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1.发明申请COMPOSITION FOR TREATMENT AND PREVENTION OF HAIR LOSS AND PREMATURE GRAYING OF HAIR 审中-公开用于治疗和预防头发的损失和预防毛发的组合物公开(公告)号：US20110281802A1
公开(公告)日：2011-11-17
申请号：US12745247
申请日：2008-12-01
CPC分类号： A61K38/08 , A61K8/64 , A61K38/2292 , A61Q7/00
摘要： Composition for treatment and prevention of human hair loss and/or hair greying, comprising an effective amount of thymic peptides of the family thymulin, thymosin alpha-1 and thymosin beta-4 and pharmaceutical excipient, diluent or carrier. Method and pharmaceutical composition for treatment and prevention of balding, hair loss, and alopecia.
摘要翻译： 用于治疗和预防人脱发和/或头发变灰的组合物，其包含有效量的家族胸腺素，胸腺素α-1和胸腺素β-4的胸腺肽和药物赋形剂，稀释剂或载体。 用于治疗和预防秃发，脱发和脱发的方法和药物组合物。
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2.发明授权Compounds with a skin pigmenting activity and pharmaceutical or cosmetic compositions containing them 有权具有皮肤着色活性的化合物和含有它们的药物或化妆品组合物公开(公告)号：US09192595B2
公开(公告)日：2015-11-24
申请号：US13807970
申请日：2011-07-15
申请人： Giammaria Giuliani , Ralf Paus , Yuval Ramot , Astrid Becker , Sergio Baroni
发明人： Giammaria Giuliani , Ralf Paus , Yuval Ramot , Astrid Becker , Sergio Baroni
IPC分类号： A61K31/232 , A61K8/36 , A61K8/37 , A61K31/202 , A61Q17/04 , A61Q19/04 , A61K31/192
CPC分类号： A61K31/232 , A61K8/361 , A61K8/37 , A61K31/192 , A61K31/202 , A61Q17/04 , A61Q19/04
摘要： The present invention relates to compounds having general formula (I): CH3—(CH═CH)n—R (I) where: n=3, 5, 7; R is chosen from —CH2—O—CO—R′, —CO—OR′ or —CO—O(−), R′ is chosen from H, C1-C22 alkyl or alkenyl, aryl or aralkyl, or sugars; and their pharmaceutically acceptable salts, such as sodium, potassium and lysine salts, for use as the active ingredient in pharmaceutical or cosmetic compositions for improving the pigmentation of the human skin, treating pigmentation disorders and/or improve both the photoprotective capacity of the skin and the intensity of its suntan.
摘要翻译： 本发明涉及具有通式（I）的化合物：CH 3 - （CH = CH）n -R（I）其中：n = 3,5,7; R选自-CH 2 -O-CO-R'，-CO-OR'或-CO-O（ - ），R'选自H，C 1 -C 22烷基或烯基，芳基或芳烷基或糖; 和其药学上可接受的盐，例如钠，钾和赖氨酸盐，用作药物或化妆品组合物中的活性成分，用于改善人皮肤的色素沉着，治疗色素沉着紊乱和/或改善皮肤的光保护能力和 其防晒的强度。
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公开(公告)号：US20050063931A1
公开(公告)日：2005-03-24
申请号：US10484591
申请日：2002-07-17
申请人： Ralf Paus , Peter Arck
发明人： Ralf Paus , Peter Arck
IPC分类号： A61K8/00 , A61K8/64 , A61K38/03 , A61K38/04 , A61P17/14 , A61Q5/00 , A61Q7/00 , A61K7/06 , A61K7/11 , A61K38/10
CPC分类号： A61K8/64 , A61K38/03 , A61K38/046 , A61Q7/00
摘要： A process for treating hair follicles and their perifollicular region comprising contacting the follicles and the perifollicular region with a composition containing an NK1-receptor antagonist compound.
