolate to isothiocyanate in the small intestine comprising orally administering to a subject an enteric-coated chemoprotectant precursor composition comprising enteric-coated glucosinolate and beta-thioglucosinodase particles. In another aspect, uncoated glucosinolate and beta-thioglucosinodase particles may be provided in an enteric-coated capsule. Preferably, the glucosinolate is glucoraphanin and the beta-thioglucosidase is myrosinase. The enteric coating targets the compound for release in the small intestine where beta-thioglucosinodase enzyme converts glucosinolate to chemoprotectant isothiocyanate.

    摘要翻译： 本发明涉及包含肠溶包衣的硫代葡萄糖苷苷和β-硫代葡糖苷酶颗粒的颗粒组合物。 本发明还提供了一种在小肠中将芥子油苷转化成异硫氰酸酯的方法，其包括向受试者口服施用包含肠溶包衣的硫代葡萄糖苷和β-硫代葡萄糖苷糖苷酶颗粒的肠溶衣化学保护剂前体组合物。 在另一方面，可以在肠溶衣胶囊中提供未包衣的硫代葡萄糖苷和β-硫代葡糖苷调节酶颗粒。 优选地，硫代葡萄糖苷是葡萄糖甙元，β-硫代葡萄糖苷酶是黑芥子酶。 肠溶衣靶向化合物在小肠中释放，其中β-硫代葡糖苷异酶将芥子油苷转化成化学保护剂异硫氰酸酯。

    Production of Glucosinolates from Agricultural By-Products & Waste
    5.
    发明申请
    Production of Glucosinolates from Agricultural By-Products & Waste 审中-公开
    从农副产品和废物生产硫代葡萄糖苷

    公开(公告)号：US20080311276A1

    公开(公告)日：2008-12-18

    申请号：US11761883

    申请日：2007-06-12

    申请人： Leslie George West ,  Theresa Pomerleau ,  Nathan V. Matusheski ,  Cathy Jean Ludwig ,  Jamie Hestekin ,  Colin Crowley ,  Nam-Cheol Kim

    发明人： Leslie George West ,  Theresa Pomerleau ,  Nathan V. Matusheski ,  Cathy Jean Ludwig ,  Jamie Hestekin ,  Colin Crowley ,  Nam-Cheol Kim

    IPC分类号： A23L1/28

    CPC分类号： C07H15/14 ,  C07H1/08

    摘要： The present invention relates to a process for producing glucosinolates, particularly glucoraphanin, from cruciferous plants. More particularly, a method is provided for producing glucosinolates from agricultural by-products and waste. The general method comprises providing a mixture of glucosinolate-containing plant material and liquid, heating the mixture to inactivate enzymes in the plant material, contacting the heat inactivated mixture with an anion exchange membrane whereby at least a portion of the glucosinolates are extracted from the liquid and absorbed onto the anion exchange membrane, and releasing the glucosinolates from the anion exchange membrane. Preferably, the extraction and release steps are repeated at least once. The glucosinolates produce by the method of the invention may be incorporated into a variety of food products, pharmaceuticals, and health supplements.

    摘要翻译： 本发明涉及一种从十字花科植物生产硫代葡萄糖苷，特别是葡糖多糖的方法。 更具体地，提供了用于从农副产物和废物生产硫代葡萄糖苷的方法。 通常的方法包括提供含有硫代葡萄糖苷的植物材料和液体的混合物，加热混合物以灭活植物材料中的酶，使热灭活的混合物与阴离子交换膜接触，由此至少一部分硫代葡萄糖苷从液体中提取 并吸收到阴离子交换膜上，并从阴离子交换膜中释放硫代葡萄糖苷。 优选地，提取和释放步骤重复至少一次。 通过本发明的方法生产的硫代葡萄糖苷可以掺入各种食品，药物和保健品中。

    Two-stage method for preparing polyol fatty acid polyesters
    9.
    发明授权
    Two-stage method for preparing polyol fatty acid polyesters 失效
    制备多元醇脂肪酸聚酯的两阶段方法

    公开(公告)号：US5681948A

    公开(公告)日：1997-10-28

    申请号：US398749

    申请日：1995-03-06

    申请人： Mark Stuart Miller ,  Leslie George West ,  Robert Charles Dinwoodie ,  Richard S. Silver

    发明人： Mark Stuart Miller ,  Leslie George West ,  Robert Charles Dinwoodie ,  Richard S. Silver

    IPC分类号： C07H1/00 ,  C07H13/04 ,  C07H13/06 ,  C07H13/02

    CPC分类号： C07H13/04 ,  C07H13/06

    摘要： A two-stage method for the preparation of polyol fatty acid polyesters is provided. The resulting polyol fatty acid polyesters are very lightly colored (i.e., colorless to slightly yellow) and have a high degree of substitution with fatty acid groups. The first stage of this two-stage method is a solvent-based esterification reaction; the second stage is an essentially solvent-free esterification reaction. In the first stage, a polyol in a solvent (e.g., sucrose in dimethylsulfoxide)) is reacted with fatty acid lower alkyl esters at relatively low temperatures using an alkaline salt catalyst. After the desired degree of esterification is obtained, the resulting partially-esterified polyol fatty acid polyesters and the solvent-containing phase are separated. The separated partially-esterified polyol fatty acid polyesters are further esterified with the same or different fatty acid lower alkyl esters in a second stage with an alkaline salt catalyst using essentially solvent-free, high temperature conditions whereby the degree of substitution is significantly increased. Most of the color bodies and other contaminants capable of producing color are removed with the solvent in the first stage and, therefore, are not present during the higher temperature reaction conditions of the second stage. The resulting polyol fatty acid polyesters, and in particular the sucrose fatty acid polyesters, are especially useful as fat substitutes in food applications and products.

    摘要翻译： 提供了制备多元醇脂肪酸聚酯的两阶段方法。 得到的多元醇脂肪酸聚酯非常浅色（即无色至微黄色）并且具有高脂肪酸基取代度。 这种两步法的第一阶段是溶剂型酯化反应; 第二阶段是基本上无溶剂的酯化反应。 在第一阶段中，使用碱性盐催化剂，在相对较低的温度下，将溶剂中的多元醇（例如二甲基亚砜中的蔗糖））与脂肪酸低级烷基酯反应。 在获得所需的酯化度之后，分离得到的部分酯化的多元醇脂肪酸聚酯和含溶剂的相。 分离的部分酯化的多元醇脂肪酸聚酯在第二阶段中用相同或不同的脂肪酸低级烷基酯进一步用碱性盐催化剂进行酯化，使用基本上无溶剂的高温条件，从而显着提高了取代度。 能够产生颜色的大多数着色体和其它污染物在第一阶段用溶剂除去，因此在第二阶段的较高温度的反应条件下不存在。 所得的多元醇脂肪酸聚酯，特别是蔗糖脂肪酸聚酯，特别适用于食品应用和产品中的脂肪替代物。