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公开(公告)号：US20090053535A1
公开(公告)日：2009-02-26
申请号：US12196959
申请日：2008-08-22
CPC分类号： G03F7/027 , B82Y10/00 , B82Y40/00 , G03F7/0002 , Y10T428/24612
摘要： A multi-layer stack for imprint lithography is formed by applying a first polymerizable composition to a substrate, polymerizing the first polymerizable composition to form a first polymerized layer, applying a second polymerizable composition to the first polymerized layer, and polymerizing the second polymerizable composition to form a second polymerized layer on the first polymerized layer. The first polymerizable composition includes a polymerizable component with a glass transition temperature less than about 25° C., and the first polymerized layer is substantially impermeable to the second polymerizable composition.
摘要翻译： 通过将第一可聚合组合物施加到基底上，聚合第一可聚合组合物以形成第一聚合层，向第一聚合层施加第二可聚合组合物，并将第二可聚合组合物聚合成 在第一聚合层上形成第二聚合层。 第一可聚合组合物包括玻璃化转变温度低于约25℃的可聚合组分，并且第一聚合层对于第二可聚合组合物基本上是不可渗透的。
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公开(公告)号：US20120288686A1
公开(公告)日：2012-11-15
申请号：US13546622
申请日：2012-07-11
IPC分类号： B32B3/30 , B05D3/10 , B05D1/38 , C08F236/20 , B32B27/08
CPC分类号： G03F7/027 , B82Y10/00 , B82Y40/00 , G03F7/0002 , Y10T428/24612
摘要： A multi-layer stack for imprint lithography is formed by applying a first polymerizable composition to a substrate, polymerizing the first polymerizable composition to form a first polymerized layer, applying a second polymerizable composition to the first polymerized layer, and polymerizing the second polymerizable composition to form a second polymerized layer on the first polymerized layer. The first polymerizable composition includes a polymerizable component with a glass transition temperature less than about 25° C., and the first polymerized layer is substantially impermeable to the second polymerizable composition.
摘要翻译： 通过将第一可聚合组合物施加到基底上，聚合第一可聚合组合物以形成第一聚合层，向第一聚合层施加第二可聚合组合物，并将第二可聚合组合物聚合成 在第一聚合层上形成第二聚合层。 第一可聚合组合物包括玻璃化转变温度低于约25℃的可聚合组分，并且第一聚合层对于第二可聚合组合物基本上是不可渗透的。
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公开(公告)号：US08377050B2
公开(公告)日：2013-02-19
申请号：US11760564
申请日：2007-06-08
申请人： David J. Lentz , Jillian K. Allen
发明人： David J. Lentz , Jillian K. Allen
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2017/003 , A61B2018/0212 , A61B2018/0262
摘要： A configuration for a cryo-catheter which optimizes both the catheter's outer diameter and the size of the catheter's internal refrigerant flow path is described. Specifically, the inner dimensions of the cryo-catheter are configured to accommodate a pre-selected flow of refrigerant into the catheter's distal tip, and a return flow of refrigerant from the distal tip. The return flow is established in the void spaces between a refrigerant supply line and the inner wall of the catheter body. The available void space varies along the catheter length and depends on the presence/absence of various catheter accessories (i.e. pull wires, pressure tubes, etc.) which typically only extend through a portion of the catheter length. The disclosed configuration ensures that the cryo-catheter does not operate in a refrigerant limited condition, maintains the refrigerant as a liquid in the supply tube, and maintains the return line pressure at about 1 atmosphere.
摘要翻译： 描述了优化导管的外径和导管的内部制冷剂流动路径的尺寸的低温导管的配置。 具体地，冷冻导管的内部尺寸被配置为容纳预先选择的制冷剂流入导管的远侧末端，以及来自远侧末端的制冷剂回流。 在制冷剂供应管线和导管体的内壁之间的空隙空间中建立回流。 可用的空隙空间沿着导管长度而变化，并且取决于通常仅延伸穿过导管长度的一部分的各种导管配件（即拉线，压力管等）的存在/不存在。 所公开的配置确保冷冻导管不在制冷剂限制条件下操作，将制冷剂保持为供应管中的液体，并将返回管线压力保持在大约1个大气压。
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公开(公告)号：US08092444B2
公开(公告)日：2012-01-10
申请号：US12642362
申请日：2009-12-18
申请人： David J. Lentz , Richard J. Koerner
发明人： David J. Lentz , Richard J. Koerner
IPC分类号： A61M25/00
CPC分类号： A61M25/0013 , A61M25/0054 , A61M25/0138
摘要： An articulation segment for a catheter includes a tube formed with a first plurality of axially aligned slits that are respectively oriented in planes perpendicular to the axis, with each slit extending azimuthally in an arc partway around the axis. The tube is also formed with a second plurality of similarly formed slits that are axially offset and diametrically opposed relative to the slits of the first plurality to allow for a bending of the catheter in a plurality of different planes. In a particular embodiment, the slits are arranged to allow the articulation segment to be reconfigured from a straight, substantially cylindrically shaped tube to a configuration in which a portion of the articulation segment is formed in the shape of a ring.
