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公开(公告)号:US07311893B2
公开(公告)日:2007-12-25
申请号:US10728028
申请日:2003-12-03
IPC分类号: A61K51/00
CPC分类号: A61K51/088 , A61K51/0497
摘要: Amyloid-targeting imaging agents such as radiolabeled amyloid targeting molecules and amyloid targeting molecule-chelator conjugates for imaging, e.g., amyloid plaques in vivo, and/or for the treatment of amyloidosis disorders. The invention provides amyloid-targeting imaging agents that are useful for imaging sites of amyloid disease. Imaging agents of the invention are capable of binding specifically to amyloid plaques, as an aid in diagnosis and/or early treatment of amyloidosis disorders.
摘要翻译: 淀粉样蛋白靶向成像剂,例如放射性标记的淀粉样蛋白靶向分子和用于成像的淀粉样蛋白靶向分子 - 螯合剂缀合物,例如体内淀粉样蛋白斑块和/或用于治疗淀粉样变性病症。 本发明提供了可用于淀粉样蛋白病成像部位的淀粉样蛋白靶向成像剂。 本发明的成像剂能够特异性结合淀粉样蛋白斑,有助于淀粉样变性病症的诊断和/或早期治疗。
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公开(公告)号:US20050048000A1
公开(公告)日:2005-03-03
申请号:US10728028
申请日:2003-12-03
CPC分类号: A61K51/088 , A61K51/0497
摘要: Amyloid-targeting imaging agents such as radiolabeled amyloid targeting molecules and amyloid targeting molecule-chelator conjugates for imaging, e.g., amyloid plaques in vivo, and/or for the treatment of amyloidosis disorders. The invention provides amyloid-targeting imaging agents that are useful for imaging sites of amyloid disease. Imaging agents of the invention are capable of binding specifically to amyloid plaques, as an aid in diagnosis and/or early treatment of amyloidosis disorders.
摘要翻译: 淀粉样蛋白靶向成像剂,例如放射性标记的淀粉样蛋白靶向分子和用于成像的淀粉样蛋白靶向分子 - 螯合剂缀合物,例如体内淀粉样蛋白斑块和/或用于治疗淀粉样变性病症。 本发明提供了可用于淀粉样蛋白病成像部位的淀粉样蛋白靶向成像剂。 本发明的成像剂能够特异性结合淀粉样蛋白斑,有助于淀粉样变性病症的诊断和/或早期治疗。
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公开(公告)号:US20100113591A1
公开(公告)日:2010-05-06
申请号:US12613412
申请日:2009-11-05
申请人: Xianqi Kong , David Migneault , Isabelle Valade , Xinfu Wu , Francine Gervais
发明人: Xianqi Kong , David Migneault , Isabelle Valade , Xinfu Wu , Francine Gervais
IPC分类号: A61K31/27 , C07C309/04 , A61K31/16 , C07C53/00 , A61K31/215 , C07C309/65 , A61K31/165 , A61P25/28 , A61P9/00 , A61P17/00
CPC分类号: C07C309/14 , C07C307/02 , C07C309/13 , C07C309/15 , C07C309/19 , C07C309/23 , C07C309/46 , C07C309/69 , C07C311/32 , C07C311/46 , C07C323/25 , C07C323/58 , C07C335/12 , C07C335/32 , C07C381/02 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/18 , C07C2602/08 , C07C2602/10 , C07C2602/42 , C07C2603/74 , C07D209/08 , C07D209/14 , C07D209/18 , C07D209/20 , C07D209/44 , C07D209/48 , C07D211/46 , C07D211/64 , C07D211/70 , C07D217/04 , C07D217/10 , C07D235/28 , C07D257/04 , C07D295/084 , C07D295/088 , C07D317/50 , C07D401/04 , C07D403/04 , C07D403/06 , C07D453/02 , C07D471/04 , C07F9/1651 , C07F9/2458 , C07K5/0812
摘要: Methods, compounds, pharmaceutical compositions and kits are described for treating or preventing amyloid-related disease.
