公开(公告)号：US20060194279A1

公开(公告)日：2006-08-31

申请号：US10563870

申请日：2004-07-07

申请人： Fujio Mizukami ,  Yoshimichi Kiyozumi ,  Takuji Ikeda ,  Akiko Kawai ,  Takako Nagase ,  Kengo Sakaguchi ,  Hiroyuki Chiku

发明人： Fujio Mizukami ,  Yoshimichi Kiyozumi ,  Takuji Ikeda ,  Akiko Kawai ,  Takako Nagase ,  Kengo Sakaguchi ,  Hiroyuki Chiku

IPC分类号： C12P21/06 ,  C07K14/47 ,  C07K14/195 ,  C12N9/00

CPC分类号： C07K1/1133 ,  C07K1/1136 ,  C07K14/245

摘要： The present invention provides a method for refolding protein produced, for example, by Escherichia coli, that is inactive due to an as yet unformed higher order structure, or protein deactivated due to a change in conformation for some reason. The invention comprises a method, refolding kit, refolding agent, and molding that activate a native function or activity inherent to a protein through treatment with zeolite beta of protein produced, for example, by Escherichia coli, that is inactive due to an as yet unformed higher order structure, or protein deactivated due to a change in conformation for some reason. The invention also comprises a method for producing an active protein that utilizes the same. As compared with conventional methods, the present invention can provide a novel method for activating protein function that is highly versatile and generalizable, that employs a simple and easy protocol, and that is inexpensive and enables repeated use of the function activator.

摘要翻译： 本发明提供了一种重新折叠由例如大肠杆菌产生的蛋白质的方法，其由于尚未形成的高级结构而不活跃，或由于某种原因由于构象变化而失活的蛋白质。 本发明包括一种方法，重折叠试剂盒，重折叠剂和模制品，其通过用例如由大肠杆菌产生的蛋白质的β沸石处理而激活蛋白质固有的天然功能或活性，其由于尚未形成 由于某些原因由于构象变化而导致高阶结构或蛋白质失活。 本发明还包括一种制备利用其的活性蛋白质的方法。 与常规方法相比，本发明可以提供一种新颖的激活蛋白质功能的方法，该蛋白质功能具有高度通用性和可广泛性，采用简单易用的方案，价格便宜，能重复使用功能活化剂。

公开(公告)号：US20070112189A1

公开(公告)日：2007-05-17

申请号：US10579720

申请日：2004-11-17

申请人： Takuji Ikeda ,  Kenichi Komura ,  Fujio Mizukami ,  Syuichi Niwa ,  Toshirou Yokoyama ,  Takaaki Hanaoka ,  Koichi Sato ,  Yoshimichi Kiyozumi ,  Yasuhisa Hasegawa ,  Sasidharan Manickam

发明人： Takuji Ikeda ,  Kenichi Komura ,  Fujio Mizukami ,  Syuichi Niwa ,  Toshirou Yokoyama ,  Takaaki Hanaoka ,  Koichi Sato ,  Yoshimichi Kiyozumi ,  Yasuhisa Hasegawa ,  Sasidharan Manickam

IPC分类号： C01B39/00 ,  C01B33/32 ,  B01J20/28 ,  C07D201/04

CPC分类号： B01D71/028 ,  B01D67/0051 ,  B01D67/0083 ,  B01D2323/08 ,  B01D2325/02 ,  B01D2325/22 ,  B01J29/04 ,  B01J29/70 ,  C01B37/02 ,  C07D223/10

摘要： A high-silica content zeolite having a novel crystal structure, a zeolite membrane and manufacturing methods for these are provided, and the present invention relates to a zeolite having the chemical composition represented by [(Si36-xTy.O72).Mz] (wherein M is a cation of an alkali metal such as Li, Na, K or Rb, T represents Al, Ga, Fe and Ce as skeleton substituting elements, x satisfies 0≦x≦3.0, y satisfies 0≦y≦1.0 and z satisfies 0≦z≦3.0), and having a micropore formed of covalent bonds between Si and O atoms, with a specific diffraction peak at 2θ in powder x-ray diffraction, together with a zeolite membrane and methods for manufacturing these.

