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公开(公告)号：US20090170766A1
公开(公告)日：2009-07-02
申请号：US12224759
申请日：2007-03-01
申请人： Felix Oehme , Heiner Apeler , Frank Dittmer , Jürgen Franz , Axel Harrenga , Michael Sperzel , Simone Greven , Jürgen Lenz
发明人： Felix Oehme , Heiner Apeler , Frank Dittmer , Jürgen Franz , Axel Harrenga , Michael Sperzel , Simone Greven , Jürgen Lenz
CPC分类号： C07K14/8114
摘要： The present invention relates to chimeras of human tissue factor inhibitor domain 1 with natural and non-natural Kunitz domains, and their preparation and use.
摘要翻译： 本发明涉及具有天然和非天然Kunitz结构域的人组织因子抑制剂结构域1的嵌合体及其制备和用途。
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公开(公告)号：US20120321619A1
公开(公告)日：2012-12-20
申请号：US13514789
申请日：2010-12-08
申请人： Lars Linden , Yong-Jiang Cao , Gabriele Leder , Beatrix Stelte-ludwig , Axel Harrenga , Ricarda Finnern , Frank Dittmer , Anke Mayer-Bartschmid , Juergen Franz , Simone Greven , Jörg Willuda , Jan Tebbe
发明人： Lars Linden , Yong-Jiang Cao , Gabriele Leder , Beatrix Stelte-ludwig , Axel Harrenga , Ricarda Finnern , Frank Dittmer , Anke Mayer-Bartschmid , Juergen Franz , Simone Greven , Jörg Willuda , Jan Tebbe
IPC分类号： C07K16/30 , C12N15/85 , A61P35/04 , C12P21/08 , A61K39/395 , C12N1/21 , C12N15/13 , C12N5/10
CPC分类号： C07K16/30 , A61K39/39558 , A61K2039/505 , C07K16/28 , C07K2317/21 , C07K2317/33 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/77 , C07K2317/92
摘要： The present invention provides recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for the membrane-anchored, 29 kDa C4.4a polypeptide, which is over expressed in several tumors, e.g. lung, colorectal, pancreas, prostate, renal and breast cancer. These antibodies, accordingly, can be used to treat these and other disorders and conditions. Antibodies of the invention also can be used in the diagnostics field, as well as for further investigating the role of C4.4a in the progression of disorders associated with cancer. The invention also provides nucleic acid sequences encoding the foregoing antibodies, vectors containing the same, pharmaceutical compositions and kits with instructions for use.
摘要翻译： 本发明提供重组抗原结合区和抗体以及含有对多个肿瘤中过表达的膜锚定的29kDa C4,4a多肽具有特异性的此类抗原结合区的功能片段。 肺，结肠直肠，胰腺，前列腺，肾和乳腺癌。 因此，这些抗体可用于治疗这些和其他病症和病症。 本发明的抗体也可用于诊断领域，以及用于进一步研究C4.4a在与癌症相关疾病进展中的作用。 本发明还提供了编码前述抗体的核酸序列，含有该抗体的载体，药物组合物和具有使用说明书的试剂盒。
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公开(公告)号：US20140050743A1
公开(公告)日：2014-02-20
申请号：US13980431
申请日：2012-01-17
申请人： Frank Dittmer , Anja Buchmüller , Christoph Gerdes , Adrian Tersteegen , Mark Jean Gnoth , Lars Linden , Axel Harrenga , Joanna Grudzinska-Goebel , Mario Jeske , Martina Schäfer , Jörg Birkenfeld , Holger Paulsen , Ricarda Finnern , Anke Mayer-Bartschmid , Andrea Eicker , Simone Greven , Susanne Steinig
发明人： Frank Dittmer , Anja Buchmüller , Christoph Gerdes , Adrian Tersteegen , Mark Jean Gnoth , Lars Linden , Axel Harrenga , Joanna Grudzinska-Goebel , Mario Jeske , Martina Schäfer , Jörg Birkenfeld , Holger Paulsen , Ricarda Finnern , Anke Mayer-Bartschmid , Andrea Eicker , Simone Greven , Susanne Steinig
IPC分类号： C07K16/44
CPC分类号： C07K16/44 , A61K2039/505 , A61K2300/00 , C07K2317/55 , C07K2317/76
摘要： The present invention relates to the identification and use of antigen-binding regions, antibodies, antigen-binding antibody fragments and antibody mimetics, neutralizing the anti-coagulant effect of an anticoagulant in vitro and/or in vivo. Antibodies and functional fragments of the invention and antibody mimetics can be used to specifically reverse the pharmacological effect of an anticoagulant e.g. a FXa inhibitor for therapeutic (antidote) and/or diagnostic purposes. The invention also provides nucleic acid sequences encoding foregoing molecules, vectors containing the same, pharmaceutical compositions and kits with instructions for use.