摘要翻译: 描述了治疗或预防淀粉样蛋白相关疾病的方法,化合物,药物组合物和试剂盒。
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4.
公开(公告)号:US20060223855A1
公开(公告)日:2006-10-05
申请号:US11316693
申请日:2005-12-21
申请人: Xianqi Kong , Xinfu Wu , Abderrahim Bouzide , Isabelle Valade , David Migneault , Francine Gervais , Daniel Delorme , Benoit Bachand , Mohamed Atfani , Sophie Levesque , Bita Samim
发明人: Xianqi Kong , Xinfu Wu , Abderrahim Bouzide , Isabelle Valade , David Migneault , Francine Gervais , Daniel Delorme , Benoit Bachand , Mohamed Atfani , Sophie Levesque , Bita Samim
IPC分类号: A61K31/445 , C07D211/06 , A61K31/185
CPC分类号: C07C309/19 , C07C309/14 , C07C309/21 , C07C309/24 , C07C309/26 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/08 , C07C2602/10 , C07C2602/42 , C07C2603/74 , C07D207/12 , C07D207/333 , C07D209/08 , C07D209/16 , C07D209/36 , C07D209/44 , C07D209/48 , C07D209/86 , C07D211/06 , C07D211/14 , C07D211/18 , C07D211/34 , C07D211/48 , C07D211/52 , C07D211/58 , C07D211/64 , C07D211/70 , C07D211/82 , C07D213/04 , C07D213/20 , C07D213/50 , C07D213/75 , C07D213/82 , C07D217/04 , C07D219/10 , C07D231/44 , C07D233/54 , C07D235/28 , C07D257/04 , C07D275/06 , C07D277/66 , C07D295/073 , C07D295/088 , C07D307/14 , C07D307/52 , C07D317/58 , C07D327/04 , C07D327/06 , C07D327/08 , C07D333/20 , C07D333/34 , C07D409/04 , C07D471/04 , C07D471/08 , C07K5/06
摘要: Methods, compounds, pharmaceutical compositions and kits are described for treating or preventing amyloid-related disease.
摘要翻译: 描述了治疗或预防淀粉样蛋白相关疾病的方法,化合物,药物组合物和试剂盒。
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公开(公告)号:US20140329746A1
公开(公告)日:2014-11-06
申请号:US14332675
申请日:2014-07-16
申请人: Xianqi Kong , Xinfu Wu , Abderrahim Bouzide , Isabelle Valade , David Migneault , Francine Gervais , Daniel Delorme , Benoit Bachand , Mohamed Atfani , Sophie Levesque , Bita Samim
发明人: Xianqi Kong , Xinfu Wu , Abderrahim Bouzide , Isabelle Valade , David Migneault , Francine Gervais , Daniel Delorme , Benoit Bachand , Mohamed Atfani , Sophie Levesque , Bita Samim
IPC分类号: C07C309/19 , C07D211/64 , C07D211/52 , C07K5/06 , C07D213/50 , C07D295/088 , C07D211/70 , C07C309/24 , C07D211/14 , C07D213/04
CPC分类号: C07C309/19 , C07C309/14 , C07C309/21 , C07C309/24 , C07C309/26 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/08 , C07C2602/10 , C07C2602/42 , C07C2603/74 , C07D207/12 , C07D207/333 , C07D209/08 , C07D209/16 , C07D209/36 , C07D209/44 , C07D209/48 , C07D209/86 , C07D211/06 , C07D211/14 , C07D211/18 , C07D211/34 , C07D211/48 , C07D211/52 , C07D211/58 , C07D211/64 , C07D211/70 , C07D211/82 , C07D213/04 , C07D213/20 , C07D213/50 , C07D213/75 , C07D213/82 , C07D217/04 , C07D219/10 , C07D231/44 , C07D233/54 , C07D235/28 , C07D257/04 , C07D275/06 , C07D277/66 , C07D295/073 , C07D295/088 , C07D307/14 , C07D307/52 , C07D317/58 , C07D327/04 , C07D327/06 , C07D327/08 , C07D333/20 , C07D333/34 , C07D409/04 , C07D471/04 , C07D471/08 , C07K5/06
摘要: Methods, compounds, pharmaceutical compositions and kits are described for treating or preventing amyloid-related disease.