摘要翻译： 提供了具有新型晶体结构的高二氧化硅含量沸石，沸石膜及其制造方法，本发明涉及具有由[（Si （其中M是碱金属如Li，Na，K或Rb的阳离子）（其中M是碱金属的阳离子，例如Li，Na，K或Rb ，T表示Al，Ga，Fe和Ce作为骨架取代元素，x满足0 <= x <= 3.0，y满足0 <= y <= 1.0，z满足0 <= z <= 3.0），并具有微孔 由Si和O原子之间的共价键形成，在粉末x射线衍射中在2θ处具有特定衍射峰，以及沸石膜及其制造方法。

公开(公告)号：US08394933B2

公开(公告)日：2013-03-12

申请号：US12593713

申请日：2008-04-04

申请人： Masayuki Kawakami ,  Tatsuo Tsunoda ,  Hideaki Togashi ,  Takayuki Nara ,  Shun-ichi Matsuura ,  Chisato Sekikawa ,  Akiko Kawai ,  Akiyoshi Kawata ,  Fujio Mizukami ,  Kengo Sakaguchi

发明人： Masayuki Kawakami ,  Tatsuo Tsunoda ,  Hideaki Togashi ,  Takayuki Nara ,  Shun-ichi Matsuura ,  Chisato Sekikawa ,  Akiko Kawai ,  Akiyoshi Kawata ,  Fujio Mizukami ,  Kengo Sakaguchi

IPC分类号： C07K1/16 ,  G01N33/538 ,  A61K38/00

CPC分类号： G01N30/52 ,  B01D15/20 ,  B01D15/206 ,  B01D15/3804 ,  B01J20/183 ,  B01J20/2803 ,  B01J2220/58 ,  C07K1/113 ,  C07K1/18 ,  G01N2030/525 ,  Y10T428/2982

摘要： It is an object of the present invention to provide: a protein refolding column filler, which is effective for the refolding, namely, the activation of the function, of an inactive protein with an as yet unformed higher order structure produced in Escherichia coli or the like, or a protein whose conformation has been changed due to a certain cause and which has become inactivated; and a column filled with the aforementioned column filler. The present invention provides a protein refolding column filler, which comprises zeolite with BEA structure (Zeolite Beta) that is granulated into a particle state.

摘要翻译： 本发明的目的是提供：一种蛋白质重折叠柱填充剂，其对于在大肠杆菌中产生的尚未形成的高级结构的无活性蛋白质重新折叠，即功能的活化是有效的， 或由于某些原因而变形失活的蛋白质， 和填充有上述柱填料的柱。 本发明提供一种蛋白质重折叠柱填充剂，其包含粒状状态的具有BEA结构的沸石（沸石β）。

公开(公告)号：US20100210820A1

公开(公告)日：2010-08-19

申请号：US12593713

申请日：2008-04-04

申请人： Masayuki Kawakami ,  Tatsuo Tsunoda ,  Hideaki Togashi ,  Takayuki Nara ,  Shun-ichi Matsuura ,  Chisato Sekikawa ,  Akiko Kawai ,  Akiyoshi Kawata ,  Fujio Mizukami ,  Kengo Sakaguchi

发明人： Masayuki Kawakami ,  Tatsuo Tsunoda ,  Hideaki Togashi ,  Takayuki Nara ,  Shun-ichi Matsuura ,  Chisato Sekikawa ,  Akiko Kawai ,  Akiyoshi Kawata ,  Fujio Mizukami ,  Kengo Sakaguchi

IPC分类号： C07K1/00 ,  C01B39/00 ,  C09K3/00 ,  B01J19/00

CPC分类号： G01N30/52 ,  B01D15/20 ,  B01D15/206 ,  B01D15/3804 ,  B01J20/183 ,  B01J20/2803 ,  B01J2220/58 ,  C07K1/113 ,  C07K1/18 ,  G01N2030/525 ,  Y10T428/2982

摘要： It is an object of the present invention to provide: a protein refolding column filler, which is effective for the refolding, namely, the activation of the function, of an inactive protein with an as yet unformed higher order structure produced in Escherichia coli or the like, or a protein whose conformation has been changed due to a certain cause and which has become inactivated; and a column filled with the aforementioned column filler. The present invention provides a protein refolding column filler, which comprises zeolite with BEA structure (Zeolite Beta) that is granulated into a particle state.

