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10 条记录 (耗时 0.025 秒)

    Process for producing a cast resin coil
    1.
    发明授权
    Process for producing a cast resin coil 失效
    铸造树脂线圈的制造方法

    公开(公告)号：US5588201A

    公开(公告)日：1996-12-31

    申请号：US122424

    申请日：1993-09-21

    申请人： Friedrich Alber ,  Rudolf Dedelmahr ,  Winfried Jungnitz ,  Hans Schott ,  Heinz Sesterheim ,  Siegfried Weiss

    发明人： Friedrich Alber ,  Rudolf Dedelmahr ,  Winfried Jungnitz ,  Hans Schott ,  Heinz Sesterheim ,  Siegfried Weiss

    IPC分类号： C07C37/72 ,  H01F7/06 ,  H01F41/12

    CPC分类号： H01F41/127 ,  H01F2027/328 ,  Y10T29/4902 ,  Y10T29/49071 ,  Y10T29/49073

    摘要： For the production of a cast resin coil consisting of a plurality of axially superimposed flat coils, it is proposed that the corresponding flat coils be first of all produced by winding a first inner partial winding and a second outer partial winding with the interposition of individual spacer members by which sector-shaped intervening spaces are formed. The individual flat coils are then placed together axially and oriented so that their intervening spaces coincide, thus forming axial cooling channels. Moldings are inserted into each of said channels. This is followed by the encapsulation of the assembled flat coils. After the curing of the casting resin, the moldings are removed from the cooling channels. A cast resin coil produced in this manner has an impregnable layer of material, preferably in the region of the cooling channels by which the wall thickness of the cooling channels is predetermined in relation to the corresponding strip conductors.

    摘要翻译： PCT No.PCT / EP91 / 00552 Sec。 371日期：1993年9月21日 102（e）日期1993年9月21日PCT 1991年3月21日PCT公布。 第WO92 / 16955号公报 日期1992年10月1日为了生产由多个轴向叠置的扁平线圈组成的铸塑树脂线圈，建议相应的扁平线圈首先通过将第一内部部分绕组和第二外部部分绕组卷绕 插入形成扇形中间空间的各个间隔件。 然后将单个扁平线圈轴向放置在一起并使其中间空间重合，从而形成轴向冷却通道。 木条插入每个所述通道中。 之后是组装的扁平线圈的封装。 浇铸树脂固化后，将模具从冷却通道中取出。 以这种方式制造的铸塑树脂线圈具有可浸渍的材料层，优选地在冷却通道的区域中，冷却通道的壁厚相对于相应的带状导体预定。

    Coil for high-voltage transformer
    3.
    发明授权
    Coil for high-voltage transformer 失效
    线圈用于高压变压器

    公开(公告)号：US5598137A

    公开(公告)日：1997-01-28

    申请号：US295762

    申请日：1994-09-26

    申请人： Friedrich Alber ,  Rudolf Dedelmahr ,  Siegfried Kromer ,  Hans Schott ,  Siegfried Weiss

    发明人： Friedrich Alber ,  Rudolf Dedelmahr ,  Siegfried Kromer ,  Hans Schott ,  Siegfried Weiss

    IPC分类号： H01F27/28

    CPC分类号： H01F27/2852 ,  H01F2027/2857 ,  Y10S174/14 ,  Y10S174/25

    摘要： In order to achieve improved mechanical properties for a coil (1), it is proposed to structure a first electroconductive winding (3) of the coil (1) as a coil former. This coil has a first connecting element (15), to which a second connecting element (17) is attached via an insulating part (25). The two connecting elements (15, 17) form the connections for the coil (1). In this way, a self-supporting coil structure is achieved. The coil (1) is particularly intended as an undervoltage winding with a low number of windings for cast resin transformers.

    摘要翻译： PCT No.PCT / DE92 / 00189 Sec。 371日期：1994年9月26日 102（e）1994年9月26日PCT 1991年3月5日PCT公布。 出版物WO93 / 日期1993年9月16日为了实现线圈（1）的改进的机械性能，提出将线圈（1）的第一导电绕组（3）构造为线圈架。 该线圈具有第一连接元件（15），第二连接元件（17）经由绝缘部件（25）附接到第一连接元件。 两个连接元件（15,17）形成线圈（1）的连接。 以这种方式实现了自支撑线圈结构。 线圈（1）特别用作铸造树脂变压器的具有低数量绕组的欠压绕组。

