公开(公告)号：US10398625B2

公开(公告)日：2019-09-03

申请号：US13800682

申请日：2013-03-13

Applicant: Fenwal, Inc.

Inventor： Craig Sandford ,  Yoshikazu Mizobuchi ,  Daniel Lynn

IPC: A61M5/32 ,  A61J1/10 ,  A01N1/02 ,  A61J1/14

Abstract: Containers for the storage of red blood cell compositions are disclosed. The container walls are made of a plastic composition that includes a polymeric material and at least one extractable agent that includes a terephthalate ester in an amount effective to suppress hemolysis in red blood cells.

公开(公告)号：US20200093690A1

公开(公告)日：2020-03-26

申请号：US16556464

申请日：2019-08-30

Applicant: Fenwal, Inc.

Inventor： Craig Sandford ,  Yoshikazu Mizobuchi ,  Daniel Lynn

IPC: A61J1/10 ,  A01N1/02

Abstract: Containers for the storage of red blood cell compositions are disclosed. The container walls are made of a plastic composition that includes a polymeric material and at least one extractable agent that includes a terephthalate ester in an amount effective to suppress hemolysis in red blood cells.

公开(公告)号：US20160045932A1

公开(公告)日：2016-02-18

申请号：US14744299

申请日：2015-06-19

Applicant: Fenwal, Inc.

Inventor： Yoshikazu Mizobuchi

IPC: B05D1/00 ,  B01D71/68 ,  B01D67/00 ,  B01D69/06 ,  A61M1/34 ,  A61M1/38

CPC classification number: B05D1/60 ,  A61M1/0272 ,  A61M1/265 ,  A61M1/3496 ,  A61M1/3672 ,  A61M1/3673 ,  A61M2205/02 ,  B01D63/16 ,  B01D67/0023 ,  B01D69/02 ,  B01D69/06 ,  B01D71/68 ,  B01D2315/02 ,  B01D2323/34 ,  B05D2254/04 ,  B05D2518/00

Abstract: A system is provided for separating a bodily fluid, such as blood, into two or more constituent parts. The system is configured to cooperate with a fluid flow circuit including a spinning membrane-type fluid separation chamber having a housing, with a fluid inlet port and at least one fluid outlet port. A rotor is positioned within the housing so as to define a gap between the rotor and an inside surface of the housing, with the rotor being rotatable relative to the housing about an axis. A membrane is mounted on the rotor and/or on the inside surface of the housing and faces the gap to separate bodily fluid within the housing into two or more constituent parts. The membrane includes an anti-thrombogenic material, which may be either incorporated into the material of the membrane or coated onto at least a portion of the membrane.

Abstract translation: 提供了用于将诸如血液之类的体液分离成两个或更多个组成部分的系统。 该系统被配置为与包括具有壳体的旋转膜型流体分离室的流体流动回路配合，具有流体入口和至少一个流体出口。 转子定位在壳体内以便在转子和壳体的内表面之间限定间隙，其中转子可绕轴线相对于壳体旋转。 膜安装在转子上和/或壳体的内表面上并且面向间隙以将壳体内的体液分离成两个或更多个组成部分。 膜包括抗血栓形成材料，其可以掺入到膜的材料中或涂覆在膜的至少一部分上。

公开(公告)号：US10052428B2

公开(公告)日：2018-08-21

申请号：US13838992

申请日：2013-03-15

Applicant: Fenwal, Inc.

Inventor： Yoshikazu Mizobuchi ,  Bruce Perry

IPC: A61M1/36

CPC classification number: A61M1/3618 ,  A61M1/3679 ,  A61M2202/0439

Abstract: Methods and systems for removing leukocytes from a biological fluid are disclosed. The methods and systems include a device that has a magnetic substrate coated with one or more polymeric materials that have an adhesion or adsorption affinity for leukocytes.

公开(公告)号：US09879223B2

公开(公告)日：2018-01-30

申请号：US14446418

申请日：2014-07-30

Applicant: FENWAL, INC.

Inventor： Yoshikazu Mizobuchi ,  JoAnne B. Alfaro

IPC: C12N5/00 ,  C12N5/07 ,  C12N5/0787

CPC classification number: C12N5/0642 ,  C12N5/0087

Abstract: Methods and systems for removing leukocytes from a biological fluid are disclosed. The methods and systems include a chamber containing particles to which the leukocytes adhere. Such particles may carry an electrostatic charge. In one example, the particles comprise a polymer having an acid number of 5 or greater.

