公开(公告)号：US20180055990A1

公开(公告)日：2018-03-01

申请号：US15686178

申请日：2017-08-25

Applicant: FUJIFILM Corporation

Inventor： Toshihito KIMURA ,  Toshiaki KUNIYASU ,  Hirotaka WATANO ,  Akira WAKABAYASHI ,  Hiroshi MAKINO

IPC: A61M1/36 ,  A61M1/02

CPC classification number: A61M1/3687 ,  A61M1/0218 ,  A61M1/0259 ,  B01L3/0275 ,  B01L3/5021 ,  B01L3/5635 ,  B01L2200/026 ,  B01L2200/16 ,  B01L2300/0845

Abstract: A medicine-holding body is disposed in a flow path of a nozzle portion of an adapter for blood dispensing. The medicine-holding body is formed of a plurality of fibers which is made of polyester and is bundled by aligning a longitudinal direction thereof in a flowing direction which is a direction in which blood flows. The medicine-holding body holds an anticoagulant for suppressing coagulation of blood, as a medicine to be mixed into blood. The surface area of the medicine-holding body is greater than or equal to 10 mm2 and less than 600 mm2. In a case where the surface area of the medicine-holding body is greater than or equal to 10 mm2, the concentration of the anticoagulant becomes greater than or equal to a lower limit value of 10 U/mL even under most severe conditions such as a dispensing speed of 500 μL/second. In a case where the surface area of the medicine-holding body is less than 600 mm2, it is possible to maintain the occurrence rate of hemolysis to be less than or equal to 10%.

公开(公告)号：US20160100786A1

公开(公告)日：2016-04-14

申请号：US14972404

申请日：2015-12-17

Applicant: FUJIFILM Corporation

Inventor： Tomonori NISHIO ,  Toshihito KIMURA ,  Toshiaki KUNIYASU ,  Kazuteru NISHIJIMA

IPC: A61B5/15 ,  A61B5/153

CPC classification number: A61B5/150755 ,  A61B5/15003 ,  A61B5/150236 ,  A61B5/150389 ,  A61B5/150503 ,  A61B5/150732 ,  A61B5/153 ,  B01L3/0275 ,  B01L3/5635 ,  B01L2200/16 ,  B01L2400/086

Abstract: There is provided an adapter for blood sample dispensing which enables change of the presence and absence of a medicine to be mixed in a blood sample or the type of the medicine thereof while suppressing contact of blood with the air, during preparation of an examination sample, and a dispensing kit and a needle kit provided therewith. Dispensing is performed using an adapter 1 for blood sample dispensing which is mounted on a distal portion of a syringe and has a piping structure, in which the adapter has a fitting portion 3 fitted to the distal portion at one end, a nozzle portion 2 at the other end, and a flange portion 4 on an outer circumference surface, and in which the adapter 1 has a medicine 5, to be mixed in the blood sample S, on the inside of the nozzle portion 2.

Abstract translation: 提供了一种用于血液样品分配的适配器，其能够在制备检查样品期间改变在血液样品中混合的药物的存在和不存在或其药物的类型，同时抑制血液与空气的接触， 和一个分配工具包和一个提供的针套件。 使用用于血液样品分配的适配器1进行分配，该适配器1安装在注射器的远端部分上并具有配管结构，其中适配器具有在一端装配到远端部分的装配部分3， 另一端和在外周面上的凸缘部4，并且其中适配器1具有要在血液样本S中混合的药剂5，在喷嘴部2的内侧。

公开(公告)号：US20130164861A1

公开(公告)日：2013-06-27

申请号：US13692395

申请日：2012-12-03

Applicant: FUJIFILM CORPORATION

Inventor： Toshihito KIMURA

IPC: G01N21/64

CPC classification number: G01N21/6428 ,  G01N21/1717 ,  G01N21/6445 ,  G01N33/582

Abstract: A laser beam is emitted onto fluorescent molecules within a solution to orient the fluorescent molecules. The direction in which the laser beam is emitted is switched to switch the transition moment direction of the fluorescent particles to be parallel or perpendicular to the vibrating direction of linearly polarized excitation light. Thereby, the fluorescent molecules of free molecules and binding molecules can be switched between an excited and a non excited state. There is a difference in the speeds at which the orientation directions change for molecules which have undergone and molecules which have not undergone antigen antibody reactions. Therefore, the fluorescence contributed by fluorescent molecules associated with free molecules and the fluorescence contributed by fluorescent molecules associated with binding molecules can be calculated respectively, to measure the concentration of a detection target substance with high sensitivity.

