公开(公告)号：US08706136B2

公开(公告)日：2014-04-22

申请号：US13166609

申请日：2011-06-22

申请人： Fred J. Anderson ,  Michael Adler ,  Sangita Mahishi ,  James C. Nicholson ,  David Alan Case

发明人： Fred J. Anderson ,  Michael Adler ,  Sangita Mahishi ,  James C. Nicholson ,  David Alan Case

IPC分类号： H04W24/00 ,  H04W36/00

CPC分类号： H04W24/02 ,  H04W84/10

摘要： In an example embodiment, a mobile wireless device, such as a mobile telephone, is employed to configure a second wireless device such as an access point. The mobile wireless device determines its location and a regulatory domain corresponding to the location. The mobile wireless device configures the second wireless device to operate in the regulatory domain.

摘要翻译： 在示例实施例中，采用诸如移动电话的移动无线设备来配置诸如接入点的第二无线设备。 移动无线设备确定其位置和对应于该位置的调节域。 移动无线设备将第二无线设备配置为在调节域中操作。

公开(公告)号：US10685129B2

公开(公告)日：2020-06-16

申请号：US15689794

申请日：2017-08-29

申请人： Michael Adler ,  Klaus-Peter Hofmann

发明人： Michael Adler ,  Klaus-Peter Hofmann

IPC分类号： G06F21/60 ,  H04L29/06 ,  G06F21/64 ,  H04L29/08

摘要： A data processing system is provided with a data verification system that is configured to perform a validation check upon receipt of a request from a field device to transfer data to the data processing system. The data verification system is also configured to verify a permission of the field device to exchange data and to validate the data integrity. A data landing zone is provided for temporary storage of the data in the event that a validation check fails, so that data errors may be corrected.

公开(公告)号：US20180060594A1

公开(公告)日：2018-03-01

申请号：US15689794

申请日：2017-08-29

申请人： Michael Adler ,  Klaus-Peter Hofmann

发明人： Michael Adler ,  Klaus-Peter Hofmann

IPC分类号： G06F21/60 ,  G06F21/64

摘要： A data processing system is provided with a data verification system that is configured to perform a validation check upon receipt of a request from a field device to transfer data to the data processing system. The data verification system is also configured to verify a permission of the field device to exchange data and to validate the data integrity. A data landing zone is provided for temporary storage of the data in the event that a validation check fails, so that data errors may be corrected.

公开(公告)号：US09021878B2

公开(公告)日：2015-05-05

申请号：US13642602

申请日：2011-04-04

申请人： Mor Grinstein ,  Jack Yehoshua Mantinband ,  Shmuel Bentov ,  Michael Adler

发明人： Mor Grinstein ,  Jack Yehoshua Mantinband ,  Shmuel Bentov ,  Michael Adler

IPC分类号： G01F1/684 ,  G01F23/26 ,  A61B5/20 ,  G01F1/00

CPC分类号： G01F23/266 ,  A61B5/208 ,  A61B2562/0271 ,  G01F1/007 ,  G01F1/684

摘要： The present invention is flow rate meters which are able to accurately measure the volumetric rate of flow of a liquid through a conduit without requiring foreknowledge of the physicochemical characteristics of the liquid, e.g., for the purpose of calibration of the thermal mass flow rate. One application of the flow meters of the invention is to incorporate them in a system for measuring the flow rate of urine excreted by a catheterized patient. The invention also provides methods for using the flow rate meters.

摘要翻译： 本发明是流量计，其能够精确地测量通过管道的液体的体积流速，而不需要预先知道液体的物理化学特性，例如用于校准热质量流量的目的。 本发明的流量计的一个应用是将它们并入用于测量由导管的患者排泄的尿液的流量的系统中。 本发明还提供了使用流量计的方法。

公开(公告)号：US08840351B2

公开(公告)日：2014-09-23

申请号：US12728355

申请日：2010-03-22

申请人： Michael Adler ,  Frank Sommerer ,  Andreas Steinert

发明人： Michael Adler ,  Frank Sommerer ,  Andreas Steinert

IPC分类号： B42C13/00 ,  B42C9/00 ,  B42C11/00 ,  B42C11/02 ,  B42B5/00 ,  B42C19/08 ,  B42C1/12

CPC分类号： B42C19/08 ,  B42C1/12 ,  B42C9/0037 ,  Y10S412/901 ,  Y10S412/902

摘要： A book binding machine includes a collating machine, a perfect binder and a transfer device disposed between the collating machine and the perfect binder. The collating machine and the perfect binder are actuated by a common control device. In each case, one transport segment is assigned to a respective book block clamp by the control device. The control device also has a program which, if a defective or missing book block clamp is detected, actuates the collating machine in such a way that no book block is collated for that book block clamp. A method for operating a book binding machine is also provided.

