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1.发明申请Substituted Indazoles, Compositions Containing The Same, And The Preparation And Use Thereof 失效取代的吲唑，含有它的组合物及其制备和使用公开(公告)号：US20070161626A1
公开(公告)日：2007-07-12
申请号：US11566382
申请日：2006-12-04
申请人： Frank Halley , Michel Tabart , Herve Bouchard , Catherine Souaille , Alain Le Brun , Fabrice Viviani , Laurence Gauzy-Lazo , Pascal Desmazeau , Odile Angouillant-Boniface , Bruno Filoche-Romme
发明人： Frank Halley , Michel Tabart , Herve Bouchard , Catherine Souaille , Alain Le Brun , Fabrice Viviani , Laurence Gauzy-Lazo , Pascal Desmazeau , Odile Angouillant-Boniface , Bruno Filoche-Romme
IPC分类号： A61K31/55 , A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/506 , A61K31/4439 , A61K31/427 , A61K31/422 , A61K31/416 , A61K31/4178 , C07D417/02 , C07D413/02 , C07D403/02
CPC分类号： C07D231/56 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14
摘要： Disclosed are novel substituted indazole compounds, pharmaceutical compositions comprising such compounds, and methods of treatment comprising such compounds.
摘要翻译： 公开了新的取代的吲唑化合物，包含这些化合物的药物组合物和包含这些化合物的治疗方法。
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2.发明授权Substituted indazoles, compositions containing the same, and the preparation and use thereof 失效取代的吲唑，含有它们的组合物及其制备和用途公开(公告)号：US07517902B2
公开(公告)日：2009-04-14
申请号：US11566382
申请日：2006-12-04
申请人： Frank Halley , Michel Tabart , Hervé Bouchard , Catherine Souaille , Alain Le Brun , Fabrice Viviani , Laurence Gauzy-Lazo , Pascal Desmazeau , Odile Angouillant-Boniface , Bruno Filoche-Romme
发明人： Frank Halley , Michel Tabart , Hervé Bouchard , Catherine Souaille , Alain Le Brun , Fabrice Viviani , Laurence Gauzy-Lazo , Pascal Desmazeau , Odile Angouillant-Boniface , Bruno Filoche-Romme
IPC分类号： A61K31/541 , A61K31/5377 , C07D417/02 , C07D413/02
CPC分类号： C07D231/56 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14
摘要： Disclosed are novel substituted indazole compounds, pharmaceutical compositions comprising such compounds, and methods of treatment comprising such compounds.
摘要翻译： 公开了新的取代的吲唑化合物，包含这些化合物的药物组合物和包含这些化合物的治疗方法。
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![Substituted tetrahydro-1H-pyrazolo [3,4-c]pyridines compositions comprising them, and use](/abs-image/US/2008/10/14/US07435820B2/abs.jpg.150x150.jpg)
3.发明授权Substituted tetrahydro-1H-pyrazolo [3,4-c]pyridines compositions comprising them, and use 失效包含它们的取代的四氢-1H-吡唑并[3,4-c]吡啶组合物，并使用公开(公告)号：US07435820B2
公开(公告)日：2008-10-14
申请号：US11419794
申请日：2006-05-23
申请人： Fabienne Thompson , Catherine Souaille , Fabrice Viviani , Michel Tabart , Patrick Mailliet , Teresa Damiano , Marie-Pierre Cherrier , Francois Clerc , Frank Halley , Herve Bouchard , Laurence Gauzy-Lazo , Bernard Baudoin
发明人： Fabienne Thompson , Catherine Souaille , Fabrice Viviani , Michel Tabart , Patrick Mailliet , Teresa Damiano , Marie-Pierre Cherrier , Francois Clerc , Frank Halley , Herve Bouchard , Laurence Gauzy-Lazo , Bernard Baudoin
IPC分类号： C07D471/02 , C07D491/02 , C07D498/02 , C07D513/02 , C07D515/02
CPC分类号： C07D471/04
摘要： Substituted tetrahydro-1H-pyrazolo[3,4-c]pyridines, compositions comprising them and use. The present invention relates in particular to novel substituted tetrahydro-1H-pyrazolo[3,4-c]pyridines having therapeutic activity, which can be used in particular in oncology.
