公开(公告)号：US11512275B2

公开(公告)日：2022-11-29

申请号：US16659242

申请日：2019-10-21

Applicant: FUJIFILM Corporation

Inventor： Toshiki Takei ,  Tadanori Yamada ,  Ryuta Takegami ,  Kuniyuki Kaminaga ,  Akihito Fukunaga ,  Kazuhide Kanemura

IPC: B01D39/18 ,  C12M1/00 ,  C12N5/078 ,  C12N5/00 ,  C12M3/06

Abstract: An object of the present invention is to provide a separation substrate having a high megakaryocyte blocking rate and a high platelet permeation rate, and a cell separation filter and a method for producing a platelet which use the same. The separation substrate of the present invention is a separation substrate including non-woven fabric for separating a platelet from a cell suspension containing a megakaryocyte and the platelet, in which an average pore diameter of the separation substrate is 2.0 μm to 15.0 μm, and a thickness of the separation substrate is 10 μm to 500 μm.

公开(公告)号：US09790338B2

公开(公告)日：2017-10-17

申请号：US15248541

申请日：2016-08-26

Applicant: FUJIFILM Corporation

Inventor： Kuniyuki Kaminaga ,  Tetsufumi Takamoto ,  Keisuke Kodama ,  Kazuomi Inoue

IPC: C08J5/22 ,  B01J41/14 ,  B01J47/12 ,  B01D71/82 ,  B01D61/48

CPC classification number: C08J5/2243 ,  B01D61/48 ,  B01D71/82 ,  B01J41/14 ,  B01J47/12 ,  C08J5/2231 ,  C08J2325/18 ,  C08J2333/24 ,  C08J2333/26

Abstract: An ion exchange membrane obtained by using an ionic monomer having at least two or more polymerizable functional groups, in which a hydrophobicity index H obtained by an expression below from a monomer for forming an ion exchange resin and a material fixed to the resin in the ion exchange membrane is 1.6 or greater, and a manufacturing method therefor. Hydrophobicity index H=Σ{(log P of each component)×(molar ratio of each material in resin)}.

公开(公告)号：US10112151B2

公开(公告)日：2018-10-30

申请号：US15248686

申请日：2016-08-26

Applicant: FUJIFILM Corporation

Inventor： Tetsufumi Takamoto ,  Kuniyuki Kaminaga

IPC: B01D39/00 ,  B01D69/12 ,  B01J41/14 ,  B01J47/12 ,  B01D69/10 ,  B01D71/40 ,  C08F220/54 ,  B01D61/44 ,  B01D67/00 ,  B01J41/04 ,  C08F22/38 ,  C08J5/22 ,  C08F222/38 ,  B01D61/00 ,  B01D61/02

Abstract: A functional polymer membrane including a porous support and a crosslinked polymer electrolyte, in which the film thickness of the functional polymer membrane is smaller than 100 μm, the crosslinked polymer electrolyte is a crosslinked polymer formed by subjecting a composition including a monomer having a (meth)acrylamide skeleton to a polymerization curing reaction, and the proportion of elemental oxygen in the elemental composition excluding elemental hydrogen and helium at the surface of the porous support is from 14.0 atom % to 25.0 atom %; and a method for producing the same are provided.

公开(公告)号：US10087263B2

公开(公告)日：2018-10-02

申请号：US15252859

申请日：2016-08-31

Applicant: FUJIFILM Corporation

Inventor： Keisuke Kodama ,  Kuniyuki Kaminaga

IPC: C08F20/58 ,  B01J39/20 ,  B01D71/40 ,  C07C309/24 ,  B01D71/82 ,  C08F222/38 ,  H01B1/12 ,  H01M8/1023 ,  H01M8/1069 ,  H01M8/1072 ,  B01D67/00 ,  C07C303/32 ,  C08J5/22 ,  B01D61/00 ,  B01D61/02 ,  B01D61/42

Abstract: There is provided a curable composition including a water-soluble acrylamide monomer represented by the following General Formula (1-1) or (1-2), a polymer functional cured product, a water-soluble acrylamide compound, and a method for manufacturing the same. In General Formulas (1-1) and (1-2), m represents an integer of 2 or greater, and L represents an m-valent group or a single bond. Here, in a case where L is a single bond, m is 2. L1 and L2 each represent a single bond or a divalent linking group. R1 to R5 each represent a hydrogen atom or a substituent, and may be bonded to each other to form a ring, and may be bonded to L, L1, or L2 to form a ring. Either one of RA and RB represents a group represented by General Formula (a), and the other represents a group represented by General Formula (b).

