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27 条记录 (耗时 0.037 秒)

    PROTEIN-REFOLDING MATERIAL
    1.
    发明申请
    PROTEIN-REFOLDING MATERIAL 审中-公开
    蛋白质重建材料

    公开(公告)号：US20090005543A1

    公开(公告)日：2009-01-01

    申请号：US12204496

    申请日：2008-09-04

    申请人： Fujio MIZUKAMI ,  Yoshimichi Kiyozumi ,  Takuji Ikeda ,  Akiko Kawai ,  Takako Nagase ,  Kengo Sakaguchi ,  Hiroyuki Chiku

    发明人： Fujio MIZUKAMI ,  Yoshimichi Kiyozumi ,  Takuji Ikeda ,  Akiko Kawai ,  Takako Nagase ,  Kengo Sakaguchi ,  Hiroyuki Chiku

    IPC分类号： C07K1/08 ,  C01B39/00 ,  B01J29/06

    CPC分类号： C07K1/1133 ,  C07K1/1136 ,  C07K14/245

    摘要： The present invention provides a method for refolding protein produced, for example, by Escherichia coli, that is inactive due to an as yet unformed higher order structure, or protein deactivated due to a change in conformation for some reason. The invention comprises a method, refolding kit, refolding agent, and molding that activate a native function or activity inherent to a protein through treatment with zeolite beta of protein produced, for example, by Escherichia coli, that is inactive due to an as yet unformed higher order structure, or protein deactivated due to a change in conformation for some reason. The invention also comprises a method for producing an active protein that utilizes the same. As compared with conventional methods, the present invention can provide a novel method for activating protein function that is highly versatile and generalizable, that employs a simple and easy protocol, and that is inexpensive and enables repeated use of the function activator.

    摘要翻译： 本发明提供了一种重新折叠由例如大肠杆菌产生的蛋白质的方法，其由于尚未形成的高级结构而不活跃，或由于某种原因由于构象变化而失活的蛋白质。 本发明包括一种方法，重折叠试剂盒，重折叠剂和模制品，其通过用例如由大肠杆菌产生的蛋白质的β沸石处理而激活蛋白质固有的天然功能或活性，其由于尚未形成 由于某些原因由于构象变化而导致高阶结构或蛋白质失活。 本发明还包括一种制备利用其的活性蛋白质的方法。 与常规方法相比，本发明可以提供一种新颖的激活蛋白质功能的方法，该蛋白质功能具有高度通用性和可广泛性，采用简单易用的方案，价格便宜，能重复使用功能活化剂。

    Protein-refolding material
    2.
    发明申请
    Protein-refolding material 审中-公开
    蛋白质重折叠材料

    公开(公告)号：US20060194279A1

    公开(公告)日：2006-08-31

    申请号：US10563870

    申请日：2004-07-07

    申请人： Fujio Mizukami ,  Yoshimichi Kiyozumi ,  Takuji Ikeda ,  Akiko Kawai ,  Takako Nagase ,  Kengo Sakaguchi ,  Hiroyuki Chiku

    发明人： Fujio Mizukami ,  Yoshimichi Kiyozumi ,  Takuji Ikeda ,  Akiko Kawai ,  Takako Nagase ,  Kengo Sakaguchi ,  Hiroyuki Chiku

    IPC分类号： C12P21/06 ,  C07K14/47 ,  C07K14/195 ,  C12N9/00

    CPC分类号： C07K1/1133 ,  C07K1/1136 ,  C07K14/245

    摘要： The present invention provides a method for refolding protein produced, for example, by Escherichia coli, that is inactive due to an as yet unformed higher order structure, or protein deactivated due to a change in conformation for some reason. The invention comprises a method, refolding kit, refolding agent, and molding that activate a native function or activity inherent to a protein through treatment with zeolite beta of protein produced, for example, by Escherichia coli, that is inactive due to an as yet unformed higher order structure, or protein deactivated due to a change in conformation for some reason. The invention also comprises a method for producing an active protein that utilizes the same. As compared with conventional methods, the present invention can provide a novel method for activating protein function that is highly versatile and generalizable, that employs a simple and easy protocol, and that is inexpensive and enables repeated use of the function activator.

    摘要翻译： 本发明提供了一种重新折叠由例如大肠杆菌产生的蛋白质的方法，其由于尚未形成的高级结构而不活跃，或由于某种原因由于构象变化而失活的蛋白质。 本发明包括一种方法，重折叠试剂盒，重折叠剂和模制品，其通过用例如由大肠杆菌产生的蛋白质的β沸石处理而激活蛋白质固有的天然功能或活性，其由于尚未形成 由于某些原因由于构象变化而导致高阶结构或蛋白质失活。 本发明还包括一种制备利用其的活性蛋白质的方法。 与常规方法相比，本发明可以提供一种新颖的激活蛋白质功能的方法，该蛋白质功能具有高度通用性和可广泛性，采用简单易用的方案，价格便宜，能重复使用功能活化剂。

    Sulfoquinovosylacylglycerol derivative, and use thereof as medicaments
    7.
    发明授权
    Sulfoquinovosylacylglycerol derivative, and use thereof as medicaments 失效
    磺基喹诺酮酰基甘油衍生物及其作为药物的用途