摘要翻译： 取代的四氢-1H-吡唑并[3,4-c]吡啶，包含它们的组合物和用途。 本发明特别涉及具有治疗活性的新型取代的四氢-1H-吡唑并[3,4-c]吡啶，其特别可用于肿瘤学。
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![Substituted tetrahydro-1H-pyrazolo [3,4-c] pyridines, compositions comprising them, and use](/abs-image/US/2005/05/05/US20050096345A1/abs.jpg.150x150.jpg)
4.发明申请Substituted tetrahydro-1H-pyrazolo [3,4-c] pyridines, compositions comprising them, and use 失效取代的四氢-1H-吡唑并[3,4-c]吡啶，包含它们的组合物，并使用公开(公告)号：US20050096345A1
公开(公告)日：2005-05-05
申请号：US10888611
申请日：2004-07-09
申请人： Fabienne Thompson , Patrick Mailliet , Teresa Damiano , Marie-Pierre Cherrier , Francois Clerc , Frank Halley , Herve Bouchard , Laurence Gauzy-Lazo , Bernard Baudoin , Catherine Souaille , Fabrice Viviani , Michel Tabart
发明人： Fabienne Thompson , Patrick Mailliet , Teresa Damiano , Marie-Pierre Cherrier , Francois Clerc , Frank Halley , Herve Bouchard , Laurence Gauzy-Lazo , Bernard Baudoin , Catherine Souaille , Fabrice Viviani , Michel Tabart
IPC分类号： A61P35/00 , C07D471/04 , C07D471/02 , A61K31/4745
CPC分类号： C07D471/04
摘要： Substituted tetrahydro-1H-pyrazolo[3,4-c]pyridines, compositions comprising them and use. The present invention relates in particular to novel substituted tetrahydro-1H-pyrazolo[3,4-c]pyridines having therapeutic activity, which can be used in particular in oncology.
摘要翻译： 取代的四氢-1H-吡唑并[3,4-c]吡啶，包含它们的组合物和用途。 本发明特别涉及具有治疗活性的新型取代的四氢-1H-吡唑并[3,4-c]吡啶，其特别可用于肿瘤学。
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![Substituted tetrahydro-1H-pyrazolo [3,4-c] pyridines, compositions comprising them, and use](/abs-image/US/2006/09/19/US07109340B2/abs.jpg.150x150.jpg)
5.发明授权Substituted tetrahydro-1H-pyrazolo [3,4-c] pyridines, compositions comprising them, and use 失效取代的四氢-1H-吡唑并[3,4-c]吡啶，包含它们的组合物，并使用公开(公告)号：US07109340B2
公开(公告)日：2006-09-19
申请号：US10888611
申请日：2004-07-09
申请人： Fabienne Thompson , Patrick Mailliet , Teresa Damiano , Marie-Pierre Cherrier , Francois Clerc , Frank Halley , Hervé Bouchard , Laurence Gauzy-Lazo , Bernard Baudoin , Catherine Souaille , Fabrice Viviani , Michel Tabart
发明人： Fabienne Thompson , Patrick Mailliet , Teresa Damiano , Marie-Pierre Cherrier , Francois Clerc , Frank Halley , Hervé Bouchard , Laurence Gauzy-Lazo , Bernard Baudoin , Catherine Souaille , Fabrice Viviani , Michel Tabart
IPC分类号： C07D471/02 , C07D491/02 , C07D498/02 , C07D513/02 , C07D515/02
CPC分类号： C07D471/04
摘要： Substituted tetrahydro-1H-pyrazolo[3,4-c]pyridines, compositions comprising them and use. The present invention relates in particular to novel substituted tetrahydro-1H-pyrazolo[3,4-c]pyridines having therapeutic activity, which can be used in particular in oncology.
摘要翻译： 取代的四氢-1H-吡唑并[3,4-c]吡啶，包含它们的组合物和用途。 本发明特别涉及具有治疗活性的新型取代的四氢-1H-吡唑并[3,4-c]吡啶，其特别可用于肿瘤学。
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![SUBSTITUTED TETRAHYDRO-1H-PYRAZOLO [3,4-C]PYRIDINES COMPOSITIONS COMPRISING THEM, AND USE](/abs-image/US/2006/09/07/US20060199837A1/abs.jpg.150x150.jpg)
6.发明申请SUBSTITUTED TETRAHYDRO-1H-PYRAZOLO [3,4-C]PYRIDINES COMPOSITIONS COMPRISING THEM, AND USE 失效取代的四氢-1H-吡唑并[3,4-C]吡啶类化合物及其用途公开(公告)号：US20060199837A1
公开(公告)日：2006-09-07
申请号：US11419794
申请日：2006-05-23
申请人： Fabienne Thompson , Patrick Mailliet , Teresa Damiano , Marie-Pierre Cherrier , Francois Clerc , Frank Halley , Herve Bouchard , Laurence Gauzy-Lazo , Bernard Baudoin , Catherine Squaille , Fabrice Viviani , Michel Tabart
发明人： Fabienne Thompson , Patrick Mailliet , Teresa Damiano , Marie-Pierre Cherrier , Francois Clerc , Frank Halley , Herve Bouchard , Laurence Gauzy-Lazo , Bernard Baudoin , Catherine Squaille , Fabrice Viviani , Michel Tabart
IPC分类号： C07D471/02 , A61K31/4745
CPC分类号： C07D471/04
摘要： Substituted tetrahydro-1H-pyrazolo[3,4-c]pyridines, compositions comprising them and use. The present invention relates in particular to novel substituted tetrahydro-1H-pyrazolo[3,4-c]pyridines having therapeutic activity, which can be used in particular in oncology.
