-
公开(公告)号：US08980837B2
公开(公告)日：2015-03-17
申请号：US13356556
申请日：2012-01-23
申请人： Frederick Cohen , Kurt Deshayes , Wayne J. Fairbrother , Bainian Feng , John A. Flygare , Lewis J. Gazzard , Vickie Hsiao-Wei Tsui
发明人： Frederick Cohen , Kurt Deshayes , Wayne J. Fairbrother , Bainian Feng , John A. Flygare , Lewis J. Gazzard , Vickie Hsiao-Wei Tsui
IPC分类号： A61K38/06 , A61K31/55 , A61K31/42 , A61K31/433 , A61K31/4436 , A61K31/426 , A61K31/415 , A61K31/381 , A61P35/04 , A61K31/4245 , A61K31/41 , A61K31/506 , C07D417/14 , C12N5/09 , A61K38/17 , C07D403/12 , C07D413/12 , C07D417/04 , C07D417/12 , C07D495/04 , C07D513/04 , C07K5/062 , C07K5/083 , C07K5/08 , C07K7/06
CPC分类号： C07D417/14 , A61K31/55 , A61K38/177 , C07D403/12 , C07D413/12 , C07D417/04 , C07D417/12 , C07D495/04 , C07D513/04 , C07K5/06026 , C07K5/0806 , C07K5/0827 , C07K7/06 , C12N5/0693
摘要： The invention provides novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies where the compounds have the general formula I: wherein X, Y, A, R1, R2, R3, R4, R4′, R5, R5′, R6 and R6′ are as described herein.
摘要翻译： 本发明提供了可用作治疗恶性肿瘤的治疗剂的新的IAP抑制剂，其中化合物具有通式I：其中X，Y，A，R 1，R 2，R 3，R 4，R 4'，R 5，R 5'，R 6和 R6'如本文所述。
-
公开(公告)号：US08907092B2
公开(公告)日：2014-12-09
申请号：US12598027
申请日：2008-04-29
申请人： John A. Flygare , Frederick Cohen , Kurt Deshayes , Michael F. T. Koehler , Lewis J. Gazzard , Lan Wang , Chudi Ndubaku
发明人： John A. Flygare , Frederick Cohen , Kurt Deshayes , Michael F. T. Koehler , Lewis J. Gazzard , Lan Wang , Chudi Ndubaku
IPC分类号： C07D277/46 , C07D513/04 , C07D417/14 , A61K31/4365 , A61K31/4436 , A61K31/427 , C07D207/16 , C07D519/00
CPC分类号： C07D417/14 , C07D207/16 , C07D519/00
摘要： The invention provides novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies where the compounds having the general formula U1-M-U2 wherein M is a linking group covalently joining R2, R3, R4 or R5 of U1 to an R2, R3, R4 or R5 group of U2; U1 and U2 have the general formula (I) and G, X1, X2, R2, R3, R3′, R4, R4′ and R5, are as described herein.
摘要翻译： 本发明提供了可用作治疗恶性肿瘤的治疗剂的新的IAP抑制剂，其中具有通式U1-M-U2的化合物，其中M是共价连接U1的R2，R3，R4或R5的连接基团与R2，R3 ，R4或R5组的U2; U1和U2具有通式（I），G，X 1，X 2，R 2，R 3，R 3'，R 4，R 4'和R 5如本文所述。
-
公开(公告)号：US20110039324A1
公开(公告)日：2011-02-17
申请号：US12835605
申请日：2010-07-13
申请人： Kurt Deshayes , Wayne Fairbrother , John Flygare , Matthew C. Franklin , Saloumeh Fischer , Domagoj Vucic
发明人： Kurt Deshayes , Wayne Fairbrother , John Flygare , Matthew C. Franklin , Saloumeh Fischer , Domagoj Vucic
CPC分类号： A61K38/08 , A61K38/00 , C07K7/08 , C07K14/001 , C07K14/4747 , C07K2319/00
摘要： The present invention is directed to compositions of matter useful for the enhancement of apoptosis in mammals and to methods of using those compositions of matter for the same.
摘要翻译： 本发明涉及用于增强哺乳动物细胞凋亡的物质组合物，以及使用这些物质组合物的方法。
-
公开(公告)号：US20070299052A1
公开(公告)日：2007-12-27
申请号：US11739030
申请日：2007-04-23
申请人： Frederick Cohen , Kurt Deshayes , Wayne Fairbrother , Bainian Feng , John Flygare , Lewis Gazzard , Vickie Tsui
发明人： Frederick Cohen , Kurt Deshayes , Wayne Fairbrother , Bainian Feng , John Flygare , Lewis Gazzard , Vickie Tsui
IPC分类号： A61K31/55 , A61K31/351 , A61K31/40 , A61K31/41 , A61P35/00 , C07D207/30 , C07D223/14 , C07D277/02 , C07D309/02 , C12N9/00 , C12N5/00 , C07D285/06 , C07D231/02 , C07D221/00 , A61P43/00 , A61K31/415 , A61K31/426 , A61K31/445
CPC分类号： C07D417/14 , A61K31/55 , A61K38/177 , C07D403/12 , C07D413/12 , C07D417/04 , C07D417/12 , C07D495/04 , C07D513/04 , C07K5/06026 , C07K5/0806 , C07K5/0827 , C07K7/06 , C12N5/0693
摘要： The invention provides novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies where the compounds have the general formula I: wherein X, Y, A, R1, R2, R3, R4, R4′, R5, R5′, R6 and R6′ are as described herein.