摘要翻译： 书籍装订机包括整理机，完美的装订器和设置在整理机和完美的装订器之间的传送装置。 整理机和完美的装订器由公共控制装置致动。 在每种情况下，通过控制装置将一个传送段分配给相应的书本夹具。 控制装置还具有程序，如果检测到有缺陷或缺失的书夹夹具，则使得对照机器以对于该书夹夹不整理书本块的方式启动。 还提供了一种操作装订机的方法。

公开(公告)号：US20120163942A1

公开(公告)日：2012-06-28

申请号：US13406097

申请日：2012-02-27

申请人： Michael Adler ,  Rolf Boettcher

发明人： Michael Adler ,  Rolf Boettcher

IPC分类号： B42B5/00

CPC分类号： B42C19/08

摘要： A book binding machine includes a book block transport system and a plurality of clamps for clamping stacks of leaves. The clamps are disposed at a distance from each other and are guided in guide tracks of a machine frame. The book block transport system includes a clamp, which is also referred to as a lubrication clamp, having a device for lubricating the guide track. An applicator is assigned to each track roller of the clamp, and the lubricant is transferred to the track rollers through the use of a respective applicator such as a brush. The track rollers transfer the lubricant to contact surfaces of the guide track. A lubrication clamp for a book block transport system in a book binding machine, is also provided.

摘要翻译： 书籍装订机包括书本传送系统和用于夹紧叶片堆叠的多个夹具。 夹具彼此间隔一定距离设置，并在机架的导轨中引导。 书本传送系统包括一个也被称为润滑夹具的夹具，具有用于润滑导轨的装置。 涂抹器被分配给夹具的每个履带辊，并且润滑剂通过使用相应的施加器例如刷子被传送到履带辊。 滚轮将润滑剂转移到导轨的接触表面。 还提供了一种用于书本装订机中的书本传送系统的润滑夹具。

公开(公告)号：US20090047101A1

公开(公告)日：2009-02-19

申请号：US12190679

申请日：2008-08-13

申请人： Michael Adler ,  Rolf Bottcher

发明人： Michael Adler ,  Rolf Bottcher

IPC分类号： B42C13/00 ,  F16N13/22

CPC分类号： B42C19/08

摘要： A book binding machine includes a book block transport system and a plurality of clamps for clamping stacks of leaves. The clamps are disposed at a distance from each other and are guided in guide tracks of a machine frame. The book block transport system includes a clamp, which is also referred to as a lubrication clamp, having a device for lubricating the guide track. An applicator is assigned to each track roller of the clamp, and the lubricant is transferred to the track rollers through the use of a respective applicator such as a brush. The track rollers transfer the lubricant to contact surfaces of the guide track. A lubrication clamp for a book block transport system in a book binding machine, is also provided.

摘要翻译： 书籍装订机包括书本传送系统和用于夹紧叶片堆叠的多个夹具。 夹具彼此间隔一定距离设置，并在机架的导轨中引导。 书本传送系统包括一个也被称为润滑夹具的夹具，具有用于润滑导轨的装置。 涂抹器被分配给夹具的每个履带辊，并且润滑剂通过使用相应的施加器例如刷子被传送到履带辊。 滚轮将润滑剂转移到导轨的接触表面。 还提供了一种用于书本装订机中的书本传送系统的润滑夹具。

公开(公告)号：US20080289542A1

公开(公告)日：2008-11-27

申请号：US11547586

申请日：2005-04-05

申请人： Suz-Chung Ko ,  Michael Adler ,  Juraj Gebauer

发明人： Suz-Chung Ko ,  Michael Adler ,  Juraj Gebauer

IPC分类号： C04B28/14 ,  C04B28/06 ,  C04B18/06

CPC分类号： C04B7/21 ,  C04B28/08 ,  C04B28/14 ,  Y02P40/143 ,  Y02W30/92 ,  Y02W30/94 ,  C04B14/041 ,  C04B14/06 ,  C04B22/062 ,  C04B22/143 ,  C04B2103/12 ,  C04B2103/32 ,  C04B14/14 ,  C04B14/28 ,  C04B22/10 ,  C04B2103/30 ,  C04B7/02 ,  C04B18/08 ,  C04B18/141

摘要： In a hydraulic binder containing slags, aluminium-silicates and calcium sulphate, slag, in particular furnace slag, in amounts below 50% (w/w) as well as aluminium-silicates different from furnace slag, as for example flue-ash and natural aluminium-silicates, as for example basalt or andesite, in amounts of 5 to 75% (w/w) respectively related to the entire blend with the requirement that the stm of slag and aluminium-silicates is between 82 and 95.9% (w/w) and as one of the activators CaSO4 in amounts between 4 and 15% (w/w) as essential components are present. Additionally alkali activators, in particular alkali hydroxides and/or carbonates of Na and/or K in amounts from 0.1 to 3% (w/w) are deployed.