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6.
公开(公告)号:US20140107027A1
公开(公告)日:2014-04-17
申请号:US14132898
申请日:2013-12-18
申请人: Xianqi Kong , David Migneault , Isabelle Valade , Xinfu Wu , Francine Gervais
发明人: Xianqi Kong , David Migneault , Isabelle Valade , Xinfu Wu , Francine Gervais
IPC分类号: C07C309/14 , C07K5/087 , C07D453/02 , C07D295/088 , C07D209/18 , C07D257/04
CPC分类号: C07C309/14 , C07C307/02 , C07C309/13 , C07C309/15 , C07C309/19 , C07C309/23 , C07C309/46 , C07C309/69 , C07C311/32 , C07C311/46 , C07C323/25 , C07C323/58 , C07C335/12 , C07C335/32 , C07C381/02 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/18 , C07C2602/08 , C07C2602/10 , C07C2602/42 , C07C2603/74 , C07D209/08 , C07D209/14 , C07D209/18 , C07D209/20 , C07D209/44 , C07D209/48 , C07D211/46 , C07D211/64 , C07D211/70 , C07D217/04 , C07D217/10 , C07D235/28 , C07D257/04 , C07D295/084 , C07D295/088 , C07D317/50 , C07D401/04 , C07D403/04 , C07D403/06 , C07D453/02 , C07D471/04 , C07F9/1651 , C07F9/2458 , C07K5/0812
摘要: Methods, compounds, pharmaceutical compositions and kits are described for treating or preventing amyloid-related disease.
摘要翻译: 描述了治疗或预防淀粉样蛋白相关疾病的方法,化合物,药物组合物和试剂盒。
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7.
公开(公告)号:US08642801B2
公开(公告)日:2014-02-04
申请号:US12613412
申请日:2009-11-05
申请人: Xianqi Kong , David Migneault , Isabelle Valade , Xinfu Wu , Francine Gervais
发明人: Xianqi Kong , David Migneault , Isabelle Valade , Xinfu Wu , Francine Gervais
IPC分类号: C07C309/19 , A61K31/185
CPC分类号: C07C309/14 , C07C307/02 , C07C309/13 , C07C309/15 , C07C309/19 , C07C309/23 , C07C309/46 , C07C309/69 , C07C311/32 , C07C311/46 , C07C323/25 , C07C323/58 , C07C335/12 , C07C335/32 , C07C381/02 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/18 , C07C2602/08 , C07C2602/10 , C07C2602/42 , C07C2603/74 , C07D209/08 , C07D209/14 , C07D209/18 , C07D209/20 , C07D209/44 , C07D209/48 , C07D211/46 , C07D211/64 , C07D211/70 , C07D217/04 , C07D217/10 , C07D235/28 , C07D257/04 , C07D295/084 , C07D295/088 , C07D317/50 , C07D401/04 , C07D403/04 , C07D403/06 , C07D453/02 , C07D471/04 , C07F9/1651 , C07F9/2458 , C07K5/0812
摘要: Methods, compounds, pharmaceutical compositions and kits are described for treating or preventing amyloid-related disease.
摘要翻译: 描述了治疗或预防淀粉样蛋白相关疾病的方法,化合物,药物组合物和试剂盒。
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8.
