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公开(公告)号：US20060160817A1
公开(公告)日：2006-07-20
申请号：US11266142
申请日：2005-11-03
申请人： Esther Martinborough , Nicole Zimmermann , Robert Perni , Michael Arnost , Upul Bandarage , Francois Maltais , Guy Bemis
发明人： Esther Martinborough , Nicole Zimmermann , Robert Perni , Michael Arnost , Upul Bandarage , Francois Maltais , Guy Bemis
IPC分类号： A61K31/506 , C07D403/02 , A61K31/505
CPC分类号： C07D409/14 , A61K31/506 , C07D239/28 , C07D239/30 , C07D239/42 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/06
摘要： In general, the invention relates to compounds useful as ion channel modulators. It has now been found that compounds of this invention, and pharmaceutically acceptable compositions thereof, are useful as inhibitors of voltage-gated sodium channels and/or calcium channels.
摘要翻译： 通常，本发明涉及可用作离子通道调节剂的化合物。 现已发现，本发明的化合物及其药学上可接受的组合物可用作电压门控钠通道和/或钙通道的抑制剂。
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公开(公告)号：US20100184753A1
公开(公告)日：2010-07-22
申请号：US12724077
申请日：2010-03-15
申请人： Esther Martinborough , Nicole Zimmermann , Robert B. Perni , Michael Arnost , Upul Bandarage , Francois Maltais , Guy Bemis
发明人： Esther Martinborough , Nicole Zimmermann , Robert B. Perni , Michael Arnost , Upul Bandarage , Francois Maltais , Guy Bemis
IPC分类号： A61K31/506 , A61K31/541 , A61K31/5377 , C07D417/04 , C07D413/00 , C07D401/14 , C07D401/04
CPC分类号： C07D409/14 , A61K31/506 , C07D239/28 , C07D239/30 , C07D239/42 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/06
摘要： In general, the invention relates to compounds useful as ion channel modulators. It has now been found that compounds of this invention, and pharmaceutically acceptable compositions thereof, are useful as inhibitors of voltage-gated sodium channels and/or calcium channels.
摘要翻译： 通常，本发明涉及可用作离子通道调节剂的化合物。 现已发现，本发明的化合物及其药学上可接受的组合物可用作电压门控钠通道和/或钙通道的抑制剂。
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公开(公告)号：US08236815B2
公开(公告)日：2012-08-07
申请号：US12724077
申请日：2010-03-15
申请人： Esther Martinborough , Nicole Zimmermann , Robert B. Perni , Michael Arnost , Upul Bandarage , Francois Maltais , Guy Bemis
发明人： Esther Martinborough , Nicole Zimmermann , Robert B. Perni , Michael Arnost , Upul Bandarage , Francois Maltais , Guy Bemis
IPC分类号： A01N43/54 , A61K31/505 , C07D239/02
CPC分类号： C07D409/14 , A61K31/506 , C07D239/28 , C07D239/30 , C07D239/42 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/06
摘要： The invention relates to ion channel modulators of formula Ia, pharmaceutical compositions thereof, and to methods of treating diseases using such compounds where activation or hyperactivity of calcium and/or sodium ion channels is implicated in the disease state.
摘要翻译： 本发明涉及式Ia的离子通道调节剂，其药物组合物，以及使用这样的化合物治疗疾病的方法，其中钙和/或钠离子通道的活化或多动症涉及疾病状态。
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公开(公告)号：US08546414B2
公开(公告)日：2013-10-01
申请号：US13538667
申请日：2012-06-29
申请人： Esther Martinborough , Nicole Zimmermann , Robert B. Perni , Michael Arnost , Upul K. Bandarage , Francois Maltais , Guy Bemis
发明人： Esther Martinborough , Nicole Zimmermann , Robert B. Perni , Michael Arnost , Upul K. Bandarage , Francois Maltais , Guy Bemis
IPC分类号： A01N43/54 , A61K31/505
CPC分类号： C07D409/14 , A61K31/506 , C07D239/28 , C07D239/30 , C07D239/42 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/06
摘要： In general, the invention relates to novel 4-phenylpyrimidine compounds useful as ion channel modulators. It has now been found that compounds of this invention, and pharmaceutically acceptable compositions thereof, are useful as inhibitors of voltage-gated sodium channels and/or calcium channels for the treatment of pain.
