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    Expression profiles for predicting septic conditions
    4.
    发明授权
    Expression profiles for predicting septic conditions 失效
    用于预测脓毒症状况的表达谱

    公开(公告)号：US08288108B2

    公开(公告)日：2012-10-16

    申请号：US12104506

    申请日：2008-04-17

    申请人： Hamid Hossain ,  Trinad Chakraborty ,  Simon Little ,  Gregor Bein ,  Thilo Menges ,  Svetlin Tchatalbachev

    发明人： Hamid Hossain ,  Trinad Chakraborty ,  Simon Little ,  Gregor Bein ,  Thilo Menges ,  Svetlin Tchatalbachev

    IPC分类号： C12Q1/68 ,  C12P19/34 ,  C12M1/34 ,  C07H21/04

    CPC分类号： C12Q1/6883 ,  C12Q2600/118 ,  C12Q2600/156 ,  C12Q2600/158

    摘要： A rapid, safe method for predicting sepsis, or a condition similar to sepsis, in a mammal is disclosed, which comprises the following steps: I) isolating RNA from a biological sample of a mammal; ii) labeling the isolated RNA of step I) with a detectable marker; iii) hybridizing the labeled isolated RNA of step ii) with at least one DNA of genes Seq.-ID 1 to Seq.-ID 6705 (Table 1), which is spotted onto a microarray and which is a sepsis-specific gene or gene fragment, under the reaction conditions for hybridizations; iv) quantitatively recording labeling signals of the hybridized RNA of step iii) in an expression profile; v) comparing the expression profile of step iv) with a control sample with respect to a stronger or weaker expression of genes or gene fragments which are specific for sepsis; and vi) combining the expression profile of step v) with protein- and metabolite patterns of the biological sample.

    摘要翻译： 公开了一种用于预测脓毒症或类似于败血症的病症的快速，安全的方法，其包括以下步骤：I）从哺乳动物的生物样品中分离RNA; ii）用可检测标记物标记步骤I）的分离的RNA; iii）将步骤ii）的标记的分离的RNA与基因Seq.-ID 1至Seq.-ID 6705（表1）的至少一个DNA杂交，其被点样到微阵列上，其是败血症特异性基因或基因 片段，在反应条件下进行杂交; iv）定量记录步骤iii）的杂交RNA的标记信号在表达谱中; v）将步骤iv）的表达谱与对照样品相对于对败血症特异的基因或基因片段的更强或更弱的表达进行比较; 和vi）将步骤v）的表达谱与生物样品的蛋白质和代谢物图案相结合。

    EXPRESSION PROFILES FOR PREDICTING SEPTIC CONDITIONS
    7.
    发明申请
    EXPRESSION PROFILES FOR PREDICTING SEPTIC CONDITIONS 失效
    用于预测分解条件的表达式

    公开(公告)号：US20090203534A1

    公开(公告)日：2009-08-13

    申请号：US12104506

    申请日：2008-04-17

    申请人： Hamid Hossain ,  Trinad Chakraborty ,  Simon Little ,  Gregor Bein ,  Thilo Menges ,  Svetlin Tchatalbachev

    发明人： Hamid Hossain ,  Trinad Chakraborty ,  Simon Little ,  Gregor Bein ,  Thilo Menges ,  Svetlin Tchatalbachev

    IPC分类号： C40B30/04 ,  C40B40/08

    CPC分类号： C12Q1/6883 ,  C12Q2600/118 ,  C12Q2600/156 ,  C12Q2600/158

    摘要： A rapid, safe method for predicting sepsis, or a condition similar to sepsis, in a mammal is disclosed, which comprises the following steps: I) isolating RNA from a biological sample of a mammal; ii) labeling the isolated RNA of step I) with a detectable marker; iii) hybridizing the labeled isolated RNA of step ii) with at least one DNA of genes Seq.-ID 1 to Seq.-ID 6705 (Table 1), which is spotted onto a microarray and which is a sepsis-specific gene or gene fragment, under the reaction conditions for hybridizations; iv) quantitatively recording labeling signals of the hybridized RNA of step iii) in an expression profile; v) comparing the expression profile of step iv) with a control sample with respect to a stronger or weaker expression of genes or gene fragments which are specific for sepsis; and vi) combining the expression profile of step v) with protein- and metabolite patterns of the biological sample.

    摘要翻译： 公开了一种用于预测脓毒症或类似于败血症的病症的快速，安全的方法，其包括以下步骤：I）从哺乳动物的生物样品中分离RNA; ii）用可检测标记物标记步骤I）的分离的RNA; iii）将步骤ii）的标记的分离的RNA与基因Seq.-ID 1至Seq.-ID 6705（表1）的至少一个DNA杂交，其被点样到微阵列上，其是败血症特异性基因或基因 片段，在反应条件下进行杂交; iv）定量记录步骤iii）的杂交RNA的标记信号在表达谱中; v）将步骤iv）的表达谱与对照样品相对于对败血症特异的基因或基因片段的更强或更弱的表达进行比较; 和vi）将步骤v）的表达谱与生物样品的蛋白质和代谢物图案相结合。

    Recombinant listeria
    9.
    发明授权
    Recombinant listeria 失效
    重组李斯特菌

    公开(公告)号：US06825028B1

    公开(公告)日：2004-11-30

    申请号：US09581005

    申请日：2000-06-06

    申请人： Christoph Von Eichel-Streiber ,  Trinad Chakraborty

    发明人： Christoph Von Eichel-Streiber ,  Trinad Chakraborty

    IPC分类号： C12N120

    CPC分类号： C12N15/85 ,  A61K48/00 ,  A61K48/0008 ,  A61K2039/522 ,  A61K2039/523 ,  C12N15/87

    摘要： Disclosed is a TGC method for inducting targeted somatic transgenesis in an animal host, whereby bacteria with a foreign DNA integrated into an episomal vector release, under the control of eukaryotic regulatory elements for ulterior transcription and expression, said foreign DNA in the case of infection of a foreign organism, organ, tissue, cell line or individual cells, causing transcription and expression of foreign DNA and/or foreign protein in said location.

    摘要翻译： 公开了用于在动物宿主中诱导靶向体细胞转位的TGC方法，其中外源DNA整合到附加型载体释放中的细菌在真核调节元件的控制下用于不规则转录和表达，在外源DNA在感染的情况下 外来生物，器官，组织，细胞系或个体细胞，在所述位置引起外源DNA和/或外源蛋白质的转录和表达。