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    Fluorescent Fiberoptic Probe for Tissue Health Discrimination and Method of Use Thereof
    4.
    发明申请
    Fluorescent Fiberoptic Probe for Tissue Health Discrimination and Method of Use Thereof 失效
    用于组织健康歧视的荧光光纤探针及其使用方法

    公开(公告)号：US20120046554A1

    公开(公告)日：2012-02-23

    申请号：US13215096

    申请日：2011-08-22

    申请人： Alex R. Zelenchuk

    发明人： Alex R. Zelenchuk

    IPC分类号： A61B6/00

    CPC分类号： A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0088 ,  A61B5/4255 ,  A61B5/4331 ,  A61B5/7267

    摘要： A system and method for the in situ discrimination of healthy and diseased tissue. A fiberoptic based probe is employed to direct ultraviolet illumination onto a tissue specimen and to collect the fluorescent response radiation. The response radiation is observed at three selected wavelengths, one of which corresponds to an isosbestic point. In one example, the isosbestic point occurs at about 431 nm. The intensities of the observed signals are normalized using the 431 nm intensity. A score is determined using the ratios in a discriminant analysis. The tissue under examination is resected or not, based on the diagnosis of disease or health, according to the outcome of the discriminant analysis.

    摘要翻译： 用于原位鉴别健康和患病组织的系统和方法。 使用基于光纤的探针将紫外线照射引导到组织标本上并收集荧光反应辐射。 在三个选择的波长处观察到响应辐射，其中一个对应于等腰点。 在一个实例中，等腰点发生在约431nm处。 观察信号的强度使用431nm的强度进行归一化。 使用判别分析中的比例来确定得分。 根据判别分析的结果，根据疾病或健康的诊断，切除或不切除组织。

    Fluorescent fiberoptic probe for tissue health discrimination and method of use thereof
    6.
    发明授权
    Fluorescent fiberoptic probe for tissue health discrimination and method of use thereof 失效
    用于组织健康鉴别的荧光光纤探针及其使用方法

    公开(公告)号：US08311607B2

    公开(公告)日：2012-11-13

    申请号：US13215096

    申请日：2011-08-22

    申请人： Alex R. Zelenchuk

    发明人： Alex R. Zelenchuk

    IPC分类号： A61B5/00

    CPC分类号： A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0088 ,  A61B5/4255 ,  A61B5/4331 ,  A61B5/7267

    摘要： A system and method for the in situ discrimination of healthy and diseased tissue. A fiberoptic based probe is employed to direct ultraviolet illumination onto a tissue specimen and to collect the fluorescent response radiation. The response radiation is observed at three selected wavelengths, one of which corresponds to an isosbestic point. In one example, the isosbestic point occurs at about 431 nm. The intensities of the observed signals are normalized using the 431 nm intensity. A score is determined using the ratios in a discriminant analysis. The tissue under examination is resected or not, based on the diagnosis of disease or health, according to the outcome of the discriminant analysis.

    摘要翻译： 用于原位鉴别健康和患病组织的系统和方法。 使用基于光纤的探针将紫外线照射引导到组织标本上并收集荧光反应辐射。 在三个选择的波长处观察到响应辐射，其中一个对应于等腰点。 在一个实例中，等腰点发生在约431nm处。 观察信号的强度使用431nm的强度进行归一化。 使用判别分析中的比例来确定得分。 根据判别分析的结果，根据疾病或健康的诊断，切除或不切除组织。

    Fluorescent fiberoptic probe for tissue health discrimination
    7.
    发明授权
    Fluorescent fiberoptic probe for tissue health discrimination 失效
    荧光光纤探针用于组织健康辨别

    公开(公告)号：US07310547B2

    公开(公告)日：2007-12-18

    申请号：US10894356

    申请日：2004-07-19

    申请人： Alex R. Zelenchuk

    发明人： Alex R. Zelenchuk

    IPC分类号： A61B6/00

    CPC分类号： A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0088 ,  A61B5/4255 ,  A61B5/4331 ,  A61B5/7267

    摘要： A system and method for the in situ discrimination of healthy and diseased tissue. A fiberoptic based probe is employed to direct ultraviolet illumination onto a tissue specimen and to collect the fluorescent response radiation. The response radiation is observed at three selected wavelengths, one of which corresponds to an isosbestic point. In one example, the isosbestic point occurs at about 431 nm. The intensities of the observed signals are normalized using the 431 nm intensity. A score is determined using the ratios in a discriminant analysis. The tissue under examination is resected or not, based on the diagnosis of disease or health, according to the outcome of the discriminant analysis.