摘要翻译： 通常，本发明涉及可用作离子通道调节剂的新型4-苯基嘧啶化合物。 现在已经发现，本发明的化合物及其药学上可接受的组合物可用作用于治疗疼痛的电压门控钠通道和/或钙通道的抑制剂。
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公开(公告)号：US20120270318A1
公开(公告)日：2012-10-25
申请号：US13538667
申请日：2012-06-29
申请人： ESTHER MARTINBOROUGH , Nicole Zimmermann , Robert B. Perni , Michael Arnost , Upul K. Bandarage , Francois Maltais , Guy Bemis
发明人： ESTHER MARTINBOROUGH , Nicole Zimmermann , Robert B. Perni , Michael Arnost , Upul K. Bandarage , Francois Maltais , Guy Bemis
IPC分类号： C12N5/071
CPC分类号： C07D409/14 , A61K31/506 , C07D239/28 , C07D239/30 , C07D239/42 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/06
摘要： In general, the invention relates to compounds useful as ion channel modulators. It has now been found that compounds of this invention, and pharmaceutically acceptable compositions thereof, are useful as inhibitors of voltage-gated sodium channels and/or calcium channels.
摘要翻译： 通常，本发明涉及可用作离子通道调节剂的化合物。 现已发现，本发明的化合物及其药学上可接受的组合物可用作电压门控钠通道和/或钙通道的抑制剂。
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公开(公告)号：US07767680B2
公开(公告)日：2010-08-03
申请号：US11266142
申请日：2005-11-03
申请人： Esther Martinborough , Nicole Zimmermann , Robert B. Perni , Michael Arnost , Upul K. Bandarage , Francois Maltais , Guy Bemis
发明人： Esther Martinborough , Nicole Zimmermann , Robert B. Perni , Michael Arnost , Upul K. Bandarage , Francois Maltais , Guy Bemis
IPC分类号： A61K31/497 , A61K31/505 , C07D403/00 , C07D239/02
CPC分类号： C07D409/14 , A61K31/506 , C07D239/28 , C07D239/30 , C07D239/42 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D413/06
摘要： In general, the invention relates to novel 4-phenylpyrimidine compounds useful as ion channel modulators. It has now been found that compounds of this invention, and pharmaceutically acceptable compositions thereof, are useful as inhibitors of voltage-gated sodium channels and/or calcium channels.
摘要翻译： 通常，本发明涉及可用作离子通道调节剂的新型4-苯基嘧啶化合物。 现已发现，本发明的化合物及其药学上可接受的组合物可用作电压门控钠通道和/或钙通道的抑制剂。
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公开(公告)号：US20080096901A1
公开(公告)日：2008-04-24
申请号：US11787165
申请日：2007-04-13
申请人： Michael Arnost , Guy Bemis , Robert Davies , Cornelia Forster , Ronald Grey , Mark Ledeboer , Brian Ledford , Craig Marhefka , David Messersmith , Albert Pierce , Francesco Salituro , Jian Wang
发明人： Michael Arnost , Guy Bemis , Robert Davies , Cornelia Forster , Ronald Grey , Mark Ledeboer , Brian Ledford , Craig Marhefka , David Messersmith , Albert Pierce , Francesco Salituro , Jian Wang
IPC分类号： A61K31/4196 , C07D401/04 , A61K31/4439 , A61K31/496 , C07D403/04 , C07D249/08 , A61P11/06 , A61P27/14 , A61P29/00 , A61P37/08 , A61P37/00 , A61P35/00 , A61P25/16 , A61P25/28
CPC分类号： C07D401/04 , C07D249/14 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/14 , C07D417/04
摘要： The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention, processes for preparing the compounds and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及蛋白激酶抑制剂。 本发明还提供包含本发明化合物的药物组合物，制备化合物的方法和使用该组合物治疗各种疾病的方法。
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公开(公告)号：US08921376B2
