公开(公告)号：US20220375548A1

公开(公告)日：2022-11-24

申请号：US17634080

申请日：2020-10-02

Applicant: FIRMENICH SA

Inventor： Ben SMITH ,  Patrick PFISTER ,  Lily WU ,  Hyo Young JEONG ,  Daniel RAPS ,  Maria BORISOVSKA

IPC: G16C20/30 ,  C11B9/00

Abstract: The composition tonality determination method includes:
inputting at least one volatile molecule digital identifier, the volatile molecule digital identifier representative of a fragrant volatile molecule, the input defining a formula,
calculating, by a computing system, for at least one volatile molecule digital identifier of the formula, a value representative of an impact of each molecule on an activity level of an odorant receptor, represented by an odorant receptor digital identifier, each volatile molecule digital identifier being associated with at least one odorant receptor digital identifier, the association being a many-to-many association, and
determining, by a computing system, for the formula and as a function of at least one odorant receptor activity level impact calculated and a value representative of an odorant receptor activation threshold, a value representative of at least one tonality forming a composition, each odorant receptor digital identifier being associated with one tonality digital identifier, the association being a one-to-one association.

公开(公告)号：US20180298069A1

公开(公告)日：2018-10-18

申请号：US15580110

申请日：2016-06-09

Applicant: FIRMENICH SA

Inventor： Hyo-Young JEONG ,  Patrick PFISTER ,  Matthew ROGERS

IPC: C07K14/47 ,  C07K14/705 ,  C12N15/86 ,  C12N15/11 ,  C12N9/22 ,  G01N33/50

Abstract: Provided herein is a cell line with improved odorant receptor function comprising an activated endogenous RTP1 gene, which further expresses an RTP1 protein. Further provided herein is a method for specifically activating an endogenous RTP1 gene in a eukaryotic cell using a CRISPR/Cas9 derived technique. Also provided herein is a method for identifying compounds with desired effects such as perfume or aroma modulators in said cell line.

公开(公告)号：US20180208637A1

公开(公告)日：2018-07-26

申请号：US15877215

申请日：2018-01-22

Applicant: Firmenich SA

Inventor： Patrick PFISTER ,  Matthew ROGERS ,  Khalid Jerod PARRIS

IPC: C07K14/705 ,  C12Q1/6809 ,  G01N33/50

CPC classification number: C07K14/705 ,  C12Q1/6809 ,  C12Q2600/136 ,  G01N33/5058 ,  G01N2333/705 ,  G01N2500/04 ,  G01N2570/00

Abstract: Provided here are new methods to identify specific families of mammalian odorant receptors for odorants or aroma, particularly indole and skatole malodors and their use in assays that may be used to discover compounds that modulate (blocking, enhancing, masking or mimicking compounds) their activity. Orphan mouse odorant receptors are identified from olfactory sensory neurons that respond to target compounds. The resulting receptors as well as their human counterparts can be screened in assays against test compounds to confirm their identity as odorant or aroma receptors, particularly malodor receptors and subsequently discover for example modulators that inhibit the perception of the malodor in humans.

公开(公告)号：US20230233425A1

公开(公告)日：2023-07-27

申请号：US18067164

申请日：2022-12-16

Applicant: Firmenich SA

Inventor： Huey-Ling KAO ,  Stefan Alexander RUIDER ,  Ben SMITH ,  Gary MARR ,  Matthew ROGERS ,  Mushhood SHEIKH ,  Zhenan WU ,  Patrick PFISTER ,  Anthony Alexander BIRKBECK ,  Julien COULOMB

IPC: A61K8/33 ,  A61K8/31 ,  A61K8/34 ,  A61K8/368 ,  A61K8/41 ,  A61K8/49 ,  C11B9/00 ,  C11C5/00 ,  A61K8/35

CPC classification number: A61K8/33 ,  A61K8/31 ,  A61K8/347 ,  A61K8/368 ,  A61K8/41 ,  A61K8/4926 ,  A61K8/4973 ,  C11B9/0034 ,  C11B9/0042 ,  C11B9/0057 ,  C11C5/002 ,  A61K8/35

Abstract: The various aspects presented herein relate to the perfumery industry. More particularly, the various aspects presented herein relate to the use of volatile compositions to limit, decrease or eliminate the perception of malodor. Such compositions include at least one malodor antagonist optionally combined with perfuming ingredients. Such compositions, their use in combination with delivery systems and their applications in consumer products are also objects of the present disclosure.