-
公开(公告)号：US08232273B2
公开(公告)日：2012-07-31
申请号：US12641141
申请日：2009-12-17
申请人： Jonathan Bayldon Baell , Chinh Thien Bui , Peter Colman , Peter Czabotar , Danette A. Dudley , Wayne J. Fairbrother , John A. Flygare , Guillaume Laurent Lessene , Chudi Ndubaku , George Nikolakopoulos , Brad Edmund Sleebs , Brian John Smith , Keith Geoffrey Watson , Steven W. Elmore , Lisa A. Hasvold , Andrew M. Petros , Andrew J. Souers , Zhi-Fu Tao , Le Wang , Xilu Wang , Kurt Deshayes
发明人： Jonathan Bayldon Baell , Chinh Thien Bui , Peter Colman , Peter Czabotar , Danette A. Dudley , Wayne J. Fairbrother , John A. Flygare , Guillaume Laurent Lessene , Chudi Ndubaku , George Nikolakopoulos , Brad Edmund Sleebs , Brian John Smith , Keith Geoffrey Watson , Steven W. Elmore , Lisa A. Hasvold , Andrew M. Petros , Andrew J. Souers , Zhi-Fu Tao , Le Wang , Xilu Wang , Kurt Deshayes
IPC分类号： A61K31/5377 , C07D413/14
CPC分类号： C07D417/14 , C07D471/06 , C07D473/00 , C07D487/04 , C07D495/04 , C07D513/04 , C07D513/06
摘要： In one aspect, the present invention provides for a compound of Formula I in which the variable X1a, X1b, X1c, X1d, Q, A, R1, B, L, E, and the subscripts m and n have the meanings as described herein. In another aspect, the present invention provides for pharmaceutical compositions comprising compounds of Formula I as well as methods for using compounds of Formula I for the treatment of diseases and conditions (e.g., cancer, thrombocythemia, etc) characterized by the expression or over-expression of Bcl-2 anti-apoptotic proteins, e.g., of anti-apoptotic Bcl-xL proteins.
摘要翻译： 一方面，本发明提供了其中变量X1a，X1b，X1c，X1d，Q，A，R1，B，L，E和下标m和n具有如本文所述的含义的式I化合物 。 另一方面，本发明提供包含式I化合物的药物组合物以及使用式I化合物治疗以表达或过表达为特征的疾病和病症（例如，癌症，血小板增多症等）的方法 的Bcl-2抗凋亡蛋白，例如抗凋亡Bcl-xL蛋白。
-
公开(公告)号：US20110077265A1
公开(公告)日：2011-03-31
申请号：US12598027
申请日：2008-04-29
申请人： John A. Flygare , Frederick Cohen , Kurt Deshayes , Michael F. T. Koehler , Lewis J. Gazzard , Lan Wang , Chudi Ndubaku
发明人： John A. Flygare , Frederick Cohen , Kurt Deshayes , Michael F. T. Koehler , Lewis J. Gazzard , Lan Wang , Chudi Ndubaku
IPC分类号： A61K31/437 , C07D417/14 , C07D513/04 , C07D403/12 , C12N5/071 , C07K2/00 , A61K31/4545 , A61K31/433 , A61K31/4025 , A61K31/427 , A61P35/00
CPC分类号： C07D417/14 , C07D207/16 , C07D519/00
摘要： The invention provides novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies where the compounds having the general formula U1-M-U2 wherein M is a linking group covalently joining R2, R3, R4 or R5 of U1 to an R2, R3, R4 or R5 group of U2; U1 and U2 have the general formula (I) and G, X1, X2, R2, R3, R3′, R4, R4′ and R5, are as described herein.