摘要翻译： 用于导管的关节节段包括形成有第一多个轴向对准的狭缝的管，其分别定向在垂直于轴线的平面中，每个狭缝围绕轴线在一半弧中方位延伸。 管还形成有第二多个类似形成的狭缝，其相对于第一多个的狭缝轴向地偏置并沿直径相对，以允许导管在多个不同平面中弯曲。 在特定实施例中，狭缝被布置成允许关节运动部分从直的基本上圆柱形的管重新配置到其中关节节段的一部分形成为环形的构造。
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公开(公告)号：US20080306475A1
公开(公告)日：2008-12-11
申请号：US11760564
申请日：2007-06-08
申请人： David J. Lentz , Jillian K. Allen
发明人： David J. Lentz , Jillian K. Allen
IPC分类号： A61B18/02
CPC分类号： A61B18/02 , A61B2017/003 , A61B2018/0212 , A61B2018/0262
摘要： A configuration for a cryo-catheter which optimizes both the catheter's outer diameter and the size of the catheter's internal refrigerant flow path is described. Specifically, the inner dimensions of the cryo-catheter are configured to accommodate a pre-selected flow of refrigerant into the catheter's distal tip, and a return flow of refrigerant from the distal tip. The return flow is established in the void spaces between a refrigerant supply line and the inner wall of the catheter body. The available void space varies along the catheter length and depends on the presence/absence of various catheter accessories (i.e. pull wires, pressure tubes, etc.) which typically only extend through a portion of the catheter length. The disclosed configuration ensures that the cryo-catheter does not operate in a refrigerant limited condition, maintains the refrigerant as a liquid in the supply tube, and maintains the return line pressure at about 1 atmosphere.
摘要翻译： 描述了优化导管的外径和导管的内部制冷剂流动路径的尺寸的低温导管的配置。 具体地，冷冻导管的内部尺寸被配置为容纳预先选择的制冷剂流入导管的远侧末端，以及来自远侧末端的制冷剂回流。 在制冷剂供应管线和导管体的内壁之间的空隙空间中建立回流。 可用的空隙空间沿着导管长度而变化，并且取决于通常仅延伸穿过导管长度的一部分的各种导管配件（即拉线，压力管等）的存在/不存在。 所公开的配置确保冷冻导管不在制冷剂限制条件下操作，将制冷剂保持为供应管中的液体，并将返回管线压力保持在大约1个大气压。
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6.发明授权ePTFE small caliber vascular grafts with significant patency enhancement via a surface coating which contains covalently bonded heparin 失效ePTFE小口径血管移植物通过包含共价键合的肝素的表面涂层具有显着的通畅性增强公开(公告)号：US06306165B1
公开(公告)日：2001-10-23
申请号：US08713800
申请日：1996-09-13
IPC分类号： A61F206
CPC分类号： A61L27/34 , A61L27/507 , A61L33/0029 , A61L33/0047 , A61L33/0094
摘要： Disclosed are implantable medical devices with enhanced patency. Expanded polytetrafluoroethylene small caliber vascular grafts coated with polymer bound bio-active agents that exhibit enhanced patency are disclosed. The polymer bound bio-active agents can include anti-thrombogenic agents, antibiotics, antibacterial agents and antiviral agents. Methods of preparing same are also provided.
摘要翻译： 公开了具有增强的通畅的可植入医疗装置。 公开了扩张聚四氟乙烯小口径血管移植物，其涂覆有聚合物结合的生物活性剂，其显示增强的通畅。 聚合物结合的生物活性剂可以包括抗血栓形成剂，抗生素，抗菌剂和抗病毒剂。 还提供了制备方法。
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公开(公告)号：US6080198A
公开(公告)日：2000-06-27
申请号：US964414
申请日：1997-11-04
CPC分类号： A61F2/07 , A61F2/06 , A61F2/88 , A61L27/16 , A61L27/507 , A61F2002/072 , Y10S623/901
摘要： An implantable microporous ePTFE tubular vascular graft exhibits long-term patency, superior radial tensile strength, reduction in tear propagation, and increases in suture retention strength and crush resistance. The graft includes an ePTFE tubular structure having a preselected microporous structure. The tubular structure is wrapped externally with a PTFE yarn in a helical fashion. The helical wrap of yarn is bonded to the exterior surface of the tubular structure by application of heat or heat in combination with force to form a composite structure which substantially maintains the porosity of the underlying tubular structure while increasing the suture retention strength, radial tensile strength, crush resistance, and tear propagation resistance.
