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公开(公告)号：US20160091479A1
公开(公告)日：2016-03-31
申请号：US14809972
申请日：2015-07-27
Applicant: Fluidigm Corporation
Inventor： Hany Nassef , Geoffrey Facer , Marc Unger
IPC: G01N33/487 , G01N15/12 , G01N15/10
CPC classification number: C03C25/68 , B01L3/502707 , B01L2300/0645 , B01L2300/0816 , B01L2300/123 , B01L2400/0481 , B01L2400/0655 , G01N15/1031 , G01N15/12 , G01N27/00 , G01N27/60 , G01N33/48707 , G01N33/48721 , G01N2015/1087 , Y10T436/2575
Abstract: The presence of a detectable entity within a detection volume of a microfabricated elastomeric structure is sensed through a change in the electrical or magnetic environment of the detection volume. In embodiments utilizing electronic detection, an electric field is applied to the detection volume and a change in impedance, current, or combined impedance and current due to the presence of the detectable entity is measured. In embodiments utilizing magnetic detection, the magnetic properties of a magnetized detected entity alter the magnetic field of the detection volume. This changed magnetic field induces a current which can reveal the detectable entity. The change in resistance of a magnetoresistive element may also reveal the passage of a magnetized detectable entity.
Abstract translation: 通过检测体积的电气或磁环境的变化来检测在微制造弹性体结构的检测体积内的可检测实体的存在。 在利用电子检测的实施例中，对检测体积施加电场，并且测量由于可检测实体的存在引起的阻抗，电流或组合阻抗和电流的变化。 在利用磁检测的实施例中，磁化检测实体的磁性改变了检测体积的磁场。 这种改变的磁场诱发可以揭示可检测实体的电流。 磁阻元件的电阻变化也可以揭示磁化的可检测实体的通过。
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公开(公告)号：US09103761B2
公开(公告)日：2015-08-11
申请号：US13867555
申请日：2013-04-22
Applicant: Fluidigm Corporation
Inventor： Hany Nassef , Geoffrey Facer , Marc Unger
CPC classification number: C03C25/68 , B01L3/502707 , B01L2300/0645 , B01L2300/0816 , B01L2300/123 , B01L2400/0481 , B01L2400/0655 , G01N15/1031 , G01N15/12 , G01N27/00 , G01N27/60 , G01N33/48707 , G01N33/48721 , G01N2015/1087 , Y10T436/2575
Abstract: The presence of a detectable entity within a detection volume of a microfabricated elastomeric structure is sensed through a change in the electrical or magnetic environment of the detection volume. In embodiments utilizing electronic detection, an electric field is applied to the detection volume and a change in impedance, current, or combined impedance and current due to the presence of the detectable entity is measured. In embodiments utilizing magnetic detection, the magnetic properties of a magnetized detected entity alter the magnetic field of the detection volume. This changed magnetic field induces a current which can reveal the detectable entity. The change in resistance of a magnetoresistive element may also reveal the passage of a magnetized detectable entity.
Abstract translation: 通过检测体积的电气或磁环境的变化来检测在微制造弹性体结构的检测体积内的可检测实体的存在。 在利用电子检测的实施例中，对检测体积施加电场，并且测量由于可检测实体的存在引起的阻抗，电流或组合阻抗和电流的变化。 在利用磁检测的实施例中，磁化检测实体的磁性改变了检测体积的磁场。 这种改变的磁场诱发可以揭示可检测实体的电流。 磁阻元件的电阻变化也可以揭示磁化的可检测实体的通过。
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Patent Agency Ranking
公开(公告)号：US20140193896A1
公开(公告)日：2014-07-10
申请号：US14071598
申请日：2013-11-04
Applicant: Fluidigm Corporation
Inventor： David S. Cohen , Jing Wang , Andrew May , Robert C. Jones , Hany Nassef
IPC: B01L3/00
CPC classification number: B01L3/502738 , B01L3/5025 , B01L7/52 , B01L2200/0684 , B01L2300/0816 , B01L2300/0864 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/123 , B01L2400/0487 , B01L2400/0605 , B01L2400/0638 , B01L2400/0655 , B33Y80/00 , F16K99/0001 , F16K99/0026 , F16K99/0059 , F16K2099/0074 , F16K2099/0078 , F16K2099/008 , F16K2099/0084 , Y10T137/0318 , Y10T137/85938
Abstract: New high density microfluidic devices and methods provide precise metering of fluid volumes and efficient mixing of the metered volumes. A first solution is introduced into a segment of a flow channel in fluidic communication with a reaction chamber. A second solution is flowed through the segment so that the first solution is displaced into the reaction chamber, and a volume of the second solution enters the chamber. The chamber can then be isolated and reactions within the chamber can be initiated and/or detected. High throughput methods of genetic analysis can be carried out with greater accuracy than previously available.