摘要翻译： 在含有炉渣，铝硅酸盐和硫酸钙的水泥粘合剂中，炉渣，特别是炉渣，含量低于50％（w / w）以及不同于炉渣的铝硅酸盐，例如烟灰和天然 分别与全部混合物相关的5至75％（w / w）的量的硅酸铝，例如玄武岩或安山岩，要求炉渣和硅铝酸盐的含量为82至95.9％（w / w），并且作为其中一种活化剂CaSO 4的量为4至15％（w / w）作为必需组分。 此外，部署碱金属活化剂，特别是Na和/或K的碱金属氢氧化物和/或碳酸盐，其量为0.1至3％（w / w）。

公开(公告)号：US09345661B2

公开(公告)日：2016-05-24

申请号：US12804703

申请日：2010-07-27

申请人： Michael Adler ,  Ulla Grauschopf ,  Hanns-Christian Mahler ,  Oliver Boris Stauch

发明人： Michael Adler ,  Ulla Grauschopf ,  Hanns-Christian Mahler ,  Oliver Boris Stauch

IPC分类号： C07K16/00 ,  A61K9/00 ,  A61K9/19 ,  A61K39/395 ,  A61K47/18 ,  A61K47/26 ,  A61K47/42 ,  C07K16/32

CPC分类号： A61K39/39558 ,  A61K9/0019 ,  A61K9/08 ,  A61K9/19 ,  A61K38/47 ,  A61K39/39591 ,  A61K45/06 ,  A61K47/18 ,  A61K47/183 ,  A61K47/26 ,  A61K47/42 ,  C07K16/32 ,  C12Y302/01035

摘要： The present invention relates to a highly concentrated, stable pharmaceutical formulation of a pharmaceutically active anti-HER2 antibody, such as e.g. Trastuzumab (HERCEPTIN™), Pertuzumab or T-DM1, or a mixture of such antibody molecules for subcutaneous injection. In particular, the present invention relates to formulations comprising, in addition to a suitable amount of the anti-HER2 antibody, an effective amount of at least one hyaluronidase enzyme as a combined formulation or for use in form of a co-formulation. The formulations comprise additionally at least one buffering agent, such as e.g. a histidine buffer, a stabilizer or a mixture of two or more stabilizers (e.g. a saccharide, such as e.g. α,α-trehalose dihydrate or sucrose, and optionally methionine as a second stabilizer), a nonionic surfactant and an effective amount of at least one hyaluronidase enzyme. Methods for preparing such formulations and their uses thereof are also provided.

摘要翻译： 本发明涉及药物活性抗HER2抗体的高浓度，稳定的药物制剂，例如， 曲妥珠单抗（HERCEPTIN TM），Pertuzumab或T-DM1，或用于皮下注射的这种抗体分子的混合物。 特别地，本发明涉及包含除合适量的抗HER2抗体之外的有效量的至少一种透明质酸酶作为组合制剂或用于共同制剂形式的制剂。 制剂还包含至少一种缓冲剂，例如， 组氨酸缓冲液，稳定剂或两种或更多种稳定剂的混合物（例如糖，例如α，α-海藻糖二水合物或蔗糖，以及任选的甲硫氨酸作为第二稳定剂），非离子表面活性剂和有效量的至少 一种透明质酸酶。 还提供了制备这些制剂的方法及其用途。

公开(公告)号：US20140116128A1

公开(公告)日：2014-05-01

申请号：US14125348

申请日：2012-06-21

申请人： Jack Yehoshua Mantinband ,  Michael Adler

发明人： Jack Yehoshua Mantinband ,  Michael Adler

IPC分类号： G01F1/68

CPC分类号： G01F1/68 ,  A61B5/208 ,  G01F1/6847 ,  G01F1/69 ,  G01F1/6965 ,  G01F1/6986

摘要： The invention is an apparatus and method for measuring the flow rate of a liquid through a conduit. The apparatus is based on a flow rate meter which is adapted to accurately measure the volumetric flow rate of a liquid using a simple, cost and energy effective, and accurate method using only one temperature sensor. The method is based on applying a pulse of thermal energy to the flowing liquid and measuring the temperature increase as a function of time and energy input. By comparing these measurements to a calibration table made by performing similar measurements for known flow rates, the rate of flow can be determined. One application, which will be described to illustrate the features of the method and apparatus of the invention, is measurement of the flow rate of urine excreted by a catheterized patient.

摘要翻译： 本发明是用于测量通过导管的液体流速的装置和方法。 该装置基于流量计，其适于使用仅使用一个温度传感器的简单，成本和能量有效且准确的方法来精确地测量液体的体积流量。 该方法基于对流动液体施加热能脉冲并且根据时间和能量输入测量温度升高。 通过将这些测量值与通过对已知流速进行相似测量而产生的校准表进行比较，可以确定流量。 将描述用于说明本发明的方法和装置的特征的一个应用是测量由导管的患者排泄的尿液的流量。