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1.Adhesin antigens, antibodies and DNA fragment encoding the antigen, methods and means for diagnosis and immunization etc. 失效
标题翻译: 粘附素抗原,抗体和编码抗原的DNA片段,诊断和免疫的方法和手段等公开(公告)号:US4795803A
公开(公告)日:1989-01-03
申请号:US817849
申请日:1986-02-19
申请人: Frederick C. Lindberg , Bjorn O. Lund , Britt M. Baga , Mari E. Norgren , Mikael Goransson , Bernt E. Uhlin , Jan S. Normark , David L. Lark
发明人: Frederick C. Lindberg , Bjorn O. Lund , Britt M. Baga , Mari E. Norgren , Mikael Goransson , Bernt E. Uhlin , Jan S. Normark , David L. Lark
IPC分类号: G01N33/531 , A61K20060101 , A61K39/00 , A61K39/02 , A61K39/108 , A61P31/04 , C07H20060101 , C07H21/04 , C07K20060101 , C07K14/00 , C07K14/195 , C07K14/21 , C07K14/22 , C07K14/235 , C07K14/24 , C07K14/245 , C07K14/31 , C07K14/315 , C07K14/41 , C07K16/00 , C07K16/12 , C12N20060101 , C12N5/00 , C12N5/10 , C12N15/00 , C12N15/09 , C12N15/31 , C12N15/62 , C12P20060101 , C12P21/00 , C12P21/02 , C12P21/08 , C12R1/01 , C12R1/125 , C12R1/19 , C12R1/36 , C12R1/38 , C12R1/44 , C12R1/46 , G01N33/569 , C07K15/00 , C07K15/04
CPC分类号: C07K14/24 , C07K14/21 , C07K14/22 , C07K14/235 , C07K14/245 , C07K14/31 , C07K14/315 , A61K39/00 , C07K2319/00 , C07K2319/33 , C07K2319/40 , Y10S435/82 , Y10S530/806 , Y10S530/825
摘要: An antigen which, as its major immunizing component, comprises a determinant of an adhesin polypeptide or an immunogenically active subsequence thereof or a precursor therefor which is convertible to an immunogenically active form, antibodies against which determinant react with the adhesion polypeptide produced by pathogenic adhesin-forming bacteria which adhere to mammalian tissue, antibodies against such antigen, and DNA expressing, as a principal gene product thereof, such antigen.
摘要翻译: PCT No.PCT / DK85 / 00045 Sec。 371日期1986年2月19日 102(e)日期1986年2月19日PCT提交1985年5月2日PCT公布。 第WO85 / 05037号公报 日期:1985年11月21日。作为其主要免疫组分的抗原包含可转化为免疫原性活性形式的粘附素多肽或其免疫原性活性亚序列或其前体的决定簇,其决定簇与 由附着于哺乳动物组织的病原性粘附素形成细菌产生的粘附多肽,抗这种抗原的抗体,以及表达作为其主要基因产物的DNA。