公开(公告)日：2014-12-30
申请号：US11438748
申请日：2006-05-22
申请人： Mark Ledeboer , Marion Wannamaker , Luc Farmer , Tiansheng Wang , Albert Pierce , Gabriel Martinez-Botella , Randy Bethiel , Guy Bemis , Jian Wang , Francesco Salituro , Michael Arnost , Jon Come , Jeremy Green , Michelle Stewart , Craig Marhefka
发明人： Mark Ledeboer , Marion Wannamaker , Luc Farmer , Tiansheng Wang , Albert Pierce , Gabriel Martinez-Botella , Randy Bethiel , Guy Bemis , Jian Wang , Francesco Salituro , Michael Arnost , Jon Come , Jeremy Green , Michelle Stewart , Craig Marhefka
IPC分类号： C07D471/04 , A61K31/437 , C07D487/04
CPC分类号： C07D471/04 , C07D487/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family and ROCK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂，特别是JAK家族和ROCK家族激酶的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US20070135466A1
公开(公告)日：2007-06-14
申请号：US11438748
申请日：2006-05-22
申请人： Mark Ledeboer , Marion Wannamaker , Luc Farmer , Tiansheng Wang , Albert Pierce , Gabriel Martinez-Botella , Randy Bethiel , Guy Bemis , Jian Wang , Francesco Salituro , Michael Arnost , Jon Come , Jeremy Green , Michelle Stewart , Craig Marhefka
发明人： Mark Ledeboer , Marion Wannamaker , Luc Farmer , Tiansheng Wang , Albert Pierce , Gabriel Martinez-Botella , Randy Bethiel , Guy Bemis , Jian Wang , Francesco Salituro , Michael Arnost , Jon Come , Jeremy Green , Michelle Stewart , Craig Marhefka
IPC分类号： A61K31/506 , A61K31/4745 , C07D471/02
CPC分类号： C07D471/04 , C07D487/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family and ROCK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂，特别是JAK家族和ROCK家族激酶的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US20080014189A1
公开(公告)日：2008-01-17
申请号：US11774702
申请日：2007-07-09
申请人： Albert Pierce , Michael Arnost , Robert Davies , Cornelia Forster , Vincent Galullo , Ronald Gray , Mark Ledeboer , Shi-Kai Tian , Jinwang Xu , Hayley Binch , Brian Ledford , David Messersmith , Suganthi Nanthakumar , Andrew Jayaraj , Greg Henkel , Francesco Salituro , Jian Wang
发明人： Albert Pierce , Michael Arnost , Robert Davies , Cornelia Forster , Vincent Galullo , Ronald Gray , Mark Ledeboer , Shi-Kai Tian , Jinwang Xu , Hayley Binch , Brian Ledford , David Messersmith , Suganthi Nanthakumar , Andrew Jayaraj , Greg Henkel , Francesco Salituro , Jian Wang
IPC分类号： A61K38/50 , A61K31/4196 , A61K31/428 , A61K31/437 , A61K31/44 , A61K31/47 , A61K31/505 , A61P19/00 , A61P3/00 , C07D239/28 , C07D239/24 , A61P9/00 , A61P37/08 , A61P35/00 , A61P25/28 , A61P11/06 , A61K31/519 , A61K31/5377 , A61K31/555 , A61K31/573 , A61K31/675
CPC分类号： C07D401/04 , C07D249/10 , C07D249/14 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/14 , C07D487/04 , C07D495/04
摘要： The present invention relates to inhibitors of protein kinases. The invention also provides pharmaceutical compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders.
摘要翻译： 本发明涉及蛋白激酶抑制剂。 本发明还提供包含本发明化合物的药物组合物和使用该组合物治疗各种疾病的方法。
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