摘要翻译： 本发明提供了可用作治疗恶性肿瘤的治疗剂的新的IAP抑制剂，其中具有通式U1-M-U2的化合物，其中M是共价连接U1的R2，R3，R4或R5的连接基团与R2，R3 ，R4或R5组的U2; U1和U2具有通式（I），G，X 1，X 2，R 2，R 3，R 3'，R 4，R 4'和R 5如本文所述。
-
公开(公告)号：US20100256115A1
公开(公告)日：2010-10-07
申请号：US12727218
申请日：2010-03-18
申请人： Frederick Cohen , Kurt Deshayes , Wayne J. Fairbrother , Bainian Feng , John A. Flygare , Lewis J. Gazzard , Vickie Hsiao-Wei Tsui
发明人： Frederick Cohen , Kurt Deshayes , Wayne J. Fairbrother , Bainian Feng , John A. Flygare , Lewis J. Gazzard , Vickie Hsiao-Wei Tsui
IPC分类号： A61K31/55 , C07D209/48 , A61K31/4035 , C07D277/06 , A61K31/427 , C07D487/04 , C07D231/40 , C07D285/06 , A61K31/4155 , A61K31/433 , C07D207/323 , A61K31/40 , C07D249/06 , A61K31/4192 , C07D261/14 , A61K31/42 , C07D257/06 , A61K31/41 , C07D271/04 , A61K31/4245 , C07D417/04 , A61K31/4439 , A61P35/00 , C12N5/071
CPC分类号： C07D417/14 , A61K31/55 , A61K38/177 , C07D403/12 , C07D413/12 , C07D417/04 , C07D417/12 , C07D495/04 , C07D513/04 , C07K5/06026 , C07K5/0806 , C07K5/0827 , C07K7/06 , C12N5/0693
摘要： The invention provides novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies where the compounds have the general formula I: wherein X, Y, A, R1, R2, R3, R4, R4′, R5, R5′, R6 and R6′ are as described herein.
摘要翻译： 本发明提供了可用作治疗恶性肿瘤的治疗剂的新的IAP抑制剂，其中化合物具有通式I：其中X，Y，A，R 1，R 2，R 3，R 4，R 4'，R 5，R 5'，R 6和 R6'如本文所述。
-
公开(公告)号：US20120058953A1
公开(公告)日：2012-03-08
申请号：US13274142
申请日：2011-10-14
申请人： Kurt Deshayes , Wayne Fairbrother , John Flygare , Matthew C. Franklin , Saloumeh Fischer , Domagoj Vucic
发明人： Kurt Deshayes , Wayne Fairbrother , John Flygare , Matthew C. Franklin , Saloumeh Fischer , Domagoj Vucic
IPC分类号： A61K38/08 , C07K5/103 , C07K7/06 , A61P35/02 , C12N9/96 , C12N5/09 , A61K38/07 , A61P35/00 , C07K4/00 , C07K19/00
CPC分类号： A61K38/08 , A61K38/00 , C07K7/08 , C07K14/001 , C07K14/4747 , C07K2319/00
摘要： The present invention is directed to compositions of matter useful for the enhancement of apoptosis in mammals and to methods of using those compositions of matter for the same.
摘要翻译： 本发明涉及用于增强哺乳动物细胞凋亡的物质组合物，以及使用这些物质组合物的方法。
-
公开(公告)号：US20060233804A1
公开(公告)日：2006-10-19
申请号：US11473753
申请日：2006-06-23
申请人： Kurt Deshayes , Henry Lowman , Michelle Schaffer , Sachdev Sidhu
发明人： Kurt Deshayes , Henry Lowman , Michelle Schaffer , Sachdev Sidhu
IPC分类号： A61K39/395 , A61K38/22
CPC分类号： C07K14/4743 , A61K38/00 , C07K2299/00
摘要： Peptides are provided that antagonize the interaction of IGF-1 with its binding proteins, insulin receptor, and IGF receptor. These IGF antagonist peptides are useful in treating disorders involving IGF-1 as a causative agent, such as, for example, various cancers.
-
公开(公告)号：US20060014700A1
公开(公告)日：2006-01-19
申请号：US11174784
申请日：2005-07-05
申请人： Frederick Cohen , Kurt Deshayes , Wayne Fairbrother , Bainian Feng , John Flygare , Lewis Gazzard , Vickie Tsui
发明人： Frederick Cohen , Kurt Deshayes , Wayne Fairbrother , Bainian Feng , John Flygare , Lewis Gazzard , Vickie Tsui
IPC分类号： A61K38/05 , C07K5/04 , A61K31/421 , A61K31/426
CPC分类号： C07D417/14 , A61K31/55 , A61K38/177 , C07D403/12 , C07D413/12 , C07D417/04 , C07D417/12 , C07D495/04 , C07D513/04 , C07K5/06026 , C07K5/0806 , C07K5/0827 , C07K7/06 , C12N5/0693
摘要： The invention provides novel inhibitors of IAP that are useful as therapeutic agents for treating malignancies where the compounds have the general formula I: wherein X, Y, A, R1, R2, R3, R4, R4′, R5, R5′, R6 and R6′ are as described herein.
摘要翻译： 本发明提供可用作治疗恶性肿瘤的治疗剂的IAP的新型抑制剂，其中化合物具有通式I：其中X，Y，A，R 1，R 2， R 3，R 4，R 4，R 5，R 5，R 5， R 6，R 6和R 6'如本文所述。
-
-
-
-
-
-
-
-
-
搜索结果
16 条记录 (耗时 0.025 秒)