摘要翻译： 本发明的目的是提供：一种蛋白质重折叠柱填充剂，其对于在大肠杆菌中产生的尚未形成的高级结构的无活性蛋白质重新折叠，即功能的活化是有效的， 或由于某些原因而变形失活的蛋白质， 和填充有上述柱填料的柱。 本发明提供一种蛋白质重折叠柱填充剂，其包含粒状状态的具有BEA结构的沸石（沸石β）。

公开(公告)号：US06022519A

公开(公告)日：2000-02-08

申请号：US322687

申请日：1999-05-28

申请人： Shinichi Shimizu ,  Fujio Mizukami ,  Yoshimichi Kiyozumi

发明人： Shinichi Shimizu ,  Fujio Mizukami ,  Yoshimichi Kiyozumi

IPC分类号： B01J29/035 ,  B01J29/072 ,  B01J29/40 ,  B01J37/02 ,  C01B37/02 ,  C01B39/02 ,  C01B39/04 ,  C01B39/26 ,  C01B39/38 ,  C01B39/46 ,  C01B33/021 ,  C01B39/36 ,  C01B39/40

CPC分类号： B01J29/40 ,  B01J29/035 ,  B01J29/072 ,  B01J37/0236 ,  C01B37/02 ,  C01B39/02 ,  C01B39/04 ,  C01B39/265 ,  C01B39/38 ,  C01B39/46 ,  B01J2229/26 ,  B01J2229/36 ,  B01J2229/42 ,  Y10S423/22 ,  Y10S423/25 ,  Y10S423/29

摘要： A method of manufacturing crystalline microporous material suitable for manufacturing a variety of crystalline microporous material under mild reaction conditions and under safe working environmental conditions by using simple installation. The crystalline microporous materials obtained by the present invention may be used as adsorbent agent, catalyst or separating material. According to the characterizing features of the manufacturing method of the present invention, there are provided a method of using cation compound or amine as crystallizing modifier and using, in combination, raw material including canemite or silicon dioxide and a further method using raw material including silicon dioxide and aluminum salt. The method includes a step of mixing these components, a solid-liquid separating step for separating produced fine particles, and a crystallizing step for crystallizing the separated solid component. The invention achieves improvement in safety, economy and so on, in comparison with the coventionally practiced hydrothermal synthesis method which requires severe reaction conditions of high-temperature, high-pressure and strong alkaline. Further, the method allows freedom in adjustment of the pore diameter and allows a higher proportion of porous structure to be maintained in a product when the material is formed into a molded product.

摘要翻译： 一种制造结晶微孔材料的方法，适用于在温和的反应条件下，在安全的工作环境条件下，通过简单的安装制造各种结晶微孔材料。 通过本发明获得的结晶微孔材料可以用作吸附剂，催化剂或分离材料。 根据本发明的制造方法的特征，提供了使用阳离子化合物或胺作为结晶改性剂并且组合使用包括二硅酸钙的原料的方法，以及使用包括硅的原料的另一种方法 二氧化物和铝盐。 该方法包括混合这些组分的步骤，用于分离生成的细颗粒的固液分离步骤和用于使分离的固体组分结晶的结晶步骤。 与需要高温，高压，强碱性苛刻反应条件的常规水热合成方法相比，本发明实现了安全性，经济性等方面的改进。 此外，该方法允许调节孔径的自由度，并且当材料形成成型产品时允许在产品中保持较高比例的多孔结构。

