摘要:
Disclosed are novel substituted indazole compounds, pharmaceutical compositions comprising such compounds, and methods of treatment comprising such compounds.
摘要:
Disclosed are novel substituted indazole compounds, pharmaceutical compositions comprising such compounds, and methods of treatment comprising such compounds.
摘要:
This invention relates to compounds of formula (I) to processes for the preparation of such compounds, to pharmaceutical compositions comprising such compounds, and to methods of treatment comprising administering of such compounds.
摘要:
The invention especially relates to novel chemical compounds, especially novel benzothiazole derivatives, to compositions containing said compounds, and to the use thereof as medicaments.
摘要:
The disclosure relates to compounds of formula (I): wherein R1, R2, R3, R4, and R5 are as defined in the disclosure, to the compositions containing them and to the use thereof as medicaments, in particular as anticancer agents. The disclosure also relates to the process for preparing the compounds of formula (I) and to reaction intermediates.
摘要:
The present invention discloses and claims benzimidazole compounds of formula (I): in which A is aryl or heteroaryl; R1 is sleceted from optionally substituted alkyl, alkoxy, aryl or heteroaryl, NH-lower alkyl or NH-cycloalkyl, or halogen, NH2; 1-imidazolyl or SO2Me; R2 is selected from optionally substituted —CO-alkyl, —CO-cycloalkyl, —CO-aralkyl, —CO-aryl, —CO-alkoxy, aryl or aralkyl, or —O-amino, CO—NHR3 or CO—R3R4 wherein R3 and R4 are selecteded independently from hydrogen, alkyl, hydroxyalkyl, alkoxyalkyl, fluoroalkyl, alkynyl, heteroalkyl, alkylheteroalkyl, aryl, aralkyl or together form an alkylene chain optionally containing one to 4 heteroatoms; a pharmaceutically acceptable salt or a prodrug thereof; the use of compounds of formula (I) for the treatment of cancer, and pharmaceutical compositions comprising a compound of formula (I) and one or more pharmaceutically acceptable adjuvants or diluents.
摘要翻译:本发明公开并要求式(I)的苯并咪唑化合物:其中A是芳基或杂芳基; R 1从任选取代的烷基,烷氧基,芳基或杂芳基,NH-低级烷基或NH-环烷基取代,或卤素,NH 2; 1-咪唑基或SO2Me; R 2选自任选取代的-CO-烷基,-CO-环烷基,-CO-芳烷基,-CO-芳基,-CO-烷氧基,芳基或芳烷基,或-O-氨基,CO-NHR3或CO-R3R4,其中R3 烷基,羟基烷基,烷氧基烷基,氟代烷基,炔基,杂烷基,烷基杂烷基,芳基,芳烷基或一起形成任选含有1至4个杂原子的亚烷基链; 其药学上可接受的盐或其前药; 使用式(I)化合物治疗癌症,以及包含式(I)化合物和一种或多种药学上可接受的佐剂或稀释剂的药物组合物。
摘要:
The invention especially relates to novel chemical compounds, especially novel benzothiazole derivatives, to compositions containing said compounds, and to the use thereof as medicaments.
摘要:
The present invention discloses and claims benzimidazole compounds of formula (I): in which A is aryl or heteroaryl; R1 is selected from optionally substituted alkyl, alkoxy, aryl or heteroaryl, NH-lower alkyl or NH-cycloalkyl, or halogen, NH2; 1-imidazolyl or SO2Me; R2 is selected from optionally substituted —CO-alkyl, —CO-cycloalkyl, —CO-aralkyl, —CO-aryl, —CO-alkoxy, aryl or aralkyl, or —CO-amino, CO—NHR3 or CO—R3R4 wherein R3 and R4 are selecteded independently from hydrogen, alkyl, hydroxyalkyl, alkoxyalkyl, fluoroalkyl, alkynyl, heteroalkyl, alkylheteroalkyl, aryl, aralkyl or together form an alkylene chain optionally containing one to 4 heteroatoms; a pharmaceutically acceptable salt or a prodrug thereof; the use of compounds of formula (I) for the treatment of cancer, and pharmaceutical compositions comprising a compound of formula (I) and one or more pharmaceutically acceptable adjuvants or diluents.
摘要翻译:本发明公开并要求式(I)的苯并咪唑化合物:其中A是芳基或杂芳基; R 1选自任选取代的烷基,烷氧基,芳基或杂芳基,NH-低级烷基或NH-环烷基,或卤素,NH 2。 1-咪唑基或SO 2 Me; R 2选自任选取代的-CO-烷基,-CO-环烷基,-CO-芳烷基,-CO-芳基,-CO-烷氧基,芳基或芳烷基或-CO-氨基,CO -NHR 3或CO-R 3 R 4其中R 3和R 4 SUB 烷基,羟基烷基,烷氧基烷基,氟代烷基,炔基,杂烷基,烷基杂烷基,芳基,芳烷基或一起形成任选含有一个至四个杂原子的亚烷基链; 其药学上可接受的盐或其前药; 使用式(I)化合物治疗癌症,以及包含式(I)化合物和一种或多种药学上可接受的佐剂或稀释剂的药物组合物。