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公开(公告)号:US20100256115A1
公开(公告)日:2010-10-07
申请号:US12727218
申请日:2010-03-18
申请人: Frederick Cohen , Kurt Deshayes , Wayne J. Fairbrother , Bainian Feng , John A. Flygare , Lewis J. Gazzard , Vickie Hsiao-Wei Tsui
发明人: Frederick Cohen , Kurt Deshayes , Wayne J. Fairbrother , Bainian Feng , John A. Flygare , Lewis J. Gazzard , Vickie Hsiao-Wei Tsui
IPC分类号: A61K31/55 , C07D209/48 , A61K31/4035 , C07D277/06 , A61K31/427 , C07D487/04 , C07D231/40 , C07D285/06 , A61K31/4155 , A61K31/433 , C07D207/323 , A61K31/40 , C07D249/06 , A61K31/4192 , C07D261/14 , A61K31/42 , C07D257/06 , A61K31/41 , C07D271/04 , A61K31/4245 , C07D417/04 , A61K31/4439 , A61P35/00 , C12N5/071
CPC分类号: C07D417/14 , A61K31/55 , A61K38/177 , C07D403/12 , C07D413/12 , C07D417/04 , C07D417/12 , C07D495/04 , C07D513/04 , C07K5/06026 , C07K5/0806 , C07K5/0827 , C07K7/06 , C12N5/0693
摘要: The invention provides novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies where the compounds have the general formula I: wherein X, Y, A, R1, R2, R3, R4, R4′, R5, R5′, R6 and R6′ are as described herein.
摘要翻译: 本发明提供了可用作治疗恶性肿瘤的治疗剂的新的IAP抑制剂,其中化合物具有通式I:其中X,Y,A,R 1,R 2,R 3,R 4,R 4',R 5,R 5',R 6和 R6'如本文所述。
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公开(公告)号:US20120202750A1
公开(公告)日:2012-08-09
申请号:US13356556
申请日:2012-01-23
申请人: Frederick Cohen , Kurt Deshayes , Wayne J. Fairbrother , Bainian Feng , John A. Flygare , Lewis J. Gazzard , Vickie Hsiao-Wei Tsui
发明人: Frederick Cohen , Kurt Deshayes , Wayne J. Fairbrother , Bainian Feng , John A. Flygare , Lewis J. Gazzard , Vickie Hsiao-Wei Tsui
IPC分类号: C07D401/12 , A61K38/06 , A61K31/55 , C12N5/09 , A61K31/42 , A61K31/433 , A61K31/4436 , C07D285/10 , A61K31/426 , C07D261/14 , C07D271/08 , A61K31/415 , A61K31/381 , C07K5/08 , C07D513/04 , A61P35/04 , C07D417/04 , A61K31/4245 , C07D417/12 , C07D277/18 , C07D257/06 , A61K31/41 , C07D249/04 , C07D333/36 , A61K31/506
CPC分类号: C07D417/14 , A61K31/55 , A61K38/177 , C07D403/12 , C07D413/12 , C07D417/04 , C07D417/12 , C07D495/04 , C07D513/04 , C07K5/06026 , C07K5/0806 , C07K5/0827 , C07K7/06 , C12N5/0693
摘要: The invention provides novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies where the compounds have the general formula I: wherein X, Y, A, R1, R2, R3, R4, R4′, R5, R5′, R6 and R6′ are as described herein.
摘要翻译: 本发明提供了可用作治疗恶性肿瘤的治疗剂的新的IAP抑制剂,其中化合物具有通式I:其中X,Y,A,R 1,R 2,R 3,R 4,R 4',R 5,R 5',R 6和 R6'如本文所述。
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公开(公告)号:US08980837B2
公开(公告)日:2015-03-17
申请号:US13356556
申请日:2012-01-23
申请人: Frederick Cohen , Kurt Deshayes , Wayne J. Fairbrother , Bainian Feng , John A. Flygare , Lewis J. Gazzard , Vickie Hsiao-Wei Tsui
发明人: Frederick Cohen , Kurt Deshayes , Wayne J. Fairbrother , Bainian Feng , John A. Flygare , Lewis J. Gazzard , Vickie Hsiao-Wei Tsui
IPC分类号: A61K38/06 , A61K31/55 , A61K31/42 , A61K31/433 , A61K31/4436 , A61K31/426 , A61K31/415 , A61K31/381 , A61P35/04 , A61K31/4245 , A61K31/41 , A61K31/506 , C07D417/14 , C12N5/09 , A61K38/17 , C07D403/12 , C07D413/12 , C07D417/04 , C07D417/12 , C07D495/04 , C07D513/04 , C07K5/062 , C07K5/083 , C07K5/08 , C07K7/06
CPC分类号: C07D417/14 , A61K31/55 , A61K38/177 , C07D403/12 , C07D413/12 , C07D417/04 , C07D417/12 , C07D495/04 , C07D513/04 , C07K5/06026 , C07K5/0806 , C07K5/0827 , C07K7/06 , C12N5/0693
摘要: The invention provides novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies where the compounds have the general formula I: wherein X, Y, A, R1, R2, R3, R4, R4′, R5, R5′, R6 and R6′ are as described herein.