摘要翻译： 一种治疗毛囊及其滤泡周围区域的方法，包括使所述卵泡和所述滤泡周围区域与含有NK1受体拮抗剂化合物的组合物接触。
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4.发明申请Compounds with a Skin Pigmenting Activity And Pharmaceutical or Cosmetic Compositions Containing Them 有权具有皮肤色素活性的化合物和含有它们的药物或化妆品组合物公开(公告)号：US20130108564A1
公开(公告)日：2013-05-02
申请号：US13807970
申请日：2011-07-15
申请人： Giammaria Giuliani , Ralf Paus , Yuval Ramot , Astrid Becker , Sergio Baroni
发明人： Giammaria Giuliani , Ralf Paus , Yuval Ramot , Astrid Becker , Sergio Baroni
IPC分类号： A61K31/232 , A61K8/37 , A61K31/202 , A61K8/36 , A61K31/192
CPC分类号： A61K31/232 , A61K8/361 , A61K8/37 , A61K31/192 , A61K31/202 , A61Q17/04 , A61Q19/04
摘要： The present invention relates to compounds having general formula (I): CH3—(CH═CH)n—R (I) where: n=3, 5, 7; R is chosen from —CH2—O—CO—R′, —CO—OR′ or —CO—O(−), R′ is chosen from H, C1-C22 alkyl or alkenyl, aryl or aralkyl, or sugars; and their pharmaceutically acceptable salts, such as sodium, potassium and lysine salts, for use as the active ingredient in pharmaceutical or cosmetic compositions for improving the pigmentation of the human skin, treating pigmentation disorders and/or improve both the photoprotective capacity of the skin and the intensity of its suntan.
摘要翻译： 本发明涉及具有通式（I）的化合物：CH 3 - （CH = CH）n -R（I）其中：n = 3,5,7; R选自-CH 2 -O-CO-R'，-CO-OR'或-CO-O（ - ），R'选自H，C 1 -C 22烷基或烯基，芳基或芳烷基或糖; 和其药学上可接受的盐，例如钠，钾和赖氨酸盐，用作药物或化妆品组合物中的活性成分，用于改善人皮肤的色素沉着，治疗色素沉着紊乱和/或改善皮肤的光保护能力和 其防晒的强度。
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公开(公告)号：US20050089512A1
公开(公告)日：2005-04-28
申请号：US10871119
申请日：2004-06-18
CPC分类号： A61F2/10 , A61L27/24 , A61L27/3804 , A61L27/3869 , A61L27/3891 , A61L27/60 , A61L2430/18 , C12N5/0627 , C12N5/0698 , C12N2502/094 , C12N2502/1323
摘要： The invention relates to a skin/hair equivalent, more particularly a hair model with reconstructed papillae (pseudopapillae; PP) in a reconstructed dermis (pseudodermis; PD), to its production and to its use, more particularly for medical/pharmaceutical purposes and for application in the cosmetics industry.
摘要翻译： 本发明涉及一种皮肤/头发当量，更具体地说，在重建的真皮（假性皮肤; PD）中具有重建的乳头（pseudopapillae; PP）的毛发模型，其生产和使用，更特别地用于医疗/药物目的，以及用于 在化妆品行业的应用。
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6.发明申请Pharmaceutical Or Cosmetic Or Dietetic Composition Suitable For Promoting A Hair Pigmentation Effect 审中-公开适用于促进头发着色作用的药物或化妆品或饮食组合物公开(公告)号：US20120121705A1
公开(公告)日：2012-05-17
申请号：US13387352
申请日：2010-07-29
申请人： Ralf Paus , Giammaria Giuliani , Yuval Ramot , Astrid Becker , Sergio Baroni
发明人： Ralf Paus , Giammaria Giuliani , Yuval Ramot , Astrid Becker , Sergio Baroni
IPC分类号： A61K8/41 , A61Q5/02 , A61Q5/06 , A61K8/02 , C07C211/13
CPC分类号： A61K8/41 , A61K8/0212 , A61K8/0225 , A61K8/11 , A61K2800/222 , A61K2800/74 , A61K2800/92 , A61Q5/00 , A61Q5/002 , A61Q5/02 , A61Q5/12
摘要： The invention relates to the use of spermidine or a pharmaceutically acceptable derivative thereof as the active principle in a pharmaceutical, cosmetic or dietetic composition. The composition is used for promoting pigmentation of the hair, particularly the shaft of the hair. The invention also relates to the composition which promotes this pigmentation effect, the composition containing spermidine or a derivative thereof (such as a salt) as an active principle and is intended for topical or oral administration.
摘要翻译： 本发明涉及亚精胺或其药学上可接受的衍生物作为药物，化妆品或饮食组合物中的活性成分的用途。 该组合物用于促进头发，特别是头发的色素沉着。 本发明还涉及促进这种色素沉着效应的组合物，含有亚精胺或其衍生物（例如盐）的组合物作为活性成分并用于局部或口服给药。
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