摘要翻译： 可植入的微孔ePTFE管状血管移植物显示出长期通畅，优异的径向拉伸强度，撕裂增加的减少，以及缝线保持强度和抗压性的提高。 移植物包括具有预选微孔结构的ePTFE管状结构。 管状结构以螺旋方式用PTFE纱线外部包裹。 通过结合施加热量或热量将纱线的螺旋卷绕结合到管状结构的外表面，以形成复合结构，其基本上保持下面的管状结构的孔隙率，同时增加缝合线保持强度，径向拉伸强度 抗碎裂性和抗撕裂性。
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公开(公告)号：US6001125A
公开(公告)日：1999-12-14
申请号：US40880
申请日：1998-03-18
CPC分类号： A61L27/56 , A61F2/06 , A61L27/16 , A61L27/507 , A61F2002/0086 , A61F2002/072 , Y10S623/901
摘要： An implantable microporous ePTFE tubular vascular graft exhibits long term patency, superior radial tensile strength and suture hole elongation resistance. The graft includes a first ePTFE tube and a second ePTFE tube circumferentially disposed over the first tube. The first ePTFE tube exhibits a porosity sufficient to promote cell endothelization tissue ingrowth and healing. The second ePTFE tube exhibits enhanced radial strength in excess of the radial tensile strength of the first tube. The stent provides patency to the endoprosthesis.
摘要翻译： 可植入的微孔ePTFE管状血管移植物显示出长期通畅性，优异的径向拉伸强度和缝合孔伸长抗性。 移植物包括第一ePTFE管和周向设置在第一管上的第二ePTFE管。 第一个ePTFE管表现出足以促进细胞内皮细胞向内生长和愈合的孔隙度。 第二ePTFE管表现出超过第一管的径向拉伸强度的增强的径向强度。 支架对内假体提供通畅。
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公开(公告)号：US5607478A
公开(公告)日：1997-03-04
申请号：US616047
申请日：1996-03-14
CPC分类号： A61F2/07 , A61F2/06 , A61F2/88 , A61L27/16 , A61L27/507 , A61F2002/072 , Y10S623/901
摘要： An implantable microporous ePTFE tubular vascular graft exhibits long-term patency, superior radial tensile strength, reduction in tear propagation, and increases in suture retention strength and crush resistance. The graft includes an ePTFE tubular structure having a preselected microporous structure. The tubular structure is wrapped externally with a PTFE yarn in a helical fashion. The helical wrap of yarn is bonded to the exterior surface of the tubular structure by application of heat or heat in combination with force to form a composite structure which substantially maintains the porosity of the underlying tubular structure while increasing the suture retention strength, radial tensile strength, crush resistance, and tear propagation resistance.
摘要翻译： 可植入的微孔ePTFE管状血管移植物显示出长期通畅，优异的径向拉伸强度，撕裂增加的减少，以及缝线保持强度和抗压性的提高。 移植物包括具有预选微孔结构的ePTFE管状结构。 管状结构以螺旋方式用PTFE纱线外部包裹。 通过结合施加热量或热量将纱线的螺旋卷绕结合到管状结构的外表面，以形成复合结构，其基本上保持下面的管状结构的孔隙率，同时增加缝合线保持强度，径向拉伸强度 抗碎裂性和抗撕裂性。
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公开(公告)号：US4773902A
公开(公告)日：1988-09-27
申请号：US734817
申请日：1985-05-16
申请人： David J. Lentz , Mohammad A. Khan
发明人： David J. Lentz , Mohammad A. Khan
CPC分类号： A61L31/042 , A61L31/10 , A41D19/0062
摘要： The use of oxidized cellulose as a medical lubricant is disclosed wherein oxidized cellulose is employed as a mold release agent or a donning powder in the manufacture of surgical gloves as well as in other applications; medical devices and, particularly, a surgical glove, are provided having finely divided oxidized cellulose powder on the surface in a lubricity imparting coverage.
摘要翻译： 公开了使用氧化纤维素作为医疗润滑剂，其中在制造手术手套以及其它应用中使用氧化纤维素作为脱模剂或穿戴粉末; 提供医疗装置，特别是手术手套，其具有在润滑性赋予覆盖范围内的表面上细碎的氧化纤维素粉末。
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