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公开(公告)号：US20120019046A1
公开(公告)日：2012-01-26
申请号：US13188682
申请日：2011-07-22
申请人： Georges Driesen , Roland Doerr , Thorsen Koch , Michael Schmid , Bernd Nootbaar , Michael Dümig , Wolfgang Schüppert , Christian Stief , Peter Scheurich , Roland Trombelli
发明人： Georges Driesen , Roland Doerr , Thorsen Koch , Michael Schmid , Bernd Nootbaar , Michael Dümig , Wolfgang Schüppert , Christian Stief , Peter Scheurich , Roland Trombelli
IPC分类号： A46D3/04
CPC分类号： A46D9/025 , A46B9/028 , A46B2200/1066 , A61C17/222
摘要： The present invention relates to a method for producing a brush head for a toothbrush head in which the bristle tufts that are already fixed to a bristle support of the brush head are cut at the free ends thereof such that a desired tuft end contour is generated. According to the invention, at least one bristle tuft is bent away at least in parts and held in a bent-away position while the tuft end contour of this at least one and/or of another bristle tuft is cut.
摘要翻译： 本发明涉及一种用于制造用于牙刷头的刷头的方法，其中已经固定到刷头的刷毛支撑件的刷毛簇在其自由端处被切割，使得产生期望的绒头端部轮廓。 根据本发明，至少一个刷毛簇至少部分弯曲并保持在弯曲位置，同时切割该至少一个和/或另一个刷毛簇的绒头端轮廓。
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公开(公告)号：US08651582B2
公开(公告)日：2014-02-18
申请号：US13188682
申请日：2011-07-22
申请人： Georges Driesen , Roland Doerr , Thorsten Koch , Michael Schmid , Bernd Nootbaar , Michael Dümig , Wolfgang Schüppert , Christian Stief , Peter Scheurich , Roland Trombelli
发明人： Georges Driesen , Roland Doerr , Thorsten Koch , Michael Schmid , Bernd Nootbaar , Michael Dümig , Wolfgang Schüppert , Christian Stief , Peter Scheurich , Roland Trombelli
CPC分类号： A46D9/025 , A46B9/028 , A46B2200/1066 , A61C17/222
摘要： The present invention relates to a method for producing a brush head for a toothbrush head in which the bristle tufts that are already fixed to a bristle support of the brush head are cut at the free ends thereof such that a desired tuft end contour is generated. According to the invention, at least one bristle tuft is bent away at least in parts and held in a bent-away position while the tuft end contour of this at least one and/or of another bristle tuft is cut.
摘要翻译： 本发明涉及一种用于制造用于牙刷头的刷头的方法，其中已经固定到刷头的刷毛支撑件的刷毛簇在其自由端处被切割，使得产生期望的绒头端部轮廓。 根据本发明，至少一个刷毛簇至少部分弯曲并保持在弯曲位置，同时切割该至少一个和/或另一个刷毛簇的绒头端轮廓。
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公开(公告)号：US20100150916A1
公开(公告)日：2010-06-17
申请号：US12531000
申请日：2008-03-13
IPC分类号： A61K39/395 , C07K14/435 , C07K16/00 , C07K14/765 , C07H21/04 , C12N15/63 , C12N5/10 , A61K38/17 , A61P25/00 , A61P29/00 , A61P31/12 , A61P37/00
CPC分类号： C07K16/241 , A61K38/00 , C07K16/2878 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to a ligand which specifically binds to the human tumor necrosis factor type 1 receptor (huTNFR1), the ligand comprising one or more amino acid sequences of human origin capable of reducing the immunogenic response of the ligand in human beings and one or more amino acid sequences capable of selectively binding to huTNFR1. The present invention further relates to a nucleic acid encoding said ligand and to a pharmaceutical composition for the treatment of disorders connected to huTNFR1.