公开(公告)号：US20160236152A1

公开(公告)日：2016-08-18

申请号：US15137894

申请日：2016-04-25

Applicant: Fenwal, Inc.

Inventor： Yoshikazu Mizobuchi ,  Jo Anne Alfaro

IPC: B01D67/00 ,  A61M1/34 ,  B01D71/38 ,  B01D29/00 ,  B01D71/26

CPC classification number: B01D67/0088 ,  A61M1/0218 ,  A61M1/3496 ,  A61M1/3633 ,  A61M2202/0439 ,  A61M2207/00 ,  B01D29/0018 ,  B01D69/02 ,  B01D71/26 ,  B01D71/38 ,  B01D71/76 ,  B01D2239/0471 ,  B01D2239/0478 ,  B01D2239/0622 ,  B01D2323/08 ,  B01D2323/12 ,  B01D2323/22 ,  B01D2325/02

Abstract: Filter media, filter devices and methods of making filter media are disclosed. The filter media includes a coating on at least a portion of said outer surface. The coating may be polymeric composition having a molecular chain that includes segments of non-polar groups and segments of at least one of polar groups or segments of ionic groups.

Abstract translation: 公开了过滤介质，过滤装置和制造过滤介质的方法。 过滤介质包括在所述外表面的至少一部分上的涂层。 该涂层可以是具有分子链的聚合物组合物，该分子链包括非极性基团的段和至少一个极性基团或离子基团的区段。

公开(公告)号：US20160032246A1

公开(公告)日：2016-02-04

申请号：US14446418

申请日：2014-07-30

Applicant: FENWAL, INC.

Inventor： Yoshikazu Mizobuchi ,  JoAnne B. Alfaro

IPC: C12N5/078

CPC classification number: C12N5/0642 ,  C12N5/0087

Abstract: Methods and systems for removing leukocytes from a biological fluid are disclosed. The methods and systems include a chamber containing particles to which the leukocytes adhere. Such particles may carry an electrostatic charge. In one example, the particles comprise a polymer having an acid number of 5 or greater.

Abstract translation: 公开了从生物流体中除去白细胞的方法和系统。 所述方法和系统包括含有白细胞粘附的颗粒的室。 这样的颗粒可能带有静电电荷。 在一个实例中，颗粒包含酸值为5或更大的聚合物。

公开(公告)号：US11957639B2

公开(公告)日：2024-04-16

申请号：US16556464

申请日：2019-08-30

Applicant: Fenwal, Inc.

Inventor： Craig Sandford ,  Yoshikazu Mizobuchi ,  Daniel Lynn

IPC: A61J1/10 ,  A01N1/02 ,  A61J1/14

CPC classification number: A61J1/10 ,  A01N1/0263 ,  A61J1/1468

Abstract: Containers for the storage of red blood cell compositions are disclosed. The container walls are made of a plastic composition that includes a polymeric material and at least one extractable agent that includes a terephthalate ester in an amount effective to suppress hemolysis in red blood cells.

公开(公告)号：US10940442B2

公开(公告)日：2021-03-09

申请号：US15137894

申请日：2016-04-25

Applicant: Fenwal, Inc.

Inventor： Yoshikazu Mizobuchi ,  Jo Anne Alfaro

IPC: A61M1/34 ,  A61M1/36 ,  B01D29/00 ,  B01D67/00 ,  B01D69/02 ,  B01D71/26 ,  B01D71/38 ,  B01D71/76 ,  A61M1/02

Abstract: Filter media, filter devices and methods of making filter media are disclosed. The filter media includes a coating on at least a portion of said outer surface. The coating may be polymeric composition having a molecular chain that includes segments of non-polar groups and segments of at least one of polar groups or segments of ionic groups.

公开(公告)号：US10940248B2

公开(公告)日：2021-03-09

申请号：US15829789

申请日：2017-12-01

Applicant: Fenwal, Inc.

Inventor： Jo Anne B. Alfaro ,  Yoshikazu Mizobuchi

IPC: A61K31/7004 ,  A61M1/02 ,  A61M1/34 ,  A61M1/36 ,  B01D21/26 ,  B01D63/16

Abstract: A method of recovering white blood cells from a leukoreduction filter, the method comprising providing a solution comprising a sugar, flowing a volume of the solution through a leukoreduction filter containing captured white blood cells, and collecting elute from the leukoreduction filter, wherein the elute comprises the solution and recovered white blood cells.