公开(公告)号：US06270743B1

公开(公告)日：2001-08-07

申请号：US09469438

申请日：1999-12-21

申请人： Shinichi Shimizu ,  Fujio Mizukami ,  Yoshimichi Kiyozumi

发明人： Shinichi Shimizu ,  Fujio Mizukami ,  Yoshimichi Kiyozumi

IPC分类号： C01B3902

CPC分类号： C01B39/02 ,  B01J29/035 ,  B01J29/072 ,  B01J29/40 ,  B01J37/0236 ,  B01J2229/26 ,  B01J2229/36 ,  B01J2229/42 ,  C01B37/02 ,  C01B39/04 ,  C01B39/265 ,  C01B39/38 ,  C01B39/46 ,  Y10S423/22 ,  Y10S423/25 ,  Y10S423/29

摘要： A method of manufacturing crystalline microporous material suitable for manufacturing a variety of crystalline microporous material under mild reaction conditions and under safe working environmental conditions by using simple installation. The crystalline microporous materials obtained by the present invention may be used as adsorbent agent, catalyst or separating material. According to the characterizing features of the manufacturing method of the present invention, there are provided a method of using cation compound or amine as crystallizing modifier and using, in combination, raw material including kanemite or silicon dioxide and a further method using raw material including silicon dioxide and aluminum salt. The method includes a step of mixing these components, a solid-liquid separating step for separating produced fine particles, and a crystallizing step for crystallizing the separated solid component. The invention achieves improvement in safety, economy and so on, in comparison with the coventionally practiced hydrothermal synthesis method which requires severe reaction conditions of high-temperature, high-pressure and strong alkaline. Further, the method allows freedom in adjustment of the pore diameter and allows a higher proportion of porous structure to be maintained in a product when the material is formed into a molded product.

摘要翻译： 一种制造结晶微孔材料的方法，适用于在温和的反应条件下，在安全的工作环境条件下，通过简单的安装制造各种结晶微孔材料。 通过本发明获得的结晶微孔材料可以用作吸附剂，催化剂或分离材料。 根据本发明的制造方法的特征，提供了一种使用阳离子化合物或胺作为结晶改性剂的方法，并且组合使用包含卡米质或二氧化硅的原料，以及使用包含硅的原料的另一种方法 二氧化物和铝盐。 该方法包括混合这些组分的步骤，用于分离生成的细颗粒的固液分离步骤和用于使分离的固体组分结晶的结晶步骤。 与需要高温，高压，强碱性苛刻反应条件的常规水热合成方法相比，本发明实现了安全性，经济性等方面的改进。 此外，该方法允许调节孔径的自由度，并且当材料形成成型产品时允许在产品中保持较高比例的多孔结构。

公开(公告)号：US5595952A

公开(公告)日：1997-01-21

申请号：US401914

申请日：1995-03-09

申请人： Kazuyuki Maeda ,  Yoshimichi Kiyozumi ,  Fujio Mizukami

发明人： Kazuyuki Maeda ,  Yoshimichi Kiyozumi ,  Fujio Mizukami

IPC分类号： B01J20/18 ,  B01J20/22 ,  B01J20/281 ,  B01J27/14 ,  B01J29/83 ,  B01J31/02 ,  C01B37/08 ,  C07F9/09 ,  C07F9/38

CPC分类号： C01B37/04 ,  B01J20/0292 ,  B01J20/223 ,  B01J20/28097 ,  B01J20/284 ,  B01J29/84 ,  B01J31/0258 ,  B01J31/0259 ,  C07F9/3808 ,  B01J2220/54

摘要： There is disclosed a crystalline aluminum organophosphate stable against heating, composed of a skeleton structure having micropores therein and represented by the following formula (I) in chemical composition:formula (I)[(Al.sub.2 O.sub.3).multidot.(RPO.sub.2).sub.x ]wherein R represents an alkyl group, and x is such a number that 2.0.ltoreq.x.ltoreq.3.6. The crystalline aluminum organophosphate is a microporous material having an inner wall of pores that is hydrophobic and has a flexibility, and it may be used as a separative adsorbent, a catalyst, a packing material for chromatography, and the like.