公开(公告)号：US11771806B2

公开(公告)日：2023-10-03

申请号：US16727817

申请日：2019-12-26

Applicant: FUJIFILM Corporation

Inventor： Kazuhiro Hasegawa ,  Ryuta Takegami ,  Kuniyuki Kaminaga ,  Yusuke Mochizuki

IPC: A01N1/02 ,  A61L27/56 ,  A61L27/16 ,  A61L27/54 ,  A61L27/26

CPC classification number: A61L27/56 ,  A01N1/0231 ,  A01N1/0263 ,  A61L27/16 ,  A61L27/26 ,  A61L27/54 ,  A61L2300/43

Abstract: According to the present invention, there are provided a chamber for transplantation, including a membrane for immunoisolation including a porous membrane at at least part of a boundary between an inside and an outside of the chamber for transplantation, in which the porous membrane contains a polymer and has a layered compact portion where a pore diameter is the smallest within the membrane, a pore diameter continuously increases in a thickness direction from the compact portion toward both one surface A and the other surface B of the porous membrane, a porosity in a vicinity of the surface A is 65% or more, an average pore diameter of the surface A is larger than an average pore diameter of the surface B, and the surface B is disposed on the inside of the chamber for transplantation; and a device for transplantation including the chamber for transplantation enclosing a biological constituent therein. In the chamber for transplantation of the present invention, angiogenesis in a recipient is induced and a deterioration in substance permeability is unlikely to occur.

公开(公告)号：US20200048597A1

公开(公告)日：2020-02-13

申请号：US16659242

申请日：2019-10-21

Applicant: FUJIFILM Corporation

Inventor： Toshiki TAKEI ,  Tadanori Yamada ,  Ryuta Takegami ,  Kuniyuki Kaminaga ,  Akihito Fukunaga ,  Kazuhide Kanemura

IPC: C12M1/00 ,  B01D39/18 ,  C12N5/078

Abstract: An object of the present invention is to provide a separation substrate having a high megakaryocyte blocking rate and a high platelet permeation rate, and a cell separation filter and a method for producing a platelet which use the same. The separation substrate of the present invention is a separation substrate including non-woven fabric for separating a platelet from a cell suspension containing a megakaryocyte and the platelet, in which an average pore diameter of the separation substrate is 2.0 μm to 15.0 μm, and a thickness of the separation substrate is 10 μm to 500 μm.

公开(公告)号：US20190240641A1

公开(公告)日：2019-08-08

申请号：US16383088

申请日：2019-04-12

Applicant: FUJIFILM Corporation

Inventor： Kuniyuki Kaminaga ,  Ryuta Takegami

IPC: B01J20/24 ,  B01D71/16 ,  B01J20/28

CPC classification number: B01J20/24 ,  A61K35/15 ,  A61M1/02 ,  B01D71/16 ,  B01J20/28 ,  B01J20/28033 ,  B01J20/28059 ,  B01J20/28061 ,  B01J20/28085

Abstract: A filtering medium for selective adsorption of blood components contains a cellulose acylate, and has a glass transition temperature of 126° C. or higher, an average through-hole diameter of 0.1 to 50 μm, and a specific surface area of 1.0 to 100 m2/g.

