公开(公告)号：US07619016B2

公开(公告)日：2009-11-17

申请号：US10883011

申请日：2004-07-02

申请人： Sabine H. Dickens ,  Frederick C. Eichmiller

发明人： Sabine H. Dickens ,  Frederick C. Eichmiller

IPC分类号： A61K6/083 ,  A61C5/00

CPC分类号： A61K6/06 ,  A61K6/0017 ,  A61K6/0023 ,  A61K6/083 ,  A61K6/09 ,  C08L33/00 ,  C08L75/16

摘要： Remineralizing dental cements contain source(s) of calcium and phosphate ions, adhesive resin monomers, reinforcing base resin monomers, and catalysts able to initiate the polymerization of the adhesive and reinforcing base resin monomers. Such dental cements can be used as orthodontic cements, crown and bridge cements, adhesives, sealants, cavity liners, and protective coatings. The release of calcium and phosphate ions and, optionally, fluoride ions, protects tooth structure from demineralization, a precursor of tooth decay.

摘要翻译： 再矿化牙科水泥包含钙和磷酸根离子的来源，粘合树脂单体，增强基础树脂单体和能够引发粘合剂聚合和增强基础树脂单体的催化剂。 这种牙科用水泥可以用作正畸水泥，冠和桥接水泥，粘合剂，密封剂，空腔衬垫和保护涂层。 钙和磷酸根离子以及任选的氟离子的释放可保护牙齿结构免受脱朽作用，这是蛀牙的前体。

公开(公告)号：US5711866A

公开(公告)日：1998-01-27

申请号：US437817

申请日：1995-05-09

申请人： David S. Lashmore ,  Moshe P. Dariel ,  Christian E. Johnson ,  Menahem B. Ratzker ,  Anthony A. Giuseppetti ,  Frederick C. Eichmiller ,  Glenn L. Beane ,  David R. Kelley

发明人： David S. Lashmore ,  Moshe P. Dariel ,  Christian E. Johnson ,  Menahem B. Ratzker ,  Anthony A. Giuseppetti ,  Frederick C. Eichmiller ,  Glenn L. Beane ,  David R. Kelley

IPC分类号： A61K6/04 ,  B22F1/00 ,  B22F1/02 ,  B22F3/22 ,  C22C1/04 ,  C22C1/10 ,  C22C47/00 ,  C22C47/14 ,  C23C30/00 ,  C25F1/00 ,  A61C5/04

CPC分类号： C22C1/10 ,  A61K6/0008 ,  A61K6/04 ,  A61K6/043 ,  A61K6/046 ,  B22F1/0088 ,  B22F1/025 ,  B22F3/22 ,  C22C1/0466 ,  C22C47/00 ,  C22C47/14 ,  C23C30/00 ,  B22F2998/00

摘要： A metallic composite solid, containing alloys and/or intermetallics, is formed by compacting at moderate pressure a mixture of powder particles, foils or sheets at a temperature close to room temperature, well below the melting temperature of the constituent components and without the addition of low melting metals such as mercury, indium or gallium acting as a sintering agent. This low temperature consolidation of the powder mixture is enhanced by having the surface oxide of the powder particles removed, prior to consolidation, and/or by coating the particles with an oxide-replacing metal such as silver or gold. The coating process may be replacement reactions, autocatalytic reduction or electrolytic reduction. The composite formation is assisted by the addition of a liquid acid such as fluoroboric acid, sulfuric acid, fluoric acid, adipic acid, ascorbic acid, or nitric acid. A preferred embodiment of the process for metal solid composite formation is a process for forming dental restorative materials at ambient temperatures and under pressure exerted by manual dental instrumentation.

公开(公告)号：US6001289A

公开(公告)日：1999-12-14

申请号：US317729

申请日：1994-10-04

申请人： David S. Lashmore ,  Moshe P. Dariel ,  Christian E. Johnson ,  Menahem B. Ratzker ,  Anthony A. Guiseppetti ,  Frederick C. Eichmiller ,  Glenn L. Beane ,  David R. Kelley

发明人： David S. Lashmore ,  Moshe P. Dariel ,  Christian E. Johnson ,  Menahem B. Ratzker ,  Anthony A. Guiseppetti ,  Frederick C. Eichmiller ,  Glenn L. Beane ,  David R. Kelley

IPC分类号： A61K6/04 ,  B22F1/00 ,  B22F1/02 ,  B22F3/22 ,  C22C1/04 ,  C22C1/10 ,  C22C47/00 ,  C22C47/14 ,  C23C30/00 ,  B27N3/02 ,  B05D1/18 ,  B05D3/10