摘要翻译: 本发明提供了可用作治疗恶性肿瘤的治疗剂的新的IAP抑制剂,其中化合物具有通式I:其中X,Y,A,R 1,R 2,R 3,R 4,R 4',R 5,R 5',R 6和 R6'如本文所述。
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公开(公告)号:US08110568B2
公开(公告)日:2012-02-07
申请号:US12727218
申请日:2010-03-18
申请人: Frederick Cohen , Kurt Deshayes , Wayne J. Fairbrother , Bainian Feng , John A. Flygare , Lewis J. Gazzard , Vickie Hsiao-Wei Tsui
发明人: Frederick Cohen , Kurt Deshayes , Wayne J. Fairbrother , Bainian Feng , John A. Flygare , Lewis J. Gazzard , Vickie Hsiao-Wei Tsui
IPC分类号: A61K31/55 , A61K31/4035 , A61K31/427 , A61K31/4155 , A61K31/433 , A61K31/40 , A61K31/4192 , A61K31/42 , A61K31/41 , A61K31/4245 , A61K31/4439 , A61P35/00
CPC分类号: C07D417/14 , A61K31/55 , A61K38/177 , C07D403/12 , C07D413/12 , C07D417/04 , C07D417/12 , C07D495/04 , C07D513/04 , C07K5/06026 , C07K5/0806 , C07K5/0827 , C07K7/06 , C12N5/0693
摘要: The invention provides novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies where the compounds have the general formula I: wherein X, Y, A, R1, R2, R3, R4, R4′, R5, R5′, R6 and R6′ are as described herein.
摘要翻译: 本发明提供了可用作治疗恶性肿瘤的治疗剂的新的IAP抑制剂,其中化合物具有通式I:其中X,Y,A,R 1,R 2,R 3,R 4,R 4',R 5,R 5',R 6和 R6'如本文所述。
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公开(公告)号:US07244851B2
公开(公告)日:2007-07-17
申请号:US11174784
申请日:2005-07-05
申请人: Frederick Cohen , Kurt Deshayes , Wayne J. Fairbrother , Bainian Feng , John A. Flygare , Lewis J. Gazzard , Vickie Hsiao-Wei Tsui
发明人: Frederick Cohen , Kurt Deshayes , Wayne J. Fairbrother , Bainian Feng , John A. Flygare , Lewis J. Gazzard , Vickie Hsiao-Wei Tsui
IPC分类号: C07D207/09 , C07D231/12 , C07D233/60 , C07D263/32 , C07D275/02 , C07D257/04 , C07D285/06
CPC分类号: C07D417/14 , A61K31/55 , A61K38/177 , C07D403/12 , C07D413/12 , C07D417/04 , C07D417/12 , C07D495/04 , C07D513/04 , C07K5/06026 , C07K5/0806 , C07K5/0827 , C07K7/06 , C12N5/0693
摘要: The invention provides novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies where the compounds have the general formula I: wherein X, Y, A, R1, R2, R3, R4, R4′, R5, R5′, R6 and R6′ are as described herein.
摘要翻译: 本发明提供可用作治疗恶性肿瘤的治疗剂的IAP的新型抑制剂,其中化合物具有通式I:其中X,Y,A,R 1,R 2, R 3,R 4,R 4,R 5,R 5,R 5, R 6,R 6和R 6'如本文所述。
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公开(公告)号:US20110077265A1
公开(公告)日:2011-03-31
申请号:US12598027
申请日:2008-04-29
申请人: John A. Flygare , Frederick Cohen , Kurt Deshayes , Michael F. T. Koehler , Lewis J. Gazzard , Lan Wang , Chudi Ndubaku
发明人: John A. Flygare , Frederick Cohen , Kurt Deshayes , Michael F. T. Koehler , Lewis J. Gazzard , Lan Wang , Chudi Ndubaku
IPC分类号: A61K31/437 , C07D417/14 , C07D513/04 , C07D403/12 , C12N5/071 , C07K2/00 , A61K31/4545 , A61K31/433 , A61K31/4025 , A61K31/427 , A61P35/00
CPC分类号: C07D417/14 , C07D207/16 , C07D519/00
摘要: The invention provides novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies where the compounds having the general formula U1-M-U2 wherein M is a linking group covalently joining R2, R3, R4 or R5 of U1 to an R2, R3, R4 or R5 group of U2; U1 and U2 have the general formula (I) and G, X1, X2, R2, R3, R3′, R4, R4′ and R5, are as described herein.