Abstract translation: 将激光束发射到溶液中的荧光分子上以使荧光分子取向。 切换激光束的发射方向，使荧光体的过渡时刻方向与线偏振激光的振动方向平行或垂直。 因此，游离分子和结合分子的荧光分子可以在激发态和非激发态之间切换。 对于已经经历的分子和未经历抗原抗体反应的分子的取向方向变化的速度存在差异。 因此，可以分别计算与游离分子相关的荧光分子产生的荧光和与结合分子相关的荧光分子所贡献的荧光，以测定高灵敏度的检测对象物质的浓度。

公开(公告)号：US20180207633A1

公开(公告)日：2018-07-26

申请号：US15933690

申请日：2018-03-23

Applicant: FUJIFILM Corporation

Inventor： Toshiaki KUNIYASU ,  Toshihito KIMURA ,  Tomonori NISHIO ,  Kazuteru NISHIJIMA

IPC: B01L3/02 ,  G01N35/10

CPC classification number: B01L3/0275 ,  B01L3/02 ,  B01L3/0217 ,  B01L2200/025 ,  B01L2200/0615 ,  B01L2200/141 ,  B04B5/02 ,  B04B11/00 ,  G01N35/10 ,  G01N2035/103

Abstract: A pipette tip includes a body and projections. In the body, a flow passage in which liquid from the syringe flows and an ejection opening that ejects the liquid, which has flowed through the flow passage, to the outside are formed. The ejection opening is formed in a distal end portion. The projections are provided on the distal end portion and protrude from a region around the ejection opening in the ejection direction of liquid. The projections are partially disposed around the central axis of the body. Even in a case where a residual droplet adheres to the ejection opening, the residual droplet does not adhere to an injection opening of a sample container, because the projections guard a region around the residual droplet.

公开(公告)号：US20160223516A1

公开(公告)日：2016-08-04

申请号：US15006581

申请日：2016-01-26

Applicant: FUJIFILM Corporation

Inventor： Kazuteru NISHIJIMA ,  Tomonori NISHIO ,  Toshihito KIMURA ,  Toshiaki KUNIYASU

IPC: G01N33/49

CPC classification number: G01N33/491

Abstract: A centrifugal separation unit that performs centrifugal separation on a sample that has been injected into a container by rotating the container about a center axis of the container, as a rotation axis, a measurement unit that measures a sample component in the container that has been centrifugally separated by the centrifugal separation unit, and a correction unit that performs, on a result of the measurement, correction operation processing based on a change in concentration caused by evaporation of the sample during the centrifugal separation are provided.

Abstract translation: 离心分离单元，通过使容器围绕容器的中心轴线旋转作为旋转轴将已经注入到容器中的样品进行离心分离，测量单元，其测量已经离心的容器中的样品成分 由离心分离单元分离，并且提供校正单元，其在测量结果中执行基于在离心分离期间由样品蒸发引起的浓度变化的校正操作处理。

公开(公告)号：US20140017810A1

公开(公告)日：2014-01-16

申请号：US13934325

申请日：2013-07-03

Applicant: FUJIFILM Corporation

Inventor： Toshihito KIMURA

IPC: G01N33/543

CPC classification number: G01N33/54333 ,  B82Y20/00 ,  G01N21/1717 ,  G01N21/648 ,  G01N33/54373 ,  G01N33/587

Abstract: A bio-molecule detecting device that enables a high-sensitivity measurement is provided. The orientation direction of third complexes included in blood plasma is switched by switching the vibration direction of an orientation control light. The orientation direction of the third complexes is switched between two directions in which the intensities of an electric field, which is generated between two gold nanoparticles included in the third complexes by surface plasmon resonance, are significantly different. Therefore, the intensity of fluorescence generated from the third complexes is significantly changed by the change in the orientation direction of the third complexes.

Abstract translation: 提供能够进行高灵敏度测定的生物分子检测装置。 通过切换取向控制光的振动方向来切换包含在血浆中的第三配合物的取向方向。 第三络合物的取向方向在两个方向之间切换，其中通过表面等离激元共振在包含在第三络合物中的两个金纳米颗粒之间产生的电场的强度显着不同。 因此，通过第三配合物的取向方向的变化，从第三配合物产生的荧光的强度显着变化。

公开(公告)号：US20130217035A1

公开(公告)日：2013-08-22

申请号：US13854266

申请日：2013-04-01

Applicant: FUJIFILM Corporation

Inventor： Toshihito KIMURA

IPC: G01N21/64

CPC classification number: G01N21/6486 ,  G01N21/6428 ,  G01N21/6445 ,  G01N21/645

Abstract: A configuration was adopted, in which the orientations of free molecules and binding molecules within a solution are switched by switching the vibration direction of orientation controlling light, thereby switching the amount of light emitted by each free molecule and each binding molecule. There is a difference in the amounts of time required for the orientations of the free molecules and the binding molecules to switch accompanying the switch in the emission direction of the orientation controlling light. Therefore, the timings at which the amounts of light emitted by each type of molecule increase differ. Accordingly, the fluorescence contributed by fluorescent molecules associated with free molecules and the fluorescent molecules associated with binding molecules can be respectively calculated, even if all of the fluorescent molecules within the solution emit fluorescence. Thereby, the concentration of a detection target substance can be accurately measured with a simple structure.