CPC分类号： C22C1/10 ,  A61K6/0008 ,  A61K6/04 ,  A61K6/043 ,  A61K6/046 ,  B22F1/0088 ,  B22F1/025 ,  B22F3/22 ,  C22C1/0466 ,  C22C47/00 ,  C22C47/14 ,  C23C30/00 ,  B22F2998/00

摘要： A metallic composite solid, containing alloys and/or intermetallics, is formed by compacting at moderate pressure a mixture of powder particles, foils or sheets at a temperature close to room temperature, well below the melting temperature of the constituent components and without the addition of low melting metals such as mercury, indium or gallium acting as a sintering agent. This low temperature consolidation of the powder mixture is enhanced by having the surface oxide of the powder particles removed, prior to consolidation, and/or by coating the particles with an oxide-replacing metal such as silver or gold. The coating process may be replacement reactions, autocatalytic reduction or electrolytic reduction. The composite formation is assisted by the addition of a liquid acid such as fluoroboric acid, sulfuric acid, fluoric acid, adipic acid, ascorbic acid, or nitric acid. A preferred embodiment of the process for metal solid composite formation is a process for forming dental restorative materials at ambient temperatures and under pressure exerted by manual dental instrumentation.

摘要翻译： 含有合金和/或金属间化合物的金属复合固体通过在接近于室温的温度下在中等压力下压制粉末颗粒，箔或片的混合物而形成，远低于构成组分的熔融温度，并且不添加 作为烧结剂的低熔点金属如汞，铟或镓。 通过在固化之前除去粉末颗粒的表面氧化物和/或通过用诸如银或金的氧化物置换金属涂覆颗粒来增强粉末混合物的低温固化。 涂覆过程可以是替代反应，自动催化还原或电解还原。 通过加入液体酸如氟硼酸，硫酸，氟酸，己二酸，抗坏血酸或硝酸来辅助复合物形成。 用于金属固体复合材料形成的方法的优选实施方案是在环境温度和手动牙科仪器施加的压力下形成牙修复材料的方法。

公开(公告)号：US07018460B2

公开(公告)日：2006-03-28

申请号：US10975190

申请日：2004-10-28

申请人： Huakun Xu ,  Laurence C. Chow ,  Shozo Takagi ,  Frederick C. Eichmiller

发明人： Huakun Xu ,  Laurence C. Chow ,  Shozo Takagi ,  Frederick C. Eichmiller

IPC分类号： C04B12/02

CPC分类号： A61L27/425 ,  A61F2/28 ,  A61F2/30965 ,  A61F2002/2835 ,  A61F2002/30032 ,  A61F2002/30062 ,  A61F2002/30069 ,  A61F2002/30971 ,  A61F2210/0004 ,  A61F2250/003 ,  A61F2310/00293 ,  A61L2430/02

摘要： A bone replacement material and therapy comprises the combination of calcium phosphate compounds and two or more soluble fillers in the form of fibers, mesh or other materials which have the dual functions of reinforcing an in vivo implant while dissolving at a programmed rate to form macropores capable of receiving natural bone ingrowth.

公开(公告)号：US06334775B2

公开(公告)日：2002-01-01

申请号：US09250690

申请日：1999-02-16

申请人： Huakun Xu ,  Frederick C. Eichmiller ,  Gary E. Schumacher

发明人： Huakun Xu ,  Frederick C. Eichmiller ,  Gary E. Schumacher

IPC分类号： A61C500

CPC分类号： A61K6/0835 ,  A61C5/00 ,  A61C5/007 ,  A61C5/30 ,  C08L33/00

摘要： Continuous fibers, resin-fiber pastes, or continuous fiber-reinforced preforms are inserted into tooth cavities to form high-strength dental restorations. The fibers may be mixed or coated with a resin monomer and may be used with fillers such as fluoride-releasing fillers and colorants. The resin-fiber mixture may be hardened into preforms suitable for inserting into tooth cavities. Conventional filling materials such as composite resins and glass ionomers may be used to complete the restoration. Other applications include endodontic posts, retention pins, provisional restorations, and indirect restorations. Fiber reinforcement results in strength, toughness and elastic modulus (stiffness) several times greater than those of currently available direct-filling composite resins. The fiber performs are easily handled and placed into tooth cavities; the restorations are aesthetic and wear compatible, and release fluoride. The final restoration has significantly reduced polymerization shrinkage because the fiber preform can be pre-hardened and therefore will shrink little during hardening of the final restoration.