公开(公告)号：US10279342B2

公开(公告)日：2019-05-07

申请号：US15251055

申请日：2016-08-30

Applicant: FUJIFILM Corporation

Inventor： Sotaro Inomata ,  Keisuke Kodama ,  Satoshi Sano ,  Kuniyuki Kaminaga

IPC: B01J41/14 ,  B01D69/10 ,  C08F220/56 ,  B01D69/02 ,  B01D71/80 ,  C08J5/22 ,  B01D71/40 ,  B01J47/12 ,  C08F222/38 ,  H01M8/1023 ,  C08F220/60 ,  H01M8/1072 ,  H01M8/22 ,  H01M8/1018

Abstract: There are provided an ion-exchange polymer including a structure represented by the following General Formula (1) and a production method therefor, an electrolyte membrane and a production method therefor, and a composition for producing an ion-exchange polymer. In a case where the sum of a1, b1, and c1 is 1.000, a1 is 0.000 to 0.750, b1 is 0.240 to 0.990, and c1 is 0.001 to 0.100. L represents an alkylene group, L1 and L2 each represent a divalent linking group, R1 is a hydrogen atom or an alkyl group, R2 and R3 each represent an alkyl group or an allyl group, X1− and X2− each represent an inorganic or organic anion, and Y represents a halogen atom. Z1 represents —O— or —NRa—, and Ra represents a hydrogen atom or an alkyl group.

公开(公告)号：US11856946B2

公开(公告)日：2024-01-02

申请号：US18090794

申请日：2022-12-29

Applicant: FUJIFILM Corporation

Inventor： Kuniyuki Kaminaga ,  Ryuta Takegami ,  Kazuhiro Hasegawa ,  Yusuke Mochizuki

IPC: A01N1/00 ,  A01N1/02 ,  B01D63/08 ,  A61B17/00

CPC classification number: A01N1/0231 ,  B01D63/089 ,  A61B2017/00969

Abstract: According to the present invention, there are provided a chamber for transplantation, as a planar chamber for transplantation which has a structure in which membranes for immunoisolation face each other, and which is capable of stably enclosing a biological constituent, including a membrane for immunoisolation at a boundary between an inside and an outside of the chamber for transplantation, in which the membranes for immunoisolation which face each other have joint portions that are joined to each other, an interior space includes a point at a distance of 10 mm or longer from any position of the joint portion, and the membrane for immunoisolation has flexibility that allows a distance of 1 mm to 13 mm as the following distance: in a case where a portion of 10 mm from a side surface of one short side of a 10 mm×30 mm rectangular test piece of the membrane for immunoisolation is vertically sandwiched between flat plates, and the flat plates are placed horizontally, a distance between a horizontal plane including a center plane in a thickness direction of the sandwiched portion of the membrane for immunoisolation, and a part, which is farthest from the horizontal plane, of a residual 20 mm-portion projecting from the flat plate; and a device for transplantation including the chamber for transplantation enclosing a biological constituent therein.

公开(公告)号：US11576370B2

公开(公告)日：2023-02-14

申请号：US16728529

申请日：2019-12-27

Applicant: FUJIFILM Corporation

Inventor： Yusuke Mochizuki ,  Kuniyuki Kaminaga ,  Kazuhiro Hasegawa ,  Ryuta Takegami

IPC: A01N1/02 ,  A61K38/28 ,  B01D69/14 ,  B01D71/68

Abstract: According to the present invention, there are provided a chamber for transplantation which has a high durability, and in which an enclosed biological constituent can be maintained for a long period of time because an interior space thereof is efficiently secured; and a method for manufacturing the chamber for transplantation. The chamber for transplantation includes one or more membranes for immunoisolation at a boundary between an inside and an outside of the chamber for transplantation, in which all of the membranes for immunoisolation include a porous membrane containing a polymer, and a joint portion at which the porous membranes are directly fusion welded to each other is provided. The method for manufacturing a chamber for transplantation includes preparing one or more porous membranes containing a polymer selected from polysulfone and polyethersulfone, bringing one part of the porous membrane into direct contact with another part of the porous membrane, and performing a heat fusion welding of the two parts that are in direct contact with each other at a temperature which is a glass transition temperature of the polymer or higher and lower than a melting point of the polymer.