公开(公告)号:US20070010573A1
公开(公告)日:2007-01-11
申请号:US11316694
申请日:2005-12-21
申请人: Xianqi Kong , David Migneault , Isabelle Valade , Xinfu Wu , Francine Gervais
发明人: Xianqi Kong , David Migneault , Isabelle Valade , Xinfu Wu , Francine Gervais
IPC分类号: A61K31/405 , A61K31/277 , A61K31/198 , C07D209/20 , C07C309/13
CPC分类号: C07C309/14 , C07C307/02 , C07C309/13 , C07C309/15 , C07C309/19 , C07C309/23 , C07C309/46 , C07C309/69 , C07C311/32 , C07C311/46 , C07C323/25 , C07C323/58 , C07C335/12 , C07C335/32 , C07C381/02 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/10 , C07C2601/14 , C07C2601/18 , C07C2602/08 , C07C2602/10 , C07C2602/42 , C07C2603/74 , C07D209/08 , C07D209/14 , C07D209/18 , C07D209/20 , C07D209/44 , C07D209/48 , C07D211/46 , C07D211/64 , C07D211/70 , C07D217/04 , C07D217/10 , C07D235/28 , C07D257/04 , C07D295/084 , C07D295/088 , C07D317/50 , C07D401/04 , C07D403/04 , C07D403/06 , C07D453/02 , C07D471/04 , C07F9/1651 , C07F9/2458 , C07K5/0812
摘要: Methods, compounds, pharmaceutical compositions and kits are described for treating or preventing amyloid-related disease.
摘要翻译: 描述了治疗或预防淀粉样蛋白相关疾病的方法,化合物,药物组合物和试剂盒。
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9.
公开(公告)号:US07414076B2
公开(公告)日:2008-08-19
申请号:US10871514
申请日:2004-06-18
申请人: Xianqi Kong , David Migneault , Isabelle Valade , Xinfu Wu , Francine Gervais
发明人: Xianqi Kong , David Migneault , Isabelle Valade , Xinfu Wu , Francine Gervais
IPC分类号: A61K31/185 , C07C309/00
CPC分类号: C07D295/084 , C07C307/02 , C07C309/13 , C07C309/14 , C07C309/15 , C07C309/46 , C07C309/69 , C07C311/32 , C07C311/46 , C07C335/32 , C07C381/02 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/08 , C07C2602/10 , C07C2602/42 , C07C2603/74 , C07D295/088 , C07F9/1651 , C07F9/2458
摘要: Methods, compounds, pharmaceutical compositions and kits are described for treating or preventing amyloid-related disease.
摘要翻译: 描述了治疗或预防淀粉样蛋白相关疾病的方法,化合物,药物组合物和试剂盒。
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公开(公告)号:US08835654B2
公开(公告)日:2014-09-16
申请号:US13237576
申请日:2011-09-20
申请人: Xianqi Kong , Xinfu Wu , Abderrahim Bouzide , Isabelle Valade , David Migneault , Francine Gervais , Daniel Delorme , Benoit Bachand , Mohamed Atfani , Sophie Levesque , Bita Samim
发明人: Xianqi Kong , Xinfu Wu , Abderrahim Bouzide , Isabelle Valade , David Migneault , Francine Gervais , Daniel Delorme , Benoit Bachand , Mohamed Atfani , Sophie Levesque , Bita Samim
IPC分类号: A61K31/381 , C07D409/12 , C07D333/22 , C07D333/36 , C07D333/58
CPC分类号: C07C309/19 , C07C309/14 , C07C309/21 , C07C309/24 , C07C309/26 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/08 , C07C2602/10 , C07C2602/42 , C07C2603/74 , C07D207/12 , C07D207/333 , C07D209/08 , C07D209/16 , C07D209/36 , C07D209/44 , C07D209/48 , C07D209/86 , C07D211/06 , C07D211/14 , C07D211/18 , C07D211/34 , C07D211/48 , C07D211/52 , C07D211/58 , C07D211/64 , C07D211/70 , C07D211/82 , C07D213/04 , C07D213/20 , C07D213/50 , C07D213/75 , C07D213/82 , C07D217/04 , C07D219/10 , C07D231/44 , C07D233/54 , C07D235/28 , C07D257/04 , C07D275/06 , C07D277/66 , C07D295/073 , C07D295/088 , C07D307/14 , C07D307/52 , C07D317/58 , C07D327/04 , C07D327/06 , C07D327/08 , C07D333/20 , C07D333/34 , C07D409/04 , C07D471/04 , C07D471/08 , C07K5/06
摘要: Methods, compounds, pharmaceutical compositions and kits are described for treating or preventing amyloid-related disease.
摘要翻译: 描述了治疗或预防淀粉样蛋白相关疾病的方法,化合物,药物组合物和试剂盒。
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