摘要翻译： 将连续纤维，树脂纤维浆料或连续纤维增强的预成型件插入牙齿腔以形成高强度牙科修复体。 纤维可以与树脂单体混合或涂覆，并且可以与填料如氟化物释放填料和着色剂一起使用。 树脂纤维混合物可以硬化成适合于插入牙齿腔的预成型件。 常规的填充材料如复合树脂和玻璃离聚物可用于完成修复。 其他应用包括根管柱，保留针，临时修复和间接修复。 纤维增强导致强度，韧性和弹性模量（刚度）比目前可用的直接填充复合树脂的几倍大。 纤维表面易于处理并放入牙腔; 修复体是美观和兼容的，并释放氟化物。 最终的修复可以显着降低聚合收缩率，因为纤维预制件可以被预硬化，因此在最终的修复体的硬化期间几乎不会收缩。

公开(公告)号：US06955716B2

公开(公告)日：2005-10-18

申请号：US10086484

申请日：2002-03-01

申请人： Huakun Xu ,  Laurence C. Chow ,  Shozo Takagi ,  Frederick C. Eichmiller

发明人： Huakun Xu ,  Laurence C. Chow ,  Shozo Takagi ,  Frederick C. Eichmiller

IPC分类号： A61F2/00 ,  A61F2/02 ,  A61F2/28 ,  A61F2/30 ,  A61L27/42 ,  C04B12/02

CPC分类号： A61L27/425 ,  A61F2/28 ,  A61F2/30965 ,  A61F2002/2835 ,  A61F2002/30032 ,  A61F2002/30062 ,  A61F2002/30069 ,  A61F2002/30971 ,  A61F2210/0004 ,  A61F2250/003 ,  A61F2310/00293 ,  A61L2430/02

摘要： A bone replacement material and therapy comprises the combination of calcium phosphate compounds and two or more soluble fillers in the form of fibers, mesh or other materials which have the dual functions of reinforcing an in vivo implant while dissolving at a programmed rate to form macropores capable of receiving natural bone ingrowth.

摘要翻译： 骨替代材料和治疗包括磷酸钙化合物和纤维，网状物或其他材料形式的两种或更多种可溶性填料的组合，其具有增强体内植入物的双重功能，同时以编程速率溶解以形成具有足够能力的大孔 接受天然骨向内生长。

公开(公告)号：US06871550B2

公开(公告)日：2005-03-29

申请号：US10640774

申请日：2003-08-14

申请人： Frederick C. Eichmiller

发明人： Frederick C. Eichmiller

IPC分类号： A61K6/00 ,  G01N3/00 ,  G01N3/08 ,  G01N3/008

CPC分类号： G01N3/08 ,  G01N2203/0016 ,  G01N2203/0033 ,  G01N2203/0092

摘要： An apparatus and method for measuring the characteristics of curing polymers. The apparatus and method utilize cantilever beam technology to determine characteristics of polymers during the curing process, including but not limited to, stress-related forces that develop during the polymer curing process. The apparatus and method also provide for controlling and monitoring environmental conditions during the curing process.

摘要翻译： 用于测量固化聚合物特性的装置和方法。 该设备和方法利用悬臂梁技术来确定聚合物在固化过程中的特性，包括但不限于在聚合物固化过程中产生的应力相关力。 该设备和方法还提供了在固化过程中控制和监测环境条件。

公开(公告)号：US06458869B1

公开(公告)日：2002-10-01

申请号：US09537703

申请日：2000-03-30

申请人： Joseph M. Antonucci ,  Frederick C. Eichmiller ,  Gary E. Schumacher

发明人： Joseph M. Antonucci ,  Frederick C. Eichmiller ,  Gary E. Schumacher

IPC分类号： A61K724

CPC分类号： A61K6/0029 ,  A61K6/0023 ,  A61K6/0052 ,  A61K6/083 ,  C08L33/10

摘要： The present invention is directed to an etchant/primer composition, an etchant/primer/adhesive monomer composition, kits using the same and methods using the same for improved bonding to dental structures. The etchant/primer composition comprises a compound having the formula: RN(CH2YCO2M)2 wherein R=R1 or R2; R1=an aromatic group; R2=a conjugated unsaturated aliphatic group; Y=a single bond, CH2, CHCH3 or C═CH2; and each M is independently H, an alkali metal, an alkaline earth metal, aluminum, a transition or redox metal or an alkyl group having 1 to 18 carbon atoms, with the proviso that when both M groups are alkyl groups, said compound is capable of being easily hydrolyzed, displaced, or exchanged with other reagents present in the etchant/primer composition, a polar solvent system, and nitric acid. The etchant/primer/adhesive monomer composition comprises a compound having the formula (I) as noted above, a polar solvent system, an acid selected from the group consisting of nitric acid, hydrochloric acid, citric acid, lactic acid, glycolic acid, formic acid, pyruvic acid and combinations thereof, and adhesive monomer resin, and an initiator. The above-noted compositions are applied to dental structures requiring dental restoration for improved bonding of adhesive resins and polymers to dental structures.