Abstract translation: 新的高密度微流体装置和方法提供流体体积的精确计量和计量体积的有效混合。 将第一溶液引入与反应室流体连通的流动通道的段中。 第二溶液流过该段，使得第一溶液移入反应室，并且第二溶液的体积进入该室。 然后可以分离室，并且可以启动和/或检测室内的反应。 遗传分析的高通量方法可以比以前更高的精度进行。
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公开(公告)号：US20130302785A1
公开(公告)日：2013-11-14
申请号：US13867555
申请日：2013-04-22
Applicant: Fluidigm Corporation
Inventor： Hany Nassef , Geoffrey Facer , Marc Unger
IPC: G01N27/00
CPC classification number: C03C25/68 , B01L3/502707 , B01L2300/0645 , B01L2300/0816 , B01L2300/123 , B01L2400/0481 , B01L2400/0655 , G01N15/1031 , G01N15/12 , G01N27/00 , G01N27/60 , G01N33/48707 , G01N33/48721 , G01N2015/1087 , Y10T436/2575
Abstract: The presence of a detectable entity within a detection volume of a microfabricated elastomeric structure is sensed through a change in the electrical or magnetic environment of the detection volume. In embodiments utilizing electronic detection, an electric field is applied to the detection volume and a change in impedance, current, or combined impedance and current due to the presence of the detectable entity is measured. In embodiments utilizing magnetic detection, the magnetic properties of a magnetized detected entity alter the magnetic field of the detection volume. This changed magnetic field induces a current which can reveal the detectable entity. The change in resistance of a magnetoresistive element may also reveal the passage of a magnetized detectable entity.
Abstract translation: 通过检测体积的电气或磁环境的变化来检测在微制造弹性体结构的检测体积内的可检测实体的存在。 在利用电子检测的实施例中，对检测体积施加电场，并且测量由于可检测实体的存在引起的阻抗，电流或组合阻抗和电流的变化。 在利用磁检测的实施例中，磁化检测实体的磁性改变了检测体积的磁场。 这种改变的磁场诱发可以揭示可检测实体的电流。 磁阻元件的电阻变化也可以揭示磁化的可检测实体的通过。
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公开(公告)号：US09381512B2
公开(公告)日：2016-07-05
申请号：US14071598
申请日：2013-11-04
Applicant: Fluidigm Corporation
Inventor： David S. Cohen , Jing Wang , Andrew May , Robert C. Jones , Hany Nassef
CPC classification number: B01L3/502738 , B01L3/5025 , B01L7/52 , B01L2200/0684 , B01L2300/0816 , B01L2300/0864 , B01L2300/087 , B01L2300/0874 , B01L2300/0887 , B01L2300/123 , B01L2400/0487 , B01L2400/0605 , B01L2400/0638 , B01L2400/0655 , B33Y80/00 , F16K99/0001 , F16K99/0026 , F16K99/0059 , F16K2099/0074 , F16K2099/0078 , F16K2099/008 , F16K2099/0084 , Y10T137/0318 , Y10T137/85938
Abstract: New high density microfluidic devices and methods provide precise metering of fluid volumes and efficient mixing of the metered volumes. A first solution is introduced into a segment of a flow channel in fluidic communication with a reaction chamber. A second solution is flowed through the segment so that the first solution is displaced into the reaction chamber, and a volume of the second solution enters the chamber. The chamber can then be isolated and reactions within the chamber can be initiated and/or detected. High throughput methods of genetic analysis can be carried out with greater accuracy than previously available.
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公开(公告)号：US08845914B2
公开(公告)日：2014-09-30
申请号：US13894296
申请日：2013-05-14
Applicant: Fluidigm Corporation
Inventor： Hany Nassef , Geoffrey Richard Facer , Marc Unger
CPC classification number: C03C25/68 , B01L3/502707 , B01L2300/0645 , B01L2300/0816 , B01L2300/123 , B01L2400/0481 , B01L2400/0655 , G01N15/1031 , G01N15/12 , G01N27/00 , G01N27/60 , G01N33/48707 , G01N33/48721 , G01N2015/1087 , Y10T436/2575
Abstract: The presence of a detectable entity within a detection volume of a microfabricated elastomeric structure is sensed through a change in the electrical or magnetic environment of the detection volume. In embodiments utilizing electronic detection, an electric field is applied to the detection volume and a change in impedance, current, or combined impedance and current due to the presence of the detectable entity is measured. In embodiments utilizing magnetic detection, the magnetic properties of a magnetized detected entity alter the magnetic field of the detection volume. This changed magnetic field induces a current which can reveal the detectable entity. The change in resistance of a magnetoresistive element may also reveal the passage of a magnetized detectable entity.
Abstract translation: 通过检测体积的电气或磁环境的变化来检测在微制造弹性体结构的检测体积内的可检测实体的存在。 在利用电子检测的实施例中，对检测体积施加电场，并且测量由于可检测实体的存在引起的阻抗，电流或组合阻抗和电流的变化。 在利用磁检测的实施例中，磁化检测实体的磁性改变了检测体积的磁场。 这种改变的磁场诱发可以揭示可检测实体的电流。 磁阻元件的电阻变化也可以揭示磁化的可检测实体的通过。
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公开(公告)号：US20130252234A1
公开(公告)日：2013-09-26
申请号：US13894296
申请日：2013-05-14
Applicant: Fluidigm Corporation
Inventor： Hany Nassef , Greoffrey Facer , Marc Unger
IPC: G01N27/60
CPC classification number: C03C25/68 , B01L3/502707 , B01L2300/0645 , B01L2300/0816 , B01L2300/123 , B01L2400/0481 , B01L2400/0655 , G01N15/1031 , G01N15/12 , G01N27/00 , G01N27/60 , G01N33/48707 , G01N33/48721 , G01N2015/1087 , Y10T436/2575
Abstract: The presence of a detectable entity within a detection volume of a microfabricated elastomeric structure is sensed through a change in the electrical or magnetic environment of the detection volume. In embodiments utilizing electronic detection, an electric field is applied to the detection volume and a change in impedance, current, or combined impedance and current due to the presence of the detectable entity is measured. In embodiments utilizing magnetic detection, the magnetic properties of a magnetized detected entity alter the magnetic field of the detection volume. This changed magnetic field induces a current which can reveal the detectable entity. The change in resistance of a magnetoresistive element may also reveal the passage of a magnetized detectable entity.
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