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    Nanoparticles comprising biologically active TNF which is immobilized on the same
    1.
    发明授权
    Nanoparticles comprising biologically active TNF which is immobilized on the same 失效
    包含固定在其上的生物活性TNF的纳米颗粒

    公开(公告)号：US07368295B2

    公开(公告)日：2008-05-06

    申请号：US10488374

    申请日：2002-08-16

    申请人： Günter Tovar ,  Thomas Schiestel ,  Herwig Brunner ,  Klaus Pfizenmaier ,  Matthias Grell ,  Peter Scheurich ,  Angela Hammer

    发明人： Günter Tovar ,  Thomas Schiestel ,  Herwig Brunner ,  Klaus Pfizenmaier ,  Matthias Grell ,  Peter Scheurich ,  Angela Hammer

    IPC分类号： G01N33/553

    CPC分类号： B82Y5/00 ,  A61K38/191 ,  A61K47/62 ,  A61K47/6923 ,  A61K47/6933 ,  C07K17/06

    摘要： The present invention relates to nanoparticles with tumor necrosis factor (TNF) or cytokine immobilized thereon, where TNF or the cytokine is preferably immobilized in the form of a trimer in directed fashion and with retention of its biological activity on the carrier, to methods for the directed immobilization of TNF or cytokine on nanoparticles, to the use of the nanoparticles having immobilized TNF or cytokine for the identification and/or isolation of cytokine- or TNF-binding partners and for the identification and/or isolation of inhibitors of the interaction between TNF or cytokine and its binding partners, to the use of such nanoparticles for preparing a pharmaceutical composition, in particular for the therapy of tumors, and to pharmaceutical and diagnostic compositions which comprise such nanoparticles.

    摘要翻译： 本发明涉及具有固定在其上的肿瘤坏死因子（TNF）或细胞因子的纳米颗粒，其中TNF或细胞因子优选以三聚体的形式以有针对性的方式固定并保持其在载体上的生物活性， 将TNF或细胞因子定向固定在纳米颗粒上，使用具有固定的TNF或细胞因子的纳米颗粒用于鉴定和/或分离细胞因子或TNF结合配偶体，以及鉴定和/或分离TNF相互作用的抑制剂 或细胞因子及其结合配偶体，使用这种纳米颗粒来制备药物组合物，特别是用于治疗肿瘤，以及包含这种纳米颗粒的药物和诊断组合物。