    公开(公告)号：US06518410B2

    公开(公告)日：2003-02-11

    申请号：US09949907

    申请日：2001-09-10

    申请人： Takayuki Yamazaki ,  Fumio Sugawara ,  Keisuke Ohta ,  Kazuyoshi Masaki ,  Kotaro Nakayama ,  Kengo Sakaguchi ,  Noriyuki Sato ,  Hiroeki Sahara ,  Tatsuya Fujita

    发明人： Takayuki Yamazaki ,  Fumio Sugawara ,  Keisuke Ohta ,  Kazuyoshi Masaki ,  Kotaro Nakayama ,  Kengo Sakaguchi ,  Noriyuki Sato ,  Hiroeki Sahara ,  Tatsuya Fujita

    IPC分类号： A61K3170

    CPC分类号： C07H15/04 ,  A61K31/7032 ,  C07H13/00

    摘要： A method for immunosuppression in a subject comprising administering to the subject in need thereof, a pharmaceutically effective amount of at least one sulfoquinovosylacylglycerol derivative represented by General formula (1-1): wherein R101 represents an acyl residue of a higher fatty acid, and R102 represents a hydrogen atom or an acyl residue of a higher fatty acid; and a pharmaceutically acceptable salt thereof. Of the sulfoquinovosylacylglycerol derivatives, &bgr;-sulfoquinovosylacylglycerols are novel compounds. The present invention also relates to pharmaceutical composition comprising a pharmaceutically effective amount of the &bgr;-sulfoquinovosylacylglycerols and/or its pharmaceutically acceptable salt; and a pharmaceutically acceptable excipient. The pharmaceutical composition may be used as an immunosuppressive agent, anticancer agent and DNA polymerase &agr; inhibitor.

    摘要翻译： 一种受试者的免疫抑制方法，包括向有需要的受试者施用药学上有效量的通式（1-1）表示的至少一种磺基秋水仙酰基甘油衍生物：其中，R 101表示高级脂肪酸的酰基残基，R 102 表示氢原子或高级脂肪酸的酰基残基; 及其药学上可接受的盐。 在磺基奎诺糖基酰基甘油衍生物中，β-磺基奎诺乙酰基酰基甘油是新化合物。 本发明还涉及药物组合物，其包含药学上有效量的β-磺基奎诺乙酰基酰基甘油和/或其药学上可接受的盐; 和药学上可接受的赋形剂。 药物组合物可以用作免疫抑制剂，抗癌剂和DNA聚合酶α抑制剂。

    COMPOUND HAVING TUMOR-RESIDENT PROPERTY
    10.
    发明申请
    COMPOUND HAVING TUMOR-RESIDENT PROPERTY 审中-公开
    具有肿瘤活性物质的化合物

    公开(公告)号：US20100202971A1

    公开(公告)日：2010-08-12

    申请号：US12688153

    申请日：2010-01-15

    申请人： Keisuke OHTA ,  Masahiko Miura ,  Kengo Sakaguchi ,  Fumio Sugawara ,  Masahiro Ishima ,  Hiroshi Murata

    发明人： Keisuke OHTA ,  Masahiko Miura ,  Kengo Sakaguchi ,  Fumio Sugawara ,  Masahiro Ishima ,  Hiroshi Murata

    IPC分类号： A61K49/00 ,  C07D315/00 ,  A61K31/70

    CPC分类号： C07H15/10 ,  A61K47/551 ,  C07H15/04 ,  C07H15/06 ,  C07H15/08 ,  C07H15/18

    摘要： The problem to be solved of the present invention is to provide a novel compound which specifically resides in a tumor, a method for allowing it to reside in a tumor, and a method for detecting, diagnosing, and treating tumor with use thereof. Means for solving the problem is a compound represented by chemical formula (I) wherein R is an anionic group binding to hydrogen, R1 is OH, OCOH, OCO(CH2)hCH3, or an acting group, h being an integer of 0 or more, R2 is H, OH, OCOH, OCO(CH2)iCH3, or an acting group, i being an integer of 0 or more, R3 is OH, SO3H, or an acting group, R4 is OH, SO3H, or an acting group, and R5 is OH, SO3H, or an acting group, at least one of R1, R2, R3, R4, and R5 containing an acting group, or pharmaceutically acceptable salts thereof.

    摘要翻译： 本发明要解决的问题是提供一种特异性存在于肿瘤中的新型化合物，使其能够存在于肿瘤中的方法，以及使用该方法检测，诊断和治疗肿瘤的方法。 用于解决问题的方法是由化学式（I）表示的化合物，其中R是与氢结合的阴离子基团，R 1是OH，OCOH，OCO（CH 2）h CH 3或作用基团，h是0或更大的整数 ，R2为H，OH，OCOH，OCO（CH2）iCH3或作用基，i为0以上的整数，R3为OH，SO3H或作用基，R4为OH，SO3H或作用基团 R5为OH，SO3H或作用基团，含有作用基团的R1，R2，R3，R4和R5中的至少一个或其药学上可接受的盐。