摘要翻译： 本发明涉及抗原结合区，抗体，抗原结合抗体片段和抗体模拟物的鉴定和用途，其中和抗凝血剂在体外和/或体内的抗凝血作用。 本发明的抗体和功能片段和抗体模拟物可用于特异性地逆转抗凝血剂的药理学作用。 用于治疗（解毒剂）和/或诊断目的的FXa抑制剂。 本发明还提供了编码前述分子的核酸序列，含有该分子的载体，药物组合物和具有使用说明书的试剂盒。
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公开(公告)号：US20100105673A1
公开(公告)日：2010-04-29
申请号：US12518717
申请日：2007-12-08
申请人： Adrian Tersteegen , Dirk Heimbach , Kai Thede , Reinhold Welker , Beate Fast , Arnold Paessens , Frank Dittmer , Rudolf Schohe-Loop , Axel Harrenga , Alexander Hillisch , Kerstin Henninger , Walter Hübsch , Marcus Bauser , Susanne Greschat , Dirk Schneider , Tobias Marquardt , Andreas Göller , Andreas Urban , Steffen Wildum , Daniela Paulsen
发明人： Adrian Tersteegen , Dirk Heimbach , Kai Thede , Reinhold Welker , Beate Fast , Arnold Paessens , Frank Dittmer , Rudolf Schohe-Loop , Axel Harrenga , Alexander Hillisch , Kerstin Henninger , Walter Hübsch , Marcus Bauser , Susanne Greschat , Dirk Schneider , Tobias Marquardt , Andreas Göller , Andreas Urban , Steffen Wildum , Daniela Paulsen
IPC分类号： A61K31/365 , A61K31/5377 , A61K31/438 , C07D413/12 , C07D491/107 , C07D307/94 , A61P31/18 , A61P31/12
CPC分类号： C07D307/94 , C07D491/10
摘要： The present invention relates to novel substituted aminofurans, to methods for their preparation, to their use in the treatment and/or prophylaxis of diseases as well as their use in the manufacture of medical products for the treatment and/or prophylaxis of diseases, in particular retroviral disorders, in humans and/or animals.
摘要翻译： 本发明涉及新型取代的氨基呋喃，其制备方法，其用于治疗和/或预防疾病及其在制备用于治疗和/或预防疾病的医药产品中的用途，特别是 逆转录病毒疾病，在人和/或动物中。
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公开(公告)号：US08314089B2
公开(公告)日：2012-11-20
申请号：US12884113
申请日：2010-09-16
申请人： Rudolf Schohe-Loop , Reinhold Welker , Arnold Paessens , Marcus Bauser , Friederike Stoll , Frank Dittmer , Kerstin Henninger , Daniela Paulsen , Dieter Lang
发明人： Rudolf Schohe-Loop , Reinhold Welker , Arnold Paessens , Marcus Bauser , Friederike Stoll , Frank Dittmer , Kerstin Henninger , Daniela Paulsen , Dieter Lang
IPC分类号： A61K31/4155 , A61K31/5377 , A61K31/5386 , A61K31/553 , A61K31/496 , C07D413/06 , C07D417/06 , C07D403/06 , A61P31/12
CPC分类号： C07D231/14 , A61K31/4155 , C07D401/06 , C07D403/06 , C07D413/06 , C07D417/06 , C07D451/06 , C07D491/08 , C07D498/08
摘要： The present invention relates to novel substituted pyrazolamides, methods for their preparation, their use for the treatment and/or prophylaxis of diseases, as well as their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially of retroviral diseases, in humans and/or animals.