    Ligands of the Natural Killer (NK) Cell Surface Marker CD27 and Therapeutic Uses Thereof,
    4.
    发明申请
    Ligands of the Natural Killer (NK) Cell Surface Marker CD27 and Therapeutic Uses Thereof, 审中-公开
    天然杀伤剂（NK）细胞表面标记物CD27及其治疗用途的配体，

    公开(公告)号：US20110052579A1

    公开(公告)日：2011-03-03

    申请号：US12864761

    申请日：2009-02-16

    申请人： Siegfried Weiss ,  Nuno Viegas

    发明人： Siegfried Weiss ,  Nuno Viegas

    IPC分类号： A61K39/395 ,  G01N33/53 ,  C40B30/04 ,  C12N5/078 ,  A61P31/16 ,  A61P35/00

    CPC分类号： C07K16/2878 ,  A61K2039/505 ,  C07K16/2875

    摘要： The present invention relates to the modulation of Natural Killer (NK) cells in vitro or in vivo through the use of activating or inhibiting ligands of CD27, such as antibodies, for a regulation of the immune response against several different diseases, such as viral infections, cancer, bacterial infections, sepsis as well as immunological diseases. In a preferred embodiment, the inventors were able to improve the host resistance against Influenza virus and cancer through the application of anti-CD27 antibodies. In a different setting the inventors were able to prevent the onset of a lethal bacterial sepsis by preventing the activation of NK cells via CD27. The invention furthermore relates to screening assays for ligands of the surface marker CD27.

    摘要翻译： 本发明涉及通过使用激活或抑制CD27的配体（例如抗体）在体外或体内调节天然杀伤（NK）细胞来调节针对若干不同疾病例如病毒感染的免疫应答 ，癌症，细菌感染，败血症以及免疫疾病。 在优选的实施方案中，本发明人能够通过应用抗CD27抗体来改善宿主对流感病毒和癌症的抗性。 在不同的设置中，发明人能够通过防止CD27激活NK细胞来防止致死细菌性败血症的发生。 本发明还涉及表面标志物CD27的配体的筛选测定。

    TUMOR-SPECIFIC BACTERIAL PROMOTER ELEMENTS
    6.
    发明申请
    TUMOR-SPECIFIC BACTERIAL PROMOTER ELEMENTS 审中-公开
    肿瘤特异性细菌促进因子

    公开(公告)号：US20120244621A1

    公开(公告)日：2012-09-27

    申请号：US13321777

    申请日：2010-05-28

    申请人： Siegfried Weiss ,  Sara Bartels ,  Holger Loessner ,  Igor Deyneko ,  Dirk Bumann ,  Kathrin Westphal-Daniel

    发明人： Siegfried Weiss ,  Sara Bartels ,  Holger Loessner ,  Igor Deyneko ,  Dirk Bumann ,  Kathrin Westphal-Daniel

    IPC分类号： C12N1/21 ,  C12N15/70 ,  C12N15/74

    CPC分类号： A61K48/0058 ,  C12N15/1051 ,  C12N15/1086 ,  C12N15/70 ,  C12N15/85 ,  C12N2830/008

    摘要： The invention relates to bacterial promoter elements which constitute or which are comprised in promoter regions and which confer tumour specificity to the promoter region activity, resulting in transcription of a transgene, which can be a heterologous or a homologous gene, which transgene is functionally arranged downstream of the promoter region at presence of a host bacterium in tumour tissue, while essentially conferring inactivity of the promoter region and no transcription at presence of the host bacterium in non-tumour tissue. Accordingly, the invention relates to bacterial promoter regions containing these tumour specific promoter elements.

    摘要翻译： 本发明涉及构成或包含在启动子区中并且赋予启动子区活性的肿瘤特异性的细菌启动子元件，导致可以是异源或同源基因的转基因的转录，转基因功能上被布置在下游 在肿瘤组织中宿主细菌存在下的启动子区域，而基本上赋予启动子区域的不活动并且在非肿瘤组织中存在宿主细菌时没有转录。 因此，本发明涉及含有这些肿瘤特异性启动子元件的细菌启动子区域。

    Bacterial vector
    8.
    发明授权
    Bacterial vector 有权
    细菌载体

    公开(公告)号：US08093025B2

    公开(公告)日：2012-01-10

    申请号：US11667034

    申请日：2005-09-02

    申请人： Holger Loessner ,  Anne Endmann ,  Sara Leschner ,  Siegfried Weiss

    发明人： Holger Loessner ,  Anne Endmann ,  Sara Leschner ,  Siegfried Weiss

    IPC分类号： C12N13/00

    CPC分类号： C12N15/70

    摘要： The present invention relates to a combination of compounds for introducing nucleic acids and/or protein into animal cells, tissue, organs or organisms in vitro, extracorporal, or in vivo. This combination comprises preparations suitable for administration to an animal or human for medical purposes, comprising as one component a bacterial vector genetically manipulated to contain nucleic acid sequences comprising a transgene, and a second component for the subsequent transcription, possibly translation of the transgene by controlled induction of bacterial vector as it is present within the animal or human.