摘要翻译： 公开了一种稳定的加热稳定的结晶铝有机磷酸酯，其由具有微孔的骨架结构组成，其化学组成如下式（I）所示：式（I）[（Al 2 O 3）x（RPO 2）x]其中R表示 烷基，x是2.0≤X≤3.6的数。 结晶有机磷酸铝是具有疏水性且具有柔软性的孔内壁的微孔材料，可以用作分离吸附剂，催化剂，色谱用填充材料等。

公开(公告)号：US20120145038A1

公开(公告)日：2012-06-14

申请号：US13391881

申请日：2010-08-24

申请人： Hajime Tsuda ,  Katsumi Motegi ,  Yusuke Takechi ,  Kazunori Kawasaki ,  Takeo Ebina ,  Fujio Mizukami

发明人： Hajime Tsuda ,  Katsumi Motegi ,  Yusuke Takechi ,  Kazunori Kawasaki ,  Takeo Ebina ,  Fujio Mizukami

IPC分类号： C09D1/00 ,  B28B13/02

CPC分类号： H01L51/0097 ,  C01B33/40 ,  H01L51/0096 ,  H01L51/5253 ,  Y02E10/549 ,  Y02P70/521

摘要： An object of the present invention is to provide a clay dispersion liquid which is capable of obtaining a clay film which realizes compatibility between heat resistance and water resistance, and a method for producing the same; a clay film and a transparent material, produced from the lay dispersion. The clay dispersion liquid of the present invention contains a liquid containing water as a main component, and a tetraphenylphosphonium-modified clay. The clay film and the transparent material of the present invention are obtained by applying the clay dispersion liquid on a surface of a supporting body to form a film.

摘要翻译： 本发明的目的是提供一种能获得实现耐热性和耐水性之间的相容性的粘土膜的粘土分散液及其制造方法。 一种粘土膜和一种透明材料，由敷料分散体制成。 本发明的粘土分散液含有以水为主要成分的液体和四苯基鏻改性粘土。 本发明的粘土膜和透明材料通过将粘土分散液涂布在支撑体的表面上以形成膜而获得。

公开(公告)号：US20110288287A1

公开(公告)日：2011-11-24

申请号：US13142897

申请日：2009-12-25

申请人： Masahiro Sato ,  Hajime Kawanami ,  Fujio Mizukami

发明人： Masahiro Sato ,  Hajime Kawanami ,  Fujio Mizukami

IPC分类号： C07H5/02 ,  B01J19/00

CPC分类号： C07H5/02 ,  A61K51/0491 ,  B01J19/0093 ,  B01J2219/00788 ,  B01J2219/00891 ,  C07B63/00 ,  C07H1/00 ,  Y02P20/544

摘要： The present invention provides: a method for synthesizing a halogen-substituted saccharide from a leaving group-substituted saccharide in a short-time and continuously; a reaction composition; and a device for synthesis of same, i.e., the method being for synthesizing a halogen-substituted saccharide from a leaving group-substituted saccharide by a halogen-substituted saccharide synthesis reaction using a subcritical fluid or a supercritical fluid as the reaction solvent; the reaction composition of the same being an aqueous solution of halogen-substituted saccharide; and the device for synthesis being a device for producing the same, the method being for producing a halogen-substituted saccharide with a subcritical fluid or a supercritical fluid at a temperature of 100 to 400° C. and a pressure of 0.1 to 40 MPa or a mixed solvent of aprotic organic solvent or inorganic solvent mixed therein as the reaction solvent, under catalyst-free condition, by introducing the leaving group-substituted saccharide and the reaction solvent into a circulating-type high-temperature and high-pressure device to produce selectively a halogen-substituted saccharide while reducing the amount of energy consumption and the amount of waste, at high yield, high selectivity, high speed and continuously.