公开(公告)号：US20200345601A1

公开(公告)日：2020-11-05

申请号：US16760031

申请日：2018-11-21

Applicant: Firmenich SA

Inventor： Huey-Ling KAO ,  Stefan Alexander RUIDER ,  Ben SMITH ,  Gary MARR ,  Matthew ROGERS ,  Mushhood SHEIKH ,  Anna WU ,  Patrick PFISTER ,  Anthony Alexander BIRKBECK ,  Julien COULOMB

IPC: A61K8/33 ,  A61K8/34 ,  A61K8/49 ,  A61K8/31 ,  A61K8/41 ,  A61K8/368 ,  C11B9/00 ,  C11C5/00

Abstract: The various aspects presented herein relate to the perfumery industry. More particularly, the various aspects presented herein relate to the use of volatile compositions to limit, decrease or eliminate the perception of malodor. Such compositions include at least one malodor antagonist optionally combined with perfuming ingredients. Such compositions, their use in combination with delivery systems and their applications in consumer products are also objects of the present disclosure.

公开(公告)号：US20230125249A1

公开(公告)日：2023-04-27

申请号：US18056426

申请日：2022-11-17

Applicant: FIRMENICH SA

Inventor： Patrick PFISTER ,  Matthew ROGERS ,  Jana PIKA ,  Florian DE NANTEUIL ,  Nicholas O'LEARY ,  Christie DELAURA

IPC: C11B9/00 ,  A61K8/35

Abstract: The various aspects presented herein relate to the perfumery industry. More particularly, the various aspects presented herein relate to compositions and/or ingredients that increase a subject's perception of musk compounds, methods for intensifying a subject's perception of musk compounds, as well as to the perfumed articles or perfuming compositions comprising as an active ingredient, a compound of Formula (I).

公开(公告)号：US20230065799A1

公开(公告)日：2023-03-02

申请号：US17635651

申请日：2020-10-02

Applicant: FIRMENICH SA

Inventor： Ben SMITH ,  Patrick PFISTER ,  Lily WU ,  Hyo Young JEONG ,  Daniel RAPS

IPC: G16C20/30 ,  C11B9/00 ,  G16C60/00

Abstract: The present invention relates to the perfumery industry. More particularly, the present invention relates to assays and methods for screening and identifying compositions and/or ingredients that intensify a subjects perception of target odorant compounds based on the use of particular olfactory receptors activated by the target odorant compound.

公开(公告)号：US20210003553A1

公开(公告)日：2021-01-07

申请号：US16638179

申请日：2018-11-21

Applicant: FIRMENICH SA

Inventor： Huey-Ling KAO ,  Mushhood SHEIKH ,  Patrick PFISTER ,  Cristinel SANDU ,  Barry EVANS ,  Nicholas O'LEARY ,  Ben SMITH

IPC: G01N33/50 ,  G01N33/566 ,  G01N33/68

Abstract: The present disclosure relates to a method for identifying a compound that binds, suppresses, blocks, inhibits, and/or modulates the activity of an olfactory receptor that is activated by a laundry malodor causing substance, a moldy malodour causing substance and/or a sweat malodor-causing substance. The method includes contacting a test substance and the laundry malodor and/or sweat malodor-causing substance to an olfactory receptor polypeptide.

公开(公告)号：US20200048326A1

公开(公告)日：2020-02-13

申请号：US15580476

申请日：2016-06-09

Applicant: Firmenich SA

Inventor： Patrick PFISTER ,  Matthew ROGERS

IPC: C07K14/72 ,  G01N33/50

Abstract: Provided herein are polypeptides that bind to Musk compounds. Also provided are nucleic acid sequences that encode for the polypeptides. Further provided herein is a method for identifying a compound that activates, mimics, blocks, inhibits, modulates, and/or enhances the activity of an olfactory receptor that is activated by a polycyclic Musk or a nitro Musk wherein the receptor is a polypeptide having an amino acid sequence that is at least 75% identical to Olfr96 or OR11A1, wherein the method includes a) contacting the receptor, or a chimera or fragment thereof with a compound and b) determining whether the compound has an effect on the activity of the receptor.