摘要翻译： 本发明涉及特异性结合人类肿瘤坏死因子1型受体（huTNFR1）的配体，该配体包含一个或多个人源氨基酸序列，其能够降低人体中配体的免疫原性应答， 能够选择性结合huTNFR1的更多氨基酸序列。 本发明还涉及编码所述配体的核酸和用于治疗与huTNFR1相关的病症的药物组合物。
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4.发明申请Recombinant Polypeptides of the Members of the Tnf Ligand Family and Use Thereof 有权Tnf配体家族成员的重组多肽及其用途公开(公告)号：US20070286843A1
公开(公告)日：2007-12-13
申请号：US10594189
申请日：2005-03-24
IPC分类号： A61K38/02 , A61K31/7088 , A61K48/00 , A61P25/00 , A61P35/00 , C12N1/00 , C12N15/63 , C12N15/64 , C12N15/11 , C07K2/00 , A61P31/00 , A61P19/02 , A61K35/14
CPC分类号： C07K14/525 , A61K38/00 , A61K45/06 , C07K14/70575 , C07K16/40 , C07K2317/622 , C07K2319/00 , G01N33/53 , G01N33/543 , G01N33/544 , G01N33/6863 , G01N2333/525 , Y10S530/811 , Y10S530/812
摘要： The invention relates to polypeptides comprising, as constituent A, at least three monomers of a member of the TNF ligand family and, as constituent B, at least two peptide linkers that link the monomers of the member of the TNF ligand family to one another. The invention also relates to the use of these polypeptides for treating diseases and for producing a medicament or a vaccine. The invention also relates to methods for producing and isolating these polypeptides, to nucleic acids that code for these polypeptides, to vectors containing these nucleic acids, to host cells transfected with these vectors, and to pharmaceutical compositions containing these inventive objects. Finally, the invention relates to methods for the extracorporeal manipulation, depletion and/or removal of components contained in body fluids, e.g. by means of apheresis.
摘要翻译： 本发明涉及包含作为组分A的至少三种TNF配体家族成员的单体和作为组分B的至少两个将TNF配体家族成员的单体相互连接的肽接头的多肽。 本发明还涉及这些多肽用于治疗疾病和用于制备药物或疫苗的用途。 本发明还涉及生产和分离这些多肽的方法，编码这些多肽的核酸，含有这些核酸的载体，宿主用这些载体转染的细胞，以及含有这些发明物质的药物组合物。 最后，本发明涉及用于体外操作，耗尽和/或去除体液中所含组分的体外操作方法。 通过血液分离术。
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5.发明授权Nanoparticles comprising biologically active TNF which is immobilized on the same 失效包含固定在其上的生物活性TNF的纳米颗粒公开(公告)号：US07368295B2
公开(公告)日：2008-05-06
申请号：US10488374
申请日：2002-08-16
申请人： Günter Tovar , Thomas Schiestel , Herwig Brunner , Klaus Pfizenmaier , Matthias Grell , Peter Scheurich , Angela Hammer
发明人： Günter Tovar , Thomas Schiestel , Herwig Brunner , Klaus Pfizenmaier , Matthias Grell , Peter Scheurich , Angela Hammer
IPC分类号： G01N33/553
CPC分类号： B82Y5/00 , A61K38/191 , A61K47/62 , A61K47/6923 , A61K47/6933 , C07K17/06
摘要： The present invention relates to nanoparticles with tumor necrosis factor (TNF) or cytokine immobilized thereon, where TNF or the cytokine is preferably immobilized in the form of a trimer in directed fashion and with retention of its biological activity on the carrier, to methods for the directed immobilization of TNF or cytokine on nanoparticles, to the use of the nanoparticles having immobilized TNF or cytokine for the identification and/or isolation of cytokine- or TNF-binding partners and for the identification and/or isolation of inhibitors of the interaction between TNF or cytokine and its binding partners, to the use of such nanoparticles for preparing a pharmaceutical composition, in particular for the therapy of tumors, and to pharmaceutical and diagnostic compositions which comprise such nanoparticles.