Abstract translation: 采用其中通过切换取向控制光的振动方向来切换溶液中游离分子和结合分子的取向，从而切换由每个游离分子和每个结合分子发射的光量的配置。 在取向控制光的发射方向上，自由分子和结合分子的取向与伴随开关的切换所需的时间量存在差异。 因此，由各种分子发出的光量增加的时间不同。 因此，即使溶液中的全部荧光分子发出荧光，也可以分别计算与游离分子相关的荧光分子和与结合分子相关的荧光分子所产生的荧光。 由此，能够以简单的结构精确地测定检测对象物质的浓度。

公开(公告)号：US20150355175A1

公开(公告)日：2015-12-10

申请号：US14730378

申请日：2015-06-04

Applicant: FUJIFILM Corporation

Inventor： Nobuhiko FUJIWARA ,  Noriyuki KASAGI ,  Toshihito KIMURA ,  Kazuhiro NAKAMURA

IPC: G01N33/543

CPC classification number: G01N33/54386 ,  G01N21/553 ,  G01N21/64 ,  G01N21/648 ,  G01N21/82 ,  G01N33/54373 ,  G01N33/553 ,  G01N2021/825

Abstract: To provide a test substance measurement method and a test substance measurement kit adapted to improve the accuracy of the measurement of a test substance. A test substance measurement kit includes: fluorescent particles which are modified with a first binding substance having specific bindability to a test substance; non-fluorescent particles which are modified with a second binding substance having no specific bindability to the test substance; and a substrate on which a first metal film to which a third binding substance having specific bindability to the test substance is fixed, and a second metal film to which a fourth binding substance having no bindability to the test substance, but having bindability to the first binding substance is fixed, and which has a smaller thickness than the first metal film are formed.

Abstract translation: 提供测试物质测量方法和用于提高测试物质测量精度的测试物质测量套件。 测试物质测量试剂盒包括：用与测试物质具有特异性结合性的第一结合物修饰的荧光颗粒; 用对被检物质没有特异性结合性的第二结合物修饰的非荧光粒子; 和固定具有与测试物质具有特异性结合力的第三结合物质的第一金属膜的基材，以及第二金属膜，对测试物质不具有粘合性但与第一粘合物具有粘合性的第四结合物质 固定物质，并且形成比第一金属膜小的厚度。

公开(公告)号：US20150110674A1

公开(公告)日：2015-04-23

申请号：US14521970

申请日：2014-10-23

Applicant: FUJIFILM Corporation

Inventor： Toshihito KIMURA

IPC: G01N21/78 ,  G01N21/27 ,  G01N35/00 ,  G01N21/25

CPC classification number: G01N21/78 ,  G01N21/251 ,  G01N21/274 ,  G01N21/5907 ,  G01N35/00693 ,  G01N2201/062

Abstract: In a coloration analysis device that analyzes a coloration state in a coloration region of a dry analysis element in which a coloration region is formed which reacts with a test substance in a specimen solution and is colored, the effects of irradiation intensity unevenness of measuring light or light-receiving position sensitivity unevenness of a light-receiving optical system are eliminated, and it is possible to perform accurate analysis. A coloration region of the dry analysis element 12 and reference measurement plates 110 and 111 are irradiated with measuring light by a photometric head 96, reflected light from a measurement object is two-dimensionally detected as an image, and correction processing is performed for each pixel of an image of the coloration region, using corresponding pixel information of images of a black reference measurement plate 110 and a white reference measurement plate 111.

Abstract translation: 在着色分析装置中，分析其中形成有着色区域的干燥分析元件的着色区域中的着色状态，其与样品溶液中的测试物质反应并着色，测量光的照射强度不均匀性或 光接收光学系统的光接收位置灵敏度不均匀性被消除，并且可以进行精确的分析。 干法分析元件12和参考测量板110和111的着色区域通过测光头96被测量光照射，来自测量对象的反射光被二维地检测为图像，并且对每个像素执行校正处理 使用黑色参考测量板110和白色参考测量板111的图像的相应像素信息来显示着色区域的图像。

公开(公告)号：US20160221005A1

公开(公告)日：2016-08-04

申请号：US15008075

申请日：2016-01-27

Applicant: FUJIFILM Corporation

Inventor： Tomonori NISHIO ,  Kazuteru NISHIJIMA ,  Toshihito KIMURA ,  Toshiaki KUNIYASU

IPC: B04B7/08 ,  B05D7/22 ,  B05D1/00

CPC classification number: B04B7/08 ,  B04B5/0407 ,  B05D1/005 ,  B05D7/227

Abstract: In a container for centrifugal separation that includes a container main body including a retention part in which a sample is retained, and in which a component of the sample in the retention part is centrifugally separated by rotating the container main body about its center axis, as a rotation axis, material having thixotropic properties has been applied to an entire bottom surface of the retention part.

Abstract translation: 在用于离心分离的容器中，其包括容器主体，该容器主体包括保持部件，其中保持有样品，并且其中通过使容器主体围绕其中心轴线旋转将离心分离出的保持部件中的样品的部件作为 具有触变特性的旋转轴已经被施加到保持部的整个底面。