摘要翻译： 本发明涉及一种蚀刻剂/底漆组合物，蚀刻剂/底漆/粘合剂单体组合物，使用该组合物的试剂盒以及使用该蚀刻剂/底漆/粘合剂单体组合物的方法，以改进与牙科结构的结合。 蚀刻剂/底漆组合物包含具有下式的化合物：其中R = R 1或R 2; R 1 =芳族基团; R 2 =共轭不饱和脂族基; Y =单键，CH 2，CHCH 3或C = CH 2; M独立地为H，碱金属，碱土金属，铝，过渡金属或氧化还原金属或具有1至18个碳原子的烷基，条件是当两个M基都是烷基时，所述化合物能够 易于水解，置换或与存在于蚀刻剂/底漆组合物中的其它试剂，极性溶剂体系和硝酸交换。 蚀刻剂/底漆/粘合剂单体组合物包含如上所述的具有式（I）的化合物，极性溶剂体系，选自硝酸，盐酸，柠檬酸，乳酸，乙醇酸，甲酸的酸 酸，丙酮酸及其组合，以及粘合单体树脂和引发剂。 将上述组合物应用于需要牙齿修复的牙科结构，以改善粘合剂树脂和聚合物与牙科结构的粘合。

公开(公告)号：US06375894B1

公开(公告)日：2002-04-23

申请号：US08437650

申请日：1995-05-09

申请人： David S. Lashmore ,  Moshe P. Dariel ,  Christian E. Johnson ,  Menahem B. Ratzker ,  Anthony A. Guiseppetti ,  Frederick C. Eichmiller ,  Glenn L. Beane ,  David R. Kelley

发明人： David S. Lashmore ,  Moshe P. Dariel ,  Christian E. Johnson ,  Menahem B. Ratzker ,  Anthony A. Guiseppetti ,  Frederick C. Eichmiller ,  Glenn L. Beane ,  David R. Kelley

IPC分类号： A61C500

CPC分类号： C22C1/10 ,  A61K6/0008 ,  A61K6/04 ,  A61K6/043 ,  A61K6/046 ,  B22F1/0088 ,  B22F1/025 ,  B22F3/22 ,  B22F2998/00 ,  C22C1/0466 ,  C22C47/00 ,  C22C47/14 ,  C23C30/00 ,  B22F3/225 ,  B22F3/20 ,  B22F3/227

摘要： A metallic composite solid, containing alloys and/or intermetallics, is formed by compacting at moderate pressure a mixture of powder particles, foils or sheets at a temperature close to room temperature, well below the melting temperature of the constituent components and without the addition of low melting metals such as mercury, indium or gallium acting as a sintering agent. This low temperature consolidation of the powder mixture is enhanced by having the surface oxide of the powder particles removed, prior to consolidation, and/or by coating the particles with an oxide-replacing metal such as silver or gold. The coating process may be replacement reactions, autocatalytic reduction or electrolytic reduction. The composite formation is assisted by the addition of a liquid acid such as fluoroboric acid, sulfuric acid, fluoric acid, adipic acid, ascorbic acid, or nitric acid. A preferred embodiment of the process for metal solid composite formation is a process for forming dental restorative materials at ambient temperatures and under pressure exerted by manual dental instrumentation.

公开(公告)号：US5861445A

公开(公告)日：1999-01-19

申请号：US852900

申请日：1997-05-08

申请人： Huakun Xu ,  Frederick C. Eichmiller

发明人： Huakun Xu ,  Frederick C. Eichmiller

IPC分类号： A61K6/083 ,  C03C14/00 ,  C08K7/02 ,  C08K9/00 ,  C08K3/40

CPC分类号： A61K6/083 ,  A61K6/0008 ,  A61K6/0205 ,  A61K6/0835 ,  C03C14/002 ,  C03C14/004 ,  C08K7/02 ,  C03C2214/03 ,  C03C2214/07 ,  C03C2214/30

摘要： A composition useful as a restorative material includes a curable matrix with whiskers which preferably have a silicon dioxide containing coating thereon that are then silanized and may also include optional particulate filler of the type which may release fluorides. The polymeric matrix bonds more tightly to the whiskers due to the coating of silicon dioxide on the surface of the whiskers and the coaction between said silicon dioxide and the silane compound. Particles adhered to the whisker also enhance the mechanical properties by virtue of the whisker's surface being thereby roughened. A method of manufacture is also disclosed.

摘要翻译： 可用作修复材料的组合物包括具有晶须的可固化基质，其中优选其上含有二氧化硅的涂层然后被硅烷化，并且还可以包括可以释放氟化物的任选的颗粒填料。 由于在晶须的表面上涂覆二氧化硅和所述二氧化硅和硅烷化合物之间的共同作用，所以聚合物基体与晶须更紧密地结合。 粘附在晶须上的颗粒也会因晶须的表面被粗糙化而增强机械性能。 还公开了一种制造方法。