摘要翻译： 本发明涉及具有固定在其上的肿瘤坏死因子（TNF）或细胞因子的纳米颗粒，其中TNF或细胞因子优选以三聚体的形式以有针对性的方式固定并保持其在载体上的生物活性， 将TNF或细胞因子定向固定在纳米颗粒上，使用具有固定的TNF或细胞因子的纳米颗粒用于鉴定和/或分离细胞因子或TNF结合配偶体，以及鉴定和/或分离TNF相互作用的抑制剂 或细胞因子及其结合配偶体，使用这种纳米颗粒来制备药物组合物，特别是用于治疗肿瘤，以及包含这种纳米颗粒的药物和诊断组合物。
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6.发明授权Recombinant polypeptides of the members of the TNF ligand family and use thereof 有权TNF配体家族成员的重组多肽及其用途公开(公告)号：US08927205B2
公开(公告)日：2015-01-06
申请号：US10594189
申请日：2005-03-24
IPC分类号： G01N33/48 , G01N33/49 , G01N33/50 , G01N33/53 , G01N33/543 , C07K14/525 , A61K45/06 , C07K14/705 , C07K16/40 , G01N33/544 , G01N33/68 , A61K38/00
CPC分类号： C07K14/525 , A61K38/00 , A61K45/06 , C07K14/70575 , C07K16/40 , C07K2317/622 , C07K2319/00 , G01N33/53 , G01N33/543 , G01N33/544 , G01N33/6863 , G01N2333/525 , Y10S530/811 , Y10S530/812
摘要： The invention relates to polypeptides comprising, as constituent A, at least three monomers of a member of the TNF ligand family and, as constituent B, at least two peptide linkers that link the monomers of the member of the TNF ligand family to one another. The invention also relates to the use of these polypeptides for treating diseases and for producing a medicament or a vaccine. The invention also relates to methods for producing and isolating these polypeptides, to nucleic acids that code for these polypeptides, to vectors containing these nucleic acids, to host cells transfected with these vectors, and to pharmaceutical compositions containing these inventive objects. Finally, the invention relates to methods for the extracorporeal manipulation, depletion and/or removal of components contained in body fluids, e.g. by means of apheresis.
摘要翻译： 本发明涉及包含作为组分A的至少三种TNF配体家族成员的单体和作为组分B的至少两个将TNF配体家族成员的单体相互连接的肽接头的多肽。 本发明还涉及这些多肽用于治疗疾病和用于制备药物或疫苗的用途。 本发明还涉及生产和分离这些多肽的方法，编码这些多肽的核酸，含有这些核酸的载体，宿主用这些载体转染的细胞，以及含有这些发明物质的药物组合物。 最后，本发明涉及用于体外操作，耗尽和/或去除体液中所含组分的体外操作方法。 通过血液分离术。
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公开(公告)号：US08404238B2
公开(公告)日：2013-03-26
申请号：US12531000
申请日：2008-03-13
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/241 , A61K38/00 , C07K16/2878 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to a ligand, which specifically binds to human tumor necrosis factor type 1 receptor (huTNFR1). The ligand includes one or more amino acid sequences of human origin capable of reducing the immunogenic response of the ligand in humans and one or more amino acid sequences capable of selectively binding to huTNFR1. The present invention also relates to a nucleic acid sequence encoding the ligand and to a pharmaceutical composition for the treatment of disorders related to huTNFR1.
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8.发明授权Monoclonal antibodies with specific binding against membrane proteins on human cells, and pharmaceutical compositions containing them 失效对人细胞上的膜蛋白具有特异性结合的单克隆抗体，以及含有它们的药物组合物
公开(公告)号：US5736138A
公开(公告)日：1998-04-07
申请号：US654257
申请日：1991-02-12
IPC分类号： A61K39/00 , A61K38/00 , A61K39/395 , A61P29/00 , A61P31/12 , A61P31/18 , A61P35/00 , A61P37/00 , C07K1/16 , C07K1/22 , C07K14/52 , C07K14/525 , C07K14/705 , C07K14/715 , C07K16/00 , C07K16/28 , C12N5/10 , C12N5/18 , C12N5/20 , C12N15/02 , C12P21/08 , C12R1/91 , C07K16/18
CPC分类号： C07K16/2866 , A61K38/00 , Y10S424/809 , Y10S530/866
摘要： A monoclonal antibody, or fragments thereof, against human TNF receptor protein which antibody neutralizes the known actions of TNF.alpha. and/or TNF.beta. is disclosed. The antibody may be chimeric or humanized. Furthermore, the present invention provides a process for obtaining the above monoclonal antibody, as well as a pharmaceutical composition containing the above monoclonal antibody and/or the above protein with antibody properties.
摘要翻译： 公开了针对人TNF受体蛋白的单克隆抗体或其片段，其抗体中和TNFα和/或TNFβ的已知作用。 抗体可以是嵌合的或人源化的。 此外，本发明提供了获得上述单克隆抗体的方法，以及含有上述单克隆抗体和/或具有抗体特性的上述蛋白质的药物组合物。
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