    摘要翻译： 用于原位鉴别健康和患病组织的系统和方法。 使用基于光纤的探针将紫外线照射引导到组织标本上并收集荧光反应辐射。 在三个选择的波长处观察到响应辐射，其中一个对应于等腰点。 在一个实例中，等腰点发生在约431nm处。 观察信号的强度使用431nm的强度进行归一化。 使用判别分析中的比例来确定得分。 根据判别分析的结果，根据疾病或健康的诊断，切除或不切除组织。

    Optical determination of in vivo properties
    8.
    发明授权
    Optical determination of in vivo properties 失效
    光学测定体内特性

    公开(公告)号：US07225005B2

    公开(公告)日：2007-05-29

    申请号：US11011714

    申请日：2004-12-14

    申请人： Howard B. Kaufman ,  Alex R. Zelenchuk

    发明人： Howard B. Kaufman ,  Alex R. Zelenchuk

    IPC分类号： A61B5/00

    CPC分类号： A61B5/14535 ,  A61B5/1455 ,  A61B5/489 ,  A61B5/681 ,  A61B5/6824 ,  A61B5/742

    摘要： A system and method for determining an in vivo property of a tissue or blood is described. The in vivo property may be a hematocrit value, a hemoglobin concentration, or a combination thereof. The system can automatically determine a location of a subcutaneous blood vessel. Based on the automatically determined location, the system illuminates the blood vessel with a light beam and detects light resulting from the illumination. The system determines the in vivo property based on the detected light. Alternatively, or in combination, the system displays an image corresponding to a spatial relationship between a subcutaneous blood vessel and a light beam. Based on the image, an operator can adjust the light beam with respect to the blood vessel to have a selected spatial relationship. The system determines an in vivo property based on the illumination of the blood vessel when the light beam has the selected spatial relationship.

    摘要翻译： 描述了用于确定组织或血液的体内特性的系统和方法。 体内性质可以是血细胞比容值，血红蛋白浓度或其组合。 系统可以自动确定皮下血管的位置。 基于自动确定的位置，系统用光束照射血管并检测照明产生的光。 该系统基于检测到的光来确定体内特性。 或者或组合地，系统显示对应于皮下血管和光束之间的空间关系的图像。 基于图像，操作者可以相对于血管调节光束以具有选定的空间关系。 当光束具有选择的空间关系时，该系统基于血管的照明确定体内特性。

    Fluorescent fiberoptic probe for tissue health discrimination and method of use thereof
    9.
    发明授权
    Fluorescent fiberoptic probe for tissue health discrimination and method of use thereof 有权

    公开(公告)号：US06768918B2

    公开(公告)日：2004-07-27

    申请号：US10192836

    申请日：2002-07-10

    申请人： Alex R. Zelenchuk

    发明人： Alex R. Zelenchuk

    IPC分类号： A61B600

    CPC分类号： A61B5/0071 ,  A61B5/0075 ,  A61B5/0084 ,  A61B5/0088 ,  A61B5/4255 ,  A61B5/4331 ,  A61B5/7267

    摘要： A system and method for the in situ discrimination of healthy and diseased tissue. A fiberoptic based probe is employed to direct ultraviolet illumination onto a tissue specimen and to collect the fluorescent response radiation. The response radiation is observed at three selected wavelengths, one of which corresponds to an isosbestic point. In one example, the isosbestic point occurs at about 431 nm. The intensities of the observed signals are normalized using the 431 nm intensity. A score is determined using the ratios in a discriminant analysis. The tissue under examination is resected or not, based on the diagnosis of disease or health, according to the outcome of the discriminant analysis.