摘要翻译： 取代的四氢-1H-吡唑并[3,4-c]吡啶，包含它们的组合物和用途。 本发明特别涉及具有治疗活性的新型取代的四氢-1H-吡唑并[3,4-c]吡啶，其特别可用于肿瘤学。
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7.发明申请公开(公告)号：US20080139606A1
公开(公告)日：2008-06-12
申请号：US11870640
申请日：2007-10-11
申请人： Michel Tabart , Eric Bacque , Frank Halley , Baptiste Ronan , Pascal Desmazeau , Fabrice Viviani , Catherine Souaille
发明人： Michel Tabart , Eric Bacque , Frank Halley , Baptiste Ronan , Pascal Desmazeau , Fabrice Viviani , Catherine Souaille
IPC分类号： A61K31/437 , C07D471/04 , A61P35/00
CPC分类号： C07D471/04
摘要： The invention relates to compounds of formula (I): wherein Ra, R1, Ar, L, A, W, Y, and Z are as defined in the disclosure; to compositions containing them; and to the preparation and use thereof, in particular as anticancer agents.
摘要翻译： 本发明涉及式（I）化合物：其中R a，R 1，Ar，L，A，W，Y和Z如本公开所定义; 含有它们的组合物; 以及其制备和使用，特别是抗癌剂。
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8.发明授权Substituted pyrrolopyridines, compositions containing them, manufacturing process therefor and use thereof 失效取代的吡咯并吡啶，含有它们的组合物，其制备方法和用途公开(公告)号：US07947706B2
公开(公告)日：2011-05-24
申请号：US11870640
申请日：2007-10-11
申请人： Michel Tabart , Eric Bacque , Frank Halley , Baptiste Ronan , Pascal Desmazeau , Fabrice Viviani , Catherine Souaille
发明人： Michel Tabart , Eric Bacque , Frank Halley , Baptiste Ronan , Pascal Desmazeau , Fabrice Viviani , Catherine Souaille
IPC分类号： A61K31/437 , C07D471/04 , A61P35/00
CPC分类号： C07D471/04
摘要： The invention relates to compounds of formula (I): wherein Ra, R1, Ar, L, A, W, Y, and Z are as defined in the disclosure; to compositions containing them; and to the preparation and use thereof, in particular as anticancer agents.
摘要翻译： 本发明涉及式（I）化合物：其中R a，R 1，Ar，L，A，W，Y和Z如本公开所定义; 含有它们的组合物; 以及其制备和使用，特别是抗癌剂。
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9.发明授权Substituted pyrroles, compositions containing same, method for making same and use thereof 失效取代的吡咯，含有它们的组合物，其制备方法和用途公开(公告)号：US07592365B2
公开(公告)日：2009-09-22
申请号：US11832208
申请日：2007-08-01
申请人： Baptiste Ronan , Michel Tabart , Catherine Souaille , Fabrice Viviani , Eric Bacque , Jean-Philippe Letallec , Pascal Desmazeau
发明人： Baptiste Ronan , Michel Tabart , Catherine Souaille , Fabrice Viviani , Eric Bacque , Jean-Philippe Letallec , Pascal Desmazeau
IPC分类号： A61K31/4025 , A61K31/166 , C12N9/99 , C07C233/57 , C07D207/34
CPC分类号： C07D207/34
摘要： The disclosure concerns substituted pyrroles of formula (I): wherein A, L, Ar, R1, R2, R5, and Ra are as defined in the disclosure, compositions containing the same, methods for making the same and uses thereof, in particular as anti-cancer agents.
摘要翻译： 本公开涉及式（I）的取代吡咯：其中A，L，Ar，R 1，R 2，R 5和R a如本公开所定义，含有该取代吡咯的组合物，其制备方法及其用途，特别是 抗癌剂。
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10.发明授权Substituted indoles, compositions containing them, method for the production thereof and their use 失效取代的吲哚，含有它们的组合物，其制备方法及其用途公开(公告)号：US07566736B2
公开(公告)日：2009-07-28
申请号：US11757613
申请日：2007-06-04
申请人： Frank Halley , Catherine Souaille , Michel Tabart , Eric Bacque , Fabrice Viviani , Baptiste Ronan , Jean-Philippe Letallec , Bruno Filoche-Rommé
发明人： Frank Halley , Catherine Souaille , Michel Tabart , Eric Bacque , Fabrice Viviani , Baptiste Ronan , Jean-Philippe Letallec , Bruno Filoche-Rommé
IPC分类号： A61K31/4045 , C07D209/04
CPC分类号： C07D401/04 , C07D209/42 , C07D401/12 , C07D403/12 , C07D413/12 , C07D471/04
摘要： Compounds of formula (I): wherein R1, R5, R6, R7, Ar, L, A, and Q are as defined in the description, and to salts thereof, to compositions containing them, to the process for preparing them, and to their use as medicinal products, in particular as anticancer agents.
摘要翻译： 式（I）化合物：其中R 1，R 5，R 6，R 7，Ar，L，A和Q如说明书中所定义，及其盐，含有它们的组合物，其制备方法，以及 其用作药用产品，特别是作为抗癌剂。
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