摘要翻译： 本发明涉及新型取代的吡唑啉酰胺，其制备方法，其用于治疗和/或预防疾病的用途，以及其用于制备用于治疗和/或预防疾病尤其是逆转录病毒疾病的药物的用途 ，在人类和/或动物中。
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公开(公告)号：US20160024222A1
公开(公告)日：2016-01-28
申请号：US14770222
申请日：2014-03-14
申请人： Ye JIN , John E. MURPHY , Terry HERMISTON , Frank DITTMER , Michael STRERATH , Uwe GRITZAN , Timothy MYLES
发明人： Ye Jin , John E. Murphy , Terry Hermiston , Timothy Myles , Frank Dittmer , Michael Strerath , Uwe Gritzan
IPC分类号： C07K16/36
CPC分类号： C07K16/36 , A61K38/4846 , A61K45/06 , C07K16/18 , C07K16/38 , C07K2317/21 , C07K2317/32 , C07K2317/33 , C07K2317/55 , C07K2317/565
摘要： This patent document relates to antibodies, antigen-binding antibody fragments (Fabs), and other protein scaffolds, directed against human antithrombin β complexed with heparin and/or heparin-like structure (ATβH). These ATβH binding proteins can block the anti-coagulant activity of ATβ to induce coagulation. Therapeutic uses of these antibodies and binders are described herein as are methods of panning and screening specific antibodies.
摘要翻译： 该专利文献涉及针对人抗凝血酶的抗体，抗原结合抗体片段（Fabs）和其它蛋白质支架; 与肝素和/或肝素样结构复合（AT＆amp; H）。 这些AT＆Bgr H结合蛋白可以阻断AT＆Bgr的抗凝血活性; 诱导凝血。 这些抗体和结合物的治疗用途在本文中描述为淘选和筛选特异性抗体的方法。
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公开(公告)号：US20110172207A1
公开(公告)日：2011-07-14
申请号：US12884113
申请日：2010-09-16
申请人： Rudolf SCHOHE-LOOP , Reinhold Welker , Arnold Paessens , Marcus Bauser , Friederike Stoll , Frank Dittmer , Kerstin Henninger , Daniela Paulsen , Dieter Lang
发明人： Rudolf SCHOHE-LOOP , Reinhold Welker , Arnold Paessens , Marcus Bauser , Friederike Stoll , Frank Dittmer , Kerstin Henninger , Daniela Paulsen , Dieter Lang
IPC分类号： A61K31/4155 , C07D413/06 , C07D403/06 , C07D417/06 , A61K31/5377 , A61K31/553 , A61K31/427 , A61K31/5386 , A61K31/541 , A61K31/496 , A61P31/12 , A61P31/18
CPC分类号： C07D231/14 , A61K31/4155 , C07D401/06 , C07D403/06 , C07D413/06 , C07D417/06 , C07D451/06 , C07D491/08 , C07D498/08
摘要： The present invention relates to novel substituted pyrazolamides, methods for their preparation, their use for the treatment and/or prophylaxis of diseases, as well as their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially of retroviral diseases, in humans and/or animals.
摘要翻译： 本发明涉及新型取代的吡唑啉酰胺，其制备方法，其用于治疗和/或预防疾病的用途，以及其用于制备用于治疗和/或预防疾病尤其是逆转录病毒疾病的药物的用途 ，在人类和/或动物中。
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