摘要翻译: 本发明提供了可用作治疗恶性肿瘤的治疗剂的新的IAP抑制剂,其中具有通式U1-M-U2的化合物,其中M是共价连接U1的R2,R3,R4或R5的连接基团与R2,R3 ,R4或R5组的U2; U1和U2具有通式(I),G,X 1,X 2,R 2,R 3,R 3',R 4,R 4'和R 5如本文所述。
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公开(公告)号:US08907092B2
公开(公告)日:2014-12-09
申请号:US12598027
申请日:2008-04-29
申请人: John A. Flygare , Frederick Cohen , Kurt Deshayes , Michael F. T. Koehler , Lewis J. Gazzard , Lan Wang , Chudi Ndubaku
发明人: John A. Flygare , Frederick Cohen , Kurt Deshayes , Michael F. T. Koehler , Lewis J. Gazzard , Lan Wang , Chudi Ndubaku
IPC分类号: C07D277/46 , C07D513/04 , C07D417/14 , A61K31/4365 , A61K31/4436 , A61K31/427 , C07D207/16 , C07D519/00
CPC分类号: C07D417/14 , C07D207/16 , C07D519/00
摘要: The invention provides novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies where the compounds having the general formula U1-M-U2 wherein M is a linking group covalently joining R2, R3, R4 or R5 of U1 to an R2, R3, R4 or R5 group of U2; U1 and U2 have the general formula (I) and G, X1, X2, R2, R3, R3′, R4, R4′ and R5, are as described herein.
摘要翻译: 本发明提供了可用作治疗恶性肿瘤的治疗剂的新的IAP抑制剂,其中具有通式U1-M-U2的化合物,其中M是共价连接U1的R2,R3,R4或R5的连接基团与R2,R3 ,R4或R5组的U2; U1和U2具有通式(I),G,X 1,X 2,R 2,R 3,R 3',R 4,R 4'和R 5如本文所述。
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公开(公告)号:US20090318409A1
公开(公告)日:2009-12-24
申请号:US12538794
申请日:2009-08-10
IPC分类号: A61K31/427 , C07D417/04 , C07D417/14 , C07D471/04 , C12N5/00 , A61K31/5377 , A61K31/454 , A61K31/4709 , A61K31/437 , A61P35/00
CPC分类号: C07D471/04 , C07D417/04 , C07D417/14
摘要: The invention provides novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies where the compounds have the general formula I: wherein A, Q, X1, X2, Y, R1, R2, R3, R4, R4′, R5, R6 and R6′ are as described herein.
摘要翻译: 本发明提供了可用作治疗恶性肿瘤的治疗剂的新的IAP抑制剂,其中化合物具有通式I:其中A,Q,X 1,X 2,Y,R 1,R 2,R 3,R 4,R 4',R 5,R 6 和R6'如本文所述。
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公开(公告)号:US08609845B2
公开(公告)日:2013-12-17
申请号:US12538794
申请日:2009-08-10
IPC分类号: C07D277/20 , C07D453/02 , C07D471/14
CPC分类号: C07D471/04 , C07D417/04 , C07D417/14
摘要: The invention provides novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies where the compounds have the general formula I: wherein A, Q, X1, X2, Y, R1, R2, R3, R4, R4′, R5, R6 and R6′ are as described herein.
摘要翻译: 本发明提供了可用作治疗恶性肿瘤的治疗剂的新的IAP抑制剂,其中化合物具有通式I:其中A,Q,X 1,X 2,Y,R 1,R 2,R 3,R 4,R 4',R 5,R 6 和R6'如本文所述。
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公开(公告)号:US20090176822A1
公开(公告)日:2009-07-09
申请号:US12105109
申请日:2008-04-17
IPC分类号: A61K31/44 , C07D417/00 , C12N5/06 , C07D277/30 , C07D217/02 , C07D471/02
CPC分类号: C07D471/04 , C07D417/04 , C07D417/14
摘要: The invention provides novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies where the compounds have the general formula I: wherein A, Q, X1, X2, Y, R1, R2, R3, R4, R4′, R5, R6 and R6′ are as described herein.
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