摘要翻译： 本发明提供一种短时间连续地从离去基取代的糖中合成卤素取代的糖类的方法， 反应组合物; 以及其合成装置，即通过使用亚临界流体或超临界流体作为反应溶剂的卤素取代的糖合成反应从离去基团取代的糖合成卤素取代的糖的方法; 其反应组合物为卤素取代的糖的水溶液; 并且该合成装置是用于制备该装置的方法，该方法用于在100至400℃的温度和0.1至40MPa的压力下用亚临界流体或超临界流体制备卤素取代的糖，或 作为反应溶剂混合的非质子有机溶剂或无机溶剂的混合溶剂，在无催化剂条件下，通过将离去基取代的糖和反应溶剂引入循环型高温高压装置中来生产 选择性地卤素取代的糖，同时以高产率，高选择性，高速度和连续地降低能量消耗量和废物量。

公开(公告)号：US20110206919A1

公开(公告)日：2011-08-25

申请号：US13126568

申请日：2009-10-29

申请人： Naofumi Nagai ,  Fujio Mizukami

发明人： Naofumi Nagai ,  Fujio Mizukami

IPC分类号： B32B5/16 ,  B32B5/18 ,  C01F7/02 ,  C09K11/64 ,  B29C39/02 ,  B29D7/01

CPC分类号： C01F7/441 ,  B01D67/0048 ,  B01D69/02 ,  B01D71/025 ,  B01D2325/02 ,  B82Y30/00 ,  C01F7/30 ,  C01P2002/72 ,  C01P2002/74 ,  C01P2004/04 ,  C01P2004/10 ,  C01P2004/54 ,  C01P2004/62 ,  C01P2004/64 ,  C01P2006/16 ,  C01P2006/17 ,  C04B35/115 ,  C04B35/62218 ,  C04B35/624 ,  C04B38/0022 ,  C04B2111/00793 ,  C04B2111/00801 ,  C04B2111/00853 ,  C04B2235/3218 ,  C04B2235/441 ,  C04B2235/5224 ,  C04B2235/526 ,  C04B2235/5264 ,  C04B2235/5276 ,  C04B2235/5296 ,  C04B2235/72 ,  C04B2235/726 ,  Y10T428/268 ,  C04B38/0054 ,  C04B38/0074

摘要： The present invention provides a porous alumina self-supporting film which has a sufficient strength to be used as a self-supporting film, is flexible and has a high transparency; an alumina sol that is composed of fibrous or needle-like boehmite particles dispersed in a solution and that has a high storage stability; and methods for producing such a film and such an alumina sol. More specifically, the invention provides a porous alumina self-supporting film which is composed of a collection of fibrous or needle-like alumina hydrate particles or alumina particles having an average breadth of 1 to 10 nm, an average aspect ratio (length/breadth) of 30 to 5,000 and an average length of 100 to 10,000 nm, has an orientation, has a pore distribution with a pore diameter dpeak of 0.5 to 20 nm, is flexible, has a high transparency, and has the ability to luminesce when excited by ultraviolet light; an alumina sol which has a Na, K and SO4 content of 0 to 1 ppm, has an orientation when the particles are collected, and luminesces when excited by ultraviolet light after being fired at 250 to 900° C.; and methods for producing such a film and such an alumina sol.

摘要翻译： 本发明提供一种多孔氧化铝自支撑膜，其具有足够的强度用作自支撑膜，是柔性的并且具有高透明度; 由分散在溶液中的纤维状或针状勃姆石粒子构成的具有高储存稳定性的氧化铝溶胶; 以及制造这种膜和这种氧化铝溶胶的方法。 更具体地，本发明提供一种多孔氧化铝自支撑膜，其由平均宽度为1至10nm，平均纵横比（长/宽）的纤维或针状氧化铝水合物颗粒或氧化铝颗粒的集合组成， 30〜5000nm，平均长度为100〜10000nm，具有孔径dpeak为0.5〜20nm的孔分布，具有柔软性，透明性高，并且当被激发时具有发光能力 紫外光线; Na，K和SO4含量为0〜1ppm的氧化铝溶胶在收集粒子时具有取向，当在250〜900℃下烧成后用紫外线激发时发光。 以及制造这种膜和这种氧化铝溶胶的方法。