    摘要翻译： 本发明涉及用于将核酸和/或蛋白质在体外，体外或体内的动物细胞，组织，器官或生物体中引入的化合物的组合。 这种组合包括适合于给予动物或人类用于医疗目的的制剂，其包含作为一种组分的基因操作的细菌载体以含有包含转基因的核酸序列，以及用于随后转录的第二组分，可能通过受控的转化转基因 诱导细菌载体，因为其存在于动物或人体内。

    Bacterial Vector
    9.
    发明申请
    Bacterial Vector 有权
    细菌载体

    公开(公告)号：US20080112928A1

    公开(公告)日：2008-05-15

    申请号：US11667034

    申请日：2005-09-02

    申请人： Holger Loessner ,  Anne Endmann ,  Sara Leschner ,  Siegfried Weiss

    发明人： Holger Loessner ,  Anne Endmann ,  Sara Leschner ,  Siegfried Weiss

    IPC分类号： A61K48/00 ,  A01N63/00 ,  C12N15/74

    CPC分类号： C12N15/70

    摘要： The present invention relates to a combination of compounds for introducing nucleic acids and/or protein into animal cells, tissue, organs or organisms in vitro, extracorporal, or in vivo. This combination comprises preparations suitable for administration to an animal or human for medical purposes, comprising as one component a bacterial vector genetically manipulated to contain nucleic acid sequences comprising a transgene, and a second component for the subsequent transcription, possibly translation of the transgene by controlled induction of bacterial vector as it is present within the animal or human.

    摘要翻译： 本发明涉及用于将核酸和/或蛋白质在体外，体外或体内的动物细胞，组织，器官或生物体中引入的化合物的组合。 这种组合包括适合于给予动物或人类用于医疗目的的制剂，其包含作为一种组分的基因操作的细菌载体以含有包含转基因的核酸序列，以及用于随后转录的第二组分，可能通过受控的转化转基因 诱导细菌载体，因为其存在于动物或人体内。

    Bearing-mounted plastic wheel
    10.
    发明授权
    Bearing-mounted plastic wheel 失效
    轴承塑料轮

    公开(公告)号：US4490128A

    公开(公告)日：1984-12-25

    申请号：US512214

    申请日：1983-07-08

    申请人： Siegfried Weiss ,  Gunther Heurich ,  Werner Kotzab

    发明人： Siegfried Weiss ,  Gunther Heurich ,  Werner Kotzab

    IPC分类号： B60B33/00 ,  F16H55/36

    CPC分类号： B60B33/0063 ,  B60B33/0028 ,  F16C13/006 ,  F16C35/067 ,  F16C19/08 ,  Y10T29/49453 ,  Y10T29/49455

    摘要： An annular wheel of plastic is rotatably mounted on a central bearing. The wheel has a generally H-shaped cross-section, with radially outward and radially inward arms joined by a radial crossbar. An array of stiffening ribs at various circumferential locations around the crossbar of the H-shaped cross-section stiffen the wheel. To prevent the peripheral travel surface of the outward arm of the wheel from developing undulations during cooling following initial molding of the plastic wheel, the ribs have recesses in their opposite, axially outwardly directed sides. Dimensional relationships between the axial width and circumferential thickness of the rib, and the peripheral surface of the wheel and the thickness of the crossbar of the wheel are disclosed.

    摘要翻译： 塑料环形轮可旋转地安装在中心轴承上。 轮具有大致H形的横截面，径向向外和径向向内的臂通过径向横杆连接。 在H形横截面的横梁周围的各种周向位置处的加强肋阵列加强了车轮。 为了防止在塑料轮的初始模制之后在冷却期间车轮的向外臂的外周行进表面发生波纹，肋在其相对的轴向向外指向的侧面具有凹部。 公开了肋的轴向宽度和圆周厚度以及车轮的周边表面和车轮的横杆的厚度之间的尺寸关系。