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    PROTEIN-REFOLDING MATERIAL
    1.
    发明申请
    PROTEIN-REFOLDING MATERIAL 审中-公开
    蛋白质重建材料

    公开(公告)号：US20090005543A1

    公开(公告)日：2009-01-01

    申请号：US12204496

    申请日：2008-09-04

    申请人： Fujio MIZUKAMI ,  Yoshimichi Kiyozumi ,  Takuji Ikeda ,  Akiko Kawai ,  Takako Nagase ,  Kengo Sakaguchi ,  Hiroyuki Chiku

    发明人： Fujio MIZUKAMI ,  Yoshimichi Kiyozumi ,  Takuji Ikeda ,  Akiko Kawai ,  Takako Nagase ,  Kengo Sakaguchi ,  Hiroyuki Chiku

    IPC分类号： C07K1/08 ,  C01B39/00 ,  B01J29/06

    CPC分类号： C07K1/1133 ,  C07K1/1136 ,  C07K14/245

    摘要： The present invention provides a method for refolding protein produced, for example, by Escherichia coli, that is inactive due to an as yet unformed higher order structure, or protein deactivated due to a change in conformation for some reason. The invention comprises a method, refolding kit, refolding agent, and molding that activate a native function or activity inherent to a protein through treatment with zeolite beta of protein produced, for example, by Escherichia coli, that is inactive due to an as yet unformed higher order structure, or protein deactivated due to a change in conformation for some reason. The invention also comprises a method for producing an active protein that utilizes the same. As compared with conventional methods, the present invention can provide a novel method for activating protein function that is highly versatile and generalizable, that employs a simple and easy protocol, and that is inexpensive and enables repeated use of the function activator.

    摘要翻译： 本发明提供了一种重新折叠由例如大肠杆菌产生的蛋白质的方法，其由于尚未形成的高级结构而不活跃，或由于某种原因由于构象变化而失活的蛋白质。 本发明包括一种方法，重折叠试剂盒，重折叠剂和模制品，其通过用例如由大肠杆菌产生的蛋白质的β沸石处理而激活蛋白质固有的天然功能或活性，其由于尚未形成 由于某些原因由于构象变化而导致高阶结构或蛋白质失活。 本发明还包括一种制备利用其的活性蛋白质的方法。 与常规方法相比，本发明可以提供一种新颖的激活蛋白质功能的方法，该蛋白质功能具有高度通用性和可广泛性，采用简单易用的方案，价格便宜，能重复使用功能活化剂。

    Protein-refolding material
    2.
    发明申请
    Protein-refolding material 审中-公开
    蛋白质重折叠材料

    公开(公告)号：US20060194279A1

    公开(公告)日：2006-08-31

    申请号：US10563870

    申请日：2004-07-07

    申请人： Fujio Mizukami ,  Yoshimichi Kiyozumi ,  Takuji Ikeda ,  Akiko Kawai ,  Takako Nagase ,  Kengo Sakaguchi ,  Hiroyuki Chiku

    发明人： Fujio Mizukami ,  Yoshimichi Kiyozumi ,  Takuji Ikeda ,  Akiko Kawai ,  Takako Nagase ,  Kengo Sakaguchi ,  Hiroyuki Chiku

    IPC分类号： C12P21/06 ,  C07K14/47 ,  C07K14/195 ,  C12N9/00

    CPC分类号： C07K1/1133 ,  C07K1/1136 ,  C07K14/245

    摘要： The present invention provides a method for refolding protein produced, for example, by Escherichia coli, that is inactive due to an as yet unformed higher order structure, or protein deactivated due to a change in conformation for some reason. The invention comprises a method, refolding kit, refolding agent, and molding that activate a native function or activity inherent to a protein through treatment with zeolite beta of protein produced, for example, by Escherichia coli, that is inactive due to an as yet unformed higher order structure, or protein deactivated due to a change in conformation for some reason. The invention also comprises a method for producing an active protein that utilizes the same. As compared with conventional methods, the present invention can provide a novel method for activating protein function that is highly versatile and generalizable, that employs a simple and easy protocol, and that is inexpensive and enables repeated use of the function activator.

    摘要翻译： 本发明提供了一种重新折叠由例如大肠杆菌产生的蛋白质的方法，其由于尚未形成的高级结构而不活跃，或由于某种原因由于构象变化而失活的蛋白质。 本发明包括一种方法，重折叠试剂盒，重折叠剂和模制品，其通过用例如由大肠杆菌产生的蛋白质的β沸石处理而激活蛋白质固有的天然功能或活性，其由于尚未形成 由于某些原因由于构象变化而导致高阶结构或蛋白质失活。 本发明还包括一种制备利用其的活性蛋白质的方法。 与常规方法相比，本发明可以提供一种新颖的激活蛋白质功能的方法，该蛋白质功能具有高度通用性和可广泛性，采用简单易用的方案，价格便宜，能重复使用功能活化剂。