公开(公告)号：US20160145691A1

公开(公告)日：2016-05-26

申请号：US14753397

申请日：2015-06-29

申请人： FOUNDATION MEDICINE, INC.

发明人： Maureen T. Cronin ,  Garrett Michael Frampton ,  Doron Lipson ,  Vincent A. Miller ,  Gary Palmer ,  Jeffrey S. Ross ,  Philip James Stephens ,  Roman Yelensky

IPC分类号： C12Q1/68 ,  A61K45/06 ,  C07K16/28 ,  C07K14/72 ,  A61K31/5415 ,  A61K31/437 ,  A61K31/423 ,  A61K31/428 ,  A61K31/472 ,  A61K31/536 ,  A61K31/416 ,  A61K31/4439

CPC分类号： C12Q1/6886 ,  A61K31/416 ,  A61K31/4196 ,  A61K31/423 ,  A61K31/428 ,  A61K31/436 ,  A61K31/437 ,  A61K31/439 ,  A61K31/4439 ,  A61K31/472 ,  A61K31/536 ,  A61K31/5415 ,  A61K31/565 ,  A61K31/567 ,  A61K31/675 ,  A61K45/06 ,  C07K14/72 ,  C07K16/2869 ,  C07K2317/34 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/156

摘要： Novel mutant ESR1 molecules and uses are disclosed.

摘要翻译： 公开了新型突变体ESR1分子和用途。

公开(公告)号：US10980804B2

公开(公告)日：2021-04-20

申请号：US14761518

申请日：2014-01-17

申请人： FOUNDATION MEDICINE, INC.

发明人： Siraj Mahamed Ali ,  Matthew J. Hawryluk ,  Jie He ,  Doron Lipson ,  Vincent A. Miller ,  Jeffrey S. Ross ,  Philip James Stephens

IPC分类号： A61K31/517 ,  A61K31/498 ,  A61K31/19 ,  A61K31/5025 ,  C12N9/12 ,  A61K31/4412 ,  A61K45/06 ,  A61K31/47 ,  A61K31/435 ,  A61K31/506 ,  A61K31/519 ,  A61K31/4439 ,  A61K31/53 ,  A61K31/404 ,  A61K31/5383 ,  A61K31/496 ,  C12Q1/6886 ,  A61K31/553 ,  C07K14/705 ,  C07K14/71 ,  C07K16/40 ,  C12N15/113 ,  C12Q1/6883 ,  G01N33/573

摘要： Methods and compositions for treating cholangiocarcinoma.

公开(公告)号：US20200211679A1

公开(公告)日：2020-07-02

申请号：US16579496

申请日：2019-09-23

申请人： FOUNDATION MEDICINE, INC.

发明人： Michael Pellini ,  Gary Palmer ,  Mary Patricia Lancelotta ,  Matthew J. Hawryluk ,  Vincent A. Miller

IPC分类号： G16H10/20 ,  G16B30/00 ,  G16H10/60 ,  G16H15/00

摘要： A system for tracking and analyzing cancer treatment and outcome information includes a user interface (UI) component for allowing selection of an alteration, an affected gene, an affected pathway, a tumor type, and/or a treatment; a processor configured to receive treatment information and outcome information associated with a patient population; organize the treatment information and the outcome information into at least one tuple; and generate outcome summary information; and an analysis component configured to compare a current patient record for a current patient to existing treatment information for the patient population, identify similar patients in the patient population based on information in the current patient record, and filter a grouping of similar patients; the processor is further configured to display, on the UI component, the outcome summary information; enable navigation within the treatment and outcome information; and identify, based on the outcome information, an appropriate treatment for the current patient.

公开(公告)号：US20170016073A1

公开(公告)日：2017-01-19

申请号：US15018640

申请日：2016-02-08

申请人： FOUNDATION MEDICINE, INC.

发明人： Maureen T. Cronin ,  Garrett Michael Frampton ,  Doron Lipson ,  Vincent A. Miller ,  Gary Palmer ,  Jeffrey S. Ross ,  Philip James Stephens ,  Roman Yelensky

IPC分类号： C12Q1/68 ,  A61K31/436 ,  A61K31/4196 ,  A61K31/567 ,  A61K45/06

CPC分类号： C12Q1/6886 ,  A61K31/416 ,  A61K31/4196 ,  A61K31/423 ,  A61K31/428 ,  A61K31/436 ,  A61K31/437 ,  A61K31/439 ,  A61K31/4439 ,  A61K31/472 ,  A61K31/536 ,  A61K31/5415 ,  A61K31/565 ,  A61K31/567 ,  A61K31/675 ,  A61K45/06 ,  C07K14/72 ,  C07K16/2869 ,  C07K2317/34 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/156

摘要： Novel mutant ESR1 molecules and uses are disclosed.

摘要翻译： 公开了新型突变体ESR1分子和用途。

公开(公告)号：US11725247B2

公开(公告)日：2023-08-15

申请号：US16080421

申请日：2017-02-27

申请人： FOUNDATION MEDICINE, INC. ,  VANDERBILT UNIVERSITY

发明人： Garrett Michael Frampton ,  Roman Yelensky ,  James Xin Sun ,  Douglas Buckner Johnson ,  Christine Marie Lovly ,  Jeffrey Alan Sosman ,  David Fabrizio ,  Philip James Stephens ,  Vincent A. Miller

IPC分类号： C12Q1/6886 ,  C07K16/28 ,  G16H50/30 ,  G16H50/20 ,  A61P35/00 ,  G16B20/00 ,  G06F17/15 ,  A61K39/00

CPC分类号： C12Q1/6886 ,  A61P35/00 ,  C07K16/2818 ,  G06F17/15 ,  G16B20/00 ,  G16H50/20 ,  G16H50/30 ,  A61K2039/505 ,  C12Q2600/106 ,  C12Q2600/156

摘要： Methods and compositions for treating cancer such as melanomas are disclosed.

公开(公告)号：US11286532B2

公开(公告)日：2022-03-29

申请号：US15877035

申请日：2018-01-22

申请人： FOUNDATION MEDICINE, INC.

发明人： Maureen T. Cronin ,  Garrett Michael Frampton ,  Doron Lipson ,  Vincent A. Miller ,  Gary Palmer ,  Jeffrey S. Ross ,  Philip James Stephens ,  Roman Yelensky

IPC分类号： C12Q1/6886 ,  A61K31/565 ,  A61K31/4196 ,  A61K31/675 ,  A61K31/439 ,  A61K31/567 ,  A61K31/416 ,  A61K31/423 ,  A61K31/428 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/472 ,  A61K31/536 ,  A61K31/5415 ,  A61K45/06 ,  C07K14/72 ,  C07K16/28 ,  A61K31/436

摘要： Novel mutant ESR1 molecules and uses are disclosed.

公开(公告)号：US20200299775A1

公开(公告)日：2020-09-24

申请号：US16683575

申请日：2019-11-14

申请人： FOUNDATION MEDICINE, INC.

发明人： Matthew J. Hawryluk ,  Doron Lipson ,  Vincent A. Miller ,  Philip James Stephens

IPC分类号： C12Q1/6886 ,  C12N15/113 ,  C12N9/12 ,  C07K14/47 ,  A61K31/519 ,  A61K31/553 ,  A61K45/06

摘要： Novel NTRK1 fusion molecules, detection reagents, and uses and kits for evaluating, identifying, assessing and/or treating a subject having a cancer are disclosed.

公开(公告)号：US20150073036A1

公开(公告)日：2015-03-12

申请号：US14473508

申请日：2014-08-29

申请人： FOUNDATION MEDICINE, INC.

发明人： Matthew J. Hawryluk ,  Doron Lipson ,  Vincent A. Miller ,  Philip James Stephens

IPC分类号： C12Q1/68 ,  A61K45/06 ,  C12N15/113 ,  A61K31/553 ,  A61K31/519

CPC分类号： C12Q1/6886 ,  A61K31/519 ,  A61K31/553 ,  A61K45/06 ,  C07K14/47 ,  C12N9/12 ,  C12N15/1138 ,  C12N2310/14 ,  C12Q2600/106 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158

摘要： Novel NTRK1 fusion molecules, detection reagents, and uses and kits for evaluating, identifying, assessing and/or treating a subject having a cancer are disclosed.

摘要翻译： 公开了用于评估，鉴定，评估和/或治疗患有癌症的受试者的新型NTRK1融合分子，检测试剂和用途和试剂盒。

公开(公告)号：US12087453B2

公开(公告)日：2024-09-10

申请号：US17885412

申请日：2022-08-10

申请人： Foundation Medicine, Inc.

发明人： Michael Pellini ,  Gary Palmer ,  Mary Patricia Lancelotta ,  Matthew J. Hawryluk ,  Vincent A. Miller

IPC分类号： G16H70/60 ,  G16B30/00 ,  G16H10/20 ,  G16H10/60 ,  G16H15/00 ,  G16H20/10 ,  G16H50/20

CPC分类号： G16H70/60 ,  G16B30/00 ,  G16H10/20 ,  G16H10/60 ,  G16H15/00 ,  G16H20/10 ,  G16H50/20

摘要： Provided are systems and methods for capturing outcome information associated with various cancer treatments. The system facilitates capture and analysis of cancer treatment information and associated outcome information. The treatment and outcome information can include genomic analysis and information on treatment of different cancers. The system can store and analyze any one or more of: tumor type, genomic alterations (e.g., genes and associated alterations, gene sequence mutations, alterations, amplifications, deletions, etc.), and treatment data (including, for example, treatments targeted to specific genes and/or genomic alterations). Users of the outcome system can supply and use the treatment and outcome information to facilitate diagnosis and therapy decisions. User interfaces within the system can be configured to allow users to easily locate outcome information associated with particular treatments of tumors having certain genomic alterations.

公开(公告)号：US11578372B2

公开(公告)日：2023-02-14

申请号：US16683575

申请日：2019-11-14

申请人： FOUNDATION MEDICINE, INC.

发明人： Matthew J. Hawryluk ,  Doron Lipson ,  Vincent A. Miller ,  Philip James Stephens

IPC分类号： C12Q1/6886 ,  C12N15/113 ,  C12N9/12 ,  C07K14/47 ,  A61K31/519 ,  A61K31/553 ,  A61K45/06

摘要： Novel NTRK1 fusion molecules, detection reagents, and uses and kits for evaluating, identifying, assessing and/